Interactions on record — worth a quick check against your medications. Based on 2 of 5 ingredients. Check your meds →
Dietary supplement

TruBifidoPRO Ingredients & Drug Interactions

by Master Supplements

TruBifidoPRO label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking TruBifidoPRO against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

TruBifidoPRO is a dietary supplement by Master Supplements with 5 active ingredients. Its ingredients are commonly taken for digestive health and regularity, infant colic and gut support, diarrhea (including antibiotic-related).Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bifidobacterium longum infantis BI-26, Bifidobacterium bifidum. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against TruBifidoPRO by Master Supplements

Ask about any prescription or over-the-counter medication and we check it for interactions with TruBifidoPRO by Master Supplements — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of TruBifidoPRO by Master Supplements

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 5 active ingredients.
  • “Proprietary Probiotic Blend” is a proprietary blend — the label gives one combined amount (212.02 mg) without saying how much of each component you get.

TruBifidoPRO contains 5 active ingredients: four Bifidobacterium species (longum infantis, two animalis lactis strains, and bifidum) plus a proprietary blend of probiotics. These are live beneficial bacteria designed to support your gut health.

The product also includes inactive ingredients like microcrystalline cellulose, sodium alginate, and silica as fillers and capsule materials.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: digestive support and gut health.
  • We looked for evidence on: Antibiotic-associated diarrhea, Colic, Clostridioides difficile infection, Constipation, Irritable bowel syndrome (IBS), Necrotizing enterocolitis (NEC) — and 4 related terms.
  • The strongest evidence on file: Bifidobacterium Bifidum is rated "Possibly Effective" for Irritable bowel syndrome (IBS) (Natural Medicines).
  • Also on file: Bifidobacterium Breve is rated "Insufficient Reliable Evidence To Rate" for Antibiotic-associated diarrhea, Constipation, Rotaviral diarrhea, Irritable bowel syndrome (IBS), and more.

Evidence for these Bifidobacterium strains is mixed. B. bifidum is rated possibly effective for irritable bowel syndrome (IBS) and respiratory tract infections.

B. longum infantis, however, is rated possibly ineffective for age-related cognitive decline and sepsis. For other conditions like hay fever, antibiotic-associated diarrhea, and anxiety, the evidence we hold is too limited to rate.

Talk with your doctor about whether this product fits your specific health goal.

The evidence, ingredient by ingredient Bifidobacterium Breve Bifidobacterium Bifidum

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

The Bifidobacterium species in this product are generally well tolerated in healthy people, but caution is warranted if you're critically ill, have a weakened immune system, or are very young. Rare cases of bacteremia (bacteria in the bloodstream) related to probiotic use have been reported, especially in critically ill infants and premature babies.

Bloating and flatulence can occur with probiotics in general. Because safety data are limited, check with your doctor or pharmacist before starting this supplement, especially if you have serious health conditions.

Side effects, ingredient by ingredient Bifidobacterium Breve Bifidobacterium Bifidum

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Bifidobacterium Breve, Bifidobacterium Bifidum.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antibiotics, double-check your timing with a pharmacist — probiotics and antibiotics shouldn't be taken at the same time. No other medication interactions are documented for the ingredients we could check, but we have no data for several of the Bifidobacterium strains in the blend.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

TruBifidoPRO is a multi-strain probiotic that may help with IBS and respiratory infections, but the evidence for other conditions is unclear. If you're taking antibiotics, time your doses carefully to avoid reducing the probiotics' effectiveness.

Anyone who is critically ill, immunocompromised, or very young should talk with their doctor first. Check your medications with our tool before you buy.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about TruBifidoPRO, straight from the product label.

Brand Master Supplements
Barcode (UPC) 804879522324
Net contents 31 Delayed Release Capsule(s)
Market status On market
Date entered into DSLD Sep 25, 2025
DSLD ID 336276
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for TruBifidoPRO by Master Supplements, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
31
UPC/BARCODE
804879522324
IngredientAmount% DV
Bifidobacterium longum infantis BI-260 NP--
Proprietary Probiotic Blend212.02 mg--
Bifidobacterium animalis lactis HN-0190 NP--
Bifidobacterium animalis lactis Bl-070 NP--
Bifidobacterium animalis lactis0 NP--
Bifidobacterium bifidum0 NP--

Other ingredients: Microcrystalline Cellulose, Sodium Alginate, Hydroxypropyl Methylcellulose, Gellan Gum, Water, Trisodium Phosphate, Magnesium Stearate, Silicon Dioxide, Ascorbic Acid, LactoStim, Calcium Silicate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

TruBifidoPRO is a high potency probiotic, protected by seven U.S. patents covering acid-proof delivery and prebiotic stimulation.

50 Billion CFU

Formulation

Each batch is laboratory tested to meet strict quality control standards; guaranteed at the time of expiration when kept refrigerated.

Professional probiotic Colon specific formula Supports digestive and immune health

Contains no: Milk, eggs, gluten, wheat, soy, casein, nuts, seafood, or beef products.

Suggested/Recommended/Usage/Directions

Suggested use: Take 1 capsule daily. Take 2 capsules a day for additional digestive support. TruBifidoPRO can be taken with antibiotics; allow at least 2 hours separation.

Precautions

Warning: If you are pregnant, nursing, on medication or have any medical condition consult a health care professional before using this product.

Discontinue use and consult a doctor if any adverse reaction occurs.

Keep out of reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This products is not intended to diagnose, treat, cure or prevent any disease.

General Statements

Available for healthcare professionals at usenzymes.com

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

TruBifidoPRO by Master Supplements label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

TruBifidoPRO label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in TruBifidoPRO by Master Supplements

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container31 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Probiotic Blend

212.02 mg per serving

Other (inactive) ingredients: Microcrystalline Cellulose, Sodium Alginate, Hydroxypropyl Methylcellulose, Gellan Gum, Water, Trisodium Phosphate, Magnesium Stearate, Silicon Dioxide, Ascorbic Acid, LactoStim, Calcium Silicate. These complete the product’s ingredient list but are not active constituents.

Interaction report

TruBifidoPRO by Master Supplements Drug Interactions

Want to check YOUR meds against TruBifidoPRO?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Bifidobacterium longum infantis BI-26 182
Bifidobacterium bifidum 182

Individual Drug Interactions

The ingredients in TruBifidoPRO interact with 182 drugs. Click any drug to see the details.

2 of the 5 ingredients in TruBifidoPRO interact with drugs. Each result below shows which ingredient is responsible. Bifidobacterium longum infantis BI-26 Bifidobacterium bifidum

Each ingredient & the kinds of drugs it affects

For each ingredient in TruBifidoPRO with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Bifidobacterium longum infantis BI-261 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B. breve.
Since B. breve preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. breve preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium longum infantis BI-26 full monograph & interactions

Bifidobacterium bifidum1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium. bifidum with antibiotic drugs might decrease the effectiveness of B. bifidum.
Since B. bifidum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. bifidum preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium bifidum full monograph & interactions
The maker

Brand information

Manufacturer and brand details for TruBifidoPRO, from the product label.

Master Supplements

See all Master Supplements products
Name
Master Supplements, Inc.
City
Victoria
State
MN
ZipCode
55386
Phone Number
800 926-2961
Pharmacist Counseling Corner

TruBifidoPRO by Master Supplements: Common Questions

Does TruBifidoPRO by Master Supplements interact with any medications?
Yes. Based on its ingredients, TruBifidoPRO has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
TruBifidoPRO contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm on an antibiotic?
Not at the same time. Antibiotics can kill the live bacteria in this supplement, making it less effective. Space your doses a few hours apart — your pharmacist can help you time them.
Is this probiotic safe if I have a weak immune system?
You should check with your doctor first. While probiotics are generally well tolerated, caution is needed for people with weakened immune systems, and rare cases of serious infection have been reported in critically ill patients.
Will this help my IBS or respiratory infections?
The Bifidobacterium bifidum in this blend is rated possibly effective for IBS and respiratory tract infections. For other conditions, the evidence we hold isn't strong enough to say either way — ask your doctor if it's right for your situation.
Are there any side effects I should know about?
Bloating and flatulence are reported with probiotics in general. One rare case of vomiting and fever was reported in a child, but it's unclear if the probiotic caused it. Most healthy people tolerate these bacteria well.
Is this safe during pregnancy or breastfeeding?
The safety data we hold for these ingredients don't include specific pregnancy and breastfeeding information. Talk with your doctor or midwife before use — they can give you personalized advice.
What are the inactive ingredients, and are there fillers?
Yes, this product contains fillers and binders: microcrystalline cellulose, sodium alginate, silica, gelatin, and others. If you're sensitive to any of these, check the full list on the label.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if TruBifidoPRO is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

TruBifidoPRO label
Go deeper

The Full Monographs Behind TruBifidoPRO’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bifidobacterium Breve

Interacts with 182 drugs

Bifidobacterium breve is a 'friendly' gut bacterium taken as a probiotic, most often to support digestion and balance the gut microbiome. Some studies suggest possible benefits for certain d...

Read the full Bifidobacterium Breve monograph → Herb & supplement monograph

Bifidobacterium Bifidum

Interacts with 182 drugs

Bifidobacterium bifidum is a 'friendly' bacteria (probiotic) that naturally lives in the human gut and is taken to support digestion and gut balance. Some evidence suggests probiotics may he...

Read the full Bifidobacterium Bifidum monograph →
Sources

Sources & How We Checked

TruBifidoPRO's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bifidobacterium Breve 9 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  4. Ohishi A, Takahashi S, Ito Y, et al. Bifidobacterium septicemia associated with postoperative probiotic therapy in a neonate with omphalocele. J Pediatr. 2010;156(4):679-81. PubMed
  5. Sakurai Y, Watanabe T, Miura Y, et al. Clinical and bacteriologic characteristics of six cases of Bifidobacterium breve bacteremia due to probiotic administration in the neonatal intensive care unit. Pediatr Infect Dis J 2022;41(1):62-65. PubMed
  6. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
  7. Wakabayashi Y, Nakayama S, Yamamoto A, et al. First case of necrotizing fasciitis and bacteremia caused by Bifidobacteriumbreve. Anaerobe 2022;76:102613.
  8. Takeda Y, Ota K, Kondo A, et al. A case of necrotizing fasciitis caused by Bifidobacterium breve. IDCases 2022;31:e01667. PubMed
  9. Suwantarat N, Romagnoli M, Wakefield T, Carroll KC. Ventriculoperitoneal shunt infection caused by Bifidobacterium breve. Anaerobe 2014;28:1-3. PubMed

See these in context on the Bifidobacterium Breve monograph →

Bifidobacterium Bifidum 7 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Rerksuppaphol S, Rerksuppaphol L. Randomized controlled trial of probiotics to reduce common cold in schoolchildren. Pediatr Int. 2012;54(5):682-7. PubMed
  4. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  5. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  6. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  7. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed

See these in context on the Bifidobacterium Bifidum monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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