Drug & supplement interaction

Teazle + Trifarotene

Trifarotene brand name: Aklief.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Teazle and Trifarotene in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Teazle and Trifarotene

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Trifarotene and Teazle in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Teazle safety at a glance

Teazle overall Not established Human safety data are very limited, so its safety profile is not well established.
Pregnancy Avoid There is not enough safety information, so it is best to avoid use during pregnancy.
Breastfeeding Avoid Safety while breastfeeding is unknown, so avoid use to be cautious.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Trifarotene and Teazle? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Trifarotene

Interactions in our licensed database are recorded against drug classes, not just single drug names. Trifarotene is filed under a single classification — topical drugs. Teazle has documented interactions with 2 drug classes — the most serious being anticholinergic drugs (moderate) and cholinergic drugs (moderate) — and none of Trifarotene’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Teazle Does Interact With Other Medications

Teazle has 219 moderate known drug interactions in our database — Trifarotene isn’t one of them. If you take anything else, check it against the full list below.

Moderate 219 No known interaction 2,611 (incl. Trifarotene)
Taking anything else?

Check Another of Your Medications Against Teazle

Covers the 2,830 medications we’ve checked against Teazle. Pick one to open its full report.

What to actually watch for

What Trifarotene’s Own FDA Label Lists

This is not an interaction — none of it involves Teazle. These are the most notable effects listed in the ADVERSE REACTIONS section of Trifarotene’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both.

  • Acne
  • Sun sensitivity
  • Itching

From the ADVERSE REACTIONS section of the FDA label for Trifarotene. Read the label on DailyMed › Teazle’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Teazle side to compare — that is a limit of the record, not a statement that Teazle has no side effects.

Everything else you take

See Every Supplement That Interacts With Trifarotene

This page covers Teazle only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Trifarotene page lists 3 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Dimethylsulfoxide (dmso) (moderate), Turpentine Oil (moderate) and Alchemilla (minor).

By severity: 2 moderate · 1 minor.

From our pharmacist’s overview on the Trifarotene page

“Trifarotene (Aklief) is a retinoid cream for acne, applied to the skin rather than swallowed, which keeps its supplement interaction list unusually short. Only three ingredients are on file, none rated major, and both moderate entries share one theme, boosting how much of a topical product soaks through the skin.”

Reviewed by 2 · Jul 18, 2026

Open the Trifarotene interaction page

How much people look this up

Where Teazle and Trifarotene Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Teazle
Steady interest

#863 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Trifarotene
Steady interest

#2,278 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Teazle reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Teazle and Trifarotene records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Teazle

What is Teazle?

Teazle
  • Lyme disease (folk use)
  • Joint and muscle pain
  • Osteoarthritis and rheumatoid arthritis
  • Skin conditions such as psoriasis
  • Wound healing

Teazle (Dipsacus fullonum) is a spiky plant used in traditional and folk medicine, most notably as a tincture marketed for Lyme disease and for joint pain and skin problems. There is very little high-quality human research to support any of these uses, so its benefits remain unproven. Talk with a pharmacist or doctor before trying it, and never use it to replace standard treatment for serious infections like Lyme disease.

Dipsacus fullonum · Caprifoliaceae · Root, leaves, and aerial parts · Tincture, tea, capsules, dried root, topical preparations

An interaction check asks whether these two react with each other — it does not ask whether Teazle is a good idea for someone in your situation. Here is what our Teazle record says about it on its own.

Teazle: dosing

There is no established or standardized dose for teazle. Dosing in folk traditions varies widely, and products such as tinctures and capsules differ in strength.If you choose to try a teazle product, follow the directions on the label and do not exceed them.

From our Teazle monograph — the full record covers uses, side effects and every documented interaction.

Read the full Teazle monograph & all interactions
Medication

About Trifarotene Topical

What Is Trifarotene Topical Used For?

Brand name: Aklief

Aklief Cream is used to treat acne vulgaris (common acne) on the face and trunk — including the chest, shoulders, and back. It is approved for patients 9 years of age and older.

See full Trifarotene Topical drug information
Keep checking

Other Drugs & Teazle

Browse every other medication we’ve checked against Teazle — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
219Moderate
0Minor
2,610No known interaction
219 Moderate 2,610 No interaction
Moderate

219 interactions

Showing 60 of 219 moderate interactions — see all 219 on the Teazle page.

No interaction 2,610 drugs checked — show the list

We also checked Teazle against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,610 medications checked with no known interaction — see the full Teazle list.

See the full Teazle interactions page
See every supplement checked against Trifarotene, ranked by severity
Evidence & sources

Teazle References

The 1 references that drive our Teazle monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Oszmianski J, Wojdylo A, Juszczyk P, Nowicka P. Roots and leaf extracts of Dipsacus fullonum L. and their biological activities. Plants (Basel) 2020;9(1):78. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Teazle and Trifarotene Together: Common Questions

Is it safe to take Teazle with Trifarotene?
We do not list a known interaction between Teazle and Trifarotene. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Teazle and Trifarotene combination checked?
Interactions in our licensed database are recorded against drug classes. Trifarotene is filed under 1 classification, and Teazle has documented interactions with 2 drug classes — none of Trifarotene's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Teazle interact with any other medications?
Yes. Teazle has 219 documented drug interactions in our database — Trifarotene is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Trifarotene interact with any supplements?
Yes. Trifarotene has documented interactions with 3 supplements in our database — Teazle is not one of them. The Trifarotene interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Teazle monograph Uses, safety profile, and every drug interaction in one place Trifarotene Topical drug information The full plain-English guide to this medication Trifarotene supplement interactions Every supplement checked against Trifarotene, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Trifarotene and Teazle?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.