Drug & supplement interaction

Adrafinil + Fenoprofen Calcium

Fenoprofen Calcium brand name: Nalfon.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Adrafinil and Fenoprofen Calcium in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Fenoprofen Calcium states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Adrafinil and Fenoprofen Calcium

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Fenoprofen Calcium and Adrafinil in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Adrafinil safety at a glance

Adrafinil overall Use caution It converts to a prescription stimulant-like drug and may stress the liver, so it should not be used casually.
Pregnancy Possibly Unsafe When used orally. Adrafinil is a precursor to the stimulant prescription drug modafinil. Modafinil has been associated with reports of intrauterine growth restr... Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used orally. Adrafinil is a precursor to the stimulant prescription drug modafinil. Modafinil has been associated with reports of intrauterine growth restr... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Fenoprofen Calcium and Adrafinil? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Fenoprofen Calcium

Interactions in our licensed database are recorded against drug classes, not just single drug names. Fenoprofen Calcium is filed under 5 classifications — including nonsteroidal anti-inflammatory drugs (nsaids), organic anion transporter 3 (oat3) substrates, organic anion transporter 1 (oat1) substrates. Adrafinil has documented interactions with 11 drug classes — the most serious being modafinil (provigil) (major), antihypertensive drugs (moderate) and cytochrome p450 1a2 (cyp1a2) substrates (moderate) — and none of Fenoprofen Calcium’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Adrafinil Does Interact With Other Medications

Adrafinil has 1 major, 1,056 moderate known drug interactions in our database — Fenoprofen Calcium isn’t one of them. If you take anything else, check it against the full list below.

Major 1 Moderate 1,056 No known interaction 1,773 (incl. Fenoprofen Calcium)
Taking anything else?

Check Another of Your Medications Against Adrafinil

Covers the 2,830 medications we’ve checked against Adrafinil. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Adrafinil and Fenoprofen Calcium May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Raised blood pressure Worth acting on Additional detail

    Adrafinil

    “Adrafinil is a precursor to the stimulant prescription drug modafinil. Modafinil has been shown to increase heart rate and diastolic and systolic blood pressure. Hypertension and tachycardia have been reported.”

    Adrafinil · Natural Medicines adverse-effect record, reported in hypertension.

    3 sources cited
    1. 104950. Urban AE, Cubala WJ. The role of eugeroics in the treatment of affective disorders. Psychiatr Pol. 2020;54(1):21-33. PubMed
    2. 109225. Lowe DW, Dobson E, Jewett AG, Whisler EE. Adrafinil: Psychostimulant and purported nootropic? Am J Psych Res J. 2021;17(1):7-9. DOI
    3. 109229. Kumar R. Approved and investigational uses of modafinil: an evidence-based review. Drugs. 2008;68(13):1803-39. PubMed

    Fenoprofen Calcium

    Listed in the ADVERSE REACTIONS section of the FDA label for Fenoprofen Calcium. Read the label on DailyMed ›

  • A fast or pounding heartbeat Additional detail

    Adrafinil

    Recorded for Adrafinil in the same Natural Medicines adverse-effect record shown under Raised blood pressure above.

    Fenoprofen Calcium

    Listed in the ADVERSE REACTIONS section of the FDA label for Fenoprofen Calcium. Read the label on DailyMed ›

  • Drowsiness / Anxiety or restlessness Additional detail

    Adrafinil

    “Anecdotally, headache, poor concentration, irritability, sedation, disturbed sleep, unpleasant stimulation, and anxiety have been reported following intake of adrafinil. It is unknown if individuals reporting these symptoms were also taking other substances.

    Adrafinil is a precursor to the stimulant prescription drug modafinil. Insomnia, headache, and nervousness are common adverse effects of modafinil.”

    Adrafinil · Natural Medicines adverse-effect record, reported in anxiety.

    4 sources cited
    1. 109225. Lowe DW, Dobson E, Jewett AG, Whisler EE. Adrafinil: Psychostimulant and purported nootropic? Am J Psych Res J. 2021;17(1):7-9. DOI
    2. 104950. Urban AE, Cubala WJ. The role of eugeroics in the treatment of affective disorders. Psychiatr Pol. 2020;54(1):21-33. PubMed
    3. 109229. Kumar R. Approved and investigational uses of modafinil: an evidence-based review. Drugs. 2008;68(13):1803-39. PubMed
    4. 109226. Thobois S, Xie J, Mollion H, Benatru I, Broussolle E. Adrafinil-induced orofacial dyskinesia. Mov Disord 2004;19(8):965-6. PubMed

    Fenoprofen Calcium

    Listed in the ADVERSE REACTIONS section of the FDA label for Fenoprofen Calcium. Read the label on DailyMed ›

  • Tiredness Additional detail

    Adrafinil

    “Anecdotally, feelings of withdrawal have been reported following cessation of adrafinil. Symptoms included fatigue, irritability, lack of focus, headache, and gastrointestinal symptoms. It is unknown if individuals reporting these symptoms were also taking other substances.

    Adrafinil is a precursor to the stimulant prescription drug modafinil.”

    Adrafinil · Natural Medicines adverse-effect record, reported in cluster headache.

    3 sources cited
    1. 109225. Lowe DW, Dobson E, Jewett AG, Whisler EE. Adrafinil: Psychostimulant and purported nootropic? Am J Psych Res J. 2021;17(1):7-9. DOI
    2. 104950. Urban AE, Cubala WJ. The role of eugeroics in the treatment of affective disorders. Psychiatr Pol. 2020;54(1):21-33. PubMed
    3. 109229. Kumar R. Approved and investigational uses of modafinil: an evidence-based review. Drugs. 2008;68(13):1803-39. PubMed

    Fenoprofen Calcium

    Listed in the ADVERSE REACTIONS section of the FDA label for Fenoprofen Calcium. Read the label on DailyMed ›

  • Headache Additional detail

    Adrafinil

    “There is limited reliable information available about the safe use of adrafinil. However, adrafinil is a precursor to the stimulant prescription drug modafinil and may cause similar adverse effects.

    Most Common Adverse Effects:

    Orally: Disturbed sleep, headache, malodorous urine, and unpleasant stimulation.

    Serious Adverse Effects (Rare):

    Orally: Orofacial dyskinesia.”

    Adrafinil · Natural Medicines adverse-effect record, reported in cluster headache.

    Fenoprofen Calcium

    Listed in the ADVERSE REACTIONS section of the FDA label for Fenoprofen Calcium. Read the label on DailyMed ›

  • Nausea Additional detail

    Adrafinil

    “Adrafinil is a precursor to the stimulant prescription drug modafinil. Nausea is a common adverse effect of modafinil. Decreased appetite is common in children and adolescents and may be related to weight loss.”

    Adrafinil · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    2 sources cited
    1. 104950. Urban AE, Cubala WJ. The role of eugeroics in the treatment of affective disorders. Psychiatr Pol. 2020;54(1):21-33. PubMed
    2. 109229. Kumar R. Approved and investigational uses of modafinil: an evidence-based review. Drugs. 2008;68(13):1803-39. PubMed

    Fenoprofen Calcium

    Listed in the ADVERSE REACTIONS section of the FDA label for Fenoprofen Calcium. Read the label on DailyMed ›

Reported for Adrafinil but not commonly for Fenoprofen Calcium: a severe skin reaction, reduced appetite, mood changes or irritability and weight loss.

Effects for Fenoprofen Calcium come from the ADVERSE REACTIONS section of its FDA label; effects for Adrafinil come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Adrafinil in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When used orally. Adrafinil is a precursor to the stimulant prescription drug modafinil. Modafinil has been associated with reports of intrauterine growth restriction and spontaneous abortion. Also, animal studies show that developmental toxicity occurs with use of modafinil during pregnancy. Although modafinil, and possibly adrafinil, might have addictive potential, the potential for abuse is low. However, there have been anecdotal reports of withdrawal symptoms following use of adrafinil, alone or in combination with other products. Avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Fenoprofen Calcium Products Have a Food Rule — Adrafinil Should Not Break It

At least one FDA label for a product containing Fenoprofen Calcium says to take it with food. If you take Adrafinil on an empty stomach out of habit, keep them separate — and take Fenoprofen Calcium with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Fenoprofen Calcium products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Fenoprofen Calcium may be administered with meals or with milk.

From the Dosage and Administration section of the FDA label we read for Fenoprofen Calcium — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Fenoprofen Calcium

This page covers Adrafinil only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Fenoprofen Calcium page lists 32 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Siberian Cocklebur (major) and Wine (major).

By severity: 5 major · 16 moderate · 11 minor.

From our pharmacist’s overview on the Fenoprofen Calcium page

“The kidneys and the stomach lining take the brunt of any NSAID, and fenoprofen calcium (Nalfon), prescribed for arthritis and other pain, is no exception. This list of 32 interacting supplements deserves real caution; five carry a major rating, and understanding those five comes first.”

Reviewed by 2 · Jul 18, 2026

Open the Fenoprofen Calcium interaction page

One more smart check

Taking Adrafinil as Part of a Dietary Supplement Product? Check It for Interactions

We hold 7 real supplement products containing Adrafinil, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Adrafinil. Even though Adrafinil itself has no known interaction with Fenoprofen Calcium, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Adrafinil and Fenoprofen Calcium Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Adrafinil
Top half

#511 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Fenoprofen Calcium
Top 25%

#375 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Adrafinil reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Adrafinil and Fenoprofen Calcium records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Adrafinil

What is Adrafinil?

Adrafinil
  • Wakefulness and alertness
  • Fatigue
  • Focus and concentration
  • Cognitive enhancement (nootropic)
  • Daytime sleepiness

Adrafinil is a synthetic compound that the body converts into modafinil, a prescription wakefulness-promoting drug. It is sometimes sold as a nootropic supplement, but it is unregulated, carries real risks (especially to the liver), and is banned in some sports and countries. Talk with a doctor or pharmacist before using it.

Synthetic compound (not from a plant) · Capsules, tablets, powder

An interaction check asks whether these two react with each other — it does not ask whether Adrafinil is a good idea for someone in your situation. Here is what our Adrafinil record says about it on its own.

Adrafinil: dosing

There is no officially established or standardized supplement dose for adrafinil, and it is not approved as a dietary supplement by health authorities. Doses used historically as a prescription medicine were determined by doctors and are not the same as casual self-dosing.If a product is used, follow the directions on the label and do not exceed them. Because of the liver risk, it is generally not recommended for daily or long-term use, and periodic liver function testing may be wise.

From our Adrafinil monograph — the full record covers uses, side effects and every documented interaction.

Read the full Adrafinil monograph & all interactions
Medication

About Fenoprofen

What Is Fenoprofen Used For?

Brand name: Nalfon

Fenoprofen is used in adults to relieve mild to moderate pain. It also treats the signs and symptoms of rheumatoid arthritis and osteoarthritis, including pain, swelling, and stiffness in the joints.

These uses are supported by products sold as Fenoprofen Calcium, Fenopron, and Nalfon capsules, as well as Nalfon tablets — all taken by mouth.

See full Fenoprofen drug information
Keep checking

Other Drugs & Adrafinil

Browse every other medication we’ve checked against Adrafinil — both the ones with a known interaction and the ones without. Select any drug for the full detail.

1Major
1,056Moderate
0Minor
1,772No known interaction
1 Major 1,056 Moderate 1,772 No interaction
Major

1 interaction

Moderate

1,056 interactions

Showing 60 of 1,056 moderate interactions — see all 1,056 on the Adrafinil page.

No interaction 1,772 drugs checked — show the list

We also checked Adrafinil against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,772 medications checked with no known interaction — see the full Adrafinil list.

See the full Adrafinil interactions page
See every supplement checked against Fenoprofen Calcium, ranked by severity
Evidence & sources

Adrafinil References

The 7 references that drive our Adrafinil monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Urban AE, Cubala WJ. The role of eugeroics in the treatment of affective disorders. Psychiatr Pol. 2020;54(1):21-33. PubMed
  2. Lowe DW, Dobson E, Jewett AG, Whisler EE. Adrafinil: Psychostimulant and purported nootropic? Am J Psych Res J. 2021;17(1):7-9. DOI
  3. Thobois S, Xie J, Mollion H, Benatru I, Broussolle E. Adrafinil-induced orofacial dyskinesia. Mov Disord 2004;19(8):965-6. PubMed
  4. Chariot J, Appia F, Vaille C, Rozé C. Effect of modafinil on pancreatic exocrine secretion in rats. A comparison with adrafinil and related drugs. Fundam Clin Pharmacol 1987;1(4):243-52. PubMed
  5. Kumar R. Approved and investigational uses of modafinil: an evidence-based review. Drugs. 2008;68(13):1803-39. PubMed
  6. Provigil (modafinil) [package insert]. North Wales, PA: Teva Pharmaceuticals USA, Inc. Published: January 2015. Accessed on: Nov 11, 2022.
  7. Kinslow, CJ, Shapiro SD, Grunebaum MF, Miller EC. Acute hypertensive crisis and severe headache after concurrent use of armodafinil and tranylcypromine: Case report and review of the literature. Clinical Short Communication. October 2018; 393:1-3. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Adrafinil and Fenoprofen Calcium Together: Common Questions

Is it safe to take Adrafinil with Fenoprofen Calcium?
We do not list a known interaction between Adrafinil and Fenoprofen Calcium. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Adrafinil and Fenoprofen Calcium have any of the same side effects?
Yes — our sources link each of them separately to 7 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Adrafinil and Fenoprofen Calcium at the same time of day?
At least one FDA label for a product containing Fenoprofen Calcium says to take it with food. If you take Adrafinil on an empty stomach out of habit, keep them separate and take Fenoprofen Calcium with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Fenoprofen Calcium products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Adrafinil and Fenoprofen Calcium combination checked?
Interactions in our licensed database are recorded against drug classes. Fenoprofen Calcium is filed under 5 classifications, and Adrafinil has documented interactions with 11 drug classes — none of Fenoprofen Calcium's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Adrafinil interact with any other medications?
Yes. Adrafinil has 1,057 documented drug interactions in our database — Fenoprofen Calcium is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Fenoprofen Calcium interact with any supplements?
Yes. Fenoprofen Calcium has documented interactions with 32 supplements in our database — Adrafinil is not one of them. The Fenoprofen Calcium interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Adrafinil monograph Uses, safety profile, and every drug interaction in one place Fenoprofen drug information The full plain-English guide to this medication Fenoprofen Calcium supplement interactions Every supplement checked against Fenoprofen Calcium, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 7 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Fenoprofen Calcium and Adrafinil?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.