Tea Tree Oil Drug Interactions, Uses, Effectiveness, Safety & More
What is this page for?
First and foremost: how Tea Tree Oil interacts with medications. The heart of this page is the interaction list — every drug Tea Tree Oil is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what Tea Tree Oil is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
Check Tea Tree Oil against your medication
Add one medicationDrugs that interact with Tea Tree Oil
0 medications have a known interaction with Tea Tree Oil, graded by severity. Select any drug for the full evidence-based detail.
We don’t currently list any known drug interactions for Tea Tree Oil. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.
What Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact Tea Tree Oil combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Tea Tree Oil: Uses, Safety & Side Effects
Tea tree oil is an essential oil used on the skin for acne, fungal infections, and other skin problems, with some supportive but limited evidence. It is for topical use only and should never be swallowed, as it can be toxic. Always dilute it, do a patch test first, and check with your pharmacist or doctor before using.
- Scientific name
- Melaleuca alternifolia
- Family
- Myrtaceae
- Part used
- Leaves and twigs (steam-distilled into essential oil)
- Common forms
- Essential oil, creams, gels, ointments, soaps, shampoos, mouthwash
- Acne
- Fungal skin infections (athlete's foot, nail fungus)
- Dandruff
- Minor wounds and insect bites
- Lice
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
Generally safe when used diluted on the skin, but it is toxic if swallowed.
When used topically and appropriately.
Read the full breastfeeding detailPregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
Tea tree oil is an essential oil made from the leaves of the Melaleuca alternifolia plant, a small tree native to Australia. The leaves are steam-distilled to create a strong-smelling oil that people have used for many years in traditional and folk medicine.
Today it is a popular ingredient in skincare and personal-care products. You will find it in acne treatments, antifungal creams, shampoos, soaps, and mouthwashes. It is used on the skin only and should not be swallowed.
How it works
Tea tree oil contains many natural compounds. One of the most studied is terpinen-4-ol, which researchers believe gives the oil much of its activity against bacteria, fungi, and possibly inflammation.
In laboratory studies, tea tree oil can slow or kill certain microbes and may calm skin redness and swelling. However, much of this work is done in test tubes or on animals, so it does not always predict how well the oil works on real skin conditions in people.
Does Tea Tree Oil work?
How to read these evidence grades
Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.
Possibly Effective Acne
Some clinical research shows that topical tea tree oil seems to improve symptoms of acne in adults and adolescents.
Possibly Effective Onychomycosis
Some clinical research suggests that topical pure tea tree oil seems to be beneficial for onychomycosis. It is unclear if the diluted oil is beneficial.
Possibly Effective Tinea pedis
Some clinical research suggests that topical tea tree oil 25% or 50% seems to be beneficial for tinea pedis, although it does not seem to work as well as standard treatments.
Also studied for 30 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Bacterial vaginosis
Although there is interest in using intravaginal tea tree oil for bacterial vaginosis, there is insufficient reliable information about the clinical effects of tea tree oil for this condition.
Insufficient Reliable Evidence To Rate Blepharitis
Topical tea tree oil has only been evaluated in combination with other ingredients; its effect when used alone is unclear.
Insufficient Reliable Evidence To Rate Cheilitis
Although there is interest in using topical tea tree oil for cheilitis, there is insufficient reliable information about the clinical effects of tea tree oil for this purpose.
Insufficient Reliable Evidence To Rate Contact dermatitis
Preliminary clinical research suggests that topical tea tree oil is beneficial for nickel-induced contact dermatitis.
Insufficient Reliable Evidence To Rate Dandruff
It is unclear if topical tea tree oil is beneficial for dandruff in adults and adolescents.
Insufficient Reliable Evidence To Rate Dental plaque
It is unclear if brushing or rinsing with tea tree oil is beneficial for dental plaque; the available evidence is conflicting.
Insufficient Reliable Evidence To Rate Dry eye
It is unclear if topical tea tree oil is beneficial for improving symptoms of dry eye due to cataract surgery or meibomian gland dysfunction.
Insufficient Reliable Evidence To Rate Furuncles (boils)
Although there is interest in using topical tea tree oil for boils, there is insufficient reliable information about the clinical effects of tea tree oil for this condition.
Insufficient Reliable Evidence To Rate Gingivitis
It is unclear if brushing or rinsing with tea tree oil is beneficial for gingivitis; the available evidence is conflicting.
Insufficient Reliable Evidence To Rate Halitosis
It is unclear if tea tree oil mouth rinses are beneficial for halitosis.
Insufficient Reliable Evidence To Rate Hemorrhoids
Topical tea tree oil has only been evaluated in combination with other ingredients; its effect when used alone is unclear.
Insufficient Reliable Evidence To Rate Herpes labialis (cold sores)
It is unclear if topical tea tree oil is beneficial for herpes labialis.
Insufficient Reliable Evidence To Rate Hirsutism
Topical tea tree oil has only been evaluated in combination with other ingredients; its effect when used alone is unclear.
Insufficient Reliable Evidence To Rate Insect bite
Although there is interest in using topical tea tree oil for insect bites, there is insufficient reliable information about the clinical effects of tea tree oil for this purpose.
Insufficient Reliable Evidence To Rate Lice
Topical tea tree oil has only been evaluated in combination with other ingredients; its effect when used alone is unclear.
Insufficient Reliable Evidence To Rate Methicillin-resistant Staphylococcus aureus (MRSA)
It is unclear if topical tea tree oil is beneficial for the prevention of MRSA colonization or the treatment of MRSA infection.
Insufficient Reliable Evidence To Rate Nipple Fissures
It is unclear if topical tea tree oil improves nipple-related complications of breastfeeding, such as nipple fissures and pain.
Insufficient Reliable Evidence To Rate Ocular demodicosis
It is unclear if topical tea tree oil is beneficial for ocular demodicosis; available evidence is conflicting.
Insufficient Reliable Evidence To Rate Oropharyngeal candidiasis
It is unclear if rinsing the mouth with tea tree oil is beneficial for the prevention of oropharyngeal candidiasis in various populations.
Insufficient Reliable Evidence To Rate Otitis externa
Although there is interest in using tea tree oil in the ear for otitis externa, there is insufficient reliable information about the clinical effects of tea tree oil for this condition.
Insufficient Reliable Evidence To Rate Otitis media
Although there is interest in using tea tree oil in the ear for otitis media, there is insufficient reliable information about the clinical effects of tea tree oil for this condition.
Insufficient Reliable Evidence To Rate Pharyngitis
Although there is interest in gargling with tea tree oil for pharyngitis, there is insufficient reliable information about the clinical effects of tea tree oil for this purpose.
Insufficient Reliable Evidence To Rate Rosacea
Topical tea tree oil has only been evaluated in combination with other ingredients; its effect when used alone is unclear.
Insufficient Reliable Evidence To Rate Scabies
Although there is interest in using topical tea tree oil for scabies, there is insufficient reliable information about the clinical effects of tea tree oil for this condition.
Insufficient Reliable Evidence To Rate Seborrheic dermatitis
Although there is interest in using topical tea tree oil for seborrheic dermatitis, there is insufficient reliable information about the clinical effects of tea tree oil for this condition.
Insufficient Reliable Evidence To Rate Tinea corporis
Although there is interest in using topical tea tree oil for tinea corporis, there is insufficient reliable information about the clinical effects of tea tree oil for this condition.
Insufficient Reliable Evidence To Rate Toothache
Although there is interest in rinsing the mouth with tea tree oil for toothache, there is insufficient reliable information about the clinical effects of tea tree oil for this purpose.
Insufficient Reliable Evidence To Rate Vaccine reaction
Topical tea tree oil has only been evaluated in combination with other ingredients; its effect when used alone is unclear.
Insufficient Reliable Evidence To Rate Water warts
It is unclear if topical tea tree oil is beneficial for water warts in children.
Insufficient Reliable Evidence To Rate Wound healing
Although there is interest in topical tea tree oil for wound healing, there is insufficient reliable information about the clinical effects of tea tree oil for this purpose.
Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.
Safety & precautions
Tea tree oil is for external use only. Swallowing it can cause serious poisoning, including confusion, loss of coordination, and other dangerous effects. Keep it well out of reach of children and pets.
Always dilute the oil with a carrier oil (such as coconut or olive oil) before applying it, and do a small patch test on your skin first to check for a reaction. Avoid getting it in the eyes, inside the nose, or on broken or very sensitive skin.
Because there is little safety data, pregnant and breastfeeding people should be cautious—avoid swallowing it entirely, limit topical use, keep it away from the breast and nipple area, and talk with a doctor or pharmacist first.
Side effects
The most common side effects are skin-related: redness, itching, burning, dryness, or a rash where the oil is applied. Using it undiluted makes irritation more likely.
Some people develop an allergic skin reaction (contact dermatitis), which can get worse with repeated use. Older or oxidized oil may be more irritating. There have also been reports linking topical tea tree oil products to temporary breast tissue growth in young boys, though this is not fully understood. Stop use and seek care if you notice swelling, a severe rash, or trouble breathing.
Tea Tree Oil: Reported Adverse Effects
Documented safety reports on Tea Tree Oil from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.
Orally, tea tree oil can cause significant toxicity and should not be used. Topically, tea tree oil is generally well tolerated.
Most Common Adverse Effects:
Topically: Allergic reactions, burning, dryness, irritation, pruritus, redness, and stinging.
Acne Dermatologic
Ingestion of as little as 2.5 mL of tea tree oil can cause petechial body rash. It can take up to a week for symptoms to resolve.
Topically, tea tree oil is usually well tolerated. However, it can cause local irritation and inflammation in some patients. Treatment with topical corticosteroids may be needed in some cases. Severe allergic contact dermatitis has also been reported. Tea tree oil can cause skin dryness, and less frequently pruritus, stinging, burning, and redness in patients with acne. It may also cause mild oral mucosal burning.
- Elliott C. Tea tree oil poisoning. Med J Aust 1993;159:830-1.
- Satchell AC, Saurajen A, Bell C, Barnetson RS. Treatment of interdigital tinea pedis with 25% and 50% tea tree oil solution: a randomized, placebo-controlled, blinded study. Australas J Dermatol 2002;43:175-8..
- Martin KW, Ernst E. Herbal medicines for treatment of fungal infections: a systematic review of controlled clinical trials. Mycoses 2004;47:87-92.
- Enshaieh S, Jooya A, Siadat AH, and Iraji F. The efficacy of 5% topical tea tree oil gel in mild to moderate acne vulgaris: a randomized, double-blind placebo-controlled study. Indian J Dermatol Venereol Leprol 2007;73(1):22-25.
- Christoffers WA, Blömeke B, Coenraads PJ, Schuttelaar ML. Co-sensitization to ascaridole and tea tree oil. Contact Dermatitis. 2013 Sep;69(3):187-9.
- Corazza M, Borghi A, Gallo R, Schena D, Pigatto P, Lauriola MM, Guarneri F, Stingeni L, Vincenzi C, Foti C, Virgili A. Topical botanically derived products: use, skin reactions, and usefulness of patch tests. A multicentre Italian study. Contact Dermatiti
- Navarro-Triviño FJ, Prados-Carmona Á, Ruiz-Villaverde R. Systemic allergic contact dermatitis caused by tea tree oil in a cream for treatment of molluscum contagiosum. Contact Dermatitis 2022;87(3):285-287.
- Bekhof AMW, van Hunsel FPAM, van de Koppel S, Woerdenbag HJ. Safety assessment and adverse drug reaction reporting of tea tree oil (Melaleuca aetheroleum). Phytother Res 2022.
- Ambrogio F, Foti C, Cazzato G, et al. Spreading Allergic Contact Dermatitis to Tea Tree Oil in an Over-the-Counter Product Applied on a Wart. Medicina (Kaunas) 2022;58(5):561.
- Samaran Q, Litovsky J, Girod M, Dereure O, Raison-Peyron N. Allergic Contact Dermatitis to Tea Tree Oil With No Sensitization to Fragrance Markers. Dermatitis 2023.
- Bassett IB, Pannowitz DL, Barnetson RS. A comparative study of tea-tree oil versus benzoylperoxide in the treatment of acne. Med J Aust 1990;153:455-8.
- Kwon HH, Yoon JY, Park SY, Min S, Suh DH. Comparison of clinical and histological effects between lactobacillus-fermented Chamaecyparis obtusa and tea tree oil for the treatment of acne: an eight-week double-blind randomized controlled split-face study. D
- Jandourek A, Vaishampayan JK, Vazquez JA. Efficacy of melaleuca oral solution for the treatment of fluconazole refractory oral candidiasis in AIDS patients. AIDS 1998;12:1033-7.
Depression Neurologic/CNS
Orally, tea tree oil can cause ataxia and CNS depression.
Dermatitis Immunologic
Orally, tea tree oil can cause or worsen systemic contact dermatitis. Topically, tea tree oil is usually well tolerated. However, it can cause allergic contact eczema and allergic contact dermatitis in some children and adults. Corticosteroids may be needed in some cases.
In young children, ingestion of 10 mL or less of tea tree oil can cause significant ataxia, drowsiness, disorientation, and coma.
- Carson CF, Riley TV, Cookson BD. Efficacy and safety of tea tree oil as a topical antimicrobial agent. J Hosp Infect 1998;40:175-8.
- De Groot A. C. and Weyland J. W. Systemic contact dermatitis from tea tree oil. Contact Dermatitis 1992;27(4):279-280.
- De Groot AC. Airborn allergic contact dermatitis from tea tree oil. Contact Dermatitis 1996;35:304-5.
- Rubel DM, Freeman S, Southwell IA. Tea tree oil allergy: what is the offending agent? Report of three cases of tea tree oil allergy and review of the literature. Australas J Dermatol 1998;39:244-7.
- Bhushan M, Beck MH. Allergic contact dermatitis from tea tree oil in a wart paint. Contact Dermatitis 1997;36:117-8.
- Knight TE, Hausen BM. Melaleuca oil (tea tree oil) dermatitis. J Am Acad Dermatol 1994;30:423-7..
- Bruynzeel DP. Contact dermatitis due to tea tree oil. Trop Med Int Health 1999;4:630.
- Greig JE, Thoo SL, Carson CF, Riley TV. Allergic contact dermatitis following use of a tea tree oil hand-wash not due to tea tree oil. Contact Dermatitis 1999;41:354-5.
- Varma S, Blackford S, Statham BN, Blackwell A. Combined contact allergy to tea tree oil and lavender oil complicating chronic vulvovaginitis. Contact Dermatitis 2000;42:309-10.
- Khanna M, Qasem K, Sasseville D. Allergic contact dermatitis to tea tree oil with erythema multiforme-like id reaction. Am J Contact Dermat 2000;11:238-42..
- Corazza M, Borghi A, Gallo R, Schena D, Pigatto P, Lauriola MM, Guarneri F, Stingeni L, Vincenzi C, Foti C, Virgili A. Topical botanically derived products: use, skin reactions, and usefulness of patch tests. A multicentre Italian study. Contact Dermatiti
- Martínez Campayo N, Goday Buján JJ, Fonseca Capdevila E. Allergic contact dermatitis due to tea tree oil. Actas Dermosifiliogr (Engl Ed). 2020;111(9):787-788.
- Lauriola MM, Sena P, De Bitonto A, Corazza M. Allergic contact dermatitis due to "therapeutic uses" of tea tree oil on the lips and toenails. Dermatitis. 2021;32(3):e40-e41.
- Bekhof AMW, van Hunsel FPAM, van de Koppel S, Woerdenbag HJ. Safety assessment and adverse drug reaction reporting of tea tree oil (Melaleuca aetheroleum). Phytother Res 2022.
- Ambrogio F, Foti C, Cazzato G, et al. Spreading Allergic Contact Dermatitis to Tea Tree Oil in an Over-the-Counter Product Applied on a Wart. Medicina (Kaunas) 2022;58(5):561.
- Samaran Q, Litovsky J, Girod M, Dereure O, Raison-Peyron N. Allergic Contact Dermatitis to Tea Tree Oil With No Sensitization to Fragrance Markers. Dermatitis 2023.
- Del Beccaro MA. Melaleuca oil poisoning in a 17-month-old. Vet Hum Toxicol 1995;37:557-8.
- Jacobs MR, Hornfeldt CS. Melaleuca oil poisoning. J Toxicol Clin Toxicol 1994;32:461-4..
- Morris MC, Donoghue A, Markowitz JA, Osterhoudt KC. Ingestion of tea tree oil (Melaleuca oil) by a 4-year-old boy. Pediatr Emerg Care 2003;19:169-71.
Drug-induced hearing loss Ocular/Otic
There is some concern that topical use of tea tree oil in the middle ear for treatment of ear infections might cause ototoxicity. There is preliminary evidence from animal research that preparations of pure tea tree oil can cause ototoxicity and impaired hearing. However, so far there are no reports of ototoxicity in humans. Until more is known, tell patients to avoid pure or highly concentrated tea tree oil preparations. Concentrations of 2% seem less likely to have this effect.
Adverse-effects data: Natural Medicines, Therapeutic Research Center
Dosing
There is no official standardized dose for tea tree oil. Many skin products contain it at low concentrations, often diluted to a small percentage of the total product.
The safest approach is to follow the directions on the product label and not apply more or more often than directed. If you are using pure essential oil, dilute it with a carrier oil before use. When in doubt about strength or how to use it, ask your pharmacist or doctor. Never take it by mouth.
Tea Tree Oil & Pregnancy
Tea Tree Oil & Breastfeeding
© 2026 Therapeutic Research Center
Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center
References & further reading
The 31 references that drive our Tea Tree Oil monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Robbers JE, Tyler VE. Tyler's Herbs of Choice: The Therapeutic Use of Phytomedicinals. New York, NY: The Haworth Herbal Press, 1999.
- Foster S, Tyler VE. Tyler's Honest Herbal, 4th ed., Binghamton, NY: Haworth Herbal Press, 1999. DOI
- De Groot AC. Airborn allergic contact dermatitis from tea tree oil. Contact Dermatitis 1996;35:304-5.
- Rubel DM, Freeman S, Southwell IA. Tea tree oil allergy: what is the offending agent? Report of three cases of tea tree oil allergy and review of the literature. Australas J Dermatol 1998;39:244-7. PubMed
- Carson CF, Riley TV, Cookson BD. Efficacy and safety of tea tree oil as a topical antimicrobial agent. J Hosp Infect 1998;40:175-8. PubMed
- Bhushan M, Beck MH. Allergic contact dermatitis from tea tree oil in a wart paint. Contact Dermatitis 1997;36:117-8. PubMed
- Del Beccaro MA. Melaleuca oil poisoning in a 17-month-old. Vet Hum Toxicol 1995;37:557-8.
- Jandourek A, Vaishampayan JK, Vazquez JA. Efficacy of melaleuca oral solution for the treatment of fluconazole refractory oral candidiasis in AIDS patients. AIDS 1998;12:1033-7. DOI
- Zhang SY, Robertson D. A study of tea tree oil ototoxicity. Audiol Neurootol 2000;5:64-8. PubMed
- Bassett IB, Pannowitz DL, Barnetson RS. A comparative study of tea-tree oil versus benzoylperoxide in the treatment of acne. Med J Aust 1990;153:455-8. PubMed
- Jacobs MR, Hornfeldt CS. Melaleuca oil poisoning. J Toxicol Clin Toxicol 1994;32:461-4.. PubMed
- Elliott C. Tea tree oil poisoning. Med J Aust 1993;159:830-1. PubMed
- Knight TE, Hausen BM. Melaleuca oil (tea tree oil) dermatitis. J Am Acad Dermatol 1994;30:423-7.. PubMed
- Bruynzeel DP. Contact dermatitis due to tea tree oil. Trop Med Int Health 1999;4:630.
- Greig JE, Thoo SL, Carson CF, Riley TV. Allergic contact dermatitis following use of a tea tree oil hand-wash not due to tea tree oil. Contact Dermatitis 1999;41:354-5. PubMed
- Varma S, Blackford S, Statham BN, Blackwell A. Combined contact allergy to tea tree oil and lavender oil complicating chronic vulvovaginitis. Contact Dermatitis 2000;42:309-10.
- Khanna M, Qasem K, Sasseville D. Allergic contact dermatitis to tea tree oil with erythema multiforme-like id reaction. Am J Contact Dermat 2000;11:238-42..
- Satchell AC, Saurajen A, Bell C, Barnetson RS. Treatment of interdigital tinea pedis with 25% and 50% tea tree oil solution: a randomized, placebo-controlled, blinded study. Australas J Dermatol 2002;43:175-8.. PubMed
- Morris MC, Donoghue A, Markowitz JA, Osterhoudt KC. Ingestion of tea tree oil (Melaleuca oil) by a 4-year-old boy. Pediatr Emerg Care 2003;19:169-71. PubMed
- Martin KW, Ernst E. Herbal medicines for treatment of fungal infections: a systematic review of controlled clinical trials. Mycoses 2004;47:87-92. PubMed
- De Groot A. C. and Weyland J. W. Systemic contact dermatitis from tea tree oil. Contact Dermatitis 1992;27(4):279-280. PubMed
- Enshaieh S, Jooya A, Siadat AH, and Iraji F. The efficacy of 5% topical tea tree oil gel in mild to moderate acne vulgaris: a randomized, double-blind placebo-controlled study. Indian J Dermatol Venereol Leprol 2007;73(1):22-25. PubMed
- Christoffers WA, Blömeke B, Coenraads PJ, Schuttelaar ML. Co-sensitization to ascaridole and tea tree oil. Contact Dermatitis. 2013 Sep;69(3):187-9. PubMed
- Corazza M, Borghi A, Gallo R, Schena D, Pigatto P, Lauriola MM, Guarneri F, Stingeni L, Vincenzi C, Foti C, Virgili A. Topical botanically derived products: use, skin reactions, and usefulness of patch tests. A multicentre Italian study. Contact Dermatiti
- Kwon HH, Yoon JY, Park SY, Min S, Suh DH. Comparison of clinical and histological effects between lactobacillus-fermented Chamaecyparis obtusa and tea tree oil for the treatment of acne: an eight-week double-blind randomized controlled split-face study. D PubMed
- Martínez Campayo N, Goday Buján JJ, Fonseca Capdevila E. Allergic contact dermatitis due to tea tree oil. Actas Dermosifiliogr (Engl Ed). 2020;111(9):787-788. DOI
- Lauriola MM, Sena P, De Bitonto A, Corazza M. Allergic contact dermatitis due to "therapeutic uses" of tea tree oil on the lips and toenails. Dermatitis. 2021;32(3):e40-e41. PubMed
- Navarro-Triviño FJ, Prados-Carmona Á, Ruiz-Villaverde R. Systemic allergic contact dermatitis caused by tea tree oil in a cream for treatment of molluscum contagiosum. Contact Dermatitis 2022;87(3):285-287. PubMed
- Bekhof AMW, van Hunsel FPAM, van de Koppel S, Woerdenbag HJ. Safety assessment and adverse drug reaction reporting of tea tree oil (Melaleuca aetheroleum). Phytother Res 2022.
- Ambrogio F, Foti C, Cazzato G, et al. Spreading Allergic Contact Dermatitis to Tea Tree Oil in an Over-the-Counter Product Applied on a Wart. Medicina (Kaunas) 2022;58(5):561. PubMed
- Samaran Q, Litovsky J, Girod M, Dereure O, Raison-Peyron N. Allergic Contact Dermatitis to Tea Tree Oil With No Sensitization to Fragrance Markers. Dermatitis 2023. PubMed
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Tea Tree Oil: Common Questions
What is Tea Tree Oil used for, and does it work?
Does Tea Tree Oil interact with prescription medications?
How are Tea Tree Oil interactions rated?
Is it safe to take Tea Tree Oil with my medications?
Where does this Tea Tree Oil interaction information come from?
What is Tea Tree Oil mainly used for?
Can I swallow Tea Tree Oil?
Do I need to dilute Tea Tree Oil before using it?
Is Tea Tree Oil safe during pregnancy or breastfeeding?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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