Cade Drug Interactions, Uses, Safety & More
What is this page for?
First and foremost: how Cade interacts with medications. The heart of this page is the interaction list — every drug Cade is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what Cade is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
Check Cade against your medication
Add one medicationDrugs that interact with Cade
0 medications have a known interaction with Cade, graded by severity. Select any drug for the full evidence-based detail.
We don’t currently list any known drug interactions for Cade. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.
What Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact Cade combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Cade: Uses, Safety & Side Effects
Cade oil (juniper tar) is a dark, tar-like oil distilled from the wood of the prickly juniper and is used almost entirely on the skin and scalp for conditions like psoriasis, eczema, and dandruff. Good-quality human research is limited, and there are real safety concerns, so it should only be used on the skin, carefully and in small amounts. Talk with a pharmacist or doctor before using it, and never take it by mouth.
- Scientific name
- Juniperus oxycedrus
- Family
- Cupressaceae
- Part used
- Wood and branches, used to make cade oil (juniper tar)
- Common forms
- Cade oil (juniper tar), topical creams, ointments, shampoos, and soaps
- Psoriasis and eczema
- Itchy or scaly scalp (dandruff)
- Minor skin irritation
- Antiseptic for the skin
- Hair and scalp care
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
Generally used topically only and in small amounts; not for internal use and best used under guidance.
There is insufficient reliable information available about the safety of cade in pregnancy and lactation; avoid using.
Read the full pregnancy detailThere is insufficient reliable information available about the safety of cade in pregnancy and lactation; avoid using.
Read the full breastfeeding detailPregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
Cade comes from the prickly juniper tree (Juniperus oxycedrus), an evergreen shrub or small tree found around the Mediterranean and parts of southern Europe, North Africa, and the Middle East. The most well-known product made from it is cade oil, also called juniper tar, which is a thick, dark, smoky-smelling oil made by heating the wood and branches.
Cade oil has a long history in traditional medicine and is still used today mostly on the skin and scalp. You may find it as an ingredient in medicated shampoos, soaps, creams, and ointments aimed at flaky, itchy, or irritated skin. It has also been used historically in veterinary care and in some perfumes and fragrances for its distinctive woody, smoky scent.
Uses & effectiveness
People most often use cade oil on the skin for conditions like psoriasis, eczema, and dandruff (seborrheic dermatitis), as well as for general itching and minor skin irritation. It belongs to a family of "tar" products that have been used in skin care for a very long time.
The honest picture is that high-quality human studies on cade oil specifically are limited. Much of the support for its use comes from tradition, laboratory work, and the broader (but still imperfect) experience with tar-based skin products. While some people find tar products helpful for scaling and itching, we do not have strong, modern clinical trials proving how well cade oil works or how it compares to standard treatments.
Because of this, cade oil is best thought of as a traditional remedy with promising but unproven effects. If you have a skin condition like psoriasis or eczema, it is wise to check with a pharmacist or dermatologist about treatments that have stronger evidence.
How it works
Cade oil contains many natural compounds, including phenols, guaiacol, cresols, and sesquiterpenes such as cadinene. These give it antiseptic and anti-itch qualities and are thought to help slow the rapid build-up of skin cells seen in conditions like psoriasis.
Like other tar products, cade oil is believed to reduce scaling, itching, and inflammation when applied to the skin. It is important to know that most of this understanding comes from laboratory studies and traditional use rather than large, modern human trials, so the exact way it works in people is not fully proven.
Safety & precautions
Cade oil is meant for external (topical) use only. It should not be swallowed, because it can be toxic when taken by mouth. Keep it away from the eyes, broken skin, and mucous membranes, and store it safely away from children and pets.
Some tar-related and phenol-containing compounds have raised concerns about skin irritation, sun sensitivity, and possible long-term safety with heavy use. Because of this, it is best to use small amounts, for short periods, and ideally under the guidance of a healthcare professional. Do a small patch test first to check for a reaction.
Pregnancy and breastfeeding: there is not enough reliable safety information, so the safest choice is to avoid cade oil during pregnancy and while breastfeeding. People with sensitive skin, allergies, or widespread skin disease should be especially cautious and talk with a doctor or pharmacist first.
Side effects
The most common side effects are on the skin and include redness, itching, burning, dryness, or irritation where it is applied. Some people may develop an allergic skin reaction (contact dermatitis).
Tar-type products can also make the skin more sensitive to sunlight, so protect treated areas from sun exposure. Serious problems are more likely if the oil is swallowed or used on large areas of broken skin. Stop using it and seek medical advice if you notice severe irritation, a spreading rash, or any signs of an allergic reaction.
Cade: Reported Adverse Effects
Documented safety reports on Cade from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.
Topical application of rectified cade oil 1% to 5% is well tolerated. Oral use of rectified or crude cade oil and topical use of crude cade oil are associated with serious adverse effects when taken either in single or multiple doses. Adverse effects associated with topical application generally occur in infants and children. Symptoms include respiratory distress, agitation, acute renal failure, metabolic acidosis, hepatic damage, hypotension, tachycardia, heart failure, mydriasis, electrolyte disturbances, convulsions, anemia, leukopenia, neutropenia, thrombocytopenia, hypotonia, delirium, somnolence, and coma. The effects are similar to phenol poisoning and are thought to be due to phenol, cresol, and guaiacols present in cade oil. In a series of 30 cases describing the adverse effects of cade oil in Moroccan patients, there were 3 deaths: two involved oral ingestion and one topical, two were in infants, and two were due to acute renal failure.
A 30-day old baby presented 30 minutes after a thick layer of cade oil had been applied to the face, neck and arms. Symptoms included respiratory distress with an oxygen saturation of 50%, hypotonia, convulsions, severe hypotension, tachycardia, pulmonary edema, acute renal failure, liver dysfunction, and metabolic acidosis. With symptomatic treatment, the baby recovered within one week, although it took three weeks for renal function to completely normalize.
A 4-month old baby given a rectal enema containing cade oil to treat atopic dermatitis, presented with respiratory failure, diffuse pulmonary edema, hypotonia, severe hypotension, and coma requiring intensive supportive treatment.
A 32-year old man who ingested a "spoonful" of homemade cade oil presented with fever, headache, myalgias, nausea, vomiting, dyspepsia, gingival erosions, productive cough, and hypotension. Symptoms progressed to tachycardia, tachypnea, hypothermia, acute renal failure, thrombocytopenia, and a maculopapular rash with pustular lesions around the nose and mouth. He received supportive and symptomatic treatment for 11 days and made a full recovery.
There is no reliable information about the adverse effects of cade leaves and berries.
- Gennaro A. Remington: The Science and Practice of Pharmacy. 19th ed. Lippincott: Williams & Wilkins, 1996.
- Achour S, Abourazzak S, Mokhtari A, et al. Juniper tar (cade oil) poisoning in new born after a cutaneous application. BMJ Case Reports 2011 Oct 28;2011.
- Skalli S, Chebat A, Badrane N, Bencheikh RS. Side effects of cade oil in Morocco: an analysis of reports in the Moroccan herbal products database from 2004 to 2012. Food Chem Toxicol 2014;64:81-5.
- Koruk, S. T., Ozyilkan, E., Kaya, P., Colak, D., Donderici, O., and Cesaretli, Y. Juniper tar poisoning. Clin.Toxicol.(Phila) 2005;43(1):47-49.
- Rahmani H, Leonhardt S, Beladdale D, et al. Severe acute lung oedema after rectal enema with cade oil (abstract). European Association of Poisons Centres and Clinical Toxicologists XXIV International Congress, Strasbourg, 2004. Clin Toxicol 2004;42(4):487
Acute respiratory distress syndrome (ARDS) Pulmonary/Respiratory
Oral ingestion and topical application of cade oil have been associated with respiratory distress, tachypnea, and pulmonary edema.
- Achour S, Abourazzak S, Mokhtari A, et al. Juniper tar (cade oil) poisoning in new born after a cutaneous application. BMJ Case Reports 2011 Oct 28;2011.
- Rahmani H, Leonhardt S, Beladdale D, et al. Severe acute lung oedema after rectal enema with cade oil (abstract). European Association of Poisons Centres and Clinical Toxicologists XXIV International Congress, Strasbourg, 2004. Clin Toxicol 2004;42(4):487
Anemia Hematologic
Oral ingestion and topical application of cade oil have been associated with anemia, leukopenia, neutropenia, and thrombocytopenia.
- Koruk, S. T., Ozyilkan, E., Kaya, P., Colak, D., Donderici, O., and Cesaretli, Y. Juniper tar poisoning. Clin.Toxicol.(Phila) 2005;43(1):47-49.
- Skalli S, Chebat A, Badrane N, Bencheikh RS. Side effects of cade oil in Morocco: an analysis of reports in the Moroccan herbal products database from 2004 to 2012. Food Chem Toxicol 2014;64:81-5.
Cluster headache Neurologic/CNS
Oral ingestion and topical application of cade oil have been associated with headache, convulsions, and coma.
- Koruk, S. T., Ozyilkan, E., Kaya, P., Colak, D., Donderici, O., and Cesaretli, Y. Juniper tar poisoning. Clin.Toxicol.(Phila) 2005;43(1):47-49.
- Achour S, Abourazzak S, Mokhtari A, et al. Juniper tar (cade oil) poisoning in new born after a cutaneous application. BMJ Case Reports 2011 Oct 28;2011.
- Rahmani H, Leonhardt S, Beladdale D, et al. Severe acute lung oedema after rectal enema with cade oil (abstract). European Association of Poisons Centres and Clinical Toxicologists XXIV International Congress, Strasbourg, 2004. Clin Toxicol 2004;42(4):487
Congestive heart failure (CHF) Cardiovascular
Oral ingestion and topical application of cade oil have been associated with hypotension, tachycardia, and heart failure.
- Achour S, Abourazzak S, Mokhtari A, et al. Juniper tar (cade oil) poisoning in new born after a cutaneous application. BMJ Case Reports 2011 Oct 28;2011.
- Rahmani H, Leonhardt S, Beladdale D, et al. Severe acute lung oedema after rectal enema with cade oil (abstract). European Association of Poisons Centres and Clinical Toxicologists XXIV International Congress, Strasbourg, 2004. Clin Toxicol 2004;42(4):487
Dyspepsia Gastrointestinal
Oral ingestion of a "spoonful" of homemade cade oil was associated with gingival erosions, nausea, vomiting, and dyspepsia in a 32-year old man.
Kidney failure Renal
Oral ingestion and topical application of cade oil can result in acute renal failure.
- Gennaro A. Remington: The Science and Practice of Pharmacy. 19th ed. Lippincott: Williams & Wilkins, 1996.
- Koruk, S. T., Ozyilkan, E., Kaya, P., Colak, D., Donderici, O., and Cesaretli, Y. Juniper tar poisoning. Clin.Toxicol.(Phila) 2005;43(1):47-49.
- Achour S, Abourazzak S, Mokhtari A, et al. Juniper tar (cade oil) poisoning in new born after a cutaneous application. BMJ Case Reports 2011 Oct 28;2011.
- Skalli S, Chebat A, Badrane N, Bencheikh RS. Side effects of cade oil in Morocco: an analysis of reports in the Moroccan herbal products database from 2004 to 2012. Food Chem Toxicol 2014;64:81-5.
Pregnancy-related edema Dermatologic
Topical application of cade oil can cause urticaria, localized edema, and purpura. After oral ingestion of a "spoonful" of homemade cade oil, a 32-year old man developed a maculopapular rash with pustular lesions around the nose and mouth.
- Skalli S, Chebat A, Badrane N, Bencheikh RS. Side effects of cade oil in Morocco: an analysis of reports in the Moroccan herbal products database from 2004 to 2012. Food Chem Toxicol 2014;64:81-5.
- Koruk, S. T., Ozyilkan, E., Kaya, P., Colak, D., Donderici, O., and Cesaretli, Y. Juniper tar poisoning. Clin.Toxicol.(Phila) 2005;43(1):47-49.
Pregnancy-related edema Ocular/Otic
Cade oil can irritate the cornea and cause chemosis (edema of the conjunctiva). Oral ingestion or topical application of cade oil has been associated with mydriasis.
- Gennaro A. Remington: The Science and Practice of Pharmacy. 19th ed. Lippincott: Williams & Wilkins, 1996.
- Skalli S, Chebat A, Badrane N, Bencheikh RS. Side effects of cade oil in Morocco: an analysis of reports in the Moroccan herbal products database from 2004 to 2012. Food Chem Toxicol 2014;64:81-5.
Adverse-effects data: Natural Medicines, Therapeutic Research Center
Dosing
There is no established standard dose for cade oil. It is most often found already mixed into shampoos, soaps, creams, or ointments at low concentrations rather than used as a pure oil.
The best approach is to follow the directions on the product label and not apply more or more often than recommended. Because strength varies between products and pure cade oil can be irritating, check with a pharmacist or doctor before using it, especially on the face, on children, or over large areas of skin.
Cade & Pregnancy
Cade & Breastfeeding
© 2026 Therapeutic Research Center
Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center
References & further reading
The 5 references that drive our Cade monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Gennaro A. Remington: The Science and Practice of Pharmacy. 19th ed. Lippincott: Williams & Wilkins, 1996.
- Koruk, S. T., Ozyilkan, E., Kaya, P., Colak, D., Donderici, O., and Cesaretli, Y. Juniper tar poisoning. Clin.Toxicol.(Phila) 2005;43(1):47-49. PubMed
- Achour S, Abourazzak S, Mokhtari A, et al. Juniper tar (cade oil) poisoning in new born after a cutaneous application. BMJ Case Reports 2011 Oct 28;2011. PubMed
- Skalli S, Chebat A, Badrane N, Bencheikh RS. Side effects of cade oil in Morocco: an analysis of reports in the Moroccan herbal products database from 2004 to 2012. Food Chem Toxicol 2014;64:81-5. PubMed
- Rahmani H, Leonhardt S, Beladdale D, et al. Severe acute lung oedema after rectal enema with cade oil (abstract). European Association of Poisons Centres and Clinical Toxicologists XXIV International Congress, Strasbourg, 2004. Clin Toxicol 2004;42(4):487
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Cade: Common Questions
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How are Cade interactions rated?
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Is Cade oil safe to take by mouth?
Can I use Cade oil if I'm pregnant or breastfeeding?
Can Cade oil irritate my skin?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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