Herb & supplement monograph

Wahoo Drug Interactions, Uses, Safety & More

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS ·Updated July 2026

What is this page for?

First and foremost: how Wahoo interacts with medications. The heart of this page is the interaction list — every drug Wahoo is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Wahoo is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Reviewed by licensed pharmacists Sourced from Natural Medicines

On this page

Wahoo Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, Wahoo drug interactions carry real risk, mainly because this plant contains heart-active compounds that can add to or worsen the effects of certain medications. One interaction is rated major and well documented in humans, and the rest are moderate concerns that nearly all trace back to the same heart-related risk.

Interactions deserving the most attention

The combination that matters most is digoxin, and this pairing is considered contraindicated because wahoo can duplicate the drug's effects and push it into toxic territory. Caution also applies to potassium-depleting diuretics such as furosemide and hydrochlorothiazide, and to stimulant laxatives, since losing potassium can make wahoo's heart effects more dangerous. Macrolide and tetracycline antibiotics, as well as quinine, raise a similar theoretical concern about heart toxicity.

What the rest of the list means

Although the list of interacting medications is long, almost every entry reflects one shared worry rather than many separate problems: wahoo's natural heart-active compounds. Outside of digoxin, these interactions are theoretical, based on how the combinations could behave rather than on proven harm in people. Even so, the consistent heart-related theme is why so many moderate cautions appear.

Check your medications against Wahoo

Based on HelloPharmacist’s Wahoo interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Wahoo

133 medications have a known interaction with Wahoo, graded by severity. Select any drug for the full evidence-based detail.

1 major interaction. These combinations can be clinically significant — best avoided, or used only with close professional supervision. Always check with your pharmacist before combining them with Wahoo.

Don’t want to scroll the list? Just ask.

Tell us the medications you take and we’ll check each one against Wahoo using our pharmacist-reviewed interaction data.

AI summaries are generated from our Wahoo interaction data for education only — always confirm with your pharmacist. How we use AI

2,830 drugs

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
Each drug listed above links to the full report for that exact Wahoo combination — clinical detail, likelihood, evidence level, and citations.
Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

The big picture

The kinds of drugs Wahoo affects

Every type of medication (drug category) Wahoo is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 6 drug categories Wahoo interacts with

Digoxin (lanoxin)Diuretic DrugsMacrolide AntibioticsQuinineStimulant LaxativesTetracycline Antibiotics

Digoxin (Lanoxin)

Contraindicated; using wahoo with digoxin increases risk of cardiac glycoside toxicity due to therapeutic duplication.

Likelihood Likely Evidence D

Diuretic Drugs

Theoretically, concomitant use of potassium-depleting diuretics with wahoo can increase the risk of cardiac glycoside toxicity due to potassium depletion. Some diuretics that can deplete potassium include chlorothiazide (Diuril), chlorthalidone (Thalitone), furosemide (Lasix), hydrochlorothiazide (HCTZ, Hydrodiuril, Microzide), and others.