Drug & supplement interaction

Teazle + Trihexyphenidyl

Trihexyphenidyl brand names: Artane, Trihex, Artane Sequels.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Teazle has a moderate interaction with Trihexyphenidyl. In vitro research suggests that teazle extract can inhibit acetylcholinesterase activity.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Teazle and Trihexyphenidyl

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTICHOLINERGIC DRUGS

Why this applies to Trihexyphenidyl

Trihexyphenidyl falls under ANTICHOLINERGIC DRUGS — the group Teazle interacts with.

In vitro research suggests that teazle extract can inhibit acetylcholinesterase activity. Theoretically, concurrent use of anticholinergic drugs and teazle might decrease the effectiveness of teazle or the anticholinergic agent.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist for Trihexyphenidyl (Artane). This medicine works by blocking a chemical messenger called acetylcholine, which is how it eases tremor and stiffness. Teazle, on the other hand, has shown in lab dishes that it may do the opposite, raising acetylcholine levels by blocking the enzyme that breaks it down. So in theory, the two could partly cancel each other out, meaning your trihexyphenidyl might not work quite as well.

The big caveat: this is purely theoretical, based only on test-tube studies, not real people. We don't have human evidence that teazle changes how Artane works. Still, if you notice your tremor or movement symptoms creeping back while using teazle, mention it to your pharmacist or doctor before making any changes.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Oszmianski J, Wojdylo A, Juszczyk P, Nowicka P. Roots and leaf extracts of Dipsacus fullonum L. and their biological activities. Plants (Basel) 2020;9(1):78. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Teazle Also Interacts With Other Medications

Teazle has 218 moderate known drug interactions in our database — the Trihexyphenidyl one above is one of them. If you take anything else, check it against the full list below.

Moderate 218 No known interaction 2,612 (incl. Trihexyphenidyl)
Taking anything else?

Check Another of Your Medications Against Teazle

Covers the 2,830 medications we’ve checked against Teazle. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Trihexyphenidyl

This page covers Teazle only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Trihexyphenidyl page lists 46 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Henbane (major), Scopolia (major), Angel's Trumpet (moderate) and Bacopa (moderate).

By severity: 3 major · 32 moderate · 11 minor.

From our pharmacist’s overview on the Trihexyphenidyl page

“Trihexyphenidyl (Artane) calms the tremor of Parkinson's disease and the muscle stiffness some antipsychotic drugs cause, and this is a list worth reading closely, since three of its 46 flagged ingredients carry a major rating. Two of those are herbs with the same atropine-like chemistry as the drug itself, piling on dry mouth, blurred…”

Reviewed by 2 · Jul 18, 2026

Open the Trihexyphenidyl interaction page

How much people look this up

Where Teazle and Trihexyphenidyl Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Teazle
Steady interest

#1,066 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Trihexyphenidyl
Steady interest

#1,808 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Teazle

What is Teazle?

Teazle
  • Lyme disease (folk use)
  • Joint and muscle pain
  • Osteoarthritis and rheumatoid arthritis
  • Skin conditions such as psoriasis
  • Wound healing

Teazle (Dipsacus fullonum) is a spiky plant used in traditional and folk medicine, most notably as a tincture marketed for Lyme disease and for joint pain and skin problems. There is very little high-quality human research to support any of these uses, so its benefits remain unproven. Talk with a pharmacist or doctor before trying it, and never use it to replace standard treatment for serious infections like Lyme disease.

Read the full Teazle monograph & all interactions
Medication

About Trihexyphenidyl

What Is Trihexyphenidyl Used For?

Brand names: Artane, Trihex, Artane Sequels

Trihexyphenidyl is used as part of treatment for all forms of parkinsonism — including idiopathic (the most common type), postencephalitic (following a brain infection), and arteriosclerotic parkinsonism. It is often added alongside levodopa when levodopa alone isn't fully controlling symptoms.

It is also used to control extrapyramidal reactions (involuntary movement problems) that can be caused by certain psychiatric drugs, including phenothiazines, thioxanthenes, butyrophenones, and dibenzoxazepines.

See full Trihexyphenidyl drug information
Keep checking

Other Drugs & Teazle

Browse every other medication we’ve checked against Teazle — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
218Moderate
0Minor
2,611No known interaction
218 Moderate 2,611 No interaction
Moderate

218 interactions

Showing 60 of 218 moderate interactions — see all 218 on the Teazle page.

No interaction 2,611 drugs checked — show the list

We also checked Teazle against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,611 medications checked with no known interaction — see the full Teazle list.

See the full Teazle interactions page
See every supplement checked against Trihexyphenidyl, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Teazle monograph › Uses, safety, and every drug interaction in one place Trihexyphenidyl supplement interactions › Every supplement checked against Trihexyphenidyl, ranked by severity Trihexyphenidyl drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Teazle and Trihexyphenidyl Together: Common Questions

Can you take Teazle with Trihexyphenidyl?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Teazle and Trihexyphenidyl interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Trihexyphenidyl and Teazle?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.