Medication interaction hub

What Supplements Interact with Colistimethate?

Colistimethate brand name: Coly-Mycin M. Every interaction below applies to the brands too.

27 Interactions 26 Moderate 1 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Colistimethate? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Colistimethate against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line

27 supplements and herbal ingredients have interactions with Colistimethate on file in the HelloPharmacist interaction database — 0 rated major, 26 moderate, and 1 minor. The most serious involve Bacillus Coagulans, Bacillus Subtilis, Bifidobacterium Animalis Subsp. Lactis, Bifidobacterium Bifidum and Bifidobacterium Breve.

Our assessment: none of these currently rise to the major tier, so for most people supplements are generally workable alongside Colistimethate — the value of this page is knowing which combinations to watch, not avoiding supplements altogether.

Moderate 26 Minor 1 No known interaction 1,425

Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Colistimethate: Top Interactions at a Glance

The most significant Colistimethate supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 27 interacting ingredients — plus 1,425 more checked with no known interaction. See the complete ranked list.

Start here

The Moderate Interactions to Know About

The most clinically significant Colistimethate + supplement combinations in our database, best-documented first. Open any card for the full report.

Moderate Likelihood Probable Bacillus Coagulans + Colistimethatei

Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B.

Read the full interaction Moderate Likelihood Probable Bacillus Subtilis + Colistimethatei

Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.

Read the full interaction Moderate Likelihood Probable Bifidobacterium Animalis Subsp. Lactis + Colistimethatei

Theoretically, taking Bifidobacterium lactis with antibiotic drugs might decrease the effectiveness of B.

Read the full interaction Moderate Likelihood Probable Bifidobacterium Bifidum + Colistimethatei

Theoretically, taking Bifidobacterium.

Read the full interaction Moderate Likelihood Probable Bifidobacterium Breve + Colistimethatei

Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.

Read the full interaction Moderate Likelihood Probable Bifidobacterium Longum + Colistimethatei

Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.

Read the full interaction
The complete list

Every Supplement Checked Against Colistimethate

All 1,452 ingredients in our database, ranked by severity — 27 with a Colistimethate interaction on file and 1,425 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Colistimethate?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Lactobacillus Gasseri with Colistimethate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lactobacillus gasseri with antibiotic drugs might decrease the effectiveness of L.

Full Lactobacillus Gasseri + Colistimethate answer

Can you take Lactobacillus Helveticus with Colistimethate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lactobacillus helveticus with antibiotic drugs might decrease the effectiveness of L.

Full Lactobacillus Helveticus + Colistimethate answer

Can you take Lactobacillus Jensenii with Colistimethate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lactobacillus jensenii with antibiotic drugs might decrease the effectiveness of L.

Full Lactobacillus Jensenii + Colistimethate answer

Can you take Lactobacillus Johnsonii with Colistimethate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lactobacillus johnsonii with antibiotic drugs might decrease the effectiveness of L.

Full Lactobacillus Johnsonii + Colistimethate answer

Can you take Latilactobacillus Sakei with Colistimethate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Latilactobacillus sakei with antibiotic drugs might decrease the effectiveness of L.

Full Latilactobacillus Sakei + Colistimethate answer

Can you take Levilactobacillus Brevis with Colistimethate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Levilactobacillus brevis with antibiotic drugs might decrease the effectiveness of L.

Full Levilactobacillus Brevis + Colistimethate answer

Can you take Ligilactobacillus Salivarius with Colistimethate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Ligilactobacillus salivarius with antibiotic drugs might decrease the effectiveness of L.

Full Ligilactobacillus Salivarius + Colistimethate answer

Can you take Limosilactobacillus Fermentum with Colistimethate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Limosilactobacillus fermentum with antibiotic drugs might decrease the effectiveness of L.

Full Limosilactobacillus Fermentum + Colistimethate answer

Can you take Limosilactobacillus Reuteri with Colistimethate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Limosilactobacillus reuteri with antibiotic drugs might decrease the effectiveness of L.

Full Limosilactobacillus Reuteri + Colistimethate answer

Can you take Probiotics with Colistimethate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking antibiotic drugs with certain probiotics might decrease the effectiveness of probiotics.

Full Probiotics + Colistimethate answer

Can you take Flaxseed with Colistimethate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, antibiotics might interfere with the metabolism of flaxseed constituents, which could potentially alter the effects of flaxse...

Full Flaxseed + Colistimethate answer

Can you take Soy with Colistimethate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, antibiotics may decrease the activity of soy isoflavones.

Full Soy + Colistimethate answer

Can you take Bacillus Coagulans with Colistimethate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B.

Full Bacillus Coagulans + Colistimethate answer

Can you take Bacillus Subtilis with Colistimethate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.

Full Bacillus Subtilis + Colistimethate answer

Can you take Bifidobacterium Animalis Subsp. Lactis with Colistimethate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Bifidobacterium lactis with antibiotic drugs might decrease the effectiveness of B.

Full Bifidobacterium Animalis Subsp. Lactis + Colistimethate answer

Can you take Bifidobacterium Bifidum with Colistimethate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Bifidobacterium.

Full Bifidobacterium Bifidum + Colistimethate answer

Can you take Bifidobacterium Breve with Colistimethate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.

Full Bifidobacterium Breve + Colistimethate answer

Can you take Bifidobacterium Longum with Colistimethate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.

Full Bifidobacterium Longum + Colistimethate answer

Can you take Fermented Milk with Colistimethate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, antibiotic drugs might decrease the effectiveness of fermented milk.

Full Fermented Milk + Colistimethate answer

Can you take Lacticaseibacillus Casei with Colistimethate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lacticaseibacillus casei with antibiotic drugs might decrease the effectiveness of L.

Full Lacticaseibacillus Casei + Colistimethate answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Colistimethate is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Colistimethate, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Colistimethate sits in 1 interaction category. Open any one to see what the group means:

Antibiotic Drugs 27 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

27 of the supplement ingredients on this page reach Colistimethate through this category.

About Colistimethate

Colistimethate injection is an antibiotic used to treat serious bacterial infections caused by certain gram-negative bacteria, including Pseudomonas aeruginosa, E. coli, Klebsiella pneumoniae, and Enterobacter aerogenes.

Generic name: Colistimethate  ·  Brand name: Coly-Mycin M.

See the full Colistimethate Injection drug information

Related: does Colistimethate deplete any nutrients?

Colistimethate has 7 reported nutrient associations in the research literature — see the Colistimethate nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Colistimethate

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Colistimethate.

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Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

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Pharmacist Counseling Corner

Colistimethate & Supplements: Common Questions

What supplements interact with Colistimethate?
More than you might expect — 27 in total, though they are far from equal: 0 are rated major, 26 moderate, and 1 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Bacillus Coagulans, Bacillus Subtilis, Bifidobacterium Animalis Subsp. Lactis.
Which Colistimethate supplement interactions are the most serious?
None of the Colistimethate supplement interactions on file are currently rated major. The most significant are the 26 moderate-rated ones — combinations that may need monitoring, a dose adjustment, or separated timing. Still worth a quick look through the ranked list for anything you take daily. Jump to the ranked list.
Can I take vitamins or supplements while on Colistimethate?
Usually yes — most people on Colistimethate can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Coly-Mycin M have the same supplement interactions as Colistimethate?
Yes — Coly-Mycin M all contain Colistimethate, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Colistimethate deplete any vitamins or nutrients?
It might — Colistimethate has 7 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Colistimethate nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Colistimethate and my other medications?
This page covers Colistimethate against supplements and herbal ingredients. Checking Colistimethate against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Colistimethate Injection drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.