Colistimethate Injection

Generic name: Pronounced as (koe lis" ti meth' ate)
Brand names
  • Coly-Mycin M®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 12/15/2016

Colistimethate injection is used to treat certain infections caused by bacteria. Colistimethate injection is in a class of medications called antibiotics. It works by killing bacteria.

Antibiotics such as colistimethate injection will not work for colds, flu, or other viral infections. Using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment.

Colistimethate injection comes as a powder to be mixed with a liquid and injected intravenously (into a vein) over a period of 3 to 5 minutes. Colistimethate injection may also be injected into the muscles of the buttocks or thighs. It is usually given every 6 to 12 hours. Colistimethate injection may also be given as a constant intravenous infusion over 22 to 23 hours. The length of your treatment depends on your general health, the type of infection that you have, and how well you respond to the medication.

You may receive colistimethate injection in a hospital or you may administer the medication at home. If you will be receiving colistimethate injection at home, your healthcare provider will show you how to use the medication. Be sure that you understand these directions, and ask your healthcare provider if you have any questions.

You should begin to feel better during the first few days of treatment with colistimethate injection. If your symptoms do not improve or get worse, call your doctor.

Use colistimethate injection until you finish the prescription, even if you feel better. If you stop using colistimethate injection too soon or skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics.

Colistimethate injection is also sometimes inhaled by mouth using a nebulizer (machine that turns medication into a mist that can be inhaled) to treat certain serious lung infections. Talk to your doctor about the risks of using this medication for your condition.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before using colistimethate injection,

  • tell your doctor and pharmacist if you are allergic to colistimethate, any other medications, or any of the ingredients in colistimethate injection. Ask your pharmacist for a list of the ingredients.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: amikacin, amphotericin B (Abelcet, Ambisome), capreomycin (Capastat), gentamicin (Gentak, Genoptic), kanamycin, neomycin (Neo-Fradin), paromomycin, polymyxin B, sodium citrate (in Bicitra), streptomycin, tobramycin (Tobi, Tobrex), or vancomycin (Vancocin). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • tell your doctor if you have or have ever had kidney disease.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while receiving colistimethate injection, call your doctor.

  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are receiving colistimethate injection.

  • you should know that colistimethate injection may make you dizzy or affect your coordination. Do not drive a car or operate machinery until you know how this medication affects you.

Unless your doctor tells you otherwise, continue your normal diet.

  • Colistimethate injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • upset stomach

    • hives

    • rash

  • Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

    • numbness and tingling of the arms, legs, hands, feet, or tongue

    • sensation of insects crawling under the skin

    • itching

    • slurred speech

    • muscle weakness

    • shallow, slowed, or temporarily stopped breathing

    • decreased urination

    • severe diarrhea (watery or bloody stools) with or without fever and stomach cramps that may occur up to 2 months or more after your treatment

  • Colistimethate injection may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include the following:

  • numbness and tingling

  • extreme tiredness

  • confusion

  • dizziness

  • loss of balance and coordination

  • rapid, uncontrolled eye movements

  • difficulty speaking

  • slow, shallow, or difficult breathing

  • decreased urination

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to colistimethate injection.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

  • Polymyxin E

Drug Interaction
Alendronate Alendronate The risk or severity of nephrotoxicity and hypocalcemia can be increased when Colistimethate is combined with Alendronic acid.
Cilostazol Cilostazol Colistimethate may decrease the excretion rate of Cilostazol which could result in a higher serum level.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) Colistimethate may decrease the excretion rate of Conjugated estrogens which could result in a higher serum level.
Fenofibrate Fenofibrate Colistimethate may decrease the excretion rate of Fenofibrate which could result in a higher serum level.
Guanfacine Guanfacine Colistimethate may decrease the excretion rate of Guanfacine which could result in a higher serum level.
Magnesium Gluconate Magnesium Gluconate The risk or severity of neuromuscular blockade can be increased when Colistimethate is combined with Magnesium gluconate.
Magnesium Hydroxide Magnesium Hydroxide Colistimethate may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level.
Magnesium Oxide Magnesium Oxide The risk or severity of neuromuscular blockade can be increased when Colistimethate is combined with Magnesium oxide.
Mycophenolate Mycophenolate Colistimethate may decrease the excretion rate of Mycophenolic acid which could result in a higher serum level.
Olsalazine Olsalazine The risk or severity of nephrotoxicity can be increased when Colistimethate is combined with Olsalazine.
Potassium Potassium Colistimethate may decrease the excretion rate of Potassium cation which could result in a higher serum level.
Prednisone Prednisone Colistimethate may decrease the excretion rate of Prednisone which could result in a higher serum level.
Ranitidine Ranitidine Colistimethate may decrease the excretion rate of Ranitidine which could result in a higher serum level.
Reserpine Reserpine Colistimethate may decrease the excretion rate of Reserpine which could result in a higher serum level.
Rizatriptan Rizatriptan Colistimethate may decrease the excretion rate of Rizatriptan which could result in a higher serum level.
Sumatriptan Sumatriptan Colistimethate may decrease the excretion rate of Sumatriptan which could result in a higher serum level.
Tacrolimus Tacrolimus The risk or severity of nephrotoxicity can be increased when Tacrolimus is combined with Colistimethate.
Tiludronate Tiludronate The risk or severity of nephrotoxicity and hypocalcemia can be increased when Colistimethate is combined with Etidronic acid.
Ampicillin Injection Ampicillin Injection Colistimethate may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Doxycycline Injection Doxycycline Injection Colistimethate may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Fluconazole Injection Fluconazole Injection Colistimethate may decrease the excretion rate of Fluconazole which could result in a higher serum level.
Foscarnet Injection Foscarnet Injection The risk or severity of nephrotoxicity can be increased when Colistimethate is combined with Foscarnet.
Hydromorphone Injection Hydromorphone Injection Colistimethate may decrease the excretion rate of Hydromorphone which could result in a higher serum level.
Levofloxacin Injection Levofloxacin Injection Colistimethate may decrease the excretion rate of Levofloxacin which could result in a higher serum level.
Meperidine Injection Meperidine Injection Colistimethate may decrease the excretion rate of Meperidine which could result in a higher serum level.
Metoclopramide Injection Metoclopramide Injection Colistimethate may decrease the excretion rate of Metoclopramide which could result in a higher serum level.
Pamidronate Injection Pamidronate Injection The risk or severity of nephrotoxicity and hypocalcemia can be increased when Colistimethate is combined with Pamidronic acid.
Vancomycin Injection Vancomycin Injection Colistimethate may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Altretamine Altretamine Colistimethate may decrease the excretion rate of Amphetamine which could result in a higher serum level.
Cefuroxime Cefuroxime The risk or severity of nephrotoxicity can be increased when Colistimethate is combined with Cefuroxime.
Cyclosporine Cyclosporine The risk or severity of nephrotoxicity can be increased when Cyclosporine is combined with Colistimethate.
Meloxicam Meloxicam The risk or severity of nephrotoxicity can be increased when Meloxicam is combined with Colistimethate.
Pantoprazole Pantoprazole Colistimethate may decrease the excretion rate of Pantoprazole which could result in a higher serum level.
Risedronate Risedronate The risk or severity of nephrotoxicity and hypocalcemia can be increased when Colistimethate is combined with Risedronic acid.
Temozolomide Temozolomide Colistimethate may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Zaleplon Zaleplon Colistimethate may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Perindopril Perindopril Colistimethate may decrease the excretion rate of Perindopril which could result in a higher serum level.
Tenofovir Tenofovir Colistimethate may increase the nephrotoxic activities of Tenofovir.
Choline Magnesium Trisalicylate Choline Magnesium Trisalicylate The risk or severity of nephrotoxicity can be increased when Colistimethate is combined with Choline magnesium trisalicylate.
Zonisamide Zonisamide Colistimethate may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Atomoxetine Atomoxetine Colistimethate may decrease the excretion rate of Atomoxetine which could result in a higher serum level.
Atazanavir Atazanavir The risk or severity of nephrotoxicity can be increased when Atazanavir is combined with Colistimethate.
Almotriptan Almotriptan Colistimethate may decrease the excretion rate of Almotriptan which could result in a higher serum level.
Emtricitabine Emtricitabine Colistimethate may decrease the excretion rate of Emtricitabine which could result in a higher serum level.
Memantine Memantine Colistimethate may decrease the excretion rate of Memantine which could result in a higher serum level.
Tadalafil Tadalafil Colistimethate may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Duloxetine Duloxetine Colistimethate may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Tinidazole Tinidazole Colistimethate may decrease the excretion rate of Tinidazole which could result in a higher serum level.
Cefditoren Cefditoren Colistimethate may decrease the excretion rate of Cefdinir which could result in a higher serum level.
Cyanocobalamin Injection Cyanocobalamin Injection Colistimethate may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
Eszopiclone Eszopiclone Colistimethate may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Ganciclovir Ganciclovir Colistimethate may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Ribavirin Ribavirin Colistimethate may decrease the excretion rate of Ribavirin which could result in a higher serum level.
Valganciclovir Valganciclovir Colistimethate may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Zoledronic Acid Injection Zoledronic Acid Injection The risk or severity of nephrotoxicity and hypocalcemia can be increased when Colistimethate is combined with Zoledronic acid.
Adefovir Adefovir The risk or severity of nephrotoxicity can be increased when Colistimethate is combined with Adefovir.
Dextroamphetamine Dextroamphetamine Colistimethate may decrease the excretion rate of Amphetamine which could result in a higher serum level.
Ibandronate Ibandronate The risk or severity of nephrotoxicity and hypocalcemia can be increased when Colistimethate is combined with Ibandronate.
Ramelteon Ramelteon Colistimethate may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Fentanyl Fentanyl Colistimethate may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Pregabalin Pregabalin Colistimethate may decrease the excretion rate of Pregabalin which could result in a higher serum level.
Ranolazine Ranolazine Colistimethate may decrease the excretion rate of Ranolazine which could result in a higher serum level.
Rasagiline Rasagiline Colistimethate may decrease the excretion rate of Rasagiline which could result in a higher serum level.
Sitagliptin Sitagliptin Colistimethate may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Varenicline Varenicline Colistimethate may decrease the excretion rate of Varenicline which could result in a higher serum level.
Albuterol Albuterol Colistimethate may decrease the excretion rate of Salbutamol which could result in a higher serum level.
Paliperidone Paliperidone Colistimethate may decrease the excretion rate of Paliperidone which could result in a higher serum level.
Clofarabine Injection Clofarabine Injection Colistimethate may decrease the excretion rate of Clofarabine which could result in a higher serum level.
Lubiprostone Lubiprostone Colistimethate may decrease the excretion rate of Lubiprostone which could result in a higher serum level.
Pemetrexed Injection Pemetrexed Injection Colistimethate may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Sorafenib Sorafenib Colistimethate may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Levocetirizine Levocetirizine Colistimethate may decrease the excretion rate of Levocetirizine which could result in a higher serum level.
Pegaptanib Injection Pegaptanib Injection Colistimethate may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Azacitidine Injection Azacitidine Injection Colistimethate may decrease the excretion rate of Azacitidine which could result in a higher serum level.
Lenalidomide Lenalidomide Colistimethate may decrease the excretion rate of Lenalidomide which could result in a higher serum level.
Budesonide Budesonide Colistimethate may decrease the excretion rate of Budesonide which could result in a higher serum level.
Desmopressin Desmopressin Colistimethate may decrease the excretion rate of Desmopressin which could result in a higher serum level.
OnabotulinumtoxinA Injection OnabotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Colistimethate is combined with Botulinum toxin type A.
RimabotulinumtoxinB Injection RimabotulinumtoxinB Injection The risk or severity of adverse effects can be increased when Colistimethate is combined with Botulinum Toxin Type B.
Doripenem Injection Doripenem Injection Colistimethate may decrease the excretion rate of Doripenem which could result in a higher serum level.
Arsenic Trioxide Injection Arsenic Trioxide Injection Colistimethate may decrease the excretion rate of Arsenic trioxide which could result in a higher serum level.
Desvenlafaxine Desvenlafaxine Colistimethate may decrease the excretion rate of Desvenlafaxine which could result in a higher serum level.
Cevimeline Cevimeline Colistimethate may decrease the excretion rate of Cevimeline which could result in a higher serum level.
Certolizumab Injection Certolizumab Injection Colistimethate may decrease the excretion rate of Certolizumab pegol which could result in a higher serum level.
Daptomycin Injection Daptomycin Injection Colistimethate may decrease the excretion rate of Daptomycin which could result in a higher serum level.
Methylnaltrexone Injection Methylnaltrexone Injection Colistimethate may decrease the excretion rate of Methylnaltrexone which could result in a higher serum level.
Midazolam Midazolam Colistimethate may decrease the excretion rate of Midazolam which could result in a higher serum level.
Dexrazoxane Injection Dexrazoxane Injection Colistimethate may decrease the excretion rate of Dexrazoxane which could result in a higher serum level.
Milnacipran Milnacipran Colistimethate may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Plerixafor Injection Plerixafor Injection Colistimethate may decrease the excretion rate of Plerixafor which could result in a higher serum level.
Fesoterodine Fesoterodine Colistimethate may decrease the excretion rate of Fesoterodine which could result in a higher serum level.
Prasugrel Prasugrel Colistimethate may decrease the excretion rate of Prasugrel which could result in a higher serum level.
AbobotulinumtoxinA Injection AbobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Colistimethate is combined with Botulinum toxin type A.
Pralatrexate Injection Pralatrexate Injection Colistimethate may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
Palonosetron Injection Palonosetron Injection Colistimethate may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Saxagliptin Saxagliptin Colistimethate may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
Telavancin Injection Telavancin Injection Colistimethate may decrease the excretion rate of Telavancin which could result in a higher serum level.
Topotecan Topotecan Colistimethate may decrease the excretion rate of Topotecan which could result in a higher serum level.
Dalfampridine Dalfampridine Colistimethate may decrease the excretion rate of Dalfampridine which could result in a higher serum level.
IncobotulinumtoxinA Injection IncobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Colistimethate is combined with Botulinum toxin type A.
Ceftaroline Injection Ceftaroline Injection The risk or severity of nephrotoxicity can be increased when Colistimethate is combined with Ceftaroline fosamil.
Acetaminophen Injection Acetaminophen Injection Colistimethate may decrease the excretion rate of Acetaminophen which could result in a higher serum level.
Ipilimumab Injection Ipilimumab Injection Colistimethate may decrease the excretion rate of Ipilimumab which could result in a higher serum level.
Denileukin Diftitox Injection Denileukin Diftitox Injection Colistimethate may decrease the excretion rate of Aldesleukin which could result in a higher serum level.
Terbutaline Injection Terbutaline Injection Colistimethate may decrease the excretion rate of Terbutaline which could result in a higher serum level.
Roflumilast Roflumilast Colistimethate may decrease the excretion rate of Roflumilast which could result in a higher serum level.
Rivaroxaban Rivaroxaban Colistimethate may decrease the excretion rate of Rivaroxaban which could result in a higher serum level.
Ruxolitinib Ruxolitinib Colistimethate may decrease the excretion rate of Ruxolitinib which could result in a higher serum level.
Clobazam Clobazam Colistimethate may decrease the excretion rate of Clobazam which could result in a higher serum level.
Deferiprone Deferiprone Colistimethate may decrease the excretion rate of Deferiprone which could result in a higher serum level.
Naloxone Injection Naloxone Injection Colistimethate may decrease the excretion rate of Naloxone which could result in a higher serum level.
Fondaparinux Injection Fondaparinux Injection Colistimethate may decrease the excretion rate of Fondaparinux which could result in a higher serum level.
Enzalutamide Enzalutamide Colistimethate may decrease the excretion rate of Enzalutamide which could result in a higher serum level.
Mirabegron Mirabegron Colistimethate may decrease the excretion rate of Mirabegron which could result in a higher serum level.
Teduglutide Injection Teduglutide Injection Colistimethate may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Alogliptin Alogliptin Colistimethate may decrease the excretion rate of Alogliptin which could result in a higher serum level.
Pomalidomide Pomalidomide Colistimethate may decrease the excretion rate of Pomalidomide which could result in a higher serum level.
Canagliflozin Canagliflozin Colistimethate may decrease the excretion rate of Canagliflozin which could result in a higher serum level.
Trametinib Trametinib Colistimethate may decrease the excretion rate of Trametinib which could result in a higher serum level.
Levomilnacipran Levomilnacipran Colistimethate may decrease the excretion rate of Levomilnacipran which could result in a higher serum level.
Ertapenem Injection Ertapenem Injection Colistimethate may decrease the excretion rate of Ertapenem which could result in a higher serum level.
Tigecycline Injection Tigecycline Injection The risk or severity of neuromuscular blockade can be increased when Tigecycline is combined with Colistimethate.
Vortioxetine Vortioxetine Colistimethate may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Ketorolac Injection Ketorolac Injection The risk or severity of nephrotoxicity can be increased when Ketorolac is combined with Colistimethate.
Sofosbuvir Sofosbuvir Colistimethate may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Apremilast Apremilast Colistimethate may decrease the excretion rate of Apremilast which could result in a higher serum level.
Droxidopa Droxidopa Colistimethate may decrease the excretion rate of Droxidopa which could result in a higher serum level.
Testosterone Injection Testosterone Injection Colistimethate may decrease the excretion rate of Testosterone which could result in a higher serum level.
Edoxaban Edoxaban Colistimethate may decrease the excretion rate of Edoxaban which could result in a higher serum level.
Methamphetamine Methamphetamine Colistimethate may decrease the excretion rate of Metamfetamine which could result in a higher serum level.
Tasimelteon Tasimelteon Colistimethate may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Haloperidol Injection Haloperidol Injection Colistimethate may decrease the excretion rate of Haloperidol which could result in a higher serum level.
Macitentan Macitentan Colistimethate may decrease the excretion rate of Macitentan which could result in a higher serum level.
Penicillin G Procaine Injection Penicillin G Procaine Injection Colistimethate may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level.
Ixazomib Ixazomib Colistimethate may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Lesinurad Lesinurad Colistimethate may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection Amphotericin B may increase the nephrotoxic activities of Colistimethate.
Brivaracetam Injection Brivaracetam Injection Colistimethate may decrease the excretion rate of Brivaracetam which could result in a higher serum level.
Furosemide Injection Furosemide Injection Colistimethate may decrease the excretion rate of Furosemide which could result in a higher serum level.
Lixisenatide Injection Lixisenatide Injection Colistimethate may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Doxepin (Insomnia) Doxepin (Insomnia) Colistimethate may decrease the excretion rate of Doxepin which could result in a higher serum level.
Deutetrabenazine Deutetrabenazine Colistimethate may decrease the excretion rate of Deutetrabenazine which could result in a higher serum level.
Valbenazine Valbenazine Colistimethate may decrease the excretion rate of Valbenazine which could result in a higher serum level.
Naldemedine Naldemedine Colistimethate may decrease the excretion rate of Naldemedine which could result in a higher serum level.
Benznidazole Benznidazole Colistimethate may decrease the excretion rate of Benznidazole which could result in a higher serum level.
Delafloxacin Delafloxacin Colistimethate may decrease the excretion rate of Delafloxacin which could result in a higher serum level.
Apalutamide Apalutamide Colistimethate may decrease the excretion rate of Apalutamide which could result in a higher serum level.
Baricitinib Baricitinib Colistimethate may decrease the excretion rate of Baricitinib which could result in a higher serum level.
Lofexidine Lofexidine Colistimethate may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Plazomicin Injection Plazomicin Injection Colistimethate may decrease the excretion rate of Plazomicin which could result in a higher serum level.
Stiripentol Stiripentol Colistimethate may decrease the excretion rate of Stiripentol which could result in a higher serum level.
Prucalopride Prucalopride Colistimethate may decrease the excretion rate of Prucalopride which could result in a higher serum level.
Magnesium Citrate Magnesium Citrate The risk or severity of neuromuscular blockade can be increased when Colistimethate is combined with Magnesium citrate.
Acyclovir Ophthalmic Acyclovir Ophthalmic Colistimethate may decrease the excretion rate of Acyclovir which could result in a higher serum level.
Solriamfetol Solriamfetol Colistimethate may decrease the excretion rate of Solriamfetol which could result in a higher serum level.
Pitolisant Pitolisant Colistimethate may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Viloxazine Viloxazine Colistimethate may decrease the excretion rate of Viloxazine which could result in a higher serum level.
Tobramycin Injection Tobramycin Injection Tobramycin may decrease the excretion rate of Colistimethate which could result in a higher serum level.
Fenoprofen Fenoprofen The risk or severity of nephrotoxicity can be increased when Fenoprofen is combined with Colistimethate.
Indomethacin Indomethacin The risk or severity of nephrotoxicity can be increased when Indomethacin is combined with Colistimethate.
Mefenamic Acid Mefenamic Acid The risk or severity of nephrotoxicity can be increased when Mefenamic acid is combined with Colistimethate.
Naproxen Naproxen The risk or severity of nephrotoxicity can be increased when Naproxen is combined with Colistimethate.
Tolmetin Tolmetin The risk or severity of nephrotoxicity can be increased when Tolmetin is combined with Colistimethate.
Sulindac Sulindac The risk or severity of nephrotoxicity can be increased when Sulindac is combined with Colistimethate.
Isotretinoin Isotretinoin Colistimethate may decrease the excretion rate of Isotretinoin which could result in a higher serum level.
Sucralfate Sucralfate Colistimethate may decrease the excretion rate of Sucralfate which could result in a higher serum level.
Floxuridine Floxuridine Colistimethate may decrease the excretion rate of Floxuridine which could result in a higher serum level.
Metaxalone Metaxalone Colistimethate may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Methotrexate Injection Methotrexate Injection Colistimethate may decrease the excretion rate of Methotrexate which could result in a higher serum level.
Chlorpromazine Chlorpromazine Colistimethate may decrease the excretion rate of Chlorpromazine which could result in a higher serum level.
Diazepam Diazepam Colistimethate may decrease the excretion rate of Diazepam which could result in a higher serum level.
Oxazepam Oxazepam Colistimethate may decrease the excretion rate of Oxazepam which could result in a higher serum level.
Flurazepam Flurazepam Colistimethate may decrease the excretion rate of Flurazepam which could result in a higher serum level.
Clorazepate Clorazepate Colistimethate may decrease the excretion rate of Clorazepic acid which could result in a higher serum level.
Lorazepam Lorazepam Colistimethate may decrease the excretion rate of Lorazepam which could result in a higher serum level.
Carmustine Carmustine Colistimethate may decrease the excretion rate of Carmustine which could result in a higher serum level.
Amantadine Amantadine Colistimethate may decrease the excretion rate of Amantadine which could result in a higher serum level.
Codeine Codeine Colistimethate may decrease the excretion rate of Codeine which could result in a higher serum level.
Phenelzine Phenelzine Colistimethate may decrease the excretion rate of Phenelzine which could result in a higher serum level.
Tetracycline Tetracycline Colistimethate may decrease the excretion rate of Tetracycline which could result in a higher serum level.
Minocycline Minocycline The risk or severity of neuromuscular blockade can be increased when Minocycline is combined with Colistimethate.
Demeclocycline Demeclocycline The risk or severity of neuromuscular blockade can be increased when Demeclocycline is combined with Colistimethate.
Bleomycin Bleomycin Colistimethate may decrease the excretion rate of Bleomycin which could result in a higher serum level.
Sulfadiazine Sulfadiazine Colistimethate may decrease the excretion rate of Sulfadiazine which could result in a higher serum level.
Methadone Methadone Colistimethate may decrease the excretion rate of Methadone which could result in a higher serum level.
Benztropine Benztropine Colistimethate may decrease the excretion rate of Benzatropine which could result in a higher serum level.
Maprotiline Maprotiline Colistimethate may decrease the excretion rate of Maprotiline which could result in a higher serum level.
Ibuprofen Ibuprofen Colistimethate may decrease the excretion rate of Ibuprofen which could result in a higher serum level.
Azathioprine Azathioprine Colistimethate may decrease the excretion rate of Azathioprine which could result in a higher serum level.
Methylphenidate Methylphenidate Colistimethate may decrease the excretion rate of Methylphenidate which could result in a higher serum level.
Sulfasalazine Sulfasalazine The risk or severity of nephrotoxicity can be increased when Sulfasalazine is combined with Colistimethate.
Phenazopyridine Phenazopyridine The risk or severity of nephrotoxicity can be increased when Colistimethate is combined with Phenazopyridine.
Carbamazepine Carbamazepine Colistimethate may decrease the excretion rate of Carbamazepine which could result in a higher serum level.
Methyldopa Methyldopa Colistimethate may decrease the excretion rate of Methyldopa which could result in a higher serum level.
Hydralazine Hydralazine Colistimethate may decrease the excretion rate of Hydralazine which could result in a higher serum level.
Cimetidine Cimetidine Colistimethate may decrease the excretion rate of Cimetidine which could result in a higher serum level.
Gentamicin Injection Gentamicin Injection Gentamicin may decrease the excretion rate of Colistimethate which could result in a higher serum level.
Warfarin Warfarin Colistimethate may decrease the excretion rate of Warfarin which could result in a higher serum level.
Clonazepam Clonazepam Colistimethate may decrease the excretion rate of Clonazepam which could result in a higher serum level.
Promethazine Promethazine Colistimethate may decrease the excretion rate of Promethazine which could result in a higher serum level.
Meclofenamate Meclofenamate Colistimethate may decrease the excretion rate of Meclofenamic acid which could result in a higher serum level.
Nitrofurantoin Nitrofurantoin Colistimethate may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level.
Digoxin Digoxin Colistimethate may decrease the excretion rate of Digoxin which could result in a higher serum level.
Chloroquine Chloroquine Colistimethate may decrease the excretion rate of Chloroquine which could result in a higher serum level.
Quinine Quinine The risk or severity of neuromuscular blockade can be increased when Quinine is combined with Colistimethate.
Triamterene Triamterene The risk or severity of nephrotoxicity can be increased when Triamterene is combined with Colistimethate.
Metolazone Metolazone Colistimethate may decrease the excretion rate of Metolazone which could result in a higher serum level.
Clindamycin Injection Clindamycin Injection The risk or severity of neuromuscular blockade can be increased when Colistimethate is combined with Clindamycin.
Secobarbital Secobarbital Colistimethate may decrease the excretion rate of Secobarbital which could result in a higher serum level.
Desipramine Desipramine Colistimethate may decrease the excretion rate of Desipramine which could result in a higher serum level.
Amitriptyline Amitriptyline Colistimethate may decrease the excretion rate of Amitriptyline which could result in a higher serum level.
Imipramine Imipramine Colistimethate may decrease the excretion rate of Imipramine which could result in a higher serum level.
Probenecid Probenecid Colistimethate may decrease the excretion rate of Probenecid which could result in a higher serum level.
Quinidine Quinidine Colistimethate may decrease the excretion rate of Quinidine which could result in a higher serum level.
Procainamide Procainamide Colistimethate may decrease the excretion rate of Procainamide which could result in a higher serum level.
Isoniazid Isoniazid Colistimethate may decrease the excretion rate of Isoniazid which could result in a higher serum level.
Pyrazinamide Pyrazinamide Colistimethate may decrease the excretion rate of Pyrazinamide which could result in a higher serum level.
Disopyramide Disopyramide Colistimethate may decrease the excretion rate of Disopyramide which could result in a higher serum level.
Butabarbital Butabarbital Colistimethate may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Liothyronine Liothyronine Colistimethate may decrease the excretion rate of Liothyronine which could result in a higher serum level.
Methimazole Methimazole Colistimethate may decrease the excretion rate of Methimazole which could result in a higher serum level.
Chlorpropamide Chlorpropamide Colistimethate may decrease the excretion rate of Chlorpropamide which could result in a higher serum level.
Tolbutamide Tolbutamide Colistimethate may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Tolazamide Tolazamide Colistimethate may decrease the excretion rate of Tolazamide which could result in a higher serum level.
Baclofen Baclofen Colistimethate may decrease the excretion rate of Baclofen which could result in a higher serum level.
Ethambutol Ethambutol Colistimethate may decrease the excretion rate of Ethambutol which could result in a higher serum level.
Hydrochlorothiazide Hydrochlorothiazide The risk or severity of nephrotoxicity can be increased when Hydrochlorothiazide is combined with Colistimethate.
Dantrolene Dantrolene The risk or severity of neuromuscular blockade can be increased when Colistimethate is combined with Dantrolene.
Chlorzoxazone Chlorzoxazone Colistimethate may decrease the excretion rate of Chlorzoxazone which could result in a higher serum level.
Pyridoxine Pyridoxine Colistimethate may decrease the excretion rate of Pyridoxine which could result in a higher serum level.
Folic Acid Folic Acid Colistimethate may decrease the excretion rate of Folic acid which could result in a higher serum level.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) Colistimethate may decrease the excretion rate of Propranolol which could result in a higher serum level.
Amphotericin B Injection Amphotericin B Injection Amphotericin B may increase the nephrotoxic activities of Colistimethate.
Phytonadione Phytonadione Colistimethate may decrease the excretion rate of Phylloquinone which could result in a higher serum level.
Amikacin Injection Amikacin Injection Amikacin may decrease the excretion rate of Colistimethate which could result in a higher serum level.
Nadolol Nadolol Colistimethate may decrease the excretion rate of Nadolol which could result in a higher serum level.
Allopurinol Allopurinol Colistimethate may decrease the excretion rate of Allopurinol which could result in a higher serum level.
Flavoxate Flavoxate Colistimethate may decrease the excretion rate of Flavoxate which could result in a higher serum level.
Colchicine Colchicine Colistimethate may decrease the excretion rate of Colchicine which could result in a higher serum level.
Cefaclor Cefaclor Colistimethate may decrease the excretion rate of Cefaclor which could result in a higher serum level.
Cefadroxil Cefadroxil Colistimethate may decrease the excretion rate of Cefadroxil which could result in a higher serum level.
Cefazolin Injection Cefazolin Injection The risk or severity of nephrotoxicity can be increased when Colistimethate is combined with Cefazolin.
Cephalexin Cephalexin Colistimethate may decrease the excretion rate of Cephalexin which could result in a higher serum level.
Cefoxitin Injection Cefoxitin Injection The risk or severity of nephrotoxicity can be increased when Colistimethate is combined with Cefoxitin.
Dacarbazine Dacarbazine Colistimethate may decrease the excretion rate of Dacarbazine which could result in a higher serum level.
Cefotaxime Injection Cefotaxime Injection The risk or severity of nephrotoxicity can be increased when Cefotaxime is combined with Colistimethate.
Calcitonin Salmon Injection Calcitonin Salmon Injection Colistimethate may decrease the excretion rate of Salmon calcitonin which could result in a higher serum level.
Pyrantel Pyrantel The therapeutic efficacy of Pyrantel can be increased when used in combination with Colistimethate.
Ethacrynic Acid Ethacrynic Acid The risk or severity of nephrotoxicity can be increased when Etacrynic acid is combined with Colistimethate.
Metoprolol Metoprolol Colistimethate may decrease the excretion rate of Metoprolol which could result in a higher serum level.
Aspirin Aspirin The risk or severity of nephrotoxicity can be increased when Acetylsalicylic acid is combined with Colistimethate.
Salsalate Salsalate The risk or severity of nephrotoxicity can be increased when Colistimethate is combined with Salsalate.
Alprazolam Alprazolam Colistimethate may decrease the excretion rate of Alprazolam which could result in a higher serum level.
Temazepam Temazepam Colistimethate may decrease the excretion rate of Temazepam which could result in a higher serum level.
Triazolam Triazolam Colistimethate may decrease the excretion rate of Triazolam which could result in a higher serum level.
Dicyclomine Dicyclomine Colistimethate may decrease the excretion rate of Dicyclomine which could result in a higher serum level.
Propantheline Propantheline Colistimethate may decrease the excretion rate of Propantheline which could result in a higher serum level.
Trimethoprim Trimethoprim Colistimethate may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Nifedipine Nifedipine Colistimethate may decrease the excretion rate of Nifedipine which could result in a higher serum level.
Timolol Timolol Colistimethate may decrease the excretion rate of Timolol which could result in a higher serum level.
Verapamil Verapamil Colistimethate may decrease the excretion rate of Verapamil which could result in a higher serum level.
Pindolol Pindolol Colistimethate may decrease the excretion rate of Pindolol which could result in a higher serum level.
Cisplatin Injection Cisplatin Injection Colistimethate may decrease the excretion rate of Cisplatin which could result in a higher serum level.
Diflunisal Diflunisal Colistimethate may decrease the excretion rate of Diflunisal which could result in a higher serum level.
Piroxicam Piroxicam Colistimethate may decrease the excretion rate of Piroxicam which could result in a higher serum level.
Bumetanide Bumetanide Colistimethate may decrease the excretion rate of Bumetanide which could result in a higher serum level.
Glipizide Glipizide Colistimethate may decrease the excretion rate of Glipizide which could result in a higher serum level.
Indapamide Indapamide Colistimethate may decrease the excretion rate of Indapamide which could result in a higher serum level.
Amoxicillin Amoxicillin Colistimethate may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
Oxacillin Injection Oxacillin Injection Colistimethate may decrease the excretion rate of Oxacillin which could result in a higher serum level.
Pentoxifylline Pentoxifylline Colistimethate may decrease the excretion rate of Pentoxifylline which could result in a higher serum level.
Pentamidine Injection Pentamidine Injection The risk or severity of nephrotoxicity can be increased when Pentamidine is combined with Colistimethate.
Ceftriaxone Injection Ceftriaxone Injection Colistimethate may decrease the excretion rate of Ceftriaxone which could result in a higher serum level.
Labetalol Labetalol Colistimethate may decrease the excretion rate of Labetalol which could result in a higher serum level.
Auranofin Auranofin Colistimethate may decrease the excretion rate of Auranofin which could result in a higher serum level.
Leuprolide Injection Leuprolide Injection Colistimethate may decrease the excretion rate of Leuprolide which could result in a higher serum level.
Gemfibrozil Gemfibrozil Colistimethate may decrease the excretion rate of Gemfibrozil which could result in a higher serum level.
Dipivefrin Ophthalmic Dipivefrin Ophthalmic The risk or severity of nephrotoxicity can be increased when Adefovir dipivoxil is combined with Colistimethate.
Ceftazidime Injection Ceftazidime Injection Colistimethate may decrease the excretion rate of Ceftazidime which could result in a higher serum level.
Ketoprofen Ketoprofen Colistimethate may decrease the excretion rate of Ketoprofen which could result in a higher serum level.
Cefotetan Injection Cefotetan Injection Colistimethate may decrease the excretion rate of Cefotetan which could result in a higher serum level.
Flurbiprofen Flurbiprofen Colistimethate may decrease the excretion rate of Flurbiprofen which could result in a higher serum level.
Aztreonam Injection Aztreonam Injection Colistimethate may decrease the excretion rate of Aztreonam which could result in a higher serum level.
Buspirone Buspirone Colistimethate may decrease the excretion rate of Buspirone which could result in a higher serum level.
Ciprofloxacin Ciprofloxacin Colistimethate may decrease the excretion rate of Ciprofloxacin which could result in a higher serum level.
Mesalamine Mesalamine The risk or severity of nephrotoxicity can be increased when Mesalazine is combined with Colistimethate.
Diclofenac Diclofenac The risk or severity of nephrotoxicity can be increased when Diclofenac is combined with Colistimethate.
Clozapine Clozapine Colistimethate may decrease the excretion rate of Clozapine which could result in a higher serum level.
Estazolam Estazolam Colistimethate may decrease the excretion rate of Estazolam which could result in a higher serum level.
Didanosine Didanosine Colistimethate may decrease the excretion rate of Didanosine which could result in a higher serum level.
Pentostatin Injection Pentostatin Injection Colistimethate may decrease the excretion rate of Pentostatin which could result in a higher serum level.
Etodolac Etodolac Colistimethate may decrease the excretion rate of Etodolac which could result in a higher serum level.
Fosinopril Fosinopril Colistimethate may decrease the excretion rate of Fosinopril which could result in a higher serum level.
Nabumetone Nabumetone The risk or severity of nephrotoxicity can be increased when Nabumetone is combined with Colistimethate.
Lisinopril Lisinopril Colistimethate may decrease the excretion rate of Lisinopril which could result in a higher serum level.
Oxaprozin Oxaprozin Colistimethate may decrease the excretion rate of Oxaprozin which could result in a higher serum level.
Bisoprolol Bisoprolol Colistimethate may decrease the excretion rate of Bisoprolol which could result in a higher serum level.
Isradipine Isradipine Colistimethate may decrease the excretion rate of Isradipine which could result in a higher serum level.
Venlafaxine Venlafaxine Colistimethate may decrease the excretion rate of Venlafaxine which could result in a higher serum level.
Fluvoxamine Fluvoxamine Colistimethate may decrease the excretion rate of Fluvoxamine which could result in a higher serum level.
Nefazodone Nefazodone Colistimethate may decrease the excretion rate of Nefazodone which could result in a higher serum level.
Lamotrigine Lamotrigine Colistimethate may decrease the excretion rate of Lamotrigine which could result in a higher serum level.
Valacyclovir Valacyclovir Colistimethate may decrease the excretion rate of Valaciclovir which could result in a higher serum level.
Tramadol Tramadol Colistimethate may decrease the excretion rate of Tramadol which could result in a higher serum level.
Carboplatin Injection Carboplatin Injection Colistimethate may decrease the excretion rate of Carboplatin which could result in a higher serum level.
Ifosfamide Injection Ifosfamide Injection Colistimethate may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Bupropion Bupropion Colistimethate may decrease the excretion rate of Bupropion which could result in a higher serum level.
Ticlopidine Ticlopidine Colistimethate may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
Metformin Metformin Colistimethate may decrease the excretion rate of Metformin which could result in a higher serum level.
Nisoldipine Nisoldipine Colistimethate may decrease the excretion rate of Nisoldipine which could result in a higher serum level.
Lamivudine Lamivudine Colistimethate may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Acarbose Acarbose Colistimethate may decrease the excretion rate of Acarbose which could result in a higher serum level.
Gemcitabine Injection Gemcitabine Injection Colistimethate may decrease the excretion rate of Gemcitabine which could result in a higher serum level.
Cidofovir Injection Cidofovir Injection Colistimethate may decrease the excretion rate of Cidofovir which could result in a higher serum level.
Meropenem Injection Meropenem Injection Colistimethate may decrease the excretion rate of Meropenem which could result in a higher serum level.
Clomipramine Clomipramine Colistimethate may decrease the excretion rate of Clomipramine which could result in a higher serum level.
Fosfomycin Fosfomycin Colistimethate may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Topiramate Topiramate Colistimethate may decrease the excretion rate of Topiramate which could result in a higher serum level.
Pramipexole Pramipexole Colistimethate may decrease the excretion rate of Pramipexole which could result in a higher serum level.
Nilutamide Nilutamide Colistimethate may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Flutamide Flutamide Colistimethate may decrease the excretion rate of Flutamide which could result in a higher serum level.
Tamsulosin Tamsulosin Colistimethate may decrease the excretion rate of Tamsulosin which could result in a higher serum level.
Quetiapine Quetiapine Colistimethate may decrease the excretion rate of Quetiapine which could result in a higher serum level.
Cefepime Injection Cefepime Injection The risk or severity of nephrotoxicity can be increased when Colistimethate is combined with Cefepime.
Cefprozil Cefprozil The risk or severity of nephrotoxicity can be increased when Colistimethate is combined with Cefprozil.
Cefpodoxime Cefpodoxime The risk or severity of nephrotoxicity can be increased when Colistimethate is combined with Cefpodoxime.
Cetirizine Cetirizine Colistimethate may decrease the excretion rate of Cetirizine which could result in a higher serum level.
Tolcapone Tolcapone Colistimethate may decrease the excretion rate of Tolcapone which could result in a higher serum level.
Capecitabine Capecitabine Colistimethate may decrease the excretion rate of Capecitabine which could result in a higher serum level.
Abacavir Abacavir Colistimethate may decrease the excretion rate of Abacavir which could result in a higher serum level.
Celecoxib Celecoxib The risk or severity of nephrotoxicity can be increased when Celecoxib is combined with Colistimethate.
Rosiglitazone Rosiglitazone Colistimethate may decrease the excretion rate of Rosiglitazone which could result in a higher serum level.
Tolterodine Tolterodine Colistimethate may decrease the excretion rate of Tolterodine which could result in a higher serum level.
Oseltamivir Oseltamivir Colistimethate may decrease the excretion rate of Oseltamivir which could result in a higher serum level.
Balsalazide Balsalazide The risk or severity of nephrotoxicity can be increased when Balsalazide is combined with Colistimethate.
Nateglinide Nateglinide Colistimethate may decrease the excretion rate of Nateglinide which could result in a higher serum level.
Rabeprazole Rabeprazole Colistimethate may decrease the excretion rate of Rabeprazole which could result in a higher serum level.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists