Drug & supplement interaction

Fever Bark + Pilocarpine

Pilocarpine brand names: Salagen, Pilocar, Vuity, Qlosi.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Fever Bark and Pilocarpine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Fever Bark and Pilocarpine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Pilocarpine and Fever Bark in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Fever Bark safety at a glance

Fever Bark overall Use caution The bark contains strong alkaloids and is not recommended without professional supervision.
Pregnancy Avoid Not enough safety data and potent alkaloids make it unsafe to use during pregnancy.
Breastfeeding Avoid No reliable safety information exists, so avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Pilocarpine and Fever Bark? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Pilocarpine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Pilocarpine is filed under 3 classifications — cholinergic drugs, topical drugs, oral drugs. Fever Bark has documented interactions with 9 drug classes — the most serious being anesthesia (major), monoamine oxidase inhibitors (maois) (major) and antihypertensive drugs (moderate) — and none of Pilocarpine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Fever Bark Does Interact With Other Medications

Fever Bark has 40 major, 674 moderate, 87 minor known drug interactions in our database — Pilocarpine isn’t one of them. If you take anything else, check it against the full list below.

Major 40 Moderate 674 Minor 87 No known interaction 2,029 (incl. Pilocarpine)
Taking anything else?

Check Another of Your Medications Against Fever Bark

Covers the 2,830 medications we’ve checked against Fever Bark. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Fever Bark and Pilocarpine May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • A stuffy or runny nose Additional detail

    Fever Bark

    “The yohimbine constituent of fever bark, when taken alone, may cause bronchospasm, tachynpea, cough, and rhinorrhea. The reserpine constituent of fever bark, when taken alone, may cause nasal congestion or bronchospasm (15,94328). It is not known if this occurs with fever bark.”

    Fever Bark · Natural Medicines adverse-effect record, reported in cough.

    5 sources cited
    1. 17465. Kearney T, Tu N, Haller C. Adverse drug events associated with yohimbine-containing products: a retrospective review of the California Poison Control System reported cases. Ann Pharmacother 2010;44:1022-9. PubMed
    2. 86825. Landis, E. and Shore, E. Yohimbine-induced bronchospasm. Chest 1989;96(6):1424. PubMed
    3. 86850. Charney, D. S., Heninger, G. R., and Sternberg, D. E. Assessment of alpha 2 adrenergic autoreceptor function in humans: effects of oral yohimbine. Life Sci 6-7-1982;30(23):2033-2041.
    4. 15. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
    5. 94328. Lobay D. Rauwolfia in the Treatment of Hypertension. Integr Med (Encinitas). 2015 Jun;14(3):40-6.

    Pilocarpine

    Listed in the ADVERSE REACTIONS section of the FDA label for Pilocarpine. Read the label on DailyMed ›

  • Diarrhea Additional detail

    Fever Bark

    “The yohimbine constituent of fever bark, when taken alone, causes salivation, diarrhea, and gastrointestinal distress. The reserpine constituent of fever bark, when taken alone, can cause peptic ulceration (17). It is not known if these effects occur with fever bark.”

    Fever Bark · Natural Medicines adverse-effect record, reported in diarrhea.

    6 sources cited
    1. 3970. Jacobsen FM. Fluoxetine-induced sexual dysfunction and an open trial of yohimbine. J Clin Psychiatry 1992;53:119-22.
    2. 17465. Kearney T, Tu N, Haller C. Adverse drug events associated with yohimbine-containing products: a retrospective review of the California Poison Control System reported cases. Ann Pharmacother 2010;44:1022-9. PubMed
    3. 49902. Abebe, W. An overview of herbal supplement utilization with particular emphasis on possible interactions with dental drugs and oral manifestations. J Dent.Hyg. 2003;77(1):37-46.
    4. 86780. Bagheri, H., Schmitt, L., Berlan, M., and Montastruc, J. L. Effect of 3 weeks treatment with yohimbine on salivary secretion in healthy volunteers and in depressed patients treated with tricyclic antidepressants. Br J Clin Pharmacol 1992;34(6):555-558. PubMed
    5. 86781. Bagheri, H., Bompart, G., Girolami, J. P., Montastruc, J. L., and Montastruc, P. Is yohimbine-induced increase in salivary secretion a kinin-dependent mechanism? Fundam.Clin Pharmacol 1992;6(1):17-20. PubMed
    6. 86786. Adeniyi, A. A., Brindley, G. S., Pryor, J. P., and Ralph, D. J. Yohimbine in the treatment of orgasmic dysfunction. Asian J Androl 2007;9(3):403-407. PubMed

    Pilocarpine

    Listed in the ADVERSE REACTIONS section of the FDA label for Pilocarpine. Read the label on DailyMed ›

Reported for Fever Bark but not commonly for Pilocarpine: stomach upset, an allergic reaction, heart failure and anxiety or restlessness.

Effects for Pilocarpine come from the ADVERSE REACTIONS section of its FDA label; effects for Fever Bark come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 3,286 voluntary FDA FAERS reports for Pilocarpine that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Overlapping uses

What Pilocarpine Is Prescribed For, and What Fever Bark Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Pilocarpine is a prescription medicine with approved uses on its FDA label. Fever Bark is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Pilocarpine is prescribed for: Pilocarpine eye drops are used to lower elevated pressure inside the eye in people with open-angle glaucoma or ocular hypertension, to manage acute angle-closure glaucoma, to prevent pressure spikes after laser eye surgery, and to cause pupil constriction (miosis) when needed. Vuity and Qlosi eye drops, as well as Pilocarpine Hydrochloride Ophthalmic solution, are specifically approved to treat presbyopia (age-related difficulty focusing up close) in adults. Pilocarpine tablets — including Salagen and generic pilocarpine hydrochloride tablets — are used by mouth to relieve dry mouth caused by salivary gland damage from radiation therapy for head and neck cancer, or from Sjögren's syndrome (an autoimmune condition that reduces saliva and tear production).

Fever Bark has been studied for:

  • Hypertension studied, not established Fever Bark has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Fever Bark for hypertension

    Although there is interest in using oral fever bark for hypertension, there is insufficient reliable information about the clinical effects of fever bark for this condition.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Pilocarpine on your own; if you are taking Fever Bark for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Pilocarpine

This page covers Fever Bark only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Pilocarpine page lists 40 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Bacopa (moderate), Bael (moderate), Betel Nut (moderate) and Boxwood (moderate).

By severity: 1 major · 28 moderate · 11 minor.

From our pharmacist’s overview on the Pilocarpine page

“Pilocarpine stimulates the body's cholinergic system, whether as Salagen tablets for the dry mouth of Sjogren's or radiation treatment or as eye drops like Vuity, and its supplement list calls for real care. The one major-rated interaction among the 40 on file is activated charcoal, which soaks up the drug in the gut and can cut how mu…”

Reviewed by 2 · Jul 18, 2026

Open the Pilocarpine interaction page

How much people look this up

Where Fever Bark and Pilocarpine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Fever Bark
Steady interest

#734 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Pilocarpine
Steady interest

#2,119 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Fever Bark reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Fever Bark and Pilocarpine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Fever Bark

What is Fever Bark?

Fever Bark
  • Fever
  • Diarrhea
  • Malaria (traditional)
  • Digestive complaints
  • Bitter tonic

Fever bark is the bark of the Australian tree Alstonia constricta, used in traditional medicine for fever, diarrhea, and infections. There is very little reliable human research to support these uses, and the bark contains potent alkaloids that may cause serious side effects. It is best avoided unless used under direct medical supervision.

Alstonia constricta · Apocynaceae · Bark · Bark powder, tincture, liquid extract, capsules

An interaction check asks whether these two react with each other — it does not ask whether Fever Bark is a good idea for someone in your situation. Here is what our Fever Bark record says about it on its own.

Fever Bark: dosing

There is no well-established, standardized dose for fever bark. Because the bark contains potent alkaloids that vary between products, a safe and effective dose has not been reliably determined in modern research.If a product is used at all, follow the directions on the label and do not exceed them.

From our Fever Bark monograph — the full record covers uses, side effects and every documented interaction.

Read the full Fever Bark monograph & all interactions
Medication

About Pilocarpine

What Is Pilocarpine Used For?

Brand names: Salagen, Pilocar, Vuity, Qlosi

Pilocarpine eye drops are used to lower elevated pressure inside the eye in people with open-angle glaucoma or ocular hypertension, to manage acute angle-closure glaucoma, to prevent pressure spikes after laser eye surgery, and to cause pupil constriction (miosis) when needed. Vuity and Qlosi eye drops, as well as Pilocarpine Hydrochloride Ophthalmic solution, are specifically approved to treat presbyopia (age-related difficulty focusing up close) in adults.

Pilocarpine tablets — including Salagen and generic pilocarpine hydrochloride tablets — are used by mouth to relieve dry mouth caused by salivary gland damage from radiation therapy for head and neck cancer, or from Sjögren's syndrome (an autoimmune condition that reduces saliva and tear production).

See full Pilocarpine drug information
Keep checking

Other Drugs & Fever Bark

Browse every other medication we’ve checked against Fever Bark — both the ones with a known interaction and the ones without. Select any drug for the full detail.

40Major
674Moderate
87Minor
2,028No known interaction
40 Major 674 Moderate 87 Minor 2,028 No interaction
Major

40 interactions

Moderate

674 interactions

Showing 60 of 674 moderate interactions — see all 674 on the Fever Bark page.

Minor

87 interactions

Showing 60 of 87 minor interactions — see all 87 on the Fever Bark page.

No interaction 2,028 drugs checked — show the list

We also checked Fever Bark against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,028 medications checked with no known interaction — see the full Fever Bark list.

See the full Fever Bark interactions page
See every supplement checked against Pilocarpine, ranked by severity
Evidence & sources

Fever Bark References

The 50 references that drive our Fever Bark monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Foster S, Tyler VE. Tyler's Honest Herbal: A Sensible Guide to the Use of Herbs and Related Remedies. 3rd ed., Binghamton, NY: Haworth Herbal Press, 1993.
  3. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  4. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  5. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  6. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  7. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
  8. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  9. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  10. Sklar S, et al. Drug therapy screening system. Indianapolis, IN: First Data Bank 99.1-99. 2 eds.
  11. Teloken C, Rhoden EL, Sogari P, et al. Therapeutic effects of high dose yohimbine hydrochloride on organic erectile dysfunction. J Urol 1998;159:122-4. PubMed
  12. Jacobsen FM. Fluoxetine-induced sexual dysfunction and an open trial of yohimbine. J Clin Psychiatry 1992;53:119-22.
  13. Hollander E, McCarley A. Yohimbine treatment of sexual side effects induced by serotonin reuptake blockers. J Clin Psychiatry 1992;53:207-9.
  14. Kearney T, Tu N, Haller C. Adverse drug events associated with yohimbine-containing products: a retrospective review of the California Poison Control System reported cases. Ann Pharmacother 2010;44:1022-9. PubMed
  15. VandenBrink, B. M., Foti, R. S., Rock, D. A., Wienkers, L. C., and Wahlstrom, J. L. Prediction of CYP2D6 drug interactions from in vitro data: evidence for substrate-dependent inhibition. Drug Metab Dispos. 2012;40(1):47-53. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Fever Bark and Pilocarpine Together: Common Questions

Is it safe to take Fever Bark with Pilocarpine?
We do not list a known interaction between Fever Bark and Pilocarpine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Fever Bark and Pilocarpine have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Fever Bark and Pilocarpine used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Fever Bark in each. That is a conversation for your prescriber, especially if Pilocarpine is being adjusted to a target.
How was the Fever Bark and Pilocarpine combination checked?
Interactions in our licensed database are recorded against drug classes. Pilocarpine is filed under 3 classifications, and Fever Bark has documented interactions with 9 drug classes — none of Pilocarpine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Fever Bark interact with any other medications?
Yes. Fever Bark has 801 documented drug interactions in our database — Pilocarpine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Pilocarpine interact with any supplements?
Yes. Pilocarpine has documented interactions with 40 supplements in our database — Fever Bark is not one of them. The Pilocarpine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Fever Bark monograph Uses, safety profile, and every drug interaction in one place Pilocarpine drug information The full plain-English guide to this medication Pilocarpine supplement interactions Every supplement checked against Pilocarpine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 50 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Pilocarpine and Fever Bark?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.