Herb & supplement monograph

Squill Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS ·Updated July 2026

What is this page for?

First and foremost: how Squill interacts with medications. The heart of this page is the interaction list — every drug Squill is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Squill is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Reviewed by licensed pharmacists Sourced from Natural Medicines

On this page

Squill Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, Squill drug interactions carry a genuine risk, mainly because squill contains natural heart-active compounds that can add to or amplify the effects of many common medications. One interaction is rated major and all the rest are moderate, with none considered minor.

Interactions deserving the most attention

The clearest concern is digoxin: squill contains similar heart-active compounds, so combining them doubles up the effect and is considered contraindicated due to the risk of toxicity. Also important are potassium-depleting diuretics like furosemide and hydrochlorothiazide, along with corticosteroids and stimulant laxatives, since low potassium makes squill's heart effects more dangerous. Most of these concerns rest on theory rather than human studies, but because they involve heart rhythm, they deserve respect.

What the rest of the list means

Beyond these, the long list of moderate interactions is largely based on what is known about digoxin, not on direct studies of squill itself. Certain antibiotics and quinine, for example, can raise digoxin levels, so experts predict the same could happen with squill. In other words, many of these combinations are cautionary predictions rather than effects proven to be harmful in people.

Check your medications against Squill

Based on HelloPharmacist’s Squill interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Squill

156 medications have a known interaction with Squill, graded by severity. Select any drug for the full evidence-based detail.

1 major interaction. These combinations can be clinically significant — best avoided, or used only with close professional supervision. Always check with your pharmacist before combining them with Squill.

Don’t want to scroll the list? Just ask.

Tell us the medications you take and we’ll check each one against Squill using our pharmacist-reviewed interaction data.

AI summaries are generated from our Squill interaction data for education only — always confirm with your pharmacist. How we use AI

2,830 drugs

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
Each drug listed above links to the full report for that exact Squill combination — clinical detail, likelihood, evidence level, and citations.
Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

The big picture

The kinds of drugs Squill affects

Every type of medication (drug category) Squill is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 7 drug categories Squill interacts with

Digoxin (lanoxin)CorticosteroidsDiuretic DrugsMacrolide AntibioticsQuinineStimulant LaxativesTetracycline Antibiotics

Digoxin (Lanoxin)

Squill contains cardiac glycosides. Concomitant use of digoxin and squill is contraindicated due to therapeutic duplication and increased risk of cardiac glycoside toxicity.

Likelihood Probable Evidence D

Corticosteroids

Squill contains cardiac glycosides. Concomitant use of corticosteroids and squill might increase effects and adverse effects of long-term corticosteroid use due to potassium depletion and electrolyte imbalance.