Herb & supplement monograph

Lacticaseibacillus Rhamnosus Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS ·Updated July 2026

What is this page for?

First and foremost: how Lacticaseibacillus Rhamnosus interacts with medications. The heart of this page is the interaction list — every drug Lacticaseibacillus Rhamnosus is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Lacticaseibacillus Rhamnosus is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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On this page

Interaction report

Drugs that interact with Lacticaseibacillus Rhamnosus

182 medications have a known interaction with Lacticaseibacillus Rhamnosus, graded by severity. Select any drug for the full evidence-based detail.

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Tell us the medications you take and we’ll check each one against Lacticaseibacillus Rhamnosus using our pharmacist-reviewed interaction data.

AI summaries are generated from our Lacticaseibacillus Rhamnosus interaction data for education only — always confirm with your pharmacist. How we use AI

2,830 drugs

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
Each drug listed above links to the full report for that exact Lacticaseibacillus Rhamnosus combination — clinical detail, likelihood, evidence level, and citations.
Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

The big picture

The kinds of drugs Lacticaseibacillus Rhamnosus affects

Every type of medication (drug category) Lacticaseibacillus Rhamnosus is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 1 drug category Lacticaseibacillus Rhamnosus interacts with

Antibiotic Drugs

Theoretically, taking Lacticaseibacillus rhamnosus with antibiotic drugs might decrease the effectiveness of L. rhamnosus.
L. rhamnosus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. rhamnosus preparations by at least two hours.

Likelihood Probable Evidence D

Monograph

Lacticaseibacillus Rhamnosus: Uses, Safety & Side Effects

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Reviewed July 2026 ·

The bottom line

Lacticaseibacillus rhamnosus (often labeled L. rhamnosus GG) is a well-studied probiotic bacterium used mainly for diarrhea and general gut health. It is considered safe for most healthy people, with the best evidence for preventing certain types of diarrhea, but benefits for many other uses are uncertain. People who are seriously ill or have weakened immune systems should check with a doctor first.

Scientific name: Lacticaseibacillus rhamnosus
Family: Lactobacillaceae
Part used: Whole live bacteria (probiotic strain)
Common forms: Capsules, tablets, powders, sachets, drops, fermented dairy products (yogurt, kefir)

People commonly use it for

Diarrhea (including antibiotic-related)
Digestive health
Vaginal and urinary health
Eczema and allergy prevention in children
Immune support

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance

OverallLikely safe

Generally well tolerated in healthy people, though serious infections have rarely occurred in very ill or immunocompromised individuals.

PregnancyPossibly Safe

When used orally and appropriately. Lacticaseibacillus rhamnosus GG has been used with apparent safety starting 2-4 weeks before delivery. L. rhamnosu...

Read the full pregnancy detail

BreastfeedingPossibly Safe

When used orally and appropriately. Lacticaseibacillus rhamnosus GG has been used with apparent safety when breastfeeding for up to six months and L....

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

Lacticaseibacillus rhamnosus is a type of friendly bacteria (a probiotic) that naturally lives in the human gut. It was once classified under the name Lactobacillus rhamnosus, and many products still use that older name. One of the most famous versions is the strain called L. rhamnosus GG (LGG).

This bacterium is a lactic acid producer, meaning it helps ferment sugars into lactic acid. It is found in some fermented foods and dairy products and is also added to many supplements. People take it to support digestion, immune health, and the balance of bacteria in the gut.

Probiotics like this one are sold as capsules, powders, drops, and in fortified foods such as certain yogurts and kefir.

How it works

Probiotics like L. rhamnosus are thought to work in several ways. They may help crowd out harmful bacteria by competing for space and nutrients in the gut. They also produce lactic acid and other substances that can make the environment less friendly to some germs.

This bacterium may also support the lining of the intestines and interact with the immune system in ways that could affect inflammation. Much of this understanding comes from laboratory and animal research, and how strongly these effects apply in everyday human use is still being studied.

Effectiveness

Does Lacticaseibacillus Rhamnosus work?

Here’s what the research actually shows for each use — graded by Natural Medicines and reviewed by Dr. Brian Staiger, PharmD.

Evidence overview · 63 uses evaluated

3 Possibly effective 3 Leans ineffective 57 Insufficient evidence

How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.

2Likely EffectiveGood evidence, though not yet conclusive.

3Possibly EffectiveSome evidence suggests a benefit.

4Possibly IneffectiveSome evidence it may not help.

5Likely IneffectiveFairly strong evidence it doesn’t help.

6IneffectiveStrong evidence it doesn’t work.

7Insufficient Reliable Evidence to RateToo little research to say either way.

Possibly Effective Antibiotic-associated diarrhea