Drug & supplement interaction

Teazle + Edrophonium, Atropine

Edrophonium, Atropine brand name: Enlon-Plus.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Edrophonium, Atropine falls into 2 drug categories that Teazle can interact with; the most serious is rated moderate. In vitro research suggests that teazle extract can inhibit acetylcholinesterase activity.

Read the full interaction report
SeverityModerate
LikelihoodPossible
Interactions2
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Teazle and Edrophonium, Atropine

These two interact in 2 distinct ways. Each one is explained separately below.

Why Are There 2 Interactions?

Teazle interacts with whole categories of medication. Edrophonium, Atropine falls into 2 of those categories, so it can interact with Teazle in 2 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).

Moderate

ANTICHOLINERGIC DRUGS

1 of 2

Why this applies to Edrophonium, Atropine

Edrophonium, Atropine falls under ANTICHOLINERGIC DRUGS — the group Teazle interacts with.

In vitro research suggests that teazle extract can inhibit acetylcholinesterase activity. Theoretically, concurrent use of anticholinergic drugs and teazle might decrease the effectiveness of teazle or the anticholinergic agent.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Enlon-Plus combines two medicines with opposite jobs. Edrophonium briefly blocks acetylcholinesterase so more acetylcholine is around, while atropine is an anticholinergic that quiets some of those effects. Lab tests hint that teazle may also block acetylcholinesterase, the same direction as edrophonium. On paper, that could nudge things toward too much cholinergic activity (slow heart rate, watery eyes, drooling, cramps), and it could work against atropine's calming effect.

Here's my honest take: this is theory only, drawn from test-tube studies, not from people. Enlon-Plus is also given in a controlled medical setting, so doctors are watching closely. Still, mention any teazle use to your care team beforehand. Don't change anything on your own.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Oszmianski J, Wojdylo A, Juszczyk P, Nowicka P. Roots and leaf extracts of Dipsacus fullonum L. and their biological activities. Plants (Basel) 2020;9(1):78. PubMed
Moderate

CHOLINERGIC DRUGS

2 of 2

Edrophonium, Atropine also falls under CHOLINERGIC DRUGS.

In vitro research suggests that teazle extract can inhibit acetylcholinesterase activity. Theoretically, concurrent use of teazle with other cholinergic drugs might have additive effects and increase the risk of cholinergic side effects.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the basic idea. The edrophonium part of Enlon-Plus already works by blocking an enzyme called acetylcholinesterase, which lets your body's natural "rest and digest" signal (acetylcholine) build up. Lab studies hint that teazle may block that same enzyme a little. So in theory, stacking the two could push things further in the same direction, raising the chance of cholinergic side effects like watery eyes, drooling, belly cramps, diarrhea, a slow heartbeat, or muscle twitching.

One thing to keep in mind: this is only a test-tube theory, not something proven in people, and Enlon-Plus is usually given by a clinician in a controlled setting. Still, since this medicine is potent, mention any teazle use to your doctor or pharmacist beforehand so they can keep an eye on you.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Oszmianski J, Wojdylo A, Juszczyk P, Nowicka P. Roots and leaf extracts of Dipsacus fullonum L. and their biological activities. Plants (Basel) 2020;9(1):78. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Teazle Also Interacts With Other Medications

Teazle has 218 moderate known drug interactions in our database — the Edrophonium, Atropine one above is among them. If you take anything else, check it against the full list below.

Moderate 218 No known interaction 2,612 (incl. Edrophonium, Atropine)
Taking anything else?

Check Another of Your Medications Against Teazle

Covers the 2,830 medications we’ve checked against Teazle. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Edrophonium, Atropine

This page covers Teazle only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Edrophonium, Atropine page lists 34 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Henbane (major), Scopolia (major), Angel's Trumpet (moderate), Arenaria Rubra (moderate) and Bacopa (moderate).

By severity: 2 major · 29 moderate · 3 minor.

From our pharmacist’s overview on the Edrophonium, Atropine page

“Enlon-Plus combines edrophonium, which raises levels of the nerve messenger acetylcholine, with atropine, which tempers its side effects, and the supplements listed below can tip that balance in either direction. I read this list with real caution.”

Reviewed by 2 · Jul 18, 2026

Open the Edrophonium, Atropine interaction page

How much people look this up

Where Teazle and Edrophonium, Atropine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Teazle
Steady interest

#1,117 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Edrophonium, Atropine
Top half

#1,164 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Teazle

What is Teazle?

Teazle
  • Lyme disease (folk use)
  • Joint and muscle pain
  • Osteoarthritis and rheumatoid arthritis
  • Skin conditions such as psoriasis
  • Wound healing

Teazle (Dipsacus fullonum) is a spiky plant used in traditional and folk medicine, most notably as a tincture marketed for Lyme disease and for joint pain and skin problems. There is very little high-quality human research to support any of these uses, so its benefits remain unproven. Talk with a pharmacist or doctor before trying it, and never use it to replace standard treatment for serious infections like Lyme disease.

Read the full Teazle monograph & all interactions
Keep checking

Other Drugs & Teazle

Browse every other medication we’ve checked against Teazle — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
218Moderate
0Minor
2,611No known interaction
218 Moderate 2,611 No interaction
Moderate

218 interactions

Showing 60 of 218 moderate interactions — see all 218 on the Teazle page.

No interaction 2,611 drugs checked — show the list

We also checked Teazle against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,611 medications checked with no known interaction — see the full Teazle list.

See the full Teazle interactions page
See every supplement checked against Edrophonium, Atropine, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Teazle monograph › Uses, safety, and every drug interaction in one place Edrophonium, Atropine supplement interactions › Every supplement checked against Edrophonium, Atropine, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Teazle and Edrophonium, Atropine Together: Common Questions

Can you take Teazle with Edrophonium, Atropine?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 2 interactions listed for Teazle and Edrophonium, Atropine?
Edrophonium, Atropine belongs to more than one drug category, and Teazle interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the Teazle and Edrophonium, Atropine interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.