Herb & supplement monograph

Fever Bark Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS ·Updated July 2026

What is this page for?

First and foremost: how Fever Bark interacts with medications. The heart of this page is the interaction list — every drug Fever Bark is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Fever Bark is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Reviewed by licensed pharmacists Sourced from Natural Medicines

On this page

Interaction report

Drugs that interact with Fever Bark

801 medications have a known interaction with Fever Bark, graded by severity. Select any drug for the full evidence-based detail.

40 major interactions. These combinations can be clinically significant — best avoided, or used only with close professional supervision. Always check with your pharmacist before combining them with Fever Bark.

Don’t want to scroll the list? Just ask.

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AI summaries are generated from our Fever Bark interaction data for education only — always confirm with your pharmacist. How we use AI

2,830 drugs

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
Each drug listed above links to the full report for that exact Fever Bark combination — clinical detail, likelihood, evidence level, and citations.
Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

The big picture

The kinds of drugs Fever Bark affects

Every type of medication (drug category) Fever Bark is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 9 drug categories Fever Bark interacts with

AnesthesiaMonoamine Oxidase Inhibitors (maois)Antihypertensive DrugsCytochrome P450 2d6 (cyp2d6) InhibitorsCytochrome P450 2d6 (cyp2d6) SubstratesCytochrome P450 3a4 (cyp3a4) InhibitorsPhenothiazinesStimulant DrugsAnticoagulant/antiplatelet Drugs

Anesthesia

Theoretically, fever bark might increase the risk of cardiovascular instability with general anesthesia.
Reserpine, a constituent of fever bark, has been shown to increase the risk of cardiovascular instability in patients receiving general anesthesia. It is not known if this could occur with fever bark.

Likelihood Probable Evidence D

Monoamine Oxidase Inhibitors (Maois)

Concomitant use of MAOIs with fever bark can result in additive effects.
Yohimbine, a constituent of fever bark, has MAO inhibitory effects. At high doses, yohimbine is a non-selective inhibitor of MAO. It is not known if this would occur with fever bark.

Likelihood Likely Evidence D

Antihypertensive Drugs

Theoretically, fever bark might alter the effects of antihypertensive drugs.
Yohimbine, a constituent of fever bark, is an alpha-2 adrenoceptor antagonist and has been reported to increase blood pressure in clinical research. Conversely, reserpine can reduce both systolic and diastolic blood pressure. Theoretically, concomitant use of fever bark and antihypertensive drugs can interfere with blood pressure control.

Likelihood Probable Evidence D

Cytochrome P450 2D6 (Cyp2D6) Inhibitors

Theoretically, CYP2D6 inhibitors might increase the levels and clinical effects of yohimbine, a constituent of fever bark.
In vitro and clinical research shows that the fever bark constituent, yohimbine, is metabolized by CYP2D6 isoenzymes.