Drug & supplement interaction

Wahoo + Sodium Bicarbonate (OTC Drug)

Sodium Bicarbonate (OTC Drug) brand name: Sodium Bicarbonate.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Wahoo and Sodium Bicarbonate (OTC Drug) in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Wahoo and Sodium Bicarbonate (OTC Drug)

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Sodium Bicarbonate (OTC Drug) and Wahoo in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Wahoo safety at a glance

Wahoo overall Avoid Wahoo is considered poisonous and can cause serious, even life-threatening effects.
Pregnancy Likely Unsafe When used orally. Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Sodium Bicarbonate (OTC Drug) and Wahoo? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Sodium Bicarbonate (OTC Drug)

Interactions in our licensed database are recorded against drug classes, not just single drug names. Sodium Bicarbonate (OTC Drug) is filed under 2 classifications — antacids, oral drugs. Wahoo has documented interactions with 6 drug classes — the most serious being digoxin (lanoxin) (major), diuretic drugs (moderate) and macrolide antibiotics (moderate) — and none of Sodium Bicarbonate (OTC Drug)’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Wahoo Does Interact With Other Medications

Wahoo has 1 major, 132 moderate known drug interactions in our database — Sodium Bicarbonate (OTC Drug) isn’t one of them. If you take anything else, check it against the full list below.

Major 1 Moderate 132 No known interaction 2,697 (incl. Sodium Bicarbonate (OTC Drug))
Taking anything else?

Check Another of Your Medications Against Wahoo

Covers the 2,830 medications we’ve checked against Wahoo. Pick one to open its full report.

What to actually watch for

What Wahoo Itself Has Been Linked To

This is not an interaction — nothing below involves Sodium Bicarbonate (OTC Drug). It is the side-effect record for Wahoo on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Wahoo, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • Shortness of breath Worth acting on Additional detail

    “Wahoo is considered poisonous (17). Several hours after ingesting wahoo seeds, people experience severe upset stomach, sometimes with bloody diarrhea, fever, shortness of breath, circulatory problems, signs of collapse, stupor increasing to unconsciousness, alternating with motor restlessness, severe tonic-clonic spasms with locked jaw muscles and coma.”

    Wahoo · Natural Medicines adverse-effect record, reported in diarrhea.

    1 source cited
    1. 17. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
  • Anxiety or restlessness / Stomach upset / Fever / Diarrhea Additional detail

    Recorded for Wahoo in the same Natural Medicines adverse-effect record shown under Shortness of breath above.

Everything above comes from the Natural Medicines adverse-effect record for Wahoo — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Sodium Bicarbonate (OTC Drug)’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Sodium Bicarbonate (OTC Drug) column appears here.

Special populations

Wahoo in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When used orally.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Wahoo or Sodium Bicarbonate (OTC Drug)

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Wahoo or Sodium Bicarbonate (OTC Drug), not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Sodium Bicarbonate (OTC Drug)

This page covers Wahoo only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Sodium Bicarbonate (OTC Drug) page lists 30 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Cinchona (moderate), Coffee Charcoal (moderate), European Mandrake (moderate) and Glucomannan (moderate).

By severity: 1 major · 10 moderate · 19 minor.

Open the Sodium Bicarbonate (OTC Drug) interaction page

One more smart check

Taking Wahoo as Part of a Dietary Supplement Product? Check It for Interactions

We hold 9 real supplement products containing Wahoo, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Wahoo. Even though Wahoo itself has no known interaction with Sodium Bicarbonate (OTC Drug), another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Wahoo and Sodium Bicarbonate (OTC Drug) Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Wahoo
Top half

#626 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Sodium Bicarbonate (OTC Drug)
Top 5%

#132 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Wahoo reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Wahoo and Sodium Bicarbonate (OTC Drug) records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Wahoo

What is Wahoo?

Wahoo
  • Constipation (traditional laxative)
  • Digestive complaints
  • Liver and gallbladder support (folk use)
  • Fluid retention (traditional diuretic)
  • Skin irritations (folk use)

Wahoo is a North American shrub historically used as a laxative and 'liver tonic,' but it is a poisonous plant with no proven benefit and a real risk of serious harm. Because it contains heart-affecting and other toxic compounds, we do not recommend using it, and there is no established safe dose.

Euonymus atropurpureus · Celastraceae · Dried root bark and stem bark (historically) · Historically tinctures, extracts, and powdered bark; rarely available today

An interaction check asks whether these two react with each other — it does not ask whether Wahoo is a good idea for someone in your situation. Here is what our Wahoo record says about it on its own.

Wahoo: dosing

There is no established safe or effective dose of wahoo, and we do not recommend using it. In most cases the safest choice is to avoid it entirely and use a better-studied, safer option instead.

From our Wahoo monograph — the full record covers uses, side effects and every documented interaction.

Read the full Wahoo monograph & all interactions
Medication

About Sodium Bicarbonate

What Is Sodium Bicarbonate Used For?

Brand name: Sodium Bicarbonate

Sodium bicarbonate treats several different types of discomfort depending on the product and how it is used. Taken by mouth, it relieves heartburn, sour stomach, acid indigestion, and upset stomach. EcoDent Ultimate Essential Mouthcare oral solution is used to temporarily clean minor mouth wounds and soothe minor gum inflammation from dental procedures, dentures, orthodontic appliances, or accidental injury.

Used on the skin, sodium bicarbonate products — including After Bite Kids cream, After Bite Advanced and After Bite X Tech liquids, Itch Eraser Sensitive cream, AHHH Bite Relief gel, Insect sting relief latex lotion, Insect sting relief pad, and Dermfree Insect Bite Relief liquid — temporarily relieve minor skin irritation and itching from insect bites, stings, and contact with poison ivy, oak, or sumac. AHHH Bite Relief also provides rapid relief from specific biting insects including deer flies, horse flies, black flies, mosquitoes, bees, wasps, and chiggers, and from rashes and eczema.

See full Sodium Bicarbonate drug information
Keep checking

Other Drugs & Wahoo

Browse every other medication we’ve checked against Wahoo — both the ones with a known interaction and the ones without. Select any drug for the full detail.

1Major
132Moderate
0Minor
2,696No known interaction
1 Major 132 Moderate 2,696 No interaction
Major

1 interaction

Moderate

132 interactions

Showing 60 of 132 moderate interactions — see all 132 on the Wahoo page.

No interaction 2,696 drugs checked — show the list

We also checked Wahoo against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,696 medications checked with no known interaction — see the full Wahoo list.

See the full Wahoo interactions page
See every supplement checked against Sodium Bicarbonate (OTC Drug), ranked by severity
Evidence & sources

Wahoo References

The 4 references that drive our Wahoo monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
  3. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  4. Burnham TH, ed. Drug Facts and Comparisons, Updated Monthly. Facts and Comparisons, St. Louis, MO.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Wahoo and Sodium Bicarbonate (OTC Drug) Together: Common Questions

Is it safe to take Wahoo with Sodium Bicarbonate (OTC Drug)?
We do not list a known interaction between Wahoo and Sodium Bicarbonate (OTC Drug). That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Wahoo and Sodium Bicarbonate (OTC Drug) combination checked?
Interactions in our licensed database are recorded against drug classes. Sodium Bicarbonate (OTC Drug) is filed under 2 classifications, and Wahoo has documented interactions with 6 drug classes — none of Sodium Bicarbonate (OTC Drug)'s classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Wahoo interact with any other medications?
Yes. Wahoo has 133 documented drug interactions in our database — Sodium Bicarbonate (OTC Drug) is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Sodium Bicarbonate (OTC Drug) interact with any supplements?
Yes. Sodium Bicarbonate (OTC Drug) has documented interactions with 30 supplements in our database — Wahoo is not one of them. The Sodium Bicarbonate (OTC Drug) interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Wahoo monograph Uses, safety profile, and every drug interaction in one place Sodium Bicarbonate drug information The full plain-English guide to this medication Sodium Bicarbonate (OTC Drug) supplement interactions Every supplement checked against Sodium Bicarbonate (OTC Drug), ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Sodium Bicarbonate (OTC Drug) and Wahoo?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.