Herb & supplement monograph

Adrafinil Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS ·Updated July 2026

What is this page for?

First and foremost: how Adrafinil interacts with medications. The heart of this page is the interaction list — every drug Adrafinil is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Adrafinil is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Reviewed by licensed pharmacists Sourced from Natural Medicines

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Adrafinil Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Adrafinil drug interaction appears low for most people, with one clear exception for those taking modafinil. Only one interaction is rated major, and nearly all the rest are moderate concerns based on lab research rather than proven effects in people.

Interactions deserving the most attention

The one interaction with strong evidence involves modafinil itself, because adrafinil is converted into modafinil in the body, so taking both stacks the same drug and raises the chance of serious side effects. Combining adrafinil with MAOIs also deserves caution, since modafinil has been linked to reports of dangerously high blood pressure and body temperature with these drugs. People on warfarin should know that experts suggest closer INR monitoring when starting adrafinil, even though a small human study found no change in warfarin levels. Adrafinil may also blunt blood pressure medicines or add to the effects of other stimulants.

What the rest of the list means

The long list of moderate interactions does not mean every combination is harmful. Most reflect theoretical effects on enzymes the body uses to clear medications, seen mainly in lab studies of modafinil. These predicted effects have generally not been shown to cause meaningful changes in people.

Check your medications against Adrafinil

Based on HelloPharmacist’s Adrafinil interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Adrafinil

1059 medications have a known interaction with Adrafinil, graded by severity. Select any drug for the full evidence-based detail.

1 major interaction. These combinations can be clinically significant — best avoided, or used only with close professional supervision. Always check with your pharmacist before combining them with Adrafinil.

Don’t want to scroll the list? Just ask.

Tell us the medications you take and we’ll check each one against Adrafinil using our pharmacist-reviewed interaction data.

AI summaries are generated from our Adrafinil interaction data for education only — always confirm with your pharmacist. How we use AI

2,830 drugs

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
Each drug listed above links to the full report for that exact Adrafinil combination — clinical detail, likelihood, evidence level, and citations.
Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

The big picture

The kinds of drugs Adrafinil affects

Every type of medication (drug category) Adrafinil is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 11 drug categories Adrafinil interacts with

Modafinil (provigil)Antihypertensive DrugsCytochrome P450 1a2 (cyp1a2) SubstratesCytochrome P450 2b6 (cyp2b6) SubstratesCytochrome P450 2c19 (cyp2c19) SubstratesCytochrome P450 2c9 (cyp2c9) SubstratesCytochrome P450 3a4 (cyp3a4) InhibitorsCytochrome P450 3a4 (cyp3a4) SubstratesMonoamine Oxidase Inhibitors (maois)Stimulant DrugsWarfarin (coumadin)

Modafinil (Provigil)

Concomitant use might increase the risk for serious adverse effects.
Adrafinil is a precursor to the stimulant prescription drug modafinil. Concomitant use with modafinil would be expected to result in increased clinical and adverse effects.

Likelihood Likely Evidence D

Antihypertensive Drugs

Theoretically, adrafinil might reduce the effects of antihypertensive drugs.
Adrafinil is a precursor to the stimulant prescription drug modafinil. Modafinil has been shown to increase diastolic and systolic blood pressure. Retrospective analyses show that patients taking modafinil had a small but increased rate of requiring new antihypertensive drugs or increased use of antihypertensive drugs when compared with placebo.