Drug & supplement interaction

Sodium + Tadalafil

Tadalafil brand names: Cialis, Tadliq.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Sodium and Tadalafil in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Sodium and Tadalafil

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Tadalafil and Sodium in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Sodium safety at a glance

Sodium overall Use caution Sodium is essential in small amounts, but too much is linked to high blood pressure and heart strain.
Pregnancy Likely Safe When used orally and appropriately. Sodium is safe in amounts that do not exceed the CDRR intake level of 2.3 grams daily. Read the full pregnancy detail
Breastfeeding Likely Safe When used orally and appropriately. Sodium is safe in amounts that do not exceed the CDRR intake level of 2.3 grams daily. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Tadalafil and Sodium? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Tadalafil

Interactions in our licensed database are recorded against drug classes, not just single drug names. Tadalafil is filed under 5 classifications — including phosphodiesterase-5 inhibitors, vasodilators, cytochrome p450 3a4 (cyp3a4) substrates. Sodium has documented interactions with 7 drug classes — the most serious being antihypertensive drugs (moderate), corticosteroids (moderate) and didanosine (videx) (moderate) — and none of Tadalafil’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Sodium Does Interact With Other Medications

Sodium has 205 moderate known drug interactions in our database — Tadalafil isn’t one of them. If you take anything else, check it against the full list below.

Moderate 205 No known interaction 2,625 (incl. Tadalafil)
Taking anything else?

Check Another of Your Medications Against Sodium

Covers the 2,830 medications we’ve checked against Sodium. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Sodium and Tadalafil May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Stomach upset Additional detail

    Sodium

    “In one case report, severe gastritis and a deep antral ulcer occurred in a patient who consumed 16 grams of sodium chloride in one sitting. Chronic use of high to moderately high amounts of sodium chloride has been associated with an increased risk of gastric cancer.”

    Sodium · Natural Medicines adverse-effect record, reported in cancer.

    2 sources cited
    1. 25759. Coton T, Mallaret C, Coilliot C, Carre D, Guisset M. Severe acute ulcerated gastritis induced by salt. Presse Med 2009;38(3):499-500. PubMed
    2. 29405. D'Elia L, Rossi G, Ippolito R, Cappuccio FP, Strazzullo P. Habitual salt intake and risk of gastric cancer: a meta-analysis of prospective studies. Clin Nutr 2012;31(4):489-98. PubMed

    Tadalafil

    Listed in the ADVERSE REACTIONS section of the FDA label for Tadalafil. Read the label on DailyMed ›

Reported for Sodium but not commonly for Tadalafil: weight gain, increased thirst, raised blood pressure and bone thinning.

Effects for Tadalafil come from the ADVERSE REACTIONS section of its FDA label; effects for Sodium come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 98,103 voluntary FDA FAERS reports for Tadalafil that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Sodium in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When used orally and appropriately. Sodium is safe in amounts that do not exceed the CDRR intake level of 2.3 grams daily.

Pregnancy And Lactation Possibly Unsafe

When used orally in higher doses. Higher intake can cause hypertension. Also, both the highest and the lowest pre-pregnancy sodium quintile intakes are associated with an increased risk of hypertensive disorders of pregnancy, including gestational hypertension and pre-eclampsia, and the delivery of small for gestational age (SGA) infants when compared to the middle intake quintile.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Sodium or Tadalafil

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Sodium or Tadalafil, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Tadalafil

This page covers Sodium only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tadalafil page lists 144 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Mistletoe (major), Grapefruit (major), Hawthorn (major) and St. John's Wort (major).

By severity: 5 major · 98 moderate · 41 minor.

From our pharmacist’s overview on the Tadalafil page

“Grapefruit juice is the first thing to know about if you take tadalafil (Cialis, Tadliq). It blocks CYP3A4, the enzyme that clears the drug, so blood levels climb and side effects like a steep drop in blood pressure become more likely.”

Reviewed by 2 · Jul 18, 2026

Open the Tadalafil interaction page

One more smart check

Taking Sodium as Part of a Dietary Supplement Product? Check It for Interactions

We hold 26,145 real supplement products containing Sodium, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Sodium. Even though Sodium itself has no known interaction with Tadalafil, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Sodium and Tadalafil Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Sodium
Top 10

#6 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Tadalafil
Top 1%

#16 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Sodium reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Sodium and Tadalafil records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Sodium

What is Sodium?

  • Replacing fluids and electrolytes
  • Preventing dehydration during exercise or illness
  • Treating low blood sodium (under medical care)
  • Seasoning and food preservation
  • Antacid (as sodium bicarbonate)

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from food, so supplements are rarely needed except for specific medical reasons like dehydration or low blood sodium. Talk to your doctor or pharmacist before deliberately adding sodium, especially if you have high blood pressure, heart, or kidney problems.

Mineral (dietary electrolyte) · Table salt (sodium chloride), oral rehydration solutions, sodium bicarbonate, sodium chloride IV fluids, electrolyte sports drinks

An interaction check asks whether these two react with each other — it does not ask whether Sodium is a good idea for someone in your situation. Here is what our Sodium record says about it on its own.

Sodium: dosing

There is no single "supplement dose" of sodium for general health, and most people already consume more than they need. Do not invent your own salt regimen.

From our Sodium monograph — the full record covers uses, side effects and every documented interaction.

Read the full Sodium monograph & all interactions
Medication

About Tadalafil

What Is Tadalafil Used For?

Brand names: Cialis, Tadliq

Tadalafil tablets (including Cialis and generic tadalafil) are used to treat erectile dysfunction (ED), the symptoms of benign prostatic hyperplasia (BPH — an enlarged prostate), or both conditions together. When used with the drug finasteride to start BPH treatment, this combination is recommended for up to 26 weeks.

Adcirca, Alyq (tablets), and Tadliq (oral suspension) are indicated specifically for pulmonary arterial hypertension (PAH — high blood pressure in the lungs), to improve the ability to exercise.

Most-Reported Side Effects for Tadalafil

From FAERS, the FDA’s public side-effect reporting system (99,210 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Dyspnea 11,917 reports
Headache 10,982 reports
Diarrhea 8,020 reports
Nausea 6,697 reports
Fatigue 6,080 reports
See full Tadalafil drug information
Keep checking

Other Drugs & Sodium

Browse every other medication we’ve checked against Sodium — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
205Moderate
0Minor
2,624No known interaction
205 Moderate 2,624 No interaction
Moderate

205 interactions

Showing 60 of 205 moderate interactions — see all 205 on the Sodium page.

No interaction 2,624 drugs checked — show the list

We also checked Sodium against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,624 medications checked with no known interaction — see the full Sodium list.

See the full Sodium interactions page
See every supplement checked against Tadalafil, ranked by severity
Evidence & sources

Sodium References

The 38 references that drive our Sodium monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Garabedian-Ruffalo SM, Ruffalo RL. Drug and nutrient interactions. Am Fam Physician 1986;33:165-74.
  2. Food and Drug Administration Science Background: Safety of Sodium Phosphates Oral Solution. September 17, 2001. Available at: http://www.fda.gov/cder/drug/safety/sodiumphospate.htm
  3. Coton T, Mallaret C, Coilliot C, Carre D, Guisset M. Severe acute ulcerated gastritis induced by salt. Presse Med 2009;38(3):499-500. PubMed
  4. Frings-Meuthen P, Buehlmeier J, Baecker N, et al. High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses. J Appl Physiol 2011;111(2):537-542. PubMed
  5. Frings-Meuthen P, Baecker N, Heer M. Low-grade metabolic acidosis may be the cause of sodium chloride-induced exaggerated bone resorption. J Bone Miner Res 2008;23(4):517-524. PubMed
  6. Alam S, Johnson AG. A meta-analysis of randomised controlled trials (RCT) among healthy normotensive and essential hypertensive elderly patients to determine the effect of high salt (NaCl) diet of blood pressure. J Hum Hypertens 1999;13(6):367-74.
  7. Boudville N, Ward S, Benaroia M, House AA. Increased sodium intake correlates with greater use of antihypertensive agents by subjects with chronic kidney disease. Am J Hypertens 2005;18(10):1300-5. PubMed
  8. Bennett WM. Drug interactions and consequences of sodium restriction. Am J Clin Nutr 1997;65(2 Suppl):678S-681S. PubMed
  9. Okusa MD, Crystal LJ. Clinical manifestations and management of acute lithium intoxication. Am J Med 1994;97(4):383-9. PubMed
  10. Food and Nutrition Board, Institute of Medicine. Dietary reference intakes for water, potassium, sodium, chloride, and sulfate. Washington, DC: National Academy Press, 2005. Available at: http://www.nap.edu/openbook.php?record_id=10925. DOI
  11. D'Elia L, Rossi G, Ippolito R, Cappuccio FP, Strazzullo P. Habitual salt intake and risk of gastric cancer: a meta-analysis of prospective studies. Clin Nutr 2012;31(4):489-98. PubMed
  12. Goldsmith SR. Hyponatremia in heart failure: time for a trial. J Card Fail 2013;19(6):398-400. PubMed
  13. Willocks L, Brettle R, Keen J, Valentine C, Pinching AJ. Formulations of didanosine (ddI) and salt overload. Lancet 1992;339(8786):190.
  14. Chen L, Zhang Z, Chen W, Whelton PK, Appel LJ. Lower Sodium Intake and Risk of Headaches: Results From the Trial of Nonpharmacologic Interventions in the Elderly. Am J Public Health. 2016;106(7):1270-5. PubMed
  15. Cook NR, Appel LJ, Whelton PK. Lower levels of sodium intake and reduced cardiovascular risk. Circulation. 2014;129(9):981-9. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Sodium and Tadalafil Together: Common Questions

Is it safe to take Sodium with Tadalafil?
We do not list a known interaction between Sodium and Tadalafil. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Sodium and Tadalafil have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Sodium and Tadalafil combination checked?
Interactions in our licensed database are recorded against drug classes. Tadalafil is filed under 5 classifications, and Sodium has documented interactions with 7 drug classes — none of Tadalafil's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Sodium interact with any other medications?
Yes. Sodium has 205 documented drug interactions in our database — Tadalafil is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Tadalafil interact with any supplements?
Yes. Tadalafil has documented interactions with 144 supplements in our database — Sodium is not one of them. The Tadalafil interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Sodium monograph Uses, safety profile, and every drug interaction in one place Tadalafil drug information The full plain-English guide to this medication Tadalafil supplement interactions Every supplement checked against Tadalafil, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 38 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Tadalafil and Sodium?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.