Herb & supplement monograph

Uzara Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS ·Updated July 2026

What is this page for?

First and foremost: how Uzara interacts with medications. The heart of this page is the interaction list — every drug Uzara is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Uzara is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Reviewed by licensed pharmacists Sourced from Natural Medicines

On this page

Uzara Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, most Uzara drug interactions are theoretical, but the risk is serious for anyone taking digoxin, a combination that is considered contraindicated. Only one interaction is rated major, and all the others are moderate concerns grounded in theory rather than proven human effects.

Interactions deserving the most attention

The clear standout is digoxin: Uzara works on the heart in a similar way, so taking both duplicates the effect and raises the risk of toxicity, and this is well documented in people. Next in importance are potassium-depleting diuretics such as furosemide or hydrochlorothiazide, along with overused stimulant laxatives, because losing potassium could in theory make Uzara's heart effects more dangerous. Similar theoretical concerns apply to quinine and to macrolide and tetracycline antibiotics.

What the rest of the list means

The long list of moderate interactions really reflects one theme: Uzara acts on the heart much like a cardiac glycoside, so any medicine that might deplete potassium or add to that effect gets flagged. Nearly all of these warnings come from theory or lab research rather than harm actually seen in people, so for someone not taking digoxin or at risk of low potassium, most combinations are unlikely to cause a meaningful problem.

Check your medications against Uzara

Based on HelloPharmacist’s Uzara interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Uzara

133 medications have a known interaction with Uzara, graded by severity. Select any drug for the full evidence-based detail.

1 major interaction. These combinations can be clinically significant — best avoided, or used only with close professional supervision. Always check with your pharmacist before combining them with Uzara.

Don’t want to scroll the list? Just ask.

Tell us the medications you take and we’ll check each one against Uzara using our pharmacist-reviewed interaction data.

AI summaries are generated from our Uzara interaction data for education only — always confirm with your pharmacist. How we use AI

2,830 drugs

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
Each drug listed above links to the full report for that exact Uzara combination — clinical detail, likelihood, evidence level, and citations.
Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

The big picture

The kinds of drugs Uzara affects

Every type of medication (drug category) Uzara is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 6 drug categories Uzara interacts with

Digoxin (lanoxin)Diuretic DrugsMacrolide AntibioticsQuinineStimulant LaxativesTetracycline Antibiotics

Digoxin (Lanoxin)

Using uzara with digoxin is contraindicated due to therapeutic duplication and an increased risk of cardiac glycoside toxicity.

Likelihood Likely Evidence D

Diuretic Drugs

Theoretically, concomitant use of potassium-depleting diuretics and uzara can increase the risk of cardiac glycoside toxicity due to potassium depletion. Some diuretics that can deplete potassium include chlorothiazide (Diuril), chlorthalidone (Thalitone), furosemide (Lasix), hydrochlorothiazide (HCTZ, Hydrodiuril, Microzide), and others.