Drug & supplement interaction

Aegeline + nitisinone

nitisinone brand names: Orfadin, Nityr.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Aegeline and nitisinone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Aegeline and nitisinone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between nitisinone and Aegeline in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Aegeline safety at a glance

Aegeline overall Avoid Aegeline-containing supplements have been linked to serious liver injury and regulatory warnings.
Pregnancy Avoid No safety data; avoid during pregnancy.
Breastfeeding Avoid No safety data; avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining nitisinone and Aegeline? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for nitisinone

Interactions in our licensed database are recorded against drug classes, not just single drug names. nitisinone is filed under 2 classifications — cytochrome p450 2c9 (cyp2c9) inhibitors, oral drugs. Aegeline has documented interactions with 1 drug class — the most serious being cytochrome p450 3a4 (cyp3a4) substrates (minor) — and none of nitisinone’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Aegeline Does Interact With Other Medications

Aegeline has 643 minor known drug interactions in our database — nitisinone isn’t one of them. If you take anything else, check it against the full list below.

Minor 643 No known interaction 2,187 (incl. nitisinone)
Taking anything else?

Check Another of Your Medications Against Aegeline

Covers the 2,830 medications we’ve checked against Aegeline. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Aegeline and nitisinone May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Stomach pain Additional detail

    Aegeline

    “There are numerous case reports of severe acute hepatitis with fulminant liver failure associated with use of a specific multi-ingredient product containing aegeline (Super Thermo OxyELITE Pro). Symptoms included elevated liver enzymes, dark urine, jaundice, loss of appetite, nausea, abdominal pain, and fatigue.”

    Aegeline · Natural Medicines adverse-effect record, reported in fatigue.

    6 sources cited
    1. 90904. Johnston DI, Chang A, Viray M, et al. Hepatotoxicity associated with the dietary supplement OxyELITE Pro - Hawaii, 2013. Drug Test Anal. 2016;8(3-4):319-27. PubMed
    2. 101520. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. OxyELITE Pro. [Updated 2016 May 20]. Available from: https://www.ncbi.nlm.nih.gov/
    3. 102777. Chatham-Stephens K, Taylor E, Chang A, et al. Hepatotoxicity associated with weight loss or sports dietary supplements, including OxyELITE Pro - United States, 2013. Drug Test Anal. 2017;9(1):68-74. PubMed
    4. 102779. Heidemann LA, Navarro VJ, Ahmad J, et al. Severe acute hepatocellular injury attributed to OxyELITE Pro: A case series. Dig Dis Sci. 2016;61(9):2741-8. PubMed
    5. 102780. Roytman MM, Pörzgen P, Lee CL, et al. Outbreak of severe hepatitis linked to weight-loss supplement OxyELITE Pro. Am J Gastroenterol. 2014;109(8):1296-8. PubMed
    6. 101521. Klontz KC, DeBeck HJ, LeBlanc P, et al. The Role of Adverse Event Reporting in the FDA Response to a Multistate Outbreak of Liver Disease Associated with a Dietary Supplement. Public Health Rep. 2015;130(5):526-532. PubMed

    nitisinone

    Listed in the ADVERSE REACTIONS section of the FDA label for nitisinone. Read the label on DailyMed ›

Reported for Aegeline but not commonly for nitisinone: liver problems, reduced appetite, yellowing of the skin or eyes and tiredness.

Effects for nitisinone come from the ADVERSE REACTIONS section of its FDA label; effects for Aegeline come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 948 voluntary FDA FAERS reports for nitisinone that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With nitisinone

This page covers Aegeline only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the nitisinone page lists 21 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Cannabinol (cbn) (moderate), Cannabis (moderate), Coffee Charcoal (moderate) and Delta-9-tetrahydrocannabinol (thc) (moderate).

By severity: 1 major · 11 moderate · 9 minor.

From our pharmacist’s overview on the nitisinone page

“For a child or adult with hereditary tyrosinemia type 1, nitisinone (Orfadin, Nityr) is the medication holding a dangerous metabolic disease in check, which is why the 21 supplements on this page warrant genuine care rather than a shrug. Activated charcoal is the single major-rated entry and the one to understand first, since it can so…”

Reviewed by 2 · Jul 18, 2026

Open the nitisinone interaction page

One more smart check

Taking Aegeline as Part of a Dietary Supplement Product? Check It for Interactions

We hold 7 real supplement products containing Aegeline, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Aegeline. Even though Aegeline itself has no known interaction with nitisinone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Aegeline and nitisinone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Aegeline
Top half

#422 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication nitisinone
Top half

#1,325 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Aegeline reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Aegeline and nitisinone records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Aegeline

What is Aegeline?

  • Weight loss
  • Fat burning / metabolism support
  • Sports and bodybuilding supplements
  • General 'energy' products

Aegeline is a compound originally identified in the bael tree (Aegle marmelos) that gained attention because it was added to some weight-loss and workout supplements. It is best known for being linked to serious liver injury in a product called OxyELITE Pro, and U.S. regulators warned against products containing it. There is no good evidence it safely helps with weight loss, and it should generally be avoided.

Derived from compounds found in Aegle marmelos (bael tree); aegeline is also made synthetically · Capsules and tablets (historically in some weight-loss and sports supplements)

An interaction check asks whether these two react with each other — it does not ask whether Aegeline is a good idea for someone in your situation. Here is what our Aegeline record says about it on its own.

Aegeline: dosing

There is no established safe or effective dose of aegeline. Because it has been linked to liver injury and is not considered a lawful dietary ingredient in the United States, there is no recommended amount.We do not recommend taking aegeline.

From our Aegeline monograph — the full record covers uses, side effects and every documented interaction.

Read the full Aegeline monograph & all interactions
Medication

About Nitisinone

What Is Nitisinone Used For?

Brand names: Orfadin, Nityr

Nitisinone (as Orfadin capsules, Orfadin oral suspension, Nityr tablets, and generic Nitisinone capsules) is used to treat hereditary tyrosinemia type 1 (HT-1) — a rare inherited disease in which the body cannot properly break down the amino acid tyrosine, leading to toxic buildup that damages the liver and kidneys. It is used in both adults and children, always together with a strict low-tyrosine, low-phenylalanine diet.

Harliku tablets are approved for a different rare inherited condition: alkaptonuria (AKU). In adults with AKU, Harliku reduces the level of homogentisic acid (HGA) — a harmful substance that builds up in the urine and body tissues. Harliku is not approved for HT-1, and the other nitisinone products are not approved for AKU.

Most-Reported Side Effects for nitisinone

From FAERS, the FDA’s public side-effect reporting system (948 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Amino acid level increased 133 reports
Liver transplant 118 reports
Hepatocellular carcinoma 61 reports
Alpha 1 foetoprotein increased 52 reports
Treatment noncompliance 51 reports
See full Nitisinone drug information
Keep checking

Other Drugs & Aegeline

Browse every other medication we’ve checked against Aegeline — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
643Minor
2,186No known interaction
643 Minor 2,186 No interaction
Minor

643 interactions

Showing 60 of 643 minor interactions — see all 643 on the Aegeline page.

No interaction 2,186 drugs checked — show the list

We also checked Aegeline against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,186 medications checked with no known interaction — see the full Aegeline list.

See the full Aegeline interactions page
See every supplement checked against nitisinone, ranked by severity
Evidence & sources

Aegeline References

The 8 references that drive our Aegeline monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Johnston DI, Chang A, Viray M, et al. Hepatotoxicity associated with the dietary supplement OxyELITE Pro - Hawaii, 2013. Drug Test Anal. 2016;8(3-4):319-27. PubMed
  2. Manda VK, Avula B, Chittiboyina AG, Khan IA, Walker LA, Khan SI. Inhibition of CYP3A4 and CYP1A2 by Aegle marmelos and its constituents. Xenobiotica. 2016;46(2):117-25.
  3. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. OxyELITE Pro. [Updated 2016 May 20]. Available from: https://www.ncbi.nlm.nih.gov/
  4. Klontz KC, DeBeck HJ, LeBlanc P, et al. The Role of Adverse Event Reporting in the FDA Response to a Multistate Outbreak of Liver Disease Associated with a Dietary Supplement. Public Health Rep. 2015;130(5):526-532. PubMed
  5. Chatham-Stephens K, Taylor E, Chang A, et al. Hepatotoxicity associated with weight loss or sports dietary supplements, including OxyELITE Pro - United States, 2013. Drug Test Anal. 2017;9(1):68-74. PubMed
  6. Heidemann LA, Navarro VJ, Ahmad J, et al. Severe acute hepatocellular injury attributed to OxyELITE Pro: A case series. Dig Dis Sci. 2016;61(9):2741-8. PubMed
  7. Roytman MM, Pörzgen P, Lee CL, et al. Outbreak of severe hepatitis linked to weight-loss supplement OxyELITE Pro. Am J Gastroenterol. 2014;109(8):1296-8. PubMed
  8. Skinner CM, Miousse IR, Ewing LE, et al. Impact of obesity on the toxicity of a multi-ingredient dietary supplement, OxyELITE Pro (New Formula), using the novel NZO/HILtJ obese mouse model: Physiological and mechanistic assessments. Food Chem Toxicol. 201 PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Aegeline and nitisinone Together: Common Questions

Is it safe to take Aegeline with nitisinone?
We do not list a known interaction between Aegeline and nitisinone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Aegeline and nitisinone have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Aegeline and nitisinone combination checked?
Interactions in our licensed database are recorded against drug classes. nitisinone is filed under 2 classifications, and Aegeline has documented interactions with 1 drug class — none of nitisinone's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Aegeline interact with any other medications?
Yes. Aegeline has 643 documented drug interactions in our database — nitisinone is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does nitisinone interact with any supplements?
Yes. nitisinone has documented interactions with 21 supplements in our database — Aegeline is not one of them. The nitisinone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Aegeline monograph Uses, safety profile, and every drug interaction in one place Nitisinone drug information The full plain-English guide to this medication nitisinone supplement interactions Every supplement checked against nitisinone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 8 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About nitisinone and Aegeline?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.