Drug & supplement interaction

Squill + Risedronate Sodium

Risedronate Sodium brand names: Actonel, Actonel Once a Week.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Oct 4, 2026
The bottom line No known interaction

We found no known interaction between Squill and Risedronate Sodium in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Squill and Risedronate Sodium

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Risedronate Sodium and Squill in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Squill safety at a glance

Squill overall Use caution Squill contains heart-active glycosides that can be toxic, so it should only be used under medical supervision.
Pregnancy Unsafe When used orally because it can have an abortifacient effect. Read the full pregnancy detail
Breastfeeding Unsafe When used orally. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Risedronate Sodium and Squill? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Risedronate Sodium

Interactions in our licensed database are recorded against drug classes, not just single drug names. Risedronate Sodium is filed under 2 classifications — bisphosphonates, oral drugs. Squill has documented interactions with 7 drug classes — the most serious being digoxin (lanoxin) (major), corticosteroids (moderate) and diuretic drugs (moderate) — and none of Risedronate Sodium’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Squill Does Interact With Other Medications

Squill has 1 major, 155 moderate known drug interactions in our database — Risedronate Sodium isn’t one of them. If you take anything else, check it against the full list below.

Major 1 Moderate 155 No known interaction 2,674 (incl. Risedronate Sodium)
Taking anything else?

Check Another of Your Medications Against Squill

Covers the 2,830 medications we’ve checked against Squill. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Squill and Risedronate Sodium May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 2 of them are worth acting on rather than waiting out — marked below.

  • An irregular heartbeat Worth acting on Additional detail

    Squill

    “Orally, squill can cause irregular pulse (18,94852).

    Squill poisoning resembles digoxin poisoning. The cardiovascular symptoms of squill poisoning include cardiac arrest and life-threatening arrhythmias, including ventricular tachycardia, atrial tachycardia with atrioventricular block, and ventricular fibrillation (18,3488).”

    Squill · Natural Medicines adverse-effect record, reported in arrhythmia.

    3 sources cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
    2. 94852. Nejatbakhsh F, Karegar-Borzi H, Amin G, et al. Squill Oxymel, a traditional formulation from Drimia Maritima (L.) Stearn, as an add-on treatment in patients with moderate to severe persistent asthma: A pilot, triple-blind, randomized clinical trial. J Eth PubMed
    3. 3488. Tuncok Y, Kozan O, Cavdar C, et al. Urginea maritima (squill) toxicity. J Toxicol Clin Toxicol 1995;33:83-6.

    Risedronate Sodium

    Listed in the ADVERSE REACTIONS section of the FDA label for Risedronate Sodium. Read the label on DailyMed ›

  • Low mood Worth acting on Additional detail

    Squill

    “Squill is generally regarded as unsafe for use. Any benefits of therapy might not outweigh the risk of toxicity. Orally, squill can cause gastric irritation, loss of appetite, diarrhea, nausea, vomiting, stomach disorders, headache, irregular pulse (18,94852), and convulsions (6). Squill poisoning resembles digoxin poisoning.”

    Squill · Natural Medicines adverse-effect record, reported in arrhythmia.

    4 sources cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
    2. 94852. Nejatbakhsh F, Karegar-Borzi H, Amin G, et al. Squill Oxymel, a traditional formulation from Drimia Maritima (L.) Stearn, as an add-on treatment in patients with moderate to severe persistent asthma: A pilot, triple-blind, randomized clinical trial. J Eth PubMed
    3. 6. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
    4. 3488. Tuncok Y, Kozan O, Cavdar C, et al. Urginea maritima (squill) toxicity. J Toxicol Clin Toxicol 1995;33:83-6.

    “Squill poisoning resembles digoxin poisoning. The psychiatric symptoms of squill poisoning include depression, confusion, hallucinations, and psychosis (18,3488).”

    Squill · Natural Medicines adverse-effect record, reported in depression.

    2 sources cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
    2. 3488. Tuncok Y, Kozan O, Cavdar C, et al. Urginea maritima (squill) toxicity. J Toxicol Clin Toxicol 1995;33:83-6.

    Risedronate Sodium

    Listed in the ADVERSE REACTIONS section of the FDA label for Risedronate Sodium. Read the label on DailyMed ›

  • Stomach upset / Diarrhea / Vomiting / Nausea reported in 10.0% of FDA reports for Risedronate Sodium Additional detail

    Squill

    “Orally, squill can cause gastric irritation, loss of appetite, diarrhea, nausea, vomiting, and stomach disorders (18,94852).”

    Squill · Natural Medicines adverse-effect record, reported in diarrhea.

    2 sources cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
    2. 94852. Nejatbakhsh F, Karegar-Borzi H, Amin G, et al. Squill Oxymel, a traditional formulation from Drimia Maritima (L.) Stearn, as an add-on treatment in patients with moderate to severe persistent asthma: A pilot, triple-blind, randomized clinical trial. J Eth PubMed

    Risedronate Sodium

    Listed in the ADVERSE REACTIONS section of the FDA label for Risedronate Sodium, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • A skin rash Additional detail

    Squill

    “Topically, the fresh squill bulb can cause dermatitis (18). In one case report, a 52-year-old woman presented with non-allergic irritant contact dermatitis after topical application of a squill preparation to the knee and wrist. The squill preparation was kept under occlusive dressing for 24 hours.”

    Squill · Natural Medicines adverse-effect record, reported in dermatitis.

    2 sources cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
    2. 94852. Nejatbakhsh F, Karegar-Borzi H, Amin G, et al. Squill Oxymel, a traditional formulation from Drimia Maritima (L.) Stearn, as an add-on treatment in patients with moderate to severe persistent asthma: A pilot, triple-blind, randomized clinical trial. J Eth PubMed

    Risedronate Sodium

    Listed in the ADVERSE REACTIONS section of the FDA label for Risedronate Sodium. Read the label on DailyMed ›

  • Headache Additional detail

    Squill

    “Orally, squill can cause headache and convulsions (6).

    Squill poisoning resembles digoxin poisoning. The neurologic symptoms of squill poisoning include confusion, restlessness, stupor, and seizure (18,3488).”

    Squill · Natural Medicines adverse-effect record, reported in cluster headache.

    3 sources cited
    1. 6. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
    2. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
    3. 3488. Tuncok Y, Kozan O, Cavdar C, et al. Urginea maritima (squill) toxicity. J Toxicol Clin Toxicol 1995;33:83-6.

    Risedronate Sodium

    Listed in the ADVERSE REACTIONS section of the FDA label for Risedronate Sodium. Read the label on DailyMed ›

Reported for Squill but not commonly for Risedronate Sodium: reduced appetite, hallucinations, anxiety or restlessness and seizures.

Effects for Risedronate Sodium come from the ADVERSE REACTIONS section of its FDA label; effects for Squill come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 30,902 voluntary FDA FAERS reports for Risedronate Sodium that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Squill in Pregnancy & Breastfeeding

Pregnancy Unsafe

When used orally because it can have an abortifacient effect.

Lactation Unsafe

When used orally.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Risedronate Sodium

This page covers Squill only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Risedronate Sodium page lists 23 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Calcium (moderate), Coffee Charcoal (moderate), Dolomite (moderate) and European Mandrake (moderate).

Open the Risedronate Sodium interaction page

One more smart check

Taking Squill as Part of a Dietary Supplement Product? Check It for Interactions

We hold 2 real supplement products containing Squill, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Squill. Even though Squill itself has no known interaction with Risedronate Sodium, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Squill and Risedronate Sodium Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Squill
Steady interest

#757 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Risedronate Sodium
Steady interest

#2,607 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Squill reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Squill and Risedronate Sodium records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Squill

What is Squill?

Squill
  • Cough and chest congestion
  • Fluid retention (diuretic)
  • Heart conditions (traditional 'cardiac tonic')
  • Hair loss (topical use)
  • Rodenticide (red squill, non-medicinal)

Squill is a bulb plant that contains potent cardiac glycosides, which can affect the heart much like the drug digoxin. While it has a long history of use as a cough remedy and heart tonic, it can be dangerously toxic and there is little solid evidence for its modern use, so we do not recommend taking it without close medical supervision.

Drimia maritima · Asparagaceae · Dried inner bulb scales · Dried bulb, tinctures, liquid extracts, syrups, and some traditional cough preparations

An interaction check asks whether these two react with each other — it does not ask whether Squill is a good idea for someone in your situation. Here is what our Squill record says about it on its own.

Squill: dosing

There is no well-established, standardized safe dose of squill for general use. Because the active compounds are so potent and the toxic dose is close to any possibly effective dose, self-dosing is not recommended.If a product contains squill, follow the label exactly and do not take more than directed.

From our Squill monograph — the full record covers uses, side effects and every documented interaction.

Read the full Squill monograph & all interactions
Medication

About Risedronate

What Is Risedronate Used For?

Brand names: Actonel, Actonel Once a Week

Risedronate treats and prevents postmenopausal osteoporosis (thinning bones after menopause). In postmenopausal women with osteoporosis, it lowers the chance of spine fractures and certain other osteoporosis-related fractures.

Some uses belong only to certain products. Risedronate sodium film-coated tablets are also used to increase bone mass in men with osteoporosis. They also treat and prevent glucocorticoid-induced osteoporosis (bone loss from steroid medicines) and treat Paget's disease of bone. Risedronate sodium delayed-release tablets (including Atelvia) are labeled only for treating postmenopausal osteoporosis.

Most-Reported Side Effects for Risedronate Sodium

From FAERS, the FDA’s public side-effect reporting system (30,902 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Arthralgia 3,876 reports
Nausea 3,085 reports
Dyspnea 3,028 reports
Fatigue 3,025 reports
Vomiting 2,949 reports
See full Risedronate drug information
Keep checking

Other Drugs & Squill

Browse every other medication we’ve checked against Squill — both the ones with a known interaction and the ones without. Select any drug for the full detail.

1Major
155Moderate
0Minor
2,673No known interaction
1 Major 155 Moderate 2,673 No interaction
Major

1 interaction

Moderate

155 interactions

Showing 60 of 155 moderate interactions — see all 155 on the Squill page.

No interaction 2,673 drugs checked — show the list

We also checked Squill against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,673 medications checked with no known interaction — see the full Squill list.

See the full Squill interactions page
See every supplement checked against Risedronate Sodium, ranked by severity
Evidence & sources

Squill References

The 9 references that drive our Squill monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  3. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  4. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
  5. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  6. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  7. Tuncok Y, Kozan O, Cavdar C, et al. Urginea maritima (squill) toxicity. J Toxicol Clin Toxicol 1995;33:83-6.
  8. Nejatbakhsh F, Karegar-Borzi H, Amin G, et al. Squill Oxymel, a traditional formulation from Drimia Maritima (L.) Stearn, as an add-on treatment in patients with moderate to severe persistent asthma: A pilot, triple-blind, randomized clinical trial. J Eth PubMed
  9. Moosavi ZB, Aliabdi M, Golfakhrabadi F, Namjoyan F. The comparison of therapeutic effect of Clobetasol propionate lotion and squill extract in alopecia areata: a randomized, double-blind clinical trial. Arch Dermatol Res. 2020 Apr;312(3):173-178. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Squill and Risedronate Sodium Together: Common Questions

Is it safe to take Squill with Risedronate Sodium?
We do not list a known interaction between Squill and Risedronate Sodium. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Squill and Risedronate Sodium have any of the same side effects?
Yes — our sources link each of them separately to 8 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Squill and Risedronate Sodium combination checked?
Interactions in our licensed database are recorded against drug classes. Risedronate Sodium is filed under 2 classifications, and Squill has documented interactions with 7 drug classes — none of Risedronate Sodium's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Squill interact with any other medications?
Yes. Squill has 156 documented drug interactions in our database — Risedronate Sodium is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Risedronate Sodium interact with any supplements?
Yes. Risedronate Sodium has documented interactions with 23 supplements in our database — Squill is not one of them. The Risedronate Sodium interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Squill monograph Uses, safety profile, and every drug interaction in one place Risedronate drug information The full plain-English guide to this medication Risedronate Sodium supplement interactions Every supplement checked against Risedronate Sodium, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 9 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Risedronate Sodium and Squill?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.