Drug & supplement interaction

Corn Silk + Tadalafil

Tadalafil brand names: Cialis, Tadliq.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Corn Silk and Tadalafil in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

Know someone taking this? Share

Facebook Post Reddit Email

On this page

Interaction report

Corn Silk and Tadalafil

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Tadalafil and Corn Silk in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Corn Silk safety at a glance

Corn Silk overall Use caution Generally well tolerated for short-term use, but human safety data are limited.

Pregnancy Avoid Not enough reliable safety data, so it is best avoided during pregnancy.

Breastfeeding Possibly Safe When consumed in food amounts. Insufficient reliable information available when used as medicine; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Tadalafil and Corn Silk? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Tadalafil

Interactions in our licensed database are recorded against drug classes, not just single drug names. Tadalafil is filed under 5 classifications — including phosphodiesterase-5 inhibitors, vasodilators, cytochrome p450 3a4 (cyp3a4) substrates. Corn Silk has documented interactions with 5 drug classes — the most serious being antidiabetes drugs (moderate), antihypertensive drugs (moderate) and corticosteroids (moderate) — and none of Tadalafil’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Corn Silk Does Interact With Other Medications

Corn Silk has 290 moderate known drug interactions in our database — Tadalafil isn’t one of them. If you take anything else, check it against the full list below.

Moderate 290 No known interaction 2,540 (incl. Tadalafil)

Taking anything else?

Check Another of Your Medications Against Corn Silk

Covers the 2,830 medications we’ve checked against Corn Silk. Pick one to open its full report.

What to actually watch for

What Corn Silk Itself Has Been Linked To

This is not an interaction — nothing below involves Tadalafil. It is the side-effect record for Corn Silk on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Corn Silk, this list is the first place to look. 3 entries are worth acting on rather than waiting out — marked below.

Low sodium Worth acting on Additional detail

“Orally, adverse effects to corn silk seem to be rare; however, a thorough safety evaluation has not been conducted.

Most Common Adverse Effects:

Orally: Hypokalemia, hyponatremia.”

Corn Silk · Natural Medicines adverse-effect record, reported in hypokalemia.
Low potassium Worth acting on Additional detail
“Orally, corn silk has been reported to cause hypokalemia with prolonged use (4).”

Corn Silk · Natural Medicines adverse-effect record, reported in hypokalemia.
1 source cited

4. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
Hives Worth acting on Additional detail
“Topically, corn silk can cause dermatitis and urticaria (4).”

Corn Silk · Natural Medicines adverse-effect record, reported in dermatitis.
1 source cited

4. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
A skin rash Additional detail

Recorded for Corn Silk in the same Natural Medicines adverse-effect record shown under Hives above.

Everything above comes from the Natural Medicines adverse-effect record for Corn Silk — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Tadalafil’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Tadalafil column appears here.

Special populations

Corn Silk in Pregnancy & Breastfeeding

Lactation Possibly Safe

When consumed in food amounts. Insufficient reliable information available when used as medicine; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Tadalafil Is Prescribed For, and What Corn Silk Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Tadalafil is a prescription medicine with approved uses on its FDA label. Corn Silk is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Tadalafil is prescribed for: Tadalafil tablets (including Cialis and generic tadalafil) are used to treat erectile dysfunction (ED), the symptoms of benign prostatic hyperplasia (BPH — an enlarged prostate), or both conditions together. When used with the drug finasteride to start BPH treatment, this combination is recommended for up to 26 weeks. Adcirca, Alyq (tablets), and Tadliq (oral suspension) are indicated specifically for pulmonary arterial hypertension (PAH — high blood pressure in the lungs), to improve the ability to exercise.

Corn Silk has been studied for:

Hypertension studied, not established Corn Silk has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

Corn Silk for hypertension

It is unclear if oral corn silk is beneficial in patients with hypertension.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Tadalafil on your own; if you are taking Corn Silk for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Corn Silk or Tadalafil

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Corn Silk or Tadalafil, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Tadalafil

This page covers Corn Silk only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tadalafil page lists 144 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Mistletoe (major), Grapefruit (major), Hawthorn (major) and St. John's Wort (major).

By severity: 5 major · 98 moderate · 41 minor.

From our pharmacist’s overview on the Tadalafil page

“Grapefruit juice is the first thing to know about if you take tadalafil (Cialis, Tadliq). It blocks CYP3A4, the enzyme that clears the drug, so blood levels climb and side effects like a steep drop in blood pressure become more likely.”

Reviewed by 2 · Jul 18, 2026

Open the Tadalafil interaction page

One more smart check

Taking Corn Silk as Part of a Dietary Supplement Product? Check It for Interactions

We hold 58 real supplement products containing Corn Silk, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Corn Silk. Even though Corn Silk itself has no known interaction with Tadalafil, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Corn Silk and Tadalafil Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Corn Silk

Top half

#554 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Tadalafil

Top 1%

#16 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Corn Silk reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Corn Silk and Tadalafil records this page draws on were last updated July 11, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Corn Silk

What is Corn Silk?

Urinary tract and bladder problems
Mild fluid retention (diuretic)
Kidney and prostate concerns
Bedwetting in children
Soothing urinary irritation

Corn silk is a traditional herbal remedy taken as a tea or extract, mostly for urinary and mild fluid-related complaints. High-quality human evidence for these uses is limited, so it should not replace proven treatments. It is generally considered low-risk for short-term use in healthy adults, but talk with your pharmacist or doctor before trying it.

Zea mays · Poaceae · Stigmas and styles (the silky strands) of the corn ear · Tea, dried herb, liquid extract/tincture, capsules

An interaction check asks whether these two react with each other — it does not ask whether Corn Silk is a good idea for someone in your situation. Here is what our Corn Silk record says about it on its own.

Corn Silk: dosing

There is no official, standardized dose for corn silk. It has traditionally been taken as a tea made by steeping dried corn silk in hot water, or as a liquid extract or capsule.Because product strengths vary widely, the best advice is to follow the directions on the product label and not exceed them.

From our Corn Silk monograph — the full record covers uses, side effects and every documented interaction.

Read the full Corn Silk monograph & all interactions

Medication

About Tadalafil

What Is Tadalafil Used For?

Brand names: Cialis, Tadliq

Tadalafil tablets (including Cialis and generic tadalafil) are used to treat erectile dysfunction (ED), the symptoms of benign prostatic hyperplasia (BPH — an enlarged prostate), or both conditions together. When used with the drug finasteride to start BPH treatment, this combination is recommended for up to 26 weeks.

Adcirca, Alyq (tablets), and Tadliq (oral suspension) are indicated specifically for pulmonary arterial hypertension (PAH — high blood pressure in the lungs), to improve the ability to exercise.

Most-Reported Side Effects for Tadalafil

From FAERS, the FDA’s public side-effect reporting system (99,210 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Dyspnea 11,917 reports

Headache 10,982 reports

Diarrhea 8,020 reports

Nausea 6,697 reports

Fatigue 6,080 reports

See full Tadalafil drug information

Keep checking

Other Drugs & Corn Silk

Browse every other medication we’ve checked against Corn Silk — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

290Moderate

0Minor

2,539No known interaction

290 Moderate 2,539 No interaction

Moderate

290 interactions

Showing 60 of 290 moderate interactions — see all 290 on the Corn Silk page.

No interaction 2,539 drugs checked — show the list

We also checked Corn Silk against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,539 medications checked with no known interaction — see the full Corn Silk list.

See the full Corn Silk interactions page

See every supplement checked against Tadalafil, ranked by severity

Evidence & sources

Corn Silk References

The 4 references that drive our Corn Silk monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
George GO, Idu FK. Corn silk aqueous extracts and intraocular pressure of systemic and non-systemic hypertensive subjects. Clin Exp Optom. 2015 Mar;98(2):138-49. PubMed
Sheng L, Chen Q, Di L, Li N. Evaluation of anti-diabetic potential of corn silk in high-fat diet/streptozotocin- induced type 2 diabetes mice model. Endocr Metab Immune Disord Drug Targets. 2020. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Corn Silk and Tadalafil Together: Common Questions

Is it safe to take Corn Silk with Tadalafil?

We do not list a known interaction between Corn Silk and Tadalafil. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Are Corn Silk and Tadalafil used for the same thing?

They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Corn Silk in each. That is a conversation for your prescriber, especially if Tadalafil is being adjusted to a target.

How was the Corn Silk and Tadalafil combination checked?

Interactions in our licensed database are recorded against drug classes. Tadalafil is filed under 5 classifications, and Corn Silk has documented interactions with 5 drug classes — none of Tadalafil's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Corn Silk interact with any other medications?

Yes. Corn Silk has 290 documented drug interactions in our database — Tadalafil is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Tadalafil interact with any supplements?

Yes. Tadalafil has documented interactions with 144 supplements in our database — Corn Silk is not one of them. The Tadalafil interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Corn Silk monograph Uses, safety profile, and every drug interaction in one place Tadalafil drug information The full plain-English guide to this medication Tadalafil supplement interactions Every supplement checked against Tadalafil, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Tadalafil and Corn Silk?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.