Herb & supplement monograph

Teazle Drug Interactions, Uses, Safety & More

Medically reviewed by ·Updated June 2026
What is this page for?

First and foremost: how Teazle interacts with medications. The heart of this page is the interaction list — every drug Teazle is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Teazle is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Teazle Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Teazle drug interaction appears low for most people. None of the listed interactions are rated major, and every concern in the profile comes from lab research only, not from studies in people.

Interactions deserving the most attention

The interactions that stand out involve anticholinergic drugs and cholinergic drugs. Lab research suggests teazle may block an enzyme that breaks down a chemical messenger in the nervous system. In theory, this could make teazle or an anticholinergic medicine work less well, or add to the effects of cholinergic medicines and raise the chance of side effects like those drugs can cause. Because this comes only from laboratory findings, we see it as a reason for awareness rather than alarm.

What the rest of the list means

Although teazle is listed with a large number of interacting medications, that does not mean every combination is harmful. All of these listings trace back to the same theoretical enzyme effect seen in lab studies, and none has been confirmed to cause meaningful changes in people. The long list mostly reflects how many medicines fall into these two broad drug groups.

Check your medications against Teazle

Based on HelloPharmacist’s Teazle interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Teazle

219 medications have a known interaction with Teazle, graded by severity. Select any drug for the full evidence-based detail.

2,830 drugs
AcepromazineAtravet› Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound› Acetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual› Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief› Acetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex› Acetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu› Acetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu› Acetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief› Acetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength› Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG› Acetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid› Acetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR› Acetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin› Acetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule› Acetaminophen, Chlorpheniramine, Phenylpropanolamine, PhenyltoloxamineNorel Plus› Acetaminophen, Chlorpheniramine, PseudoephedrineAlka-Seltzer PLUS Liquid Gels, Children's Tylenol Cold, Codimal, Comtrex, Extra Strength Tylenol Allergy Sinus, Lorsin +3 more› Acetaminophen, Codeine, DoxylamineMersyndol› Acetaminophen, Dextromethorphan, Doxylamine, PseudoephedrineVicks NyQuil› Acetaminophen, Dextromethorphan, Phenylpropanolamine, PyrilamineTheracaps› Acetaminophen, DiphenhydramineTylenol PM, Tylenol PM Ex Strength› Acetaminophen, Diphenhydramine, PseudoephedrineChildren's Tylenol Allergy, Cold Control, Contac Night Allergy Relief› Acetaminophen, Doxylamine, PseudoephedrineEx Strength Tylenol Sinus Nighttime› Acetaminophen, Pamabrom, PyrilamineMidol Max Strength PMS, Pamprin, Pamprin ES› Acetaminophen, Phenylephrine, ChlorpheniramineSuper Cold Tabs› AcetylcholineMiochol-E› Aclidinium BromideTudorza Pressair› Aclidinium Bromide, Formoterol Fumarate DihydrateDuaklir Pressair› Aerosphere Budesonide, Formoterol Fumarate, GlycopyrrolateBreztri› AmantadineGocovri, Osmolex ER, Symmetrel› Ambenonium ChlorideMytelase›
Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Teazle combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The big picture

The kinds of drugs Teazle affects

Every type of medication (drug category) Teazle is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 2 drug categories Teazle interacts with
Anticholinergic DrugsCholinergic Drugs
Anticholinergic Drugs

In vitro research suggests that teazle extract can inhibit acetylcholinesterase activity. Theoretically, concurrent use of anticholinergic drugs and teazle might decrease the effectiveness of teazle or the anticholinergic agent.

Likelihood Possible Evidence D
Cholinergic Drugs

In vitro research suggests that teazle extract can inhibit acetylcholinesterase activity. Theoretically, concurrent use of teazle with other cholinergic drugs might have additive effects and increase the risk of cholinergic side effects.

Likelihood Possible Evidence D
Monograph

Teazle: Uses, Safety & Side Effects

Medically reviewed by · Reviewed June 2026 ·
The bottom line

Teazle (Dipsacus fullonum) is a spiky plant used in traditional and folk medicine, most notably as a tincture marketed for Lyme disease and for joint pain and skin problems. There is very little high-quality human research to support any of these uses, so its benefits remain unproven. Talk with a pharmacist or doctor before trying it, and never use it to replace standard treatment for serious infections like Lyme disease.

Teazle
Scientific name
Dipsacus fullonum
Family
Caprifoliaceae
Part used
Root, leaves, and aerial parts
Common forms
Tincture, tea, capsules, dried root, topical preparations
People commonly use it for
  • Lyme disease (folk use)
  • Joint and muscle pain
  • Osteoarthritis and rheumatoid arthritis
  • Skin conditions such as psoriasis
  • Wound healing

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallLimited data

Human safety data are very limited, so its safety profile is not well established.

PregnancyInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Teazle (also spelled teasel) comes from the plant Dipsacus fullonum, a tall, spiky plant native to Europe and Asia and now found in many parts of North America. It is easy to recognize by its prickly, cone-shaped seed heads and grey-green leaves. In the past, the dried seed heads were even used in the textile industry to raise the nap on wool cloth.

In traditional and folk medicine, different parts of the plant—especially the root—have been used to make teas, tinctures, and capsules. People have used teazle for joint and muscle pain, skin problems, and, more recently, as a popular folk remedy for Lyme disease. A related plant used in traditional Chinese medicine, Dipsacus asperoides (sometimes called "Xu Duan"), is a different species and should not be confused with common teazle.

Uses & effectiveness

Teazle is widely promoted online and in herbal circles, but the science behind it is very weak. For nearly every use, there are no good-quality human studies to show that it works.

  • Lyme disease: Teazle root tincture is one of its most talked-about folk uses, but there is no reliable clinical evidence that it treats or cures Lyme disease. Lyme disease is a serious bacterial infection that needs proper antibiotics. Relying on teazle instead of standard treatment could be dangerous.
  • Joint and muscle pain, arthritis: Teazle has long been used for sore joints, osteoarthritis, and rheumatoid arthritis. Support for this comes mostly from tradition and a small amount of laboratory research, not from solid human trials.
  • Skin conditions and wounds: It has been applied to the skin for problems like psoriasis and to help wounds heal. Evidence here is mostly traditional or from early lab studies.

In short, teazle remains an unproven remedy. If you are considering it, view it as experimental and keep your healthcare provider informed.

How it works

Teazle contains a mix of natural plant compounds, including iridoid glycosides, phenolic acids, and saponins. In laboratory studies, some of these compounds have shown anti-inflammatory and antioxidant activity, and a few lab tests have looked at whether plant extracts can affect bacteria.

It is important to understand that these findings come mostly from test-tube and animal research. What happens in a lab dish does not always carry over to the human body. We do not have good evidence showing how teazle behaves when a person takes it, how much reaches the bloodstream, or whether it produces any meaningful effect on disease.

Safety & precautions

Because teazle has not been carefully studied in people, its overall safety is largely unknown. The plant itself is very prickly, and care is needed when handling it. As an oral remedy, the main concern is the lack of reliable safety data.

Pregnancy and breastfeeding: There is not enough information to know whether teazle is safe during pregnancy or while breastfeeding. To be safe, it is best to avoid it in both situations.

People with serious health conditions, those taking prescription medicines, and anyone with allergies to related plants should be especially cautious. Most importantly, do not use teazle as a substitute for proven treatments—especially antibiotics for Lyme disease. Always check with a pharmacist or doctor before starting it.

Side effects

The side effects of teazle are not well documented because of the limited research. As with many herbal products, possible effects could include stomach upset, nausea, or an allergic skin reaction, especially in people sensitive to plants in the same family.

Because product quality and strength can vary a lot between brands, there is also a risk of contamination or mislabeling with herbal supplements. Stop using it and seek medical care if you notice signs of an allergic reaction such as rash, swelling, or trouble breathing.

Dosing

There is no established or standardized dose for teazle. Dosing in folk traditions varies widely, and products such as tinctures and capsules differ in strength.

If you choose to try a teazle product, follow the directions on the label and do not exceed them. Because there is no proven safe and effective dose, it is wise to start cautiously and to talk with a pharmacist or doctor first, especially if you take other medicines or have a health condition.

Pregnancy & Breastfeeding

Teazle & Pregnancy

Insufficient reliable information

Insufficient reliable information available; avoid using.

Teazle & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 1 references that drive our Teazle monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Oszmianski J, Wojdylo A, Juszczyk P, Nowicka P. Roots and leaf extracts of Dipsacus fullonum L. and their biological activities. Plants (Basel) 2020;9(1):78. PubMed
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Pharmacist Counseling Corner

Teazle: Common Questions

Does Teazle interact with prescription medications?
Yes. We list 219 medications with a known interaction with Teazle. Use the checker above to see how Teazle interacts with a specific drug.
How are Teazle interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Teazle with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Teazle interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Teazle used for?
It is used in traditional and folk medicine for joint and muscle pain, arthritis, skin conditions like psoriasis, wound healing, and—most popularly online—as a remedy for Lyme disease. None of these uses are backed by strong human evidence.
Can Teazle cure Lyme disease?
There is no reliable scientific evidence that Teazle cures or treats Lyme disease. Lyme disease needs proper medical care with antibiotics, so do not rely on Teazle in place of treatment from your doctor.
Is Teazle safe to take during pregnancy or breastfeeding?
Its safety has not been studied in pregnant or breastfeeding women, so it is best to avoid it during these times.
How do people usually take Teazle?
It is most often taken as a tincture or tea made from the root, and is also sold in capsules. There is no standardized dose, so follow the product label and check with a healthcare professional.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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