Levofloxacin

Generic name: Pronounced as (lee voe flox' a sin)
Brand names
  • Levaquin®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 07/15/2019

Taking levofloxacin increases the risk that you will develop tendinitis (swelling of a fibrous tissue that connects a bone to a muscle) or have a tendon rupture (tearing of a fibrous tissue that connects a bone to a muscle) during your treatment or for up to several months afterward. These problems may affect tendons in your shoulder, your hand, the back of your ankle, or in other parts of your body. Tendinitis or tendon rupture may happen to people of any age, but the risk is highest in people over 60 years of age. Tell your doctor if you have or have ever had a kidney, heart, or lung transplant; kidney disease; a joint or tendon disorder such as rheumatoid arthritis (a condition in which the body attacks its own joints, causing pain, swelling, and loss of function); or if you participate in regular physical activity. Tell your doctor and pharmacist if you are taking oral or injectable steroids such as dexamethasone, methylprednisolone (Medrol), or prednisone (Rayos). If you experience any of the following symptoms of tendinitis, stop taking levofloxacin, rest, and call your doctor immediately: pain, swelling, tenderness, stiffness, or difficulty in moving a muscle. If you experience any of the following symptoms of tendon rupture, stop taking levofloxacin and get emergency medical treatment: hearing or feeling a snap or pop in a tendon area, bruising after an injury to a tendon area, or inability to move or bear weight on an affected area.

Taking levofloxacin may cause changes in sensation and nerve damage that may not go away even after you stop taking levofloxacin. This damage may occur soon after you begin taking levofloxacin. Tell your doctor if you have ever had peripheral neuropathy (a type of nerve damage that causes tingling, numbness, and pain in the hands and feet). If you experience any of the following symptoms, stop taking levofloxacin and call your doctor immediately: numbness, tingling, pain, burning, or weakness in the arms or legs; or a change in your ability to feel light touch, vibrations, pain, heat, or cold.

Taking levofloxacin may affect your brain or nervous system and cause serious side effects. This can occur after the first dose of levofloxacin. Tell your doctor if you have or have ever had seizures, epilepsy, cerebral arteriosclerosis (narrowing of blood vessels in or near the brain that can lead to stroke or ministroke), stroke, changed brain structure, or kidney disease. If you experience any of the following symptoms, stop taking levofloxacin and call your doctor immediately: seizures; tremors; dizziness; lightheadedness; headaches that won't go away (with or without blurred vision); difficulty falling asleep or staying asleep; nightmares; not trusting others or feeling that others want to hurt you; hallucinations (seeing things or hearing voices that do not exist); thoughts or actions towards hurting or killing yourself; feeling restless, anxious, nervous, depressed, memory problems, or confused, or other changes in your mood or behavior.

Taking levofloxacin may worsen muscle weakness in people with myasthenia gravis (a disorder of the nervous system that causes muscle weakness) and cause severe difficulty breathing or death. Tell your doctor if you have myasthenia gravis. Your doctor may tell you not to take levofloxacin. If you have myasthenia gravis and your doctor tells you that you should take levofloxacin, call your doctor immediately if you experience muscle weakness or difficulty breathing during your treatment.

Talk to your doctor about the risks of taking levofloxacin.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with levofloxacin. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs) or the manufacturer's website to obtain the Medication Guide.

Levofloxacin is used to treat certain infections such as pneumonia, and kidney, prostate (a male reproductive gland), and skin infections. Levofloxacin is also used to prevent anthrax (a serious infection that may be spread on purpose as part of a bioterror attack) in people who may have been exposed to anthrax germs in the air, and treat and prevent plague (a serious infection that may be spread on purpose as part of a bioterror attack. Levofloxacin may also be used to treat bronchitis, sinus infections, or urinary tract infections but should not be used for bronchitis and certain types of urinary tract infections if there are other treatment options available. Levofloxacin is in a class of antibiotics called fluoroquinolones. It works by killing bacteria that cause infections.

Antibiotics such as levofloxacin will not work for colds, flu, or other viral infections. Using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment.

Levofloxacin comes as a tablet and a solution (liquid) to take by mouth. It is usually taken once a day. The length of your treatment depends on the type of infection you have. Your doctor will tell you how long to take levofloxacin. The tablet may be taken with or without food. The solution should be taken 1 hour before or 2 hours after eating. Take levofloxacin at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take levofloxacin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

You should begin to feel better during the first few days of treatment with levofloxacin. If your symptoms do not improve or if they get worse, call your doctor.

Take levofloxacin until you finish the prescription, even if you feel better. Do not stop taking levofloxacin without talking to your doctor unless you experience certain serious side effects listed in the IMPORTANT WARNING or SIDE EFFECTS sections. If you stop taking levofloxacin too soon or skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics.

Levofloxacin is also sometimes used to treat endocarditis (infection of the heart lining and valves), certain sexually transmitted diseases, salmonella (an infection that causes severe diarrhea), shigella (an infection that causes severe diarrhea), inhalation anthrax (a serious infection that may be spread by anthrax germs in the air on purpose as part of a bioterror attack), and tuberculosis (TB). Levofloxacin is also sometimes used to prevent or treat traveler's diarrhea. Talk to your doctor about the risks of using this medication for your condition.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking levofloxacin,

  • tell your doctor and pharmacist if you are allergic or have had a severe reaction to levofloxacin; any other quinolone or fluoroquinolone antibiotic such as ciprofloxacin (Cipro), delafloxacin (Baxdela), gemifloxacin (Factive), moxifloxacin (Avelox), and ofloxacin, or any other medications, or if you are allergic to any of the ingredients in levofloxacin preparations. Ask your pharmacist or check the Medication Guide for a list of the ingredients.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); certain antidepressants; antipsychotics (medications to treat mental illness); diuretics ('water pills'); insulin or other medications to treat diabetes such as chlorpropamide, glimepiride (Amaryl, in Duetact), glipizide (Glucotrol), glyburide (DiaBeta), tolazamide, and tolbutamide; certain medications for irregular heartbeat such as amiodarone (Nexterone, Pacerone), procainamide, quinidine (in Nuedexta), and sotalol (Betapace, Betapace AF, Sorine, Sotylize); nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin, others) and naproxen (Aleve, Naprosyn, others); or theophylline (Elixophyllin, Theo-24, Uniphyl, others). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • if you are taking antacids containing aluminum hydroxide or magnesium hydroxide (Maalox, Mylanta, others), or certain medications such as didanosine (Videx) solution, sucralfate (Carafate), or vitamin or mineral supplements that contain iron or zinc, take these medications at least 2 hours before or after you take levofloxacin.

  • tell your doctor if you or anyone in your family has or has ever had a prolonged QT interval (a rare heart problem that may cause irregular heartbeat, fainting, or sudden death). Tell your doctor if you have or ever have had a slow or irregular heartbeat, a recent heart attack, an aortic aneurysm (swelling of the large artery that carries blood from the heart to the body), high blood pressure, peripheral vascular disease (poor circulation in the blood vessels), Marfan syndrome (a genetic condition that can affect the heart, eyes, blood vessels and bones), Ehlers-Danlos syndrome (a genetic condition that can affect skin, joints, or blood vessels), or if you have a low level of potassium or magnesium in your blood. Also tell your doctor if you have or have ever had diabetes or problems with low blood sugar or liver disease.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking levofloxacin, call your doctor.

  • do not drive a car, operate machinery, or participate in activities requiring alertness or coordination until you know how this medication affects you.

  • plan to avoid unnecessary or prolonged exposure to sunlight or ultraviolet light (tanning beds and sunlamps) and to wear protective clothing, sunglasses, and sunscreen. Levofloxacin may make your skin sensitive to sunlight or ultraviolet light. If your skin becomes reddened, swollen, or blistered, like a bad sunburn, call your doctor.

Make sure you drink plenty of water or other fluids every day while you are taking levofloxacin.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Levofloxacin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • nausea

    • vomiting

    • diarrhea

    • stomach pain

    • constipation

    • heartburn

    • vaginal itching and/or discharge

  • If you experience any of the following symptoms, or any of the symptoms described in the IMPORTANT WARNING section, stop taking levofloxacin and call your doctor immediately or get emergency medical help:

    • severe diarrhea (watery or bloody stools) that may occur with or without fever and stomach cramps (may occur up to 2 months or more after your treatment)

    • rash

    • hives

    • itching

    • peeling or blistering of the skin

    • fever

    • swelling of the eyes, face, mouth. lips, tongue, throat, hands, feet, ankles or lower legs

    • hoarseness or throat tightness

    • ongoing or worsening cough

    • difficulty breathing or swallowing

    • extreme thirst or hunger; pale skin; feeling shaky or trembling; fast or fluttering heartbeat; sweating; frequent urination; trembling; blurred vision; or unusual anxiety

    • fainting or loss of consciousness

    • yellowing of the skin or eyes; pale skin; dark urine; or light colored stool

    • seizures

    • unusual bruising or bleeding

    • sudden pain in the chest, stomach, or back

  • Levofloxacin may cause problems with bones, joints, and tissues around joints in children. Levofloxacin should not normally be given to children younger than 18 years of age unless they have plague or have been exposed to plague or anthrax in the air. If your doctor prescribes levofloxacin for your child, be sure to tell the doctor if your child has or has ever had joint-related problems. Call your doctor if your child develops joint problems, such as pain or swelling, while taking levofloxacin or after treatment with levofloxacin.

  • Talk to your doctor about the risks of taking levofloxacin or giving levofloxacin to your child.

  • Levofloxacin may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your body's response to levofloxacin. If you have diabetes, your doctor may ask you to check your blood sugar more often while taking levofloxacin.

Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking levofloxacin.

Do not let anyone else take your medication. Your prescription is probably not refillable. If you still have symptoms of infection after you finish taking levofloxacin, call your doctor.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Moxifloxacin Moxifloxacin The risk or severity of QTc prolongation can be increased when Moxifloxacin is combined with Levofloxacin.
Penbutolol Penbutolol The risk or severity of QTc prolongation can be increased when Levofloxacin is combined with Acebutolol.
Triamcinolone Triamcinolone The risk or severity of tendinopathy can be increased when Triamcinolone is combined with Levofloxacin.
Zolmitriptan Zolmitriptan The metabolism of Zolmitriptan can be decreased when combined with Levofloxacin.
Pamidronate Injection Pamidronate Injection Pamidronic acid may decrease the excretion rate of Levofloxacin which could result in a higher serum level.
Vancomycin Injection Vancomycin Injection Levofloxacin may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Trimipramine Trimipramine The risk or severity of QTc prolongation can be increased when Trimipramine is combined with Levofloxacin.
Tenofovir Tenofovir Tenofovir may decrease the excretion rate of Levofloxacin which could result in a higher serum level.
Gemifloxacin Gemifloxacin The risk or severity of QTc prolongation can be increased when Levofloxacin is combined with Gemifloxacin.
Apomorphine Injection Apomorphine Injection The risk or severity of QTc prolongation can be increased when Apomorphine is combined with Levofloxacin.
Tinidazole Tinidazole Tinidazole may decrease the excretion rate of Levofloxacin which could result in a higher serum level.
Voriconazole Voriconazole The risk or severity of QTc prolongation can be increased when Voriconazole is combined with Levofloxacin.
Pramlintide Injection Pramlintide Injection The therapeutic efficacy of Pramlintide can be increased when used in combination with Levofloxacin.
Ibandronate Ibandronate The risk or severity of QTc prolongation can be increased when Ibandronate is combined with Levofloxacin.
Insulin Detemir (rDNA Origin) Injection Insulin Detemir (rDNA Origin) Injection The therapeutic efficacy of Insulin detemir can be increased when used in combination with Levofloxacin.
Rasagiline Rasagiline The metabolism of Rasagiline can be decreased when combined with Levofloxacin.
Azacitidine Injection Azacitidine Injection Azacitidine may decrease the excretion rate of Levofloxacin which could result in a higher serum level.
Doripenem Injection Doripenem Injection Levofloxacin may decrease the excretion rate of Doripenem which could result in a higher serum level.
Bendamustine Injection Bendamustine Injection The metabolism of Bendamustine can be decreased when combined with Levofloxacin.
Betaxolol Betaxolol The risk or severity of QTc prolongation can be increased when Betaxolol is combined with Levofloxacin.
Eribulin Injection Eribulin Injection The risk or severity of QTc prolongation can be increased when Eribulin is combined with Levofloxacin.
Ceftaroline Injection Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Levofloxacin which could result in a higher serum level.
Lurasidone Lurasidone The risk or severity of QTc prolongation can be increased when Lurasidone is combined with Levofloxacin.
Ipilimumab Injection Ipilimumab Injection Levofloxacin may decrease the excretion rate of Ipilimumab which could result in a higher serum level.
Terbutaline Injection Terbutaline Injection The risk or severity of QTc prolongation can be increased when Terbutaline is combined with Levofloxacin.
Roflumilast Roflumilast Levofloxacin may decrease the excretion rate of Roflumilast which could result in a higher serum level.
Linagliptin Linagliptin The therapeutic efficacy of Linagliptin can be increased when used in combination with Levofloxacin.
Rilpivirine Rilpivirine The risk or severity of QTc prolongation can be increased when Rilpivirine is combined with Levofloxacin.
Rivaroxaban Rivaroxaban Levofloxacin may decrease the excretion rate of Rivaroxaban which could result in a higher serum level.
Ruxolitinib Ruxolitinib Levofloxacin may decrease the excretion rate of Ruxolitinib which could result in a higher serum level.
Vandetanib Vandetanib The risk or severity of QTc prolongation can be increased when Levofloxacin is combined with Vandetanib.
Vemurafenib Vemurafenib The risk or severity of QTc prolongation can be increased when Levofloxacin is combined with Vemurafenib.
Deferiprone Deferiprone Levofloxacin may decrease the excretion rate of Deferiprone which could result in a higher serum level.
Axitinib Axitinib The metabolism of Axitinib can be decreased when combined with Levofloxacin.
Crizotinib Crizotinib The risk or severity of QTc prolongation can be increased when Levofloxacin is combined with Crizotinib.
Enzalutamide Enzalutamide Levofloxacin may decrease the excretion rate of Enzalutamide which could result in a higher serum level.
Mirabegron Mirabegron The risk or severity of QTc prolongation can be increased when Levofloxacin is combined with Mirabegron.
Teduglutide Injection Teduglutide Injection Levofloxacin may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Bedaquiline Bedaquiline The risk or severity of QTc prolongation can be increased when Levofloxacin is combined with Bedaquiline.
Alogliptin Alogliptin The therapeutic efficacy of Alogliptin can be increased when used in combination with Levofloxacin.
Pomalidomide Pomalidomide The metabolism of Pomalidomide can be decreased when combined with Levofloxacin.
Canagliflozin Canagliflozin The therapeutic efficacy of Canagliflozin can be increased when used in combination with Levofloxacin.
Dabrafenib Dabrafenib The risk or severity of QTc prolongation can be increased when Dabrafenib is combined with Levofloxacin.
Trametinib Trametinib Levofloxacin may decrease the excretion rate of Trametinib which could result in a higher serum level.
Dolutegravir Dolutegravir The excretion of Levofloxacin can be decreased when combined with Dolutegravir.
Levomilnacipran Levomilnacipran Levofloxacin may decrease the excretion rate of Levomilnacipran which could result in a higher serum level.
Vortioxetine Vortioxetine Levofloxacin may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Perampanel Perampanel The metabolism of Perampanel can be decreased when combined with Levofloxacin.
Sofosbuvir Sofosbuvir Levofloxacin may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Dapagliflozin Dapagliflozin The therapeutic efficacy of Dapagliflozin can be increased when used in combination with Levofloxacin.
Apremilast Apremilast The metabolism of Apremilast can be decreased when combined with Levofloxacin.
Droxidopa Droxidopa Levofloxacin may decrease the excretion rate of Droxidopa which could result in a higher serum level.
Ceritinib Ceritinib The risk or severity of QTc prolongation can be increased when Levofloxacin is combined with Ceritinib.
Albiglutide Injection Albiglutide Injection The therapeutic efficacy of Albiglutide can be increased when used in combination with Levofloxacin.
Ferric Carboxymaltose Injection Ferric Carboxymaltose Injection Ferric carboxymaltose can cause a decrease in the absorption of Levofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Testosterone Injection Testosterone Injection Testosterone may decrease the excretion rate of Levofloxacin which could result in a higher serum level.
Empagliflozin Empagliflozin The therapeutic efficacy of Empagliflozin can be increased when used in combination with Levofloxacin.
Caspofungin Injection Caspofungin Injection The excretion of Levofloxacin can be decreased when combined with Caspofungin.
Tasimelteon Tasimelteon The metabolism of Tasimelteon can be decreased when combined with Levofloxacin.
Macitentan Macitentan Levofloxacin may decrease the excretion rate of Macitentan which could result in a higher serum level.
Ziprasidone Injection Ziprasidone Injection The risk or severity of QTc prolongation can be increased when Levofloxacin is combined with Ziprasidone.
Lixisenatide Injection Lixisenatide Injection The therapeutic efficacy of Lixisenatide can be increased when used in combination with Levofloxacin.
Tetrabenazine Tetrabenazine The risk or severity of QTc prolongation can be increased when Levofloxacin is combined with Tetrabenazine.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives Drospirenone may increase the excretion rate of Levofloxacin which could result in a lower serum level and potentially a reduction in efficacy.
Viloxazine Viloxazine Levofloxacin may decrease the excretion rate of Viloxazine which could result in a higher serum level.
Tobramycin Injection Tobramycin Injection Tobramycin may decrease the excretion rate of Levofloxacin which could result in a higher serum level.
Theophylline Theophylline The metabolism of Theophylline can be decreased when combined with Levofloxacin.
Tolmetin Tolmetin Tolmetin may decrease the excretion rate of Levofloxacin which could result in a higher serum level.
Sulindac Sulindac Sulindac may decrease the excretion rate of Levofloxacin which could result in a higher serum level.
Trazodone Trazodone The risk or severity of QTc prolongation can be increased when Trazodone is combined with Levofloxacin.
Sucralfate Sucralfate Sucralfate can cause a decrease in the absorption of Levofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Tetracycline Tetracycline Tetracycline may decrease the excretion rate of Levofloxacin which could result in a higher serum level.
Thioridazine Thioridazine The risk or severity of QTc prolongation can be increased when Levofloxacin is combined with Thioridazine.
Trifluoperazine Trifluoperazine The metabolism of Trifluoperazine can be decreased when combined with Levofloxacin.
Sulfadiazine Sulfadiazine The therapeutic efficacy of Sulfadiazine can be increased when used in combination with Levofloxacin.
Benztropine Benztropine The risk or severity of QTc prolongation can be increased when Benzatropine is combined with Levofloxacin.
Azathioprine Azathioprine The metabolism of Azathioprine can be decreased when combined with Levofloxacin.
Warfarin Warfarin The therapeutic efficacy of Warfarin can be increased when used in combination with Levofloxacin.
Triamterene Triamterene The metabolism of Triamterene can be decreased when combined with Levofloxacin.
Valproic Acid Valproic Acid The risk or severity of QTc prolongation can be increased when Levofloxacin is combined with Valproic acid.
Tamoxifen Tamoxifen The metabolism of Tamoxifen can be decreased when combined with Levofloxacin.
Liothyronine Liothyronine Liothyronine may decrease the excretion rate of Levofloxacin which could result in a higher serum level.
Tolbutamide Tolbutamide The therapeutic efficacy of Tolbutamide can be increased when used in combination with Levofloxacin.
Tolazamide Tolazamide The therapeutic efficacy of Tolazamide can be increased when used in combination with Levofloxacin.
Baclofen Baclofen Baclofen may decrease the excretion rate of Levofloxacin which could result in a higher serum level.
Mercaptopurine Mercaptopurine The metabolism of Mercaptopurine can be decreased when combined with Levofloxacin.
Thiothixene Thiothixene The risk or severity of QTc prolongation can be increased when Thiothixene is combined with Levofloxacin.
Aspirin Aspirin Acetylsalicylic acid may decrease the excretion rate of Levofloxacin which could result in a higher serum level.
Temazepam Temazepam Temazepam may decrease the excretion rate of Levofloxacin which could result in a higher serum level.
Triazolam Triazolam Triazolam may decrease the excretion rate of Levofloxacin which could result in a higher serum level.
Hyoscyamine Hyoscyamine The risk or severity of QTc prolongation can be increased when Hyoscyamine is combined with Levofloxacin.
Trimethoprim Trimethoprim Trimethoprim may decrease the excretion rate of Levofloxacin which could result in a higher serum level.
Timolol Timolol The risk or severity of QTc prolongation can be increased when Timolol is combined with Levofloxacin.
Verapamil Verapamil The excretion of Levofloxacin can be decreased when combined with Verapamil.
Auranofin Auranofin Auranofin may decrease the excretion rate of Levofloxacin which could result in a higher serum level.
Dipivefrin Ophthalmic Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Levofloxacin which could result in a higher serum level.
Aztreonam Injection Aztreonam Injection Aztreonam may decrease the excretion rate of Levofloxacin which could result in a higher serum level.
Tramadol Tramadol Tramadol may decrease the excretion rate of Levofloxacin which could result in a higher serum level.
Ticlopidine Ticlopidine Ticlopidine may decrease the excretion rate of Levofloxacin which could result in a higher serum level.
Gemcitabine Injection Gemcitabine Injection Gemcitabine may decrease the excretion rate of Levofloxacin which could result in a higher serum level.
Nelfinavir Nelfinavir The risk or severity of QTc prolongation can be increased when Nelfinavir is combined with Levofloxacin.
Celecoxib Celecoxib Celecoxib may decrease the excretion rate of Levofloxacin which could result in a higher serum level.
Tolterodine Tolterodine The risk or severity of QTc prolongation can be increased when Tolterodine is combined with Levofloxacin.
Rabeprazole Rabeprazole Rabeprazole may decrease the excretion rate of Levofloxacin which could result in a higher serum level.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists