Herb & supplement monograph

Lactiplantibacillus Plantarum Drug Interactions, Uses, Effectiveness, Safety & More

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Reviewed by licensed pharmacists Sourced from Natural Medicines

Lactiplantibacillus Plantarum Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Lactiplantibacillus Plantarum drug interaction appears low for most people, since the only documented concern works against the probiotic itself rather than any medication. Every listed interaction is rated moderate, and all of them trace back to a single issue involving antibiotics.

Interactions deserving the most attention

The one interaction worth knowing about involves antibiotic drugs. Because Lactiplantibacillus plantarum products contain live bacteria, an antibiotic taken at the same time can kill many of those organisms and blunt the probiotic's benefit. Importantly, this works in one direction only: the probiotic is not known to make the antibiotic work less well or cause harmful effects.

What the rest of the list means

The long list of interacting medications looks alarming at first, but it simply reflects the many individual antibiotics on the market, all sharing this same single mechanism. No medication in the profile carries a major or well-proven safety risk, and the practical downside is mainly a less effective probiotic rather than any danger to your treatment.

Check your medications against Lactiplantibacillus Plantarum

Based on HelloPharmacist’s Lactiplantibacillus Plantarum interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Lactiplantibacillus Plantarum

182 medications have a known interaction with Lactiplantibacillus Plantarum, graded by severity. Select any drug for the full evidence-based detail.

2,830 drugs
AmikacinAmikin, Arikayce
Moderate Antibiotic Drugs

Theoretically, taking Lactiplantibacillus plantarum with antibiotic drugs might decrease the effectiveness of L.

Read the full Lactiplantibacillus Plantarum + Amikacin interaction Amikacin drug page: uses, dosage & side effects
AmoxicillinAmix, Amoram, Amoxident, Amoxil Capsules, Amoxil Injection, Galenamox +3 more
Moderate Antibiotic Drugs

Theoretically, taking Lactiplantibacillus plantarum with antibiotic drugs might decrease the effectiveness of L.

Read the full Lactiplantibacillus Plantarum + Amoxicillin interaction Amoxicillin drug page: uses, dosage & side effects
Amoxicillin VeterinaryBiomox
Moderate Antibiotic Drugs

Theoretically, taking Lactiplantibacillus plantarum with antibiotic drugs might decrease the effectiveness of L.

Read the full Lactiplantibacillus Plantarum + Amoxicillin Veterinary interaction
Amoxicillin, Clavulanate PotassiumAugmentin, Augmentin '125/31 SF', Augmentin '250/62 SF', Augmentin XR, Augmentin-Duo 400/57, Clavulin
Moderate Antibiotic Drugs

Theoretically, taking Lactiplantibacillus plantarum with antibiotic drugs might decrease the effectiveness of L.

Read the full Lactiplantibacillus Plantarum + Amoxicillin, Clavulanate Potassium interaction
Amoxicillin, Omeprazole Magnesium, RifabutinTalicia
Moderate Antibiotic Drugs

Theoretically, taking Lactiplantibacillus plantarum with antibiotic drugs might decrease the effectiveness of L.

Read the full Lactiplantibacillus Plantarum + Amoxicillin, Omeprazole Magnesium, Rifabutin interaction
Amphotericin, TetracyclineMysteclin-F
Moderate Antibiotic Drugs

Theoretically, taking Lactiplantibacillus plantarum with antibiotic drugs might decrease the effectiveness of L.

Read the full Lactiplantibacillus Plantarum + Amphotericin, Tetracycline interaction
AmpicillinOmnipen, Omnipen-N, Penbritin, Principen, Rimacillin
Moderate Antibiotic Drugs

Theoretically, taking Lactiplantibacillus plantarum with antibiotic drugs might decrease the effectiveness of L.

Read the full Lactiplantibacillus Plantarum + Ampicillin interaction Ampicillin drug page: uses, dosage & side effects
Ampicillin, SulbactamUnasyn
Moderate Antibiotic Drugs

Theoretically, taking Lactiplantibacillus plantarum with antibiotic drugs might decrease the effectiveness of L.

Read the full Lactiplantibacillus Plantarum + Ampicillin, Sulbactam interaction
Avibactam Sodium, CeftazidimeAvycaz
Moderate Antibiotic Drugs

Theoretically, taking Lactiplantibacillus plantarum with antibiotic drugs might decrease the effectiveness of L.

Read the full Lactiplantibacillus Plantarum + Avibactam Sodium, Ceftazidime interaction Avibactam Sodium, Ceftazidime drug page: uses, dosage & side effects
AzithromycinAzasite, Zithromax, Zmax
Moderate Antibiotic Drugs

Theoretically, taking Lactiplantibacillus plantarum with antibiotic drugs might decrease the effectiveness of L.

Read the full Lactiplantibacillus Plantarum + Azithromycin interaction Azithromycin drug page: uses, dosage & side effects
AztreonamAzactam
Moderate Antibiotic Drugs

Theoretically, taking Lactiplantibacillus plantarum with antibiotic drugs might decrease the effectiveness of L.

Read the full Lactiplantibacillus Plantarum + Aztreonam interaction Aztreonam drug page: uses, dosage & side effects
BacampicillinPenglobe
Moderate Antibiotic Drugs

Theoretically, taking Lactiplantibacillus plantarum with antibiotic drugs might decrease the effectiveness of L.

Read the full Lactiplantibacillus Plantarum + Bacampicillin interaction
BacitracinBaci-IM, Baciguent, Bacitracin Ointment
Moderate Antibiotic Drugs

Theoretically, taking Lactiplantibacillus plantarum with antibiotic drugs might decrease the effectiveness of L.

Read the full Lactiplantibacillus Plantarum + Bacitracin interaction Bacitracin drug page: uses, dosage & side effects
BenznidazoleBenznidazole
Moderate Antibiotic Drugs

Theoretically, taking Lactiplantibacillus plantarum with antibiotic drugs might decrease the effectiveness of L.

Read the full Lactiplantibacillus Plantarum + Benznidazole interaction Benznidazole drug page: uses, dosage & side effects
Bismuth Subsalicylate, Metronidazole, TetracyclineHelidac
Moderate Antibiotic Drugs

Theoretically, taking Lactiplantibacillus plantarum with antibiotic drugs might decrease the effectiveness of L.

Read the full Lactiplantibacillus Plantarum + Bismuth Subsalicylate, Metronidazole, Tetracycline interaction Bismuth Subsalicylate, Metronidazole, Tetracycline drug page: uses, dosage & side effects
CapreomycinCapastat
Moderate Antibiotic Drugs

Theoretically, taking Lactiplantibacillus plantarum with antibiotic drugs might decrease the effectiveness of L.

Read the full Lactiplantibacillus Plantarum + Capreomycin interaction
Carbenicillin Indanyl SodiumGeocillin
Moderate Antibiotic Drugs

Theoretically, taking Lactiplantibacillus plantarum with antibiotic drugs might decrease the effectiveness of L.

Read the full Lactiplantibacillus Plantarum + Carbenicillin Indanyl Sodium interaction
CefaclorCeclor, Ceclor CD
Moderate Antibiotic Drugs

Theoretically, taking Lactiplantibacillus plantarum with antibiotic drugs might decrease the effectiveness of L.

Read the full Lactiplantibacillus Plantarum + Cefaclor interaction Cefaclor drug page: uses, dosage & side effects
CefadroxilCef-Tab, Duricef, Ultracef
Moderate Antibiotic Drugs

Theoretically, taking Lactiplantibacillus plantarum with antibiotic drugs might decrease the effectiveness of L.

Read the full Lactiplantibacillus Plantarum + Cefadroxil interaction Cefadroxil drug page: uses, dosage & side effects
CefamandoleMandol
Moderate Antibiotic Drugs

Theoretically, taking Lactiplantibacillus plantarum with antibiotic drugs might decrease the effectiveness of L.

Read the full Lactiplantibacillus Plantarum + Cefamandole interaction
CefazolinAncef
Moderate Antibiotic Drugs

Theoretically, taking Lactiplantibacillus plantarum with antibiotic drugs might decrease the effectiveness of L.

Read the full Lactiplantibacillus Plantarum + Cefazolin interaction Cefazolin drug page: uses, dosage & side effects
CefdinirOmnicef
Moderate Antibiotic Drugs

Theoretically, taking Lactiplantibacillus plantarum with antibiotic drugs might decrease the effectiveness of L.

Read the full Lactiplantibacillus Plantarum + Cefdinir interaction Cefdinir drug page: uses, dosage & side effects
Cefditoren PivoxilSpectracef
Moderate Antibiotic Drugs

Theoretically, taking Lactiplantibacillus plantarum with antibiotic drugs might decrease the effectiveness of L.

Read the full Lactiplantibacillus Plantarum + Cefditoren Pivoxil interaction
CefepimeMaxipime
Moderate Antibiotic Drugs

Theoretically, taking Lactiplantibacillus plantarum with antibiotic drugs might decrease the effectiveness of L.

Read the full Lactiplantibacillus Plantarum + Cefepime interaction Cefepime drug page: uses, dosage & side effects
Cefiderocol Sulfate TosylateFetroja
Moderate Antibiotic Drugs

Theoretically, taking Lactiplantibacillus plantarum with antibiotic drugs might decrease the effectiveness of L.

Read the full Lactiplantibacillus Plantarum + Cefiderocol Sulfate Tosylate interaction Cefiderocol Sulfate Tosylate drug page: uses, dosage & side effects
CefiximeSuprax
Moderate Antibiotic Drugs

Theoretically, taking Lactiplantibacillus plantarum with antibiotic drugs might decrease the effectiveness of L.

Read the full Lactiplantibacillus Plantarum + Cefixime interaction Cefixime drug page: uses, dosage & side effects
CefmetazoleZefazone
Moderate Antibiotic Drugs

Theoretically, taking Lactiplantibacillus plantarum with antibiotic drugs might decrease the effectiveness of L.

Read the full Lactiplantibacillus Plantarum + Cefmetazole interaction
CefonicidMonocid
Moderate Antibiotic Drugs

Theoretically, taking Lactiplantibacillus plantarum with antibiotic drugs might decrease the effectiveness of L.

Read the full Lactiplantibacillus Plantarum + Cefonicid interaction
CefoperazoneCefobid
Moderate Antibiotic Drugs

Theoretically, taking Lactiplantibacillus plantarum with antibiotic drugs might decrease the effectiveness of L.

Read the full Lactiplantibacillus Plantarum + Cefoperazone interaction
CefotaximeClaforan
Moderate Antibiotic Drugs

Theoretically, taking Lactiplantibacillus plantarum with antibiotic drugs might decrease the effectiveness of L.

Read the full Lactiplantibacillus Plantarum + Cefotaxime interaction Cefotaxime drug page: uses, dosage & side effects
Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Lactiplantibacillus Plantarum combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The big picture

The kinds of drugs Lactiplantibacillus Plantarum affects

Every type of medication (drug category) Lactiplantibacillus Plantarum is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 1 drug category Lactiplantibacillus Plantarum interacts with
Antibiotic Drugs
Antibiotic Drugs

Theoretically, taking Lactiplantibacillus plantarum with antibiotic drugs might decrease the effectiveness of L. plantarum.
L. plantarum preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. plantarum preparations by at least two hours.

Likelihood Probable Evidence D
Monograph

Lactiplantibacillus Plantarum: Uses, Safety & Side Effects

The bottom line

Lactiplantibacillus plantarum is a 'friendly' bacterium (probiotic) found in fermented foods and many supplements, studied mainly for digestive health. It is generally well tolerated in healthy people, but evidence is mixed and strain-specific, so benefits are not guaranteed. Talk to your pharmacist or doctor before starting, especially if you have a weakened immune system.

Scientific name
Lactiplantibacillus plantarum
Family
Lactobacillaceae
Part used
Live bacterial cells (probiotic culture)
Common forms
Capsules, tablets, powders, fermented foods, drinks, and combination probiotic products
People commonly use it for
  • Digestive health and regularity
  • Irritable bowel syndrome (IBS) symptoms
  • Bloating and gas
  • Immune support
  • Restoring gut bacteria after antibiotics

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Generally well tolerated in healthy people, but people with weak immune systems or serious illness should be cautious.

PregnancyPossibly Safe

When used orally and appropriately. Lactiplantibacillus plantarum (Lp299v, DSM 9843) has been used with apparent safety in doses of 10 billion colony-...

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

There is insufficient reliable information available about the safety of Lactiplantibacillus plantarum during lactation. However, there are currently...

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Lactiplantibacillus plantarum (formerly called Lactobacillus plantarum) is a type of beneficial bacteria known as a probiotic. It naturally lives in the human gut and is also found in many fermented foods, such as sauerkraut, pickles, kimchi, sourdough, and certain cheeses and fermented drinks.

This bacterium is very adaptable and can survive in many environments, including the acidic conditions of the stomach. Because of this, it is a popular ingredient in probiotic supplements, either alone or combined with other strains.

People take it to support digestion, gut balance, and overall wellness. Different strains of L. plantarum may behave differently, so the effects seen in one product may not apply to all.

How it works

As a probiotic, L. plantarum is thought to support a healthy balance of bacteria in the gut. It may compete with harmful bacteria for space and nutrients, helping keep unwanted microbes in check.

It produces substances like lactic acid and other compounds that can lower the pH of the gut and may slow the growth of some harmful organisms. Researchers also believe it may help strengthen the gut lining and interact with the immune system.

Many of these proposed mechanisms come from laboratory and animal studies. How strongly they apply to people in real life is still being studied.

Effectiveness

Does Lactiplantibacillus Plantarum work?

Evidence overview · 55 uses evaluated
6 Possibly effective 1 Leans ineffective 48 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.
Possibly Effective Atopic dermatitis (eczema)
Rating & evidence shown verbatim from Natural Medicines

Oral Lactiplantibacillus plantarum seems to be beneficial for the treatment of atopic dermatitis.

Possibly Effective Common cold
Rating & evidence shown verbatim from Natural Medicines

A combination of Lactiplantibacillus plantarum and Lacticaseibacillus paracasei seems to be beneficial for reducing the incidence or severity of the common cold. The effects of L. plantarum alone are unclear.

Possibly Effective Hypercholesterolemia
Rating & evidence shown verbatim from Natural Medicines

Oral Lactiplantibacillus plantarum seems to be modestly beneficial for lowering cholesterol levels.

Possibly Effective Irritable bowel syndrome (IBS)
Rating & evidence shown verbatim from Natural Medicines

Some research shows that Lactiplantibacillus plantarum, alone or as part of specific combination products, may be beneficial for IBS.

Possibly Effective Respiratory tract infections
Rating & evidence shown verbatim from Natural Medicines

Oral Lactiplantibacillus plantarum seems to prevent respiratory tract infections.

Possibly Effective Ulcerative colitis
Rating & evidence shown verbatim from Natural Medicines

Oral Lactiplantibacillus plantarum, alone or in combination with other probiotics, seems to improve remission rates and prevent symptom relapse when used in combination with standard therapy.

Possibly Ineffective Antibiotic-associated diarrhea
Rating & evidence shown verbatim from Natural Medicines

Taking Lactiplantibacillus plantarum alone does not seem to reduce the risk of antibiotic-associated diarrhea (AAD) in adults and children. However, it might reduce the risk of loose stools. It is unclear if L. plantarum is beneficial for AAD when taken in combination with other probiotics.

Also studied for 48 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Acne
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral Lactiplantibacillus plantarum is beneficial for acne.

Insufficient Reliable Evidence To Rate Aging skin
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral Lactiplantibacillus plantarum is beneficial for aging skin.

Insufficient Reliable Evidence To Rate Athletic performance
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral Lactiplantibacillus plantarum is beneficial for athletic performance.

Insufficient Reliable Evidence To Rate Autism spectrum disorder
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral Lactiplantibacillus plantarum is beneficial for autism spectrum disorder.

Insufficient Reliable Evidence To Rate Bacterial vaginosis
Rating & evidence shown verbatim from Natural Medicines

Oral or vaginal Lactiplantibacillus plantarum has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Cancer
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral Lactiplantibacillus plantarum for cancer prevention or treatment, there is insufficient reliable information about the clinical effects of L. plantarum for this condition.

Insufficient Reliable Evidence To Rate Celiac disease
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral Lactiplantibacillus plantarum for celiac disease, there is insufficient reliable information about the clinical effects of L. plantarum for this condition.

Insufficient Reliable Evidence To Rate Clostridioides difficile infection
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral Lactiplantibacillus plantarum is beneficial for C. difficile prevention.

Insufficient Reliable Evidence To Rate Cognitive function
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral Lactiplantibacillus plantarum is beneficial for improving cognitive function.

Insufficient Reliable Evidence To Rate Cognitive impairment
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral Lactiplantibacillus plantarum is beneficial for improving cognitive impairment.

Insufficient Reliable Evidence To Rate Colic
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral Lactiplantibacillus plantarum for colic, there is insufficient reliable information about the clinical effects of L. plantarum for this condition.

Insufficient Reliable Evidence To Rate Constipation
Rating & evidence shown verbatim from Natural Medicines

Oral Lactiplantibacillus plantarum has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Coronavirus disease 2019 (COVID-19)
Rating & evidence shown verbatim from Natural Medicines

Oral Lactiplantibacillus plantarum has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Critical illness (trauma)
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral Lactiplantibacillus plantarum is beneficial for critical illness.

Insufficient Reliable Evidence To Rate Depression
Rating & evidence shown verbatim from Natural Medicines

Oral Lactiplantibacillus plantarum has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Diabetes
Rating & evidence shown verbatim from Natural Medicines

Oral Lactiplantibacillus plantarum has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Diarrhea
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral Lactiplantibacillus plantarum is beneficial for acute or chronic diarrhea.

Insufficient Reliable Evidence To Rate Helicobacter pylori
Rating & evidence shown verbatim from Natural Medicines

Oral Lactiplantibacillus plantarum has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Hepatic encephalopathy
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral Lactiplantibacillus plantarum for hepatic encephalopathy, there is insufficient reliable information about the clinical effects of L. plantarum for this condition.

Insufficient Reliable Evidence To Rate HIV/AIDS
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral Lactiplantibacillus plantarum for HIV/AIDS, there is insufficient reliable information about the clinical effects of L. plantarum for this condition.

Insufficient Reliable Evidence To Rate Hypertension
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral Lactiplantibacillus plantarum is beneficial for hypertension.

Insufficient Reliable Evidence To Rate Hypertriglyceridemia
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral Lactiplantibacillus plantarum is beneficial for hypertriglyceridemia.

Insufficient Reliable Evidence To Rate Impaired glucose tolerance (prediabetes)
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral live or heat-killed Lactiplantibacillus plantarum is beneficial for prediabetes.

Insufficient Reliable Evidence To Rate Insomnia
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral Lactiplantibacillus plantarum is beneficial for insomnia.

Insufficient Reliable Evidence To Rate Iron deficiency anemia
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral Lactiplantibacillus plantarum is beneficial for improving iron status when taken in combination with iron supplements.

Insufficient Reliable Evidence To Rate Lactose intolerance
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral Lactiplantibacillus plantarum for lactose intolerance, there is insufficient reliable information about the clinical effects of L. plantarum for this condition.

Insufficient Reliable Evidence To Rate Lyme disease
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral Lactiplantibacillus plantarum for Lyme disease, there is insufficient reliable information about the clinical effects of L. plantarum for this condition.

Insufficient Reliable Evidence To Rate Malnutrition
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral Lactiplantibacillus plantarum for children with malnutrition, there is insufficient reliable information about the clinical effects of L. plantarum for this condition.

Insufficient Reliable Evidence To Rate Metabolic syndrome
Rating & evidence shown verbatim from Natural Medicines

Oral Lactiplantibacillus plantarum has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Necrotizing enterocolitis (NEC)
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral Lactiplantibacillus plantarum is beneficial or safe for NEC prevention.

Insufficient Reliable Evidence To Rate Nonalcoholic fatty liver disease (NAFLD)
Rating & evidence shown verbatim from Natural Medicines

Oral Lactiplantibacillus plantarum has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Obesity
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral live or heat-killed Lactiplantibacillus plantarum are beneficial for weight loss.

Insufficient Reliable Evidence To Rate Osteoporosis
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral Lactiplantibacillus plantarum for osteoporosis, there is insufficient reliable information about the clinical effects of L. plantarum for this condition.

Insufficient Reliable Evidence To Rate Parkinson disease
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral Lactiplantibacillus plantarum is beneficial for Parkinson disease.

Insufficient Reliable Evidence To Rate Periodontitis
Rating & evidence shown verbatim from Natural Medicines

Oral and topical Lactiplantibacillus plantarum have only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Polycystic ovary syndrome (PCOS)
Rating & evidence shown verbatim from Natural Medicines

Oral Lactiplantibacillus plantarum has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Postoperative infection
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral Lactiplantibacillus plantarum for preventing postoperative infection, there is insufficient reliable information about the clinical effects of L. plantarum for this condition.

Insufficient Reliable Evidence To Rate Pouchitis
Rating & evidence shown verbatim from Natural Medicines

Oral Lactiplantibacillus plantarum has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Pregnancy-induced nausea and vomiting
Rating & evidence shown verbatim from Natural Medicines

Oral Lactiplantibacillus plantarum has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Radiation-induced diarrhea
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral Lactiplantibacillus plantarum for preventing radiation-induced diarrhea, there is insufficient reliable information about the clinical effects of L. plantarum for this condition.

Insufficient Reliable Evidence To Rate Rheumatoid arthritis (RA)
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral Lactiplantibacillus plantarum for RA, there is insufficient reliable information about the clinical effects of L. plantarum for this condition.

Insufficient Reliable Evidence To Rate Rotaviral diarrhea
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral Lactiplantibacillus plantarum is beneficial for rotaviral diarrhea.

Insufficient Reliable Evidence To Rate Short bowel syndrome
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral Lactiplantibacillus plantarum for short bowel syndrome, there is insufficient reliable information about the clinical effects of L. plantarum for this condition.

Insufficient Reliable Evidence To Rate Stress
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral live or heat-killed Lactiplantibacillus plantarum is beneficial for stress.

Insufficient Reliable Evidence To Rate Tourette syndrome
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral Lactiplantibacillus plantarum is beneficial for Tourette syndrome.

Insufficient Reliable Evidence To Rate Urinary tract infections (UTIs)
Rating & evidence shown verbatim from Natural Medicines

It is unclear if intravaginal Lactiplantibacillus plantarum is beneficial for the prevention of UTIs.

Insufficient Reliable Evidence To Rate Vaginal candidiasis
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral or vaginal Lactiplantibacillus plantarum is beneficial for vaginal candidiasis.

Insufficient Reliable Evidence To Rate Ventilator-associated pneumonia (VAP)
Rating & evidence shown verbatim from Natural Medicines

Oral Lactiplantibacillus plantarum has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

For most healthy people, L. plantarum is considered generally safe and is found naturally in many foods. However, because it is a live organism, certain people should be careful.

People with weakened immune systems, serious illness, central venous catheters, or those who are critically ill should avoid probiotics unless a doctor recommends them, because of a rare risk of infection. The same caution applies to people who have had recent major surgery.

For pregnancy and breastfeeding, there is not enough strong research to confirm safety. Many probiotics are thought to be low risk, but it is safest to check with your doctor or pharmacist before using a supplement during these times. Give probiotics to infants and children only with medical guidance.

Side effects

Side effects are usually mild. The most common ones include gas, bloating, and mild stomach upset, especially in the first few days of use. These often improve as your body adjusts.

Serious side effects are rare. In very rare cases, probiotics have been linked to bloodstream or other infections, almost always in people who are seriously ill or have weakened immune systems.

If you notice fever, severe stomach pain, or signs of an allergic reaction, stop taking it and seek medical care.

Lactiplantibacillus Plantarum: Reported Adverse Effects

Documented safety reports on Lactiplantibacillus Plantarum from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Reports by condition
Cancer Immunologic

Since Lactiplantibacillus plantarum preparations contain live and active microorganisms, there is some concern that they might cause pathogenic infection in some patients. Lactobacilli species, including L. plantarum, have been isolated in some cases of bacteremia, sepsis, splenic abscess, endocarditis, necrotizing fasciitis, pancreatic necrosis, and meningoencephalitis. Most cases of L. plantarum infection are thought to be due to the translocation of bacteria from other locations in the body in which they occur naturally, such as the oral cavity and gastrointestinal tract. However, there are also rare case reports of pathogenic infections possibly related to intake of L. plantarum supplements in these populations. In one case report, the diagnosis of L. plantarum bacteremia in a regular consumer of the fermented food Nukazuk was thought to be related to the eventual diagnosis of rectal cancer.

A specific probiotic preparation (NBL probiotic ATP, Nobel) containing L. plantarum, Lacticaseibacillus casei, Lacticaseibacillus rhamnosus, Bifidobacterium animalis subsp. lactis, fructo-oligosaccharides, galacto-oligosaccharides, colostrum, and lactoferrin was found to be a significant risk factor for vancomycin-resistant Enterococcus colonization in premature infants. Although there was no direct link to determine causation, it was hypothesized that the probiotic mixture helped to mediate the acquisition and transfer of antibiotic resistance genes.

  1. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178.
  2. Matsuura H, Kiura Y, Ito T, et al. Lactobacillus bacteremia: a diagnostic clue of rectal cancer. QJM. 2021;114(2):122-123.
  3. Topcuoglu S, Gursoy T, Ovali F, Serce O, Karatekin G. A new risk factor for neonatal vancomycin-resistant Enterococcus colonisation: bacterial probiotics. J Matern Fetal Neonatal Med. 2015;28(12):1491-4.
Diarrhea Gastrointestinal

Orally, taking Lactiplantibacillus plantarum may cause gastrointestinal side effects including diarrhea, loose stools, nausea, stomach pain, rumbling, bloating, and flatulence; however, these events are uncommon.

  1. Krag A, Munkholm P, Israelsen H, von Ryberg B, Andersen KK, Bendtsen F. Profermin is efficacious in patients with active ulcerative colitis--a randomized controlled trial. Inflamm Bowel Dis. 2013;19(12):2584-92.
  2. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  3. Lazou Ahrén I, Berggren A, Teixeira C, Martinsson Niskanen T, Larsson N. Evaluation of the efficacy of Lactobacillus plantarum HEAL9 and Lactobacillus paracasei 8700:2 on aspects of common cold infections in children attending day care: a randomised, doub
  4. Busch R, Gruenwald J, Dudek S. Randomized, double blind and placebo controlled study using a combination of two probiotic lactobacilli to alleviate symptoms and frequency of common cold. Food Nutr Sci 2013;4(11A):13-2.
  5. Canaviri-Paz P, Oscarsson E, Kjellström A, Olsson H, Jois C, Håkansson Å. Effects on Microbiota Composition after Consumption of Quinoa Beverage Fermented by a Novel Xylose-Metabolizing L. plantarum Strain. Nutrients 2021;13(10):3318.
  6. Bengtsson J, Adlerberth I, Östblom A, Saksena P, Öresland T, Börjesson L. Effect of probiotics (Lactobacillus plantarum 299 plus Bifidobacterium Cure21) in patients with poor ileal pouch function: a randomised controlled trial. Scand J Gastroenterol 2016;
Vertigo Neurologic/CNS

Orally, use of Lactiplantibacillus plantarum 299v 10 billion colony-forming units daily has been associated with one case of transient vertigo in one clinical trial.

  1. Ducrotté P, Sawant P, Jayanthi V. Clinical trial: Lactobacillus plantarum 299v (DSM 9843) improves symptoms of irritable bowel syndrome. World J Gastroenterol 2012;18(30):4012-8.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no single official dose for L. plantarum. Probiotic amounts are usually measured in colony-forming units (CFU), and products vary widely in how much they contain and which strain they use.

The best approach is to follow the directions on the product label. Because different strains and products are studied differently, more is not always better.

If you are unsure which product or dose is right for you, ask your pharmacist or doctor. They can help you choose a reputable product and check that it is appropriate for your health situation.

Pregnancy & Breastfeeding

Lactiplantibacillus Plantarum & Pregnancy

Possibly Safe

When used orally and appropriately. Lactiplantibacillus plantarum (Lp299v, DSM 9843) has been used with apparent safety in doses of 10 billion colony-forming units (CFUs) daily in combination with iron, ascorbic acid, and folic acid daily from 10-12 weeks' gestation until delivery.

  1. Axling U, Önning G, Martinsson Niskanen T, Larsson N, Hansson SR, Hulthén L. The effect of Lactiplantibacillus plantarum 299v together with a low dose of iron on iron status in healthy pregnant women: A randomized clinical trial. Acta Obstet Gynecol Scand

Lactiplantibacillus Plantarum & Breastfeeding

Insufficient reliable information

There is insufficient reliable information available about the safety of Lactiplantibacillus plantarum during lactation. However, there are currently no reasons to expect safety concerns when used appropriately.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 12 references that drive our Lactiplantibacillus Plantarum monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Ducrotté P, Sawant P, Jayanthi V. Clinical trial: Lactobacillus plantarum 299v (DSM 9843) improves symptoms of irritable bowel syndrome. World J Gastroenterol 2012;18(30):4012-8.
  3. Krag A, Munkholm P, Israelsen H, von Ryberg B, Andersen KK, Bendtsen F. Profermin is efficacious in patients with active ulcerative colitis--a randomized controlled trial. Inflamm Bowel Dis. 2013;19(12):2584-92. PubMed
  4. Topcuoglu S, Gursoy T, Ovali F, Serce O, Karatekin G. A new risk factor for neonatal vancomycin-resistant Enterococcus colonisation: bacterial probiotics. J Matern Fetal Neonatal Med. 2015;28(12):1491-4. PubMed
  5. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  6. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  7. Axling U, Önning G, Martinsson Niskanen T, Larsson N, Hansson SR, Hulthén L. The effect of Lactiplantibacillus plantarum 299v together with a low dose of iron on iron status in healthy pregnant women: A randomized clinical trial. Acta Obstet Gynecol Scand
  8. Matsuura H, Kiura Y, Ito T, et al. Lactobacillus bacteremia: a diagnostic clue of rectal cancer. QJM. 2021;114(2):122-123. PubMed
  9. Lazou Ahrén I, Berggren A, Teixeira C, Martinsson Niskanen T, Larsson N. Evaluation of the efficacy of Lactobacillus plantarum HEAL9 and Lactobacillus paracasei 8700:2 on aspects of common cold infections in children attending day care: a randomised, doub
  10. Busch R, Gruenwald J, Dudek S. Randomized, double blind and placebo controlled study using a combination of two probiotic lactobacilli to alleviate symptoms and frequency of common cold. Food Nutr Sci 2013;4(11A):13-2. DOI
  11. Bengtsson J, Adlerberth I, Östblom A, Saksena P, Öresland T, Börjesson L. Effect of probiotics (Lactobacillus plantarum 299 plus Bifidobacterium Cure21) in patients with poor ileal pouch function: a randomised controlled trial. Scand J Gastroenterol 2016;
  12. Canaviri-Paz P, Oscarsson E, Kjellström A, Olsson H, Jois C, Håkansson Å. Effects on Microbiota Composition after Consumption of Quinoa Beverage Fermented by a Novel Xylose-Metabolizing L. plantarum Strain. Nutrients 2021;13(10):3318. PubMed
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Pharmacist Counseling Corner

Lactiplantibacillus Plantarum: Common Questions

What is Lactiplantibacillus Plantarum used for, and does it work?
People use Lactiplantibacillus Plantarum for many reasons, but the evidence varies by use. According to the Natural Medicines database, there is at least some clinical evidence supporting Lactiplantibacillus Plantarum for Atopic dermatitis (eczema), Common cold, Hypercholesterolemia and Irritable bowel syndrome (IBS). For most other uses it has been studied for, the evidence is currently insufficient to rate. See the graded list on this page, and always confirm with your pharmacist or doctor.
Does Lactiplantibacillus Plantarum interact with prescription medications?
Yes. We list 182 medications with a known interaction with Lactiplantibacillus Plantarum. Use the checker above to see how Lactiplantibacillus Plantarum interacts with a specific drug.
How are Lactiplantibacillus Plantarum interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Lactiplantibacillus Plantarum with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Lactiplantibacillus Plantarum interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Lactiplantibacillus Plantarum used for?
It is most commonly used as a probiotic to support digestive health, ease symptoms like bloating and gas, and help maintain a healthy balance of gut bacteria. Evidence is strongest for certain digestive uses but is still mixed.
Is it safe to take every day?
Most healthy adults can take it daily without problems, and similar bacteria are found in many fermented foods. If you have a weakened immune system or a serious illness, check with your doctor first.
Can I get it from food instead of a supplement?
Yes. Fermented foods like sauerkraut, kimchi, pickles, and some fermented drinks naturally contain this bacterium, though the exact strains and amounts vary.
Can I take it while pregnant or breastfeeding?
Safety data during pregnancy and breastfeeding are limited. Many probiotics are considered low risk, but it is best to talk with your doctor or pharmacist before using a supplement.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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