Herb & supplement monograph

Black Bryony Drug Interactions, Uses, Safety & More

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Interaction report

Drugs that interact with Black Bryony

0 medications have a known interaction with Black Bryony, graded by severity. Select any drug for the full evidence-based detail.

We don’t currently list any known drug interactions for Black Bryony. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Black Bryony combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Monograph

Black Bryony: Uses, Safety & Side Effects

The bottom line

Black Bryony is a toxic climbing plant whose root has been used in folk medicine, mostly applied to the skin for bruises and aches. There is little to no reliable scientific evidence that it works, and it can cause serious poisoning if swallowed or severe irritation on the skin. Because of these real risks, it is best avoided, especially without guidance from a healthcare professional.

Black Bryony
Scientific name
Dioscorea communis
Family
Dioscoreaceae
Part used
Root (tuber); occasionally berries and aerial parts (all considered toxic)
Common forms
Traditional poultices and ointments for external use; rarely sold as a modern supplement
People commonly use it for
  • Bruises and sprains (applied to the skin)
  • Joint and muscle pain
  • Chilblains
  • Rheumatic complaints
  • Skin and folk "healing" remedies

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallBest avoided

The plant contains irritant and toxic compounds and can cause poisoning, so it is generally best avoided.

PregnancyUnsafe

When used orally. All parts of the black bryony plant are considered poisonous.

Read the full pregnancy detail
BreastfeedingUnsafe

When used orally. All parts of the black bryony plant are considered poisonous.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

Black Bryony (Dioscorea communis, also called Black Bindweed or Blackeye Root) is a climbing perennial vine native to parts of Europe, North Africa, and western Asia. It has heart-shaped leaves, small greenish flowers, and bright red berries, and it grows from a large dark tuber-like root underground.

In traditional folk medicine, the root was most often crushed and applied to the skin as a poultice or rubbed on areas of bruising, swelling, or joint pain. Its many old folk names, including "Herbe aux Femmes Battues" (loosely, "herb of beaten women"), come from its long-standing use on bruises.

It is important to know that nearly all parts of this plant are considered poisonous. It is not a common modern supplement, and most authorities describe it as a toxic plant rather than a safe remedy.

Uses & effectiveness

People have traditionally used Black Bryony mostly on the skin for bruises, sprains, sore muscles, rheumatic aches, and chilblains (painful skin from cold). Some old remedies also used it internally, but this practice is dangerous.

The scientific evidence for any of these uses is very weak. There are no high-quality human studies showing that Black Bryony safely or effectively treats any health condition. Most of what is known comes from traditional use and a small amount of laboratory work, which cannot prove that the plant helps people.

Because the plant is toxic and unproven, the potential risks clearly outweigh any unconfirmed benefit. Safer, better-studied options exist for bruises, muscle aches, and joint pain.

How it works

Black Bryony contains irritant compounds, including calcium oxalate crystals (sharp microscopic needles) and saponins, along with other plant chemicals. When applied to the skin, these irritants are thought to cause redness, warmth, and a stinging or burning feeling. Some traditional users believed this irritating, "counter-irritant" effect helped draw attention away from underlying pain.

The same compounds that cause skin irritation can damage the mouth, throat, and digestive tract if the plant is swallowed. Any proposed effects are based mainly on the plant's chemistry and old folk use, not on solid clinical research in people.

Safety & precautions

Black Bryony is considered a poisonous plant. The berries, root, and other parts can cause serious poisoning if eaten. Children are especially at risk because the bright red berries may look tempting.

Even on the skin, it can cause strong irritation, blistering, and burns. People with sensitive skin or skin conditions should not use it. Anyone with a history of allergies to plants should be especially cautious.

Pregnancy and breastfeeding: Avoid Black Bryony entirely. There is no reliable safety information, and its toxic compounds make any use unsafe during these times.

Because of the real risk of poisoning and skin injury, it is best to avoid this plant altogether. Always talk with a pharmacist or doctor before using any unfamiliar herbal product, and keep this plant and its berries away from children and pets.

Side effects

On the skin, Black Bryony can cause redness, burning, itching, blistering, and skin damage. Contact with the eyes can cause severe irritation.

If swallowed, it can cause serious effects such as burning of the mouth and throat, intense stomach pain, nausea, vomiting, and diarrhea. Larger amounts may lead to more severe poisoning. If someone eats any part of this plant, seek emergency medical care or contact a poison control center right away.

Black Bryony: Reported Adverse Effects

Documented safety reports on Black Bryony from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Orally, all parts of the black bryony plant are considered poisonous due to its saponin content. Black bryony has been reported to cause severe gastrointestinal irritation, vomiting, diarrhea, seizures, respiratory failure, and kidney failure. Topically, black bryony has been reported to cause contact dermatitis.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Schmidt RJ, Moult SP. The dermatitic properties of black bryony (Tamus communis L.). Contact Dermatitis 1983;9:390-6.
  3. Kashchenko, V. B. and Kozhukhar', G. S. [Toxidermia caused by Tamus communis]. Vestn.Dermatol.Venerol. 1986;(5):50-51.
  4. Miliavskii, A. I. [Contact dermatitis caused by black bryony]. Vestn.Dermatol.Venerol. 1979;(7):49-50.
Reports by condition
Dermatitis Dermatologic

Topically, black bryony has been reported to cause contact dermatitis involving skin irritation, rash, swelling, pustules, and wheals. The histamine and calcium oxalate crystal constituents of black bryony mucilage are thought to contribute to these dermatologic reactions.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Schmidt RJ, Moult SP. The dermatitic properties of black bryony (Tamus communis L.). Contact Dermatitis 1983;9:390-6.
  3. Kashchenko, V. B. and Kozhukhar', G. S. [Toxidermia caused by Tamus communis]. Vestn.Dermatol.Venerol. 1986;(5):50-51.
  4. Miliavskii, A. I. [Contact dermatitis caused by black bryony]. Vestn.Dermatol.Venerol. 1979;(7):49-50.
Diarrhea Gastrointestinal

Orally, black bryony has been reported to cause severe mouth, pharyngeal, and gastrointestinal irritation. It has also been reported to cause vomiting and diarrhea.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Epilepsy Neurologic/CNS

Orally, black bryony has been reported to cause seizures.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Kidney failure Renal

Orally, black bryony has been reported to cause renal failure.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no established safe dose for Black Bryony. It has not been studied well enough to recommend any amount, and because it is toxic, no standard dose exists for taking it by mouth.

If you ever encounter a product that contains it, do not assume it is safe. Follow the product label only as a last resort, and check with a pharmacist or doctor first. Given the risks, the safest approach is not to use it at all.

Pregnancy & Breastfeeding

Black Bryony & Pregnancy

Unsafe

When used orally. All parts of the black bryony plant are considered poisonous.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Black Bryony & Breastfeeding

Unsafe

When used orally. All parts of the black bryony plant are considered poisonous.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 4 references that drive our Black Bryony monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Schmidt RJ, Moult SP. The dermatitic properties of black bryony (Tamus communis L.). Contact Dermatitis 1983;9:390-6.
  3. Kashchenko, V. B. and Kozhukhar', G. S. [Toxidermia caused by Tamus communis]. Vestn.Dermatol.Venerol. 1986;(5):50-51.
  4. Miliavskii, A. I. [Contact dermatitis caused by black bryony]. Vestn.Dermatol.Venerol. 1979;(7):49-50.
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Pharmacist Counseling Corner

Black Bryony: Common Questions

Does Black Bryony interact with prescription medications?
We do not currently list any known drug interactions for Black Bryony. This does not guarantee that none exist, so always confirm with your pharmacist before combining it with your medications.
How are Black Bryony interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Black Bryony with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Black Bryony interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Black Bryony used for?
Traditionally it was applied to the skin for bruises, sprains, sore joints, and chilblains. There is no strong scientific proof that it works for any of these uses.
Is Black Bryony safe to take?
No. It is considered a poisonous plant that can cause skin burns and serious poisoning if swallowed, so most experts recommend avoiding it.
Are the red berries poisonous?
Yes. The bright red berries are toxic and can be especially dangerous to children, who may be attracted to their color. Keep them away from kids and pets.
Can I use Black Bryony if I'm pregnant or breastfeeding?
No. It should be avoided during pregnancy and breastfeeding because it is toxic and there is no reliable safety information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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