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Dietary supplement

Adrafinil Ingredients & Drug Interactions

by DNA Anabolics Nootropics

Adrafinil label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Adrafinil against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Adrafinil is a dietary supplement by DNA Anabolics Nootropics with 1 active ingredient. Its ingredients are commonly taken for wakefulness and alertness, fatigue, focus and concentration.Based on those ingredients, 1,057 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are {Diphenylmethyl}Sufinyl-2 Acetohydroxamic Acid. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Adrafinil by DNA Anabolics Nootropics

Ask about any prescription or over-the-counter medication and we check it for interactions with Adrafinil by DNA Anabolics Nootropics — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Adrafinil by DNA Anabolics Nootropics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Adrafinil (listed as {Diphenylmethyl}Sufinyl-2 Acetohydroxamic Acid). Adrafinil is a precursor compound—your body converts it to modafinil, a prescription stimulant used for wakefulness and alertness.

The capsule also contains inactive ingredients: rice flour, magnesium stearate, and gelatin (the capsule itself).

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: wakefulness, alertness, focus and cognitive enhancement.
  • We looked for evidence on: Mental alertness, Age-related cognitive decline, fatigue, concentration, daytime sleepiness.
  • The closest evidence on file: Adrafinil is rated "Insufficient Reliable Evidence To Rate" for Age-related cognitive decline (Natural Medicines).
  • Also on file: Adrafinil is rated "Insufficient Reliable Evidence To Rate" for Mental alertness.

The evidence we hold does not establish that adrafinil is effective for any of the claimed uses—age-related cognitive decline, athletic performance, mental alertness, obesity, or exercise-induced muscle damage all carry a rating of Insufficient Reliable Evidence To Rate. That means the data on hand doesn't support a conclusion either way.

If you're considering this for a specific purpose, it's worth discussing with your pharmacist or doctor what the actual evidence shows.

The evidence, ingredient by ingredient Adrafinil

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Adrafinil converts to a prescription stimulant in your body and may stress your liver, so casual use is not recommended. Common side effects include disturbed sleep, headache, changes in urine odor, and unpleasant stimulation.

Some people report headache, irritability, poor concentration, anxiety, and sleep problems after taking it. Rarely, orofacial dyskinesia (involuntary mouth and tongue movements) has been reported.

There is no safety data in pregnancy or breastfeeding, so it should be avoided in both. If you are pregnant, planning to become pregnant, or breastfeeding, talk with your pharmacist or doctor before considering this supplement.

Side effects, ingredient by ingredient Adrafinil

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Adrafinil.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 1,058 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before starting this product, check your medications against these drug types: modafinil (Provigil)—a Major interaction risk—and blood pressure medications, CYP2C19 substrates, CYP2C9 substrates, CYP1A2 substrates, CYP3A4 substrates or inhibitors, and other stimulant drugs (all Moderate). Use the medication checker on this page with your specific drug names.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

Adrafinil is a precursor to a prescription stimulant and carries Major and Moderate interaction risks with over 1,000 medications, particularly blood pressure drugs and CYP-metabolized medications. It is not recommended in pregnancy or breastfeeding.

If you take any prescription medications or manage high blood pressure, check your exact drugs with the interaction tool before considering this product.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Adrafinil, straight from the product label.

Brand DNA Anabolics Nootropics
Net contents 0 Not Present
Market status On market
Date entered into DSLD Jan 25, 2017
DSLD ID 69722
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Adrafinil by DNA Anabolics Nootropics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
90
IngredientAmount% DV
{Diphenylmethyl}Sufinyl-2 Acetohydroxamic Acid300 mg--

Other ingredients: Rice Flour, Magnesium Stearate, Gelatin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Adrafinil may elevate liver enzymes.

Manufacturer's Warnings Consult your health care provider before consuming this product.

Do not use if you are pregnant or breastfeeding.

Not intended for use by persons under the age of 18.

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Suggested/Recommended/Usage/Directions

Manufacturer's Directions Take between 300 and 600mg daily, split into multiple doses, on an empty stomach. Initially avoid taking Adrafinil before bed to avoid potentially interfering with sleep, as it is stimulatory.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Adrafinil by DNA Anabolics Nootropics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Adrafinil label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Adrafinil by DNA Anabolics Nootropics

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

{Diphenylmethyl}Sufinyl-2 Acetohydroxamic Acid

Interacts with
1,057 drugs
300 mg per serving

Adrafinil is a synthetic compound that the body converts into modafinil, a prescription wakefulness-promoting drug. It is sometimes sold as a nootropi...

{Diphenylmethyl}Sufinyl-2 Acetohydroxamic Acid monograph & interactions

Other (inactive) ingredients: Rice Flour, Magnesium Stearate, Gelatin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Adrafinil by DNA Anabolics Nootropics Drug Interactions

Want to check YOUR meds against Adrafinil?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,057Drugs
1 Major 1,056 Moderate

Ingredients driving the most interactions

{Diphenylmethyl}Sufinyl-2 Acetohydroxamic Acid 1,057

Individual Drug Interactions

The ingredients in Adrafinil interact with 1,057 drugs. Click any drug to see the details.

1 of the 1 ingredient in Adrafinil interact with drugs. Each result below shows which ingredient is responsible. {Diphenylmethyl}Sufinyl-2 Acetohydroxamic Acid

Each ingredient & the kinds of drugs it affects

For each ingredient in Adrafinil with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

{Diphenylmethyl}Sufinyl-2 Acetohydroxamic Acid11 drug types · 1,057 drugs

Modafinil (Provigil)

Concomitant use might increase the risk for serious adverse effects.
Adrafinil is a precursor to the stimulant prescription drug modafinil. Concomitant use with modafinil would be expected to result in increased clinical and adverse effects.

Likelihood Likely Evidence D
Antihypertensive Drugs

Theoretically, adrafinil might reduce the effects of antihypertensive drugs.
Adrafinil is a precursor to the stimulant prescription drug modafinil. Modafinil has been shown to increase diastolic and systolic blood pressure. Retrospective analyses show that patients taking modafinil had a small but increased rate of requiring new antihypertensive drugs or increased use of antihypertensive drugs when compared with placebo.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, adrafinil might reduce the levels and clinical effects of CYP1A2 substrates.
Adrafinil is a precursor to the stimulant prescription drug modafinil. Modafinil has been shown to weakly induce CYP1A2 activity in vitro.

Likelihood Possible Evidence D
Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, adrafinil might reduce the levels and clinical effects of CYP2B6 substrates.
Adrafinil is a precursor to the stimulant prescription drug modafinil. Modafinil has been shown to weakly induce CYP2B6 activity in vitro.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, adrafinil might increase the levels and clinical effects of CYP2C19 substrates.
Adrafinil is a precursor to the stimulant prescription drug modafinil. Modafinil has been shown to inhibit CYP2C19 activity in vitro.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, adrafinil might increase the levels and clinical effects of CYP2C9 substrates.
Adrafinil is a precursor to the stimulant prescription drug modafinil. Modafinil has been shown to reduce CYP2C9 expression in vitro.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Inhibitors

Theoretically, drugs that inhibit CYP3A4 might increase the levels and clinical effects of adrafinil.
Adrafinil is a precursor to the stimulant prescription drug modafinil. Modafinil is metabolized by CYP3A4.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, adrafanil might reduce levels and clinical effects of CYP3A4 substrates.
Adrafinil is a precursor to the stimulant prescription drug modafinil. Modafinil has been shown to weakly induce CYP3A4 activity.

Likelihood Possible Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, concomitant use might increase the risk for serious adverse effects.
Adrafinil is a precursor to the stimulant prescription drug modafinil. Modafinil, and a related drug, armodafinil, have been associated with reports of serious adverse effects, such as hypertensive crisis and hyperthermia, when used in combination with MAOIs.

Likelihood Possible Evidence D
Stimulant Drugs

Theoretically, taking adrafinil with stimulant drugs might have additive stimulant effects.
Adrafinil is a precursor to the prescription drug modafinil, which has stimulant effects.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, adrafinil might alter the effects and adverse effects of warfarin.
Adrafinil is a precursor to the stimulant prescription drug modafinil. Although pharmacokinetic research shows that modafinil does not alter levels of warfarin, this study was limited to a single dose. Experts recommend monitoring international normalized ratio (INR) in patients who are taking warfarin and initiating treatment with modafinil.

Likelihood Possible Evidence D
{Diphenylmethyl}Sufinyl-2 Acetohydroxamic Acid full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Adrafinil, from the product label.

DNA Anabolics Nootropics

See all DNA Anabolics Nootropics products
Name
DNA Anabolics
Web Address
www.thednaanabolics.com
Pharmacist Counseling Corner

Adrafinil by DNA Anabolics Nootropics: Common Questions

Does Adrafinil by DNA Anabolics Nootropics interact with any medications?
Yes. Based on its ingredients, Adrafinil has a known interaction with 1,057 medications, including 1 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Adrafinil contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is adrafinil supposed to do?
Adrafinil is marketed for mental alertness, cognitive function, athletic performance, and obesity—but the evidence we have doesn't establish it works for any of these. Your body converts it to modafinil, a prescription stimulant used to promote wakefulness.
What are the side effects?
Common ones include disturbed sleep, headache, and unpleasant stimulation. Less common are irritability, poor concentration, and anxiety. Rarely, involuntary mouth and tongue movements (orofacial dyskinesia) have been reported. Some people report fatigue and irritability after stopping it.
Can I take this if I'm pregnant or breastfeeding?
No. There is no safety data for adrafinil in pregnancy or breastfeeding, and the rating is 'Possibly Unsafe' for both. Talk with your pharmacist or doctor if you're pregnant, planning to become pregnant, or breastfeeding.
Why does this interact with so many drugs?
Adrafinil converts to modafinil in your body, and modafinil affects how your liver processes many medications through several enzyme systems (CYP2C19, CYP2C9, CYP1A2, CYP3A4). It also raises blood pressure and adds stimulant effects on top of other drugs in those categories.
Is it safe to take with my blood pressure medication?
No—adrafinil can raise blood pressure and may reduce how well your blood pressure medication works. This is a Moderate-severity interaction. Check with your pharmacist or doctor before taking it.
Can I take this with coffee or energy drinks?
Theoretically, combining adrafinil with other stimulants like caffeine could add up to too much stimulation. It's safest to talk with your pharmacist before mixing it with caffeinated products.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Adrafinil label
Go deeper

The Full Monographs Behind Adrafinil’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Adrafinil

Interacts with 1,057 drugs

Adrafinil is a synthetic compound that the body converts into modafinil, a prescription wakefulness-promoting drug. It is sometimes sold as a nootropic supplement, but it is unregulated, car...

Read the full Adrafinil monograph →
Sources

Sources & How We Checked

Adrafinil's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Adrafinil 7 references
  1. Urban AE, Cubala WJ. The role of eugeroics in the treatment of affective disorders. Psychiatr Pol. 2020;54(1):21-33. PubMed
  2. Lowe DW, Dobson E, Jewett AG, Whisler EE. Adrafinil: Psychostimulant and purported nootropic? Am J Psych Res J. 2021;17(1):7-9. DOI
  3. Thobois S, Xie J, Mollion H, Benatru I, Broussolle E. Adrafinil-induced orofacial dyskinesia. Mov Disord 2004;19(8):965-6. PubMed
  4. Chariot J, Appia F, Vaille C, Rozé C. Effect of modafinil on pancreatic exocrine secretion in rats. A comparison with adrafinil and related drugs. Fundam Clin Pharmacol 1987;1(4):243-52. PubMed
  5. Kumar R. Approved and investigational uses of modafinil: an evidence-based review. Drugs. 2008;68(13):1803-39. PubMed
  6. Provigil (modafinil) [package insert]. North Wales, PA: Teva Pharmaceuticals USA, Inc. Published: January 2015. Accessed on: Nov 11, 2022.
  7. Kinslow, CJ, Shapiro SD, Grunebaum MF, Miller EC. Acute hypertensive crisis and severe headache after concurrent use of armodafinil and tranylcypromine: Case report and review of the literature. Clinical Short Communication. October 2018; 393:1-3. PubMed

See these in context on the Adrafinil monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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