Blackthorn Drug Interactions, Uses, Safety & More
What is this page for?
First and foremost: how Blackthorn interacts with medications. The heart of this page is the interaction list — every drug Blackthorn is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what Blackthorn is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
Check Blackthorn against your medication
Add one medicationDrugs that interact with Blackthorn
0 medications have a known interaction with Blackthorn, graded by severity. Select any drug for the full evidence-based detail.
We don’t currently list any known drug interactions for Blackthorn. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.
What Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact Blackthorn combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Blackthorn: Uses, Safety & Side Effects
Blackthorn is a thorny shrub whose flowers and dark blue-black fruit (sloes) are used in traditional European herbal medicine, mostly for digestive complaints and as a mild tonic. Solid human research is lacking, so its benefits are not proven, though small culinary amounts of the fruit are generally considered safe. Talk to your pharmacist or doctor before using it, especially if you are pregnant, breastfeeding, or taking other medicines.
- Scientific name
- Prunus spinosa
- Family
- Rosaceae
- Part used
- Flowers, fruit (sloes), leaves, and bark
- Common forms
- Tea, syrup, juice, tincture, jam/preserves, and liqueur (sloe gin)
- Digestive upset
- Mild constipation
- Cold and cough symptoms
- Mouth and throat irritation
- Mild diuretic ('blood cleansing') tonic
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
Culinary amounts of the fruit are generally well tolerated, but medicinal use is not well studied.
When the seeds or fresh flowers are used orally; avoid using. The seeds and fresh flowers contain small amounts of the cyanogenic glycoside amygdalin,...
Read the full pregnancy detailInsufficient reliable information available; avoid using.
Read the full breastfeeding detailPregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
Blackthorn (Prunus spinosa) is a thorny, deciduous shrub in the rose family. It is native to Europe, western Asia, and parts of North Africa, and it grows in hedgerows, woodland edges, and scrubland. In early spring it produces small white flowers, and in autumn it bears small, dark blue-black fruits called sloes.
People have used blackthorn in traditional European folk medicine for a long time. The flowers are often made into teas, while the tart sloes are turned into syrups, juices, jams, and the well-known flavored spirit called sloe gin. Different parts of the plant have been used for different purposes, mostly related to digestion and as a gentle 'spring tonic.'
Uses & effectiveness
Blackthorn is used traditionally rather than because of strong scientific proof. Common folk uses include easing mild digestive upset, acting as a mild laxative, soothing coughs and cold symptoms, and rinsing or gargling for mouth and throat irritation. Some traditions use the flowers as a mild diuretic or 'blood-cleansing' tonic.
The human evidence for these uses is very limited. Most information comes from traditional practice, along with some laboratory studies suggesting the fruit and flowers contain antioxidant compounds. These lab findings do not prove that blackthorn treats or prevents any disease in people. At this time, there is not enough reliable clinical research to say it is effective for any specific condition.
How it works
Blackthorn fruit and flowers contain plant compounds such as flavonoids, anthocyanins (the pigments that give the sloes their dark color), tannins, and organic acids. In laboratory tests, some of these compounds show antioxidant and mild astringent effects.
The tannins may explain its traditional use as a gargle and for loose stools, since astringent compounds can tighten tissues. However, most of this is based on test-tube or animal research, not on well-designed human studies. So the way blackthorn might work in the body is still largely theoretical.
Safety & precautions
Eating the cooked or processed fruit in normal food amounts (such as in jam or syrup) is generally considered safe for most healthy adults. Medicinal preparations are less well studied, so caution is wise.
Like other Prunus plants, the seeds (kernels), leaves, and bark can contain compounds that release small amounts of cyanide. For this reason, you should not crush or eat the seeds, and you should avoid homemade preparations of the leaves, bark, or kernels unless guided by a qualified professional.
Pregnancy and breastfeeding: There is not enough reliable safety information, so medicinal use should be avoided during pregnancy and while breastfeeding. People with allergies to other Prunus fruits (such as plums, cherries, or almonds) should also be cautious. Always check with your pharmacist or doctor before starting any herbal product.
Side effects
When the fruit is eaten in food amounts, side effects are uncommon. The unripe or raw sloes are very tart and astringent and may cause stomach upset. Because of the tannin content, large amounts could lead to digestive discomfort or constipation.
More serious risks come from improperly used parts of the plant. Eating the seeds, leaves, or bark in large amounts could expose you to cyanide-releasing compounds, which can be harmful. Allergic reactions are possible in people sensitive to related fruits. Stop using it and seek care if you have signs of an allergic reaction such as rash, swelling, or trouble breathing.
Blackthorn: Reported Adverse Effects
Documented safety reports on Blackthorn from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.
Reports by conditionDermatitis Dermatologic
Avoid contact with the thorns on blackthorn branches. They can break off and become embedded in the deep layers of the skin, the tendons, or in the small joints of the fingers, requiring surgical removal. When left embedded they can cause cysts, abscesses, dermatitis, cellulitis, foreign body granuloma, chronic inflammation, tendinitis, synovitis, and septic arthritis.
Adverse-effects data: Natural Medicines, Therapeutic Research Center
Dosing
There is no established or standardized medicinal dose for blackthorn. Traditional use varies widely depending on whether the flowers, fruit, or other parts are used and how they are prepared.
If you choose to use a commercial blackthorn product, follow the directions on the label and do not exceed the recommended amount. Avoid making your own preparations from the seeds, leaves, or bark. Because dosing is uncertain and product quality varies, it is best to check with your pharmacist or doctor before using blackthorn, especially if you have a health condition or take other medicines.
Blackthorn & Pregnancy
Blackthorn & Breastfeeding
© 2026 Therapeutic Research Center
Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center
References & further reading
The 3 references that drive our Blackthorn monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Sharma H, Meredith AD. Blackthorn injury: a report of three interesting cases. Emerg Med J 2004;21(3):392. PubMed
- Sharma H, Meredith AD. A report of 18 blackthorn injuries of the upper limb. Injury 2004;35(9):930-5. PubMed
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Brands that make products with Blackthorn
2 brands in our database make a supplement containing Blackthorn.
Supplement products with Blackthorn
2 products in our database contain Blackthorn. Open any to see its full ingredient list and every drug interaction we check.
Blackthorn: Common Questions
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Where does this Blackthorn interaction information come from?
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Is Blackthorn safe to eat?
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What is the difference between Blackthorn and the sloes used in sloe gin?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Products that contain Blackthorn
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