Drug & supplement interaction

Uzara + Fosinopril, Hydrochlorothiazide

Fosinopril, Hydrochlorothiazide brand name: Monopril HCT.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Uzara has a moderate interaction with Fosinopril, Hydrochlorothiazide. Theoretically, concomitant use of potassium-depleting diuretics and uzara can increase the risk of cardiac glycoside toxicity due to potassium depletion.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Uzara and Fosinopril, Hydrochlorothiazide

Here is the interaction we found between these two, with the evidence behind it.

Moderate

DIURETIC DRUGS

Why this applies to Fosinopril, Hydrochlorothiazide

Fosinopril, Hydrochlorothiazide falls under DIURETIC DRUGS — the group Uzara interacts with.

Theoretically, concomitant use of potassium-depleting diuretics and uzara can increase the risk of cardiac glycoside toxicity due to potassium depletion. Some diuretics that can deplete potassium include chlorothiazide (Diuril), chlorthalidone (Thalitone), furosemide (Lasix), hydrochlorothiazide (HCTZ, Hydrodiuril, Microzide), and others.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the thing to know about Monopril HCT: the hydrochlorothiazide part is a water pill that can slowly lower your potassium level. Uzara root contains natural compounds that act a lot like heart medications (cardiac glycosides). When potassium runs low, the heart becomes more sensitive to those glycoside-type compounds, which in theory could nudge you toward heart rhythm problems, nausea, or feeling unusually weak or dizzy.

I want to be honest that this concern is theoretical, based on how these substances behave rather than real-world reports. Still, since Uzara affects the heart and HCTZ can shift your potassium, I wouldn't pair them on your own. Please check with your pharmacist or doctor first, especially if you have any heart concerns.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Burnham TH, ed. Drug Facts and Comparisons, Updated Monthly. Facts and Comparisons, St. Louis, MO.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Uzara Also Interacts With Other Medications

Uzara has 1 major, 131 moderate known drug interactions in our database — the Fosinopril, Hydrochlorothiazide one above is one of them. If you take anything else, check it against the full list below.

Major 1 Moderate 131 No known interaction 2,698 (incl. Fosinopril, Hydrochlorothiazide)
Taking anything else?

Check Another of Your Medications Against Uzara

Covers the 2,830 medications we’ve checked against Uzara. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Fosinopril, Hydrochlorothiazide

This page covers Uzara only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Fosinopril, Hydrochlorothiazide page lists 238 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Asarabacca (major) and Dolomite (major).

By severity: 11 major · 200 moderate · 27 minor.

From our pharmacist’s overview on the Fosinopril, Hydrochlorothiazide page

“Monopril HCT combines two blood pressure medicines, the ACE inhibitor fosinopril and the water pill hydrochlorothiazide, which is why I read its supplement list with genuine wariness rather than a shrug. Eleven of the 238 ingredients on file carry a major rating and deserve your attention first, while most of the 200 rated moderate eit…”

Reviewed by 2 · Jul 18, 2026

Open the Fosinopril, Hydrochlorothiazide interaction page

How much people look this up

Where Uzara and Fosinopril, Hydrochlorothiazide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Uzara
Steady interest

#870 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Fosinopril, Hydrochlorothiazide
Top 5%

#101 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Uzara

What is Uzara?

  • Diarrhea
  • Stomach cramps
  • Menstrual cramps (dysmenorrhea)
  • Headaches
  • Digestive upset

Uzara is a traditional African root remedy used mainly for diarrhea and stomach cramps. Because it contains cardiac glycosides that can affect the heart, it should be used cautiously and for short periods only. Talk to a pharmacist or doctor before using it, especially if you have heart problems, are pregnant, or take heart medications.

Read the full Uzara monograph & all interactions
Keep checking

Other Drugs & Uzara

Browse every other medication we’ve checked against Uzara — both the ones with a known interaction and the ones without. Select any drug for the full detail.

1Major
131Moderate
0Minor
2,697No known interaction
1 Major 131 Moderate 2,697 No interaction
Major

1 interaction

Moderate

131 interactions

Showing 60 of 131 moderate interactions — see all 131 on the Uzara page.

No interaction 2,697 drugs checked — show the list

We also checked Uzara against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,697 medications checked with no known interaction — see the full Uzara list.

See the full Uzara interactions page
See every supplement checked against Fosinopril, Hydrochlorothiazide, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Uzara monograph › Uses, safety, and every drug interaction in one place Fosinopril, Hydrochlorothiazide supplement interactions › Every supplement checked against Fosinopril, Hydrochlorothiazide, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Uzara and Fosinopril, Hydrochlorothiazide Together: Common Questions

Can you take Uzara with Fosinopril, Hydrochlorothiazide?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Uzara and Fosinopril, Hydrochlorothiazide interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Fosinopril, Hydrochlorothiazide and Uzara?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.