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Dietary supplement

Adrafinil 300 mg Ingredients & Drug Interactions

by Absorb Health

Adrafinil 300 mg label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Adrafinil 300 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Adrafinil 300 mg is a dietary supplement by Absorb Health with 1 active ingredient. Its ingredients are commonly taken for wakefulness and alertness, fatigue, focus and concentration.Based on those ingredients, 1,057 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Adrafinil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Adrafinil 300 mg by Absorb Health

Ask about any prescription or over-the-counter medication and we check it for interactions with Adrafinil 300 mg by Absorb Health — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Adrafinil 300 mg by Absorb Health

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: adrafinil 300 mg per capsule. Adrafinil is a compound your body converts into modafinil, a prescription stimulant used to promote wakefulness.

The capsule also holds inactive ingredients — gelatin, maltodextrin, and silica — which are standard fillers and binders.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Cognitive support and mental alertness.
  • We looked for evidence on: Age-related cognitive decline, Mental alertness, Focus, Concentration, Wakefulness.
  • The closest evidence on file: Adrafinil is rated "Insufficient Reliable Evidence To Rate" for Age-related cognitive decline (Natural Medicines).
  • Also on file: Adrafinil is rated "Insufficient Reliable Evidence To Rate" for Mental alertness.

The evidence for adrafinil isn't established in the data we hold. For the uses listed — age-related cognitive decline, athletic performance, mental alertness, obesity, and exercise-induced muscle damage — all are rated insufficient reliable evidence to rate.

That means we don't have enough solid research to say whether it works for any of these purposes.

The evidence, ingredient by ingredient Adrafinil

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Because adrafinil converts to a prescription stimulant, you should use it cautiously and not casually. The most common side effects reported are disturbed sleep, headache, malodorous urine, and unpleasant stimulation; headache, poor concentration, irritability, sedation, anxiety, and sleep disturbance have also been reported anecdotally.

Rarely, orofacial dyskinesia (involuntary mouth and tongue movements) has occurred. Some people report withdrawal-like symptoms — fatigue, irritability, poor focus, headache, and GI symptoms — when they stop taking it.

Adrafinil should be avoided in pregnancy and breastfeeding. There is no safety data for either, so the advice is not to use it during these times.

Talk with your doctor or pharmacist about whether it's appropriate for you.

Side effects, ingredient by ingredient Adrafinil

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Adrafinil.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 1,058 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you use this product, check whether you take modafinil (Provigil) — combining them is the most serious concern. You should also verify with your pharmacist if you're on blood pressure medications, any stimulant drugs, or medications processed through your liver's CYP2C19, CYP1A2, CYP2C9, or CYP3A4 pathways, or if you take drugs that inhibit CYP3A4.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

Adrafinil is a precursor to a prescription stimulant and isn't something to take lightly. If you're curious about it, you'll need to check your medications against the interaction list first — there are many of them.

The evidence for what it actually does isn't well established. Talk with your pharmacist before you start, especially if you take any prescription drugs, blood pressure medications, or other stimulants.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 7, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Adrafinil 300 mg, straight from the product label.

Brand Absorb Health
Barcode (UPC) 025706835381
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD Jan 7, 2019
DSLD ID 181760
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Adrafinil 300 mg by Absorb Health, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
025706835381
IngredientAmount% DV
Adrafinil300 mg--

Other ingredients: Gelatin, Maltodextrin, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Warning: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Keep out of the reach of children.

Do not use if seal under cap is broken or missing.

Storage

Store at room temperature with lid tightly closed.

General Statements

Cognitive support

Shop at www.absorbyourhealth.com for All Your Mind, Body, and Spirit Needs.

Formulation

No cutting agents

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Adrafinil 300 mg by Absorb Health label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Adrafinil 300 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Adrafinil 300 mg by Absorb Health

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Adrafinil

Interacts with
1,057 drugs
300 mg per serving

Adrafinil is a synthetic compound that the body converts into modafinil, a prescription wakefulness-promoting drug. It is sometimes sold as a nootropi...

Adrafinil monograph & interactions

Other (inactive) ingredients: Gelatin, Maltodextrin, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Adrafinil 300 mg by Absorb Health Drug Interactions

Want to check YOUR meds against Adrafinil 300 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,057Drugs
1 Major 1,056 Moderate

Ingredients driving the most interactions

Adrafinil 1,057

Individual Drug Interactions

The ingredients in Adrafinil 300 mg interact with 1,057 drugs. Click any drug to see the details.

1 of the 1 ingredient in Adrafinil 300 mg interact with drugs. Each result below shows which ingredient is responsible. Adrafinil

Each ingredient & the kinds of drugs it affects

For each ingredient in Adrafinil 300 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Adrafinil11 drug types · 1,057 drugs

Modafinil (Provigil)

Concomitant use might increase the risk for serious adverse effects.
Adrafinil is a precursor to the stimulant prescription drug modafinil. Concomitant use with modafinil would be expected to result in increased clinical and adverse effects.

Likelihood Likely Evidence D
Antihypertensive Drugs

Theoretically, adrafinil might reduce the effects of antihypertensive drugs.
Adrafinil is a precursor to the stimulant prescription drug modafinil. Modafinil has been shown to increase diastolic and systolic blood pressure. Retrospective analyses show that patients taking modafinil had a small but increased rate of requiring new antihypertensive drugs or increased use of antihypertensive drugs when compared with placebo.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, adrafinil might reduce the levels and clinical effects of CYP1A2 substrates.
Adrafinil is a precursor to the stimulant prescription drug modafinil. Modafinil has been shown to weakly induce CYP1A2 activity in vitro.

Likelihood Possible Evidence D
Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, adrafinil might reduce the levels and clinical effects of CYP2B6 substrates.
Adrafinil is a precursor to the stimulant prescription drug modafinil. Modafinil has been shown to weakly induce CYP2B6 activity in vitro.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, adrafinil might increase the levels and clinical effects of CYP2C19 substrates.
Adrafinil is a precursor to the stimulant prescription drug modafinil. Modafinil has been shown to inhibit CYP2C19 activity in vitro.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, adrafinil might increase the levels and clinical effects of CYP2C9 substrates.
Adrafinil is a precursor to the stimulant prescription drug modafinil. Modafinil has been shown to reduce CYP2C9 expression in vitro.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Inhibitors

Theoretically, drugs that inhibit CYP3A4 might increase the levels and clinical effects of adrafinil.
Adrafinil is a precursor to the stimulant prescription drug modafinil. Modafinil is metabolized by CYP3A4.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, adrafanil might reduce levels and clinical effects of CYP3A4 substrates.
Adrafinil is a precursor to the stimulant prescription drug modafinil. Modafinil has been shown to weakly induce CYP3A4 activity.

Likelihood Possible Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, concomitant use might increase the risk for serious adverse effects.
Adrafinil is a precursor to the stimulant prescription drug modafinil. Modafinil, and a related drug, armodafinil, have been associated with reports of serious adverse effects, such as hypertensive crisis and hyperthermia, when used in combination with MAOIs.

Likelihood Possible Evidence D
Stimulant Drugs

Theoretically, taking adrafinil with stimulant drugs might have additive stimulant effects.
Adrafinil is a precursor to the prescription drug modafinil, which has stimulant effects.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, adrafinil might alter the effects and adverse effects of warfarin.
Adrafinil is a precursor to the stimulant prescription drug modafinil. Although pharmacokinetic research shows that modafinil does not alter levels of warfarin, this study was limited to a single dose. Experts recommend monitoring international normalized ratio (INR) in patients who are taking warfarin and initiating treatment with modafinil.

Likelihood Possible Evidence D
Adrafinil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Adrafinil 300 mg, from the product label.

Absorb Health

See all Absorb Health products
Name
Absorb Health
Web Address
www.absorbyourhealth.com
Pharmacist Counseling Corner

Adrafinil 300 mg by Absorb Health: Common Questions

Does Adrafinil 300 mg by Absorb Health interact with any medications?
Yes. Based on its ingredients, Adrafinil 300 mg has a known interaction with 1,057 medications, including 1 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Adrafinil 300 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does adrafinil actually do?
Adrafinil converts in your body to modafinil, a prescription stimulant used to promote wakefulness. The evidence for whether it works for age-related cognitive decline, mental alertness, athletic performance, obesity, or exercise-induced muscle damage isn't established in the data we hold — all are rated insufficient reliable evidence to rate.
Can I take this if I'm pregnant or breastfeeding?
No. There is no safety data for adrafinil in pregnancy or breastfeeding, so the advice is to avoid it during both. Talk with your doctor or pharmacist about your options.
What are the side effects?
The most common are disturbed sleep, headache, malodorous urine, and unpleasant stimulation. Headache, poor concentration, irritability, sedation, anxiety, and sleep problems have also been reported. Rarely, involuntary mouth and tongue movements have occurred. Some people report fatigue, irritability, poor focus, and GI symptoms when they stop taking it.
Why is this a precursor to modafinil, not modafinil itself?
Adrafinil is not a prescription drug in the United States, so it's sold as a supplement. However, your body converts it to modafinil once you take it, which is why it carries similar interaction risks and side effects.
Can I take this with my blood pressure medication?
Probably not — adrafinil may reduce how well blood pressure medications work because it can raise your blood pressure. Check with your pharmacist before you start; this is one of the more serious interaction concerns.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Adrafinil 300 mg label
Go deeper

The Full Monographs Behind Adrafinil 300 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Adrafinil

Interacts with 1,057 drugs

Adrafinil is a synthetic compound that the body converts into modafinil, a prescription wakefulness-promoting drug. It is sometimes sold as a nootropic supplement, but it is unregulated, car...

Read the full Adrafinil monograph →
Sources

Sources & How We Checked

Adrafinil 300 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Adrafinil 7 references
  1. Urban AE, Cubala WJ. The role of eugeroics in the treatment of affective disorders. Psychiatr Pol. 2020;54(1):21-33. PubMed
  2. Lowe DW, Dobson E, Jewett AG, Whisler EE. Adrafinil: Psychostimulant and purported nootropic? Am J Psych Res J. 2021;17(1):7-9. DOI
  3. Thobois S, Xie J, Mollion H, Benatru I, Broussolle E. Adrafinil-induced orofacial dyskinesia. Mov Disord 2004;19(8):965-6. PubMed
  4. Chariot J, Appia F, Vaille C, Rozé C. Effect of modafinil on pancreatic exocrine secretion in rats. A comparison with adrafinil and related drugs. Fundam Clin Pharmacol 1987;1(4):243-52. PubMed
  5. Kumar R. Approved and investigational uses of modafinil: an evidence-based review. Drugs. 2008;68(13):1803-39. PubMed
  6. Provigil (modafinil) [package insert]. North Wales, PA: Teva Pharmaceuticals USA, Inc. Published: January 2015. Accessed on: Nov 11, 2022.
  7. Kinslow, CJ, Shapiro SD, Grunebaum MF, Miller EC. Acute hypertensive crisis and severe headache after concurrent use of armodafinil and tranylcypromine: Case report and review of the literature. Clinical Short Communication. October 2018; 393:1-3. PubMed

See these in context on the Adrafinil monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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