Drug & supplement interaction

Uzara + Fidaxomicin

Fidaxomicin brand name: Dificid.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Uzara has a moderate interaction with Fidaxomicin. Theoretically, concomitant use may increase risk of cardiac glycoside toxicity.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Uzara and Fidaxomicin

Here is the interaction we found between these two, with the evidence behind it.

Moderate

MACROLIDE ANTIBIOTICS

Why this applies to Fidaxomicin

Fidaxomicin falls under MACROLIDE ANTIBIOTICS — the group Uzara interacts with.

Theoretically, concomitant use may increase risk of cardiac glycoside toxicity.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the thing to know about pairing Uzara with fidaxomicin (Dificid). Uzara naturally contains cardiac glycosides, the same family of heart-active compounds found in some prescription heart drugs. The concern on file is that certain macrolide antibiotics may raise the risk of those glycosides building up to toxic levels in the body.

I'll be honest with you: this flag is theoretical, based on how these drugs behave on paper rather than on solid real-world cases, especially since fidaxomicin stays mostly in your gut and isn't well absorbed. Still, both fidaxomicin and Uzara are used for diarrhea, so doubling up makes little sense. And glycoside excess can affect your heart rhythm, so please run this by your pharmacist or doctor before combining them.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Uzara Also Interacts With Other Medications

Uzara has 1 major, 131 moderate known drug interactions in our database — the Fidaxomicin one above is one of them. If you take anything else, check it against the full list below.

Major 1 Moderate 131 No known interaction 2,698 (incl. Fidaxomicin)
Taking anything else?

Check Another of Your Medications Against Uzara

Covers the 2,830 medications we’ve checked against Uzara. Pick one to open its full report.

From our Q&A

Questions About Uzara or Fidaxomicin

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Uzara or Fidaxomicin, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Fidaxomicin

This page covers Uzara only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Fidaxomicin page lists 92 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Oleander (major), St. John's Wort (major), Bacillus Coagulans (moderate) and Bacillus Subtilis (moderate).

By severity: 3 major · 71 moderate · 18 minor.

From our pharmacist’s overview on the Fidaxomicin page

“If you are taking fidaxomicin (Dificid) for a Clostridioides difficile infection, supplements are not a side issue, because anything that weakens this drug risks letting a hard-to-treat infection come back. Three entries rated major top my concerns.”

Reviewed by 2 · Jul 18, 2026

Open the Fidaxomicin interaction page

How much people look this up

Where Uzara and Fidaxomicin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Uzara
Top half

#686 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Fidaxomicin
Top half

#1,061 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Uzara

What is Uzara?

  • Diarrhea
  • Stomach cramps
  • Menstrual cramps (dysmenorrhea)
  • Headaches
  • Digestive upset

Uzara is a traditional African root remedy used mainly for diarrhea and stomach cramps. Because it contains cardiac glycosides that can affect the heart, it should be used cautiously and for short periods only. Talk to a pharmacist or doctor before using it, especially if you have heart problems, are pregnant, or take heart medications.

Read the full Uzara monograph & all interactions
Medication

About Fidaxomicin

What Is Fidaxomicin Used For?

Brand name: Dificid

Fidaxomicin treats C. difficile-associated diarrhea (CDAD) — a bacterial infection in the gut caused by Clostridioides difficile that leads to significant diarrhea and intestinal inflammation. Fidaxomicin tablets are approved for adult patients. Dificid (as tablets or oral suspension) is approved for both adults and children 6 months of age and older.

Because fidaxomicin works almost entirely inside the gut and is barely absorbed into the bloodstream, it is only effective against C. difficile and should not be used for any other type of infection.

See full Fidaxomicin drug information
Keep checking

Other Drugs & Uzara

Browse every other medication we’ve checked against Uzara — both the ones with a known interaction and the ones without. Select any drug for the full detail.

1Major
131Moderate
0Minor
2,697No known interaction
1 Major 131 Moderate 2,697 No interaction
Major

1 interaction

Moderate

131 interactions

Showing 60 of 131 moderate interactions — see all 131 on the Uzara page.

No interaction 2,697 drugs checked — show the list

We also checked Uzara against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,697 medications checked with no known interaction — see the full Uzara list.

See the full Uzara interactions page
See every supplement checked against Fidaxomicin, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Uzara monograph › Uses, safety, and every drug interaction in one place Fidaxomicin supplement interactions › Every supplement checked against Fidaxomicin, ranked by severity Fidaxomicin drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Uzara and Fidaxomicin Together: Common Questions

Can you take Uzara with Fidaxomicin?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Uzara and Fidaxomicin interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Fidaxomicin and Uzara?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.