Oscillococcinum Drug Interactions, Uses, Effectiveness, Safety & More
What is this page for?
First and foremost: how Oscillococcinum interacts with medications. The heart of this page is the interaction list — every drug Oscillococcinum is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what Oscillococcinum is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
Check Oscillococcinum against your medication
Add one medicationDrugs that interact with Oscillococcinum
0 medications have a known interaction with Oscillococcinum, graded by severity. Select any drug for the full evidence-based detail.
We don’t currently list any known drug interactions for Oscillococcinum. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.
What Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact Oscillococcinum combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Oscillococcinum: Uses, Safety & Side Effects
Oscillococcinum is a homeopathic product made from extremely diluted duck liver and heart, marketed to ease flu-like symptoms. High-quality research has not shown it works better than a placebo, but it is generally well tolerated. If you choose to try it, see it as a low-risk option rather than a proven treatment, and don't use it to replace a flu vaccine or needed medical care.
- Scientific name
- Anas barbariae hepatis et cordis extractum
- Part used
- Highly diluted extract of duck liver and heart (Muscovy duck)
- Common forms
- Oral pellets/granules that dissolve under the tongue
- Flu-like symptoms
- Common cold symptoms
- Body aches and chills
- Fatigue during illness
- Fever associated with the flu
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
Generally well tolerated, but evidence of benefit is lacking and it should not replace proven flu care.
Insufficient reliable information available. This product has not been studied in these patients. However, it is a homeopathic product and is intended...
Read the full pregnancy detailInsufficient reliable information available. This product has not been studied in these patients. However, it is a homeopathic product and is intended...
Read the full breastfeeding detailPregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
Oscillococcinum is a popular homeopathic product sold over the counter and often promoted for flu-like symptoms. It is made from a highly diluted extract of the liver and heart of the Muscovy duck. The starting material is diluted so many times that, by the principles of chemistry, essentially none of the original substance is likely to remain in the final pellets.
The product comes as small sugar pellets or granules that dissolve under the tongue. It is widely available in pharmacies and stores in many countries, especially during cold and flu season. People often take it at the first sign of feeling unwell.
How it works
Oscillococcinum is based on homeopathy, a system that uses extremely diluted substances and the idea that "like cures like." In this case, a duck liver and heart extract is repeatedly diluted to make the product.
The dilutions used are so extreme that no measurable amount of the original substance is expected to remain in the finished pellets. There is no accepted scientific mechanism that explains how such an ultra-diluted product could affect the flu virus or the immune system. Any reported benefit is generally thought to reflect a placebo response rather than a real biological effect.
Does Oscillococcinum work?
How to read these evidence grades
Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.
For Oscillococcinum, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.
Also studied for 3 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Chronic obstructive pulmonary disease (COPD)
It is unclear if oral Anas barbariae is beneficial in patients with COPD.
Insufficient Reliable Evidence To Rate Coronavirus disease 2019 (COVID-19)
Sublingual Anas barbariae has only been evaluated in combination with other ingredients; its effect when used alone is unclear.
Insufficient Reliable Evidence To Rate Influenza
While oral Anas barbariae does not appear to prevent influenza, small and potentially biased clinical studies suggest that it might reduce symptoms and the need for pain and fever medications in patients with influenza-like illness. It is unclear if these improvements are clinically meaningful.
Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.
Safety & precautions
Oscillococcinum is generally considered low risk because it is so diluted that it contains little or no active material. The pellets are mostly sugar (lactose and sucrose).
People with rare sugar intolerance problems, such as fructose intolerance or galactose issues, should be cautious because of the sugar base. The main safety concern is indirect: relying on an unproven product instead of getting a flu shot or proper medical care can be harmful, especially for high-risk groups.
Pregnancy and breastfeeding: There is not enough reliable safety information for these situations. Because data are lacking, it is best to avoid it or use it only after talking with your doctor or pharmacist. See your doctor promptly if you are pregnant and develop flu symptoms, since the flu can be more serious during pregnancy.
Always talk with a pharmacist or doctor before using Oscillococcinum, especially for children, older adults, or anyone with a weakened immune system or chronic illness.
Side effects
Oscillococcinum is usually well tolerated and side effects are uncommon. Because the pellets are made of sugar, the most likely issues are minor.
Rarely, people may have an allergic reaction with rash, itching, or swelling. Stop the product and get medical help right away if you notice signs of a serious allergic reaction, such as trouble breathing or swelling of the face, lips, or throat.
Oscillococcinum: Reported Adverse Effects
Documented safety reports on Oscillococcinum from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.
Reports by conditionCluster headache Neurologic/CNS
Orally, oscillococcinum has been associated with one report of headache in one clinical study.
- Papp R, Schuback G, Beck E, et al. Oscillococcinum in patients with influenza-like syndromes: a placebo-controlled double-blind evaluation. British Homoeopathic Journal 1998;87:69-76.
Influenza Immunologic
Orally, oscillococcinum has been associated with angioedema. Three cases of angioedema have been reported. In one case, a 34-year-old male developed mild stridor and a markedly swollen tongue after taking oscillococcinum for flu-like symptoms. The patient was treated with intramuscular epinephrine and intravenous diphenhydramine and methylprednisolone. Oscillococcinum was considered to be a probable cause of the angioedema.
Adverse-effects data: Natural Medicines, Therapeutic Research Center
Dosing
There is no scientifically established effective dose for Oscillococcinum, since it has not been shown to work. If you choose to use it, follow the directions on the product label exactly.
The pellets are typically dissolved under the tongue rather than swallowed with water, and packages often suggest starting at the first sign of symptoms. Do not exceed the label amount, and check with your pharmacist if you are unsure how to use it or whether it is appropriate for you.
Oscillococcinum & Pregnancy
Oscillococcinum & Breastfeeding
© 2026 Therapeutic Research Center
Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center
References & further reading
The 2 references that drive our Oscillococcinum monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Papp R, Schuback G, Beck E, et al. Oscillococcinum in patients with influenza-like syndromes: a placebo-controlled double-blind evaluation. British Homoeopathic Journal 1998;87:69-76.
- Azmi Y, Rao M, Verma I, Agrawal A. Oscillococcinum leading to angioedema, a rare adverse event. BMJ Case Rep. 2015 Jun 2;2015. PubMed
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Oscillococcinum: Common Questions
What is Oscillococcinum used for, and does it work?
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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