Herb & supplement monograph

Clematis Recta Drug Interactions, Uses, Safety & More

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Interaction report

Drugs that interact with Clematis Recta

0 medications have a known interaction with Clematis Recta, graded by severity. Select any drug for the full evidence-based detail.

We don’t currently list any known drug interactions for Clematis Recta. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Clematis Recta combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Monograph

Clematis Recta: Uses, Safety & Side Effects

The bottom line

Clematis recta is a flowering plant in the buttercup family that is mostly sold today as a homeopathic remedy. The fresh plant is toxic and irritating, and there is no reliable human evidence that it treats any condition, so it should be used cautiously and only under professional guidance.

Scientific name
Clematis recta
Family
Ranunculaceae
Part used
Fresh leaves and stems (aerial parts), usually gathered before flowering
Common forms
Homeopathic pellets, dilutions, and mother tinctures; rarely as topical preparations
People commonly use it for
  • Skin complaints and eruptions
  • Swollen or tender lymph glands
  • Urinary discomfort
  • Nerve pain
  • Men's groin and testicular discomfort (traditional homeopathic use)

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

The raw plant is toxic and irritating; only highly diluted homeopathic forms are generally considered low-risk.

PregnancyLikely Unsafe

When the fresh plant is used orally. There is insufficient reliable information available for the safety of the dried plant; avoid using.

Read the full pregnancy detail
BreastfeedingLikely Unsafe

When the fresh plant is used orally. There is insufficient reliable information available for the safety of the dried plant; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

Clematis recta is a climbing or upright flowering plant in the buttercup family (Ranunculaceae). It grows in parts of Europe and Asia and produces clusters of small white flowers. It is sometimes called upright virgin's bower.

Like many plants in its family, the fresh plant contains irritating compounds and is considered toxic if eaten or applied raw. Because of this, it is almost never used as a food or a regular herbal tea. Today it is most often found as a homeopathic remedy, where the plant material is diluted many times.

In traditional and homeopathic practice, people have used it for skin problems, swollen glands, and certain types of nerve or urinary discomfort.

Uses & effectiveness

People have traditionally used Clematis recta for skin eruptions, swollen lymph nodes, urinary complaints, and nerve pain. In homeopathy it is also a common remedy for groin and testicular discomfort in men.

The scientific evidence behind these uses is very weak. There are no high-quality human studies showing that Clematis recta treats any of these conditions. Most of what is known comes from traditional use and homeopathic texts rather than from modern clinical trials.

If you are considering it for a specific health problem, treat it as unproven and talk with a pharmacist or doctor first, especially since untreated conditions like infections or persistent swelling may need real medical care.

How it works

Plants in the Ranunculaceae family, including Clematis recta, contain a compound called protoanemonin, which is released when the fresh plant is crushed. This compound is irritating to skin and mucous membranes and is the main reason the raw plant is considered toxic.

There is no well-established mechanism explaining how Clematis recta would treat any disease. In homeopathic products, the plant is diluted so much that little or none of the original material remains, so any proposed effect is based on homeopathic theory rather than a measurable pharmacological action.

Overall, claims about how it works are based mostly on tradition and limited laboratory observations, not on solid human research.

Safety & precautions

The raw or concentrated plant is not safe to eat or apply directly. Protoanemonin can cause burning, blistering, and irritation of the skin, mouth, and digestive tract.

Highly diluted homeopathic forms are generally considered low-risk because they contain very little plant material, but this does not mean they are proven to help. People with sensitive skin, allergies to plants in the buttercup family, or chronic health conditions should be especially careful.

Pregnancy and breastfeeding: Because there is no reliable safety information, Clematis recta should be avoided during pregnancy and while breastfeeding. Children should not use it unless a qualified healthcare provider recommends it. When in doubt, check with your pharmacist or doctor before using any product containing this plant.

Side effects

With the raw or strong plant, the main risks are skin irritation, blistering, mouth and throat burning, nausea, and stomach upset. Contact with the fresh plant can cause redness and rash.

Highly diluted homeopathic products are less likely to cause these problems, but allergic reactions are still possible. Stop using it and seek care if you notice rash, swelling, trouble breathing, or any reaction that worries you.

Clematis Recta: Reported Adverse Effects

Documented safety reports on Clematis Recta from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Orally and topically, freshly harvested Clematis recta is unsafe. Any benefits of therapy may not outweigh the risk of toxicity.

Most Common Adverse Effects:

Orally: Colic, diarrhea, gastrointestinal irritation, urinary tract irritation.

Topically: Blisters, burns.

Reports by condition
Burns Dermatologic

Topically, prolonged skin contact with fresh Clematis recta can cause slow-healing blisters and burns.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Diarrhea Gastrointestinal

Orally, fresh Clematis recta can cause colic, diarrhea, and severe irritation to the gastrointestinal tract.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no established standard dose for Clematis recta. The raw plant is not recommended at all because it is toxic and irritating.

When sold as a homeopathic remedy, it comes in standardized dilutions and potencies set by the manufacturer. If you choose to use it, follow the directions on the product label exactly, and do not assume that a higher amount is safer or more effective.

Because dosing is not well defined and the plant carries real safety concerns, it is best to check with a pharmacist or doctor before starting.

Pregnancy & Breastfeeding

Clematis Recta & Pregnancy

Likely Unsafe

When the fresh plant is used orally. There is insufficient reliable information available for the safety of the dried plant; avoid using.

Clematis Recta & Breastfeeding

Likely Unsafe

When the fresh plant is used orally. There is insufficient reliable information available for the safety of the dried plant; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 1 references that drive our Clematis Recta monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Pharmacist Counseling Corner

Clematis Recta: Common Questions

Does Clematis Recta interact with prescription medications?
We do not currently list any known drug interactions for Clematis Recta. This does not guarantee that none exist, so always confirm with your pharmacist before combining it with your medications.
How are Clematis Recta interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Clematis Recta with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Clematis Recta interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Clematis Recta used for?
It is traditionally and homeopathically used for skin eruptions, swollen glands, urinary discomfort, and certain nerve or groin pains. None of these uses are backed by strong scientific evidence.
Is Clematis Recta safe to take?
The raw plant is toxic and irritating and should not be eaten or applied directly. Highly diluted homeopathic forms are generally low-risk but unproven, so use them only with guidance from a healthcare professional.
Can I use Clematis Recta during pregnancy or while breastfeeding?
No reliable safety data exists, so it should be avoided during pregnancy and breastfeeding. Talk to your doctor about safer, proven options.
Is Clematis Recta the same as the garden clematis flower?
They are related plants in the same family, and like garden clematis, the fresh plant can irritate the skin and is not meant to be eaten. Clematis Recta is the specific species used in homeopathic products.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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