Herb & supplement monograph

Oscillococcinum Drug Interactions, Uses, Effectiveness, Safety & More

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Reviewed by licensed pharmacists Sourced from Natural Medicines
Interaction report

Drugs that interact with Oscillococcinum

0 medications have a known interaction with Oscillococcinum, graded by severity. Select any drug for the full evidence-based detail.

We don’t currently list any known drug interactions for Oscillococcinum. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Oscillococcinum combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Monograph

Oscillococcinum: Uses, Safety & Side Effects

The bottom line

Oscillococcinum is a homeopathic product made from extremely diluted duck liver and heart, marketed to ease flu-like symptoms. High-quality research has not shown it works better than a placebo, but it is generally well tolerated. If you choose to try it, see it as a low-risk option rather than a proven treatment, and don't use it to replace a flu vaccine or needed medical care.

Scientific name
Anas barbariae hepatis et cordis extractum
Part used
Highly diluted extract of duck liver and heart (Muscovy duck)
Common forms
Oral pellets/granules that dissolve under the tongue
People commonly use it for
  • Flu-like symptoms
  • Common cold symptoms
  • Body aches and chills
  • Fatigue during illness
  • Fever associated with the flu

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Generally well tolerated, but evidence of benefit is lacking and it should not replace proven flu care.

PregnancyInsufficient reliable information

Insufficient reliable information available. This product has not been studied in these patients. However, it is a homeopathic product and is intended...

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available. This product has not been studied in these patients. However, it is a homeopathic product and is intended...

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

Oscillococcinum is a popular homeopathic product sold over the counter and often promoted for flu-like symptoms. It is made from a highly diluted extract of the liver and heart of the Muscovy duck. The starting material is diluted so many times that, by the principles of chemistry, essentially none of the original substance is likely to remain in the final pellets.

The product comes as small sugar pellets or granules that dissolve under the tongue. It is widely available in pharmacies and stores in many countries, especially during cold and flu season. People often take it at the first sign of feeling unwell.

How it works

Oscillococcinum is based on homeopathy, a system that uses extremely diluted substances and the idea that "like cures like." In this case, a duck liver and heart extract is repeatedly diluted to make the product.

The dilutions used are so extreme that no measurable amount of the original substance is expected to remain in the finished pellets. There is no accepted scientific mechanism that explains how such an ultra-diluted product could affect the flu virus or the immune system. Any reported benefit is generally thought to reflect a placebo response rather than a real biological effect.

Effectiveness

Does Oscillococcinum work?

Evidence overview · 3 uses evaluated
3 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.

For Oscillococcinum, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 3 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Chronic obstructive pulmonary disease (COPD)
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral Anas barbariae is beneficial in patients with COPD.

Insufficient Reliable Evidence To Rate Coronavirus disease 2019 (COVID-19)
Rating & evidence shown verbatim from Natural Medicines

Sublingual Anas barbariae has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Influenza
Rating & evidence shown verbatim from Natural Medicines

While oral Anas barbariae does not appear to prevent influenza, small and potentially biased clinical studies suggest that it might reduce symptoms and the need for pain and fever medications in patients with influenza-like illness. It is unclear if these improvements are clinically meaningful.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

Oscillococcinum is generally considered low risk because it is so diluted that it contains little or no active material. The pellets are mostly sugar (lactose and sucrose).

People with rare sugar intolerance problems, such as fructose intolerance or galactose issues, should be cautious because of the sugar base. The main safety concern is indirect: relying on an unproven product instead of getting a flu shot or proper medical care can be harmful, especially for high-risk groups.

Pregnancy and breastfeeding: There is not enough reliable safety information for these situations. Because data are lacking, it is best to avoid it or use it only after talking with your doctor or pharmacist. See your doctor promptly if you are pregnant and develop flu symptoms, since the flu can be more serious during pregnancy.

Always talk with a pharmacist or doctor before using Oscillococcinum, especially for children, older adults, or anyone with a weakened immune system or chronic illness.

Side effects

Oscillococcinum is usually well tolerated and side effects are uncommon. Because the pellets are made of sugar, the most likely issues are minor.

Rarely, people may have an allergic reaction with rash, itching, or swelling. Stop the product and get medical help right away if you notice signs of a serious allergic reaction, such as trouble breathing or swelling of the face, lips, or throat.

Oscillococcinum: Reported Adverse Effects

Documented safety reports on Oscillococcinum from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Reports by condition
Cluster headache Neurologic/CNS

Orally, oscillococcinum has been associated with one report of headache in one clinical study.

  1. Papp R, Schuback G, Beck E, et al. Oscillococcinum in patients with influenza-like syndromes: a placebo-controlled double-blind evaluation. British Homoeopathic Journal 1998;87:69-76.
Influenza Immunologic

Orally, oscillococcinum has been associated with angioedema. Three cases of angioedema have been reported. In one case, a 34-year-old male developed mild stridor and a markedly swollen tongue after taking oscillococcinum for flu-like symptoms. The patient was treated with intramuscular epinephrine and intravenous diphenhydramine and methylprednisolone. Oscillococcinum was considered to be a probable cause of the angioedema.

  1. Azmi Y, Rao M, Verma I, Agrawal A. Oscillococcinum leading to angioedema, a rare adverse event. BMJ Case Rep. 2015 Jun 2;2015.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no scientifically established effective dose for Oscillococcinum, since it has not been shown to work. If you choose to use it, follow the directions on the product label exactly.

The pellets are typically dissolved under the tongue rather than swallowed with water, and packages often suggest starting at the first sign of symptoms. Do not exceed the label amount, and check with your pharmacist if you are unsure how to use it or whether it is appropriate for you.

Pregnancy & Breastfeeding

Oscillococcinum & Pregnancy

Insufficient reliable information

Insufficient reliable information available. This product has not been studied in these patients. However, it is a homeopathic product and is intended to contain no measurable amount of active ingredient. Therefore, oscillococcinum is not expected to cause any beneficial or adverse effect.

Oscillococcinum & Breastfeeding

Insufficient reliable information

Insufficient reliable information available. This product has not been studied in these patients. However, it is a homeopathic product and is intended to contain no measurable amount of active ingredient. Therefore, oscillococcinum is not expected to cause any beneficial or adverse effect.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 2 references that drive our Oscillococcinum monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Papp R, Schuback G, Beck E, et al. Oscillococcinum in patients with influenza-like syndromes: a placebo-controlled double-blind evaluation. British Homoeopathic Journal 1998;87:69-76.
  2. Azmi Y, Rao M, Verma I, Agrawal A. Oscillococcinum leading to angioedema, a rare adverse event. BMJ Case Rep. 2015 Jun 2;2015. PubMed
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Pharmacist Counseling Corner

Oscillococcinum: Common Questions

What is Oscillococcinum used for, and does it work?
People use Oscillococcinum for a range of reasons, but according to the Natural Medicines database the current clinical evidence is insufficient to confirm it works for the specific conditions it has been studied for. See the graded list on this page, and talk to your pharmacist or doctor before relying on it for any condition.
Does Oscillococcinum interact with prescription medications?
We do not currently list any known drug interactions for Oscillococcinum. This does not guarantee that none exist, so always confirm with your pharmacist before combining it with your medications.
How are Oscillococcinum interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Oscillococcinum with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Oscillococcinum interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
Does Oscillococcinum actually work for the flu?
High-quality research, including a Cochrane review, has not found good evidence that it prevents or treats the flu better than a placebo. It should not replace the flu vaccine or proven medical care.
What is Oscillococcinum made of?
It is a homeopathic product made from an extremely diluted extract of Muscovy duck liver and heart, formed into small sugar pellets that dissolve under the tongue.
Is Oscillococcinum safe to take?
It is generally well tolerated because it is so diluted, but it is not a proven treatment. The bigger risk is using it instead of effective flu prevention or care, so talk with a pharmacist or doctor.
Can I give Oscillococcinum to my child?
Always check with a pharmacist or pediatrician first, and never use it as a substitute for the flu vaccine or needed medical attention for a sick child.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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