Levofloxacin
Levofloxacin is a fluoroquinolone antibiotic used by tablet, oral solution, or IV injection for bacterial infections such as pneumonia, skin, urinary tract, prostate and sinus infections, anthrax exposure and plague, and as eye drops for bacterial conjunctivitis and corneal ulcer.
🧬 Where this information comes from Click to expand
The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 82 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →
Levofloxacin (Levaquin) is a fluoroquinolone antibiotic, on the market since the mid-1990s and available as a generic, that kills bacteria by blocking enzymes they need to copy their DNA; it treats pneumonia, kidney, urinary, skin and prostate infections, but is now usually saved for when safer antibiotics will not do. Most people tolerate a short course well, with nausea, diarrhea, headache or trouble sleeping the usual complaints. Its boxed warning covers disabling, sometimes permanent tendon, nerve and brain or mood effects, so stop it and call your prescriber at the first tendon pain, tingling or numbness, or confusion or mood change.
Clinical pearls
- Take tablets or oral solution at least 2 hours apart from antacids and magnesium or other mineral supplements, which cut absorption.
- Tendon risk, often at the back of the ankle, is higher over 60, with prednisone-type steroids, or after a transplant.
- If you take diabetes medicines, check your blood sugar more often, since levofloxacin can push it too high or too low.
- If you have myasthenia gravis, levofloxacin can worsen muscle weakness and should be avoided, so make sure the prescriber knows.
⚠️ FDA Boxed Warning — the FDA’s strongest safety alert ▾
Fluoroquinolones like levofloxacin can cause disabling, possibly permanent side effects that may occur together. These include tendon inflammation or rupture, nerve damage (numbness, tingling, burning, weakness), and effects on the brain and mood. They can make muscle weakness worse in people with myasthenia gravis, who should avoid it.
Stop the medicine immediately and call your doctor if you notice any of these. For uncomplicated urinary tract infection, bronchitis flare-ups and sinus infection, it should be kept for people with no other treatment options.
Patient information guide A plain-language walkthrough of Levofloxacin, written from its FDA label.
What Levofloxacin is used for
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Levofloxacin treats infections caused by susceptible bacteria, depending on the product.
- Tablets, oral solution and injection (adults): nosocomial (hospital-acquired) pneumonia and community-acquired pneumonia.
- Complicated and uncomplicated skin and skin structure infections.
- Chronic bacterial prostatitis.
- Inhalational anthrax (post-exposure) and plague.
- Complicated and uncomplicated urinary tract infections, and acute pyelonephritis (kidney infection).
- Acute bacterial exacerbation of chronic bronchitis and acute bacterial sinusitis.
- Levofloxacin tablets are also used in children for inhalational anthrax (post-exposure) and plague.
- Levofloxacin injection is used when the IV route is advantageous, for example if a patient cannot tolerate an oral form.
- Eye drops: bacterial conjunctivitis, or corneal ulcer, depending on the product.
How Levofloxacin works
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Levofloxacin is a member of the fluoroquinolone class of antibacterial agents. It is meant for infections proven or strongly suspected to be caused by bacteria.
Levofloxacin dosage
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Tablets and oral solution are taken by mouth, generally once every 24 hours. The IV form is given by a healthcare professional over 60 to 90 minutes. The length of treatment depends on the infection. Follow your prescriber and the label.
- Separate tablets or oral solution from antacids, metal cations and didanosine by 2 hours.
- Drink enough fluids to stay hydrated.
- Tablets are used in children only if they weigh 30 kg or more.
Dosing details from the FDA-approved label
From the Levofloxacin prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.
- Nosocomial Pneumonia
- 750 mg every 24 hours for 7 to 14 days
- Adjust dose for creatinine clearance less than 50 mL/minute
- Community Acquired Pneumonia (1.2)
- 500 mg every 24 hours for 7 to 14 days
- Adjust dose for creatinine clearance less than 50 mL/minute
- Community Acquired Pneumonia (1.3)
- 750 mg every 24 hours for 5 days
- Adjust dose for creatinine clearance less than 50 mL/minute
- Complicated SSSI
- 750 mg every 24 hours for 7 to 14 days
- Adjust dose for creatinine clearance less than 50 mL/minute
- Uncomplicated SSSI
- 500 mg every 24 hours for 7 to 10 days
- Adjust dose for creatinine clearance less than 50 mL/minute
- Chronic Bacterial Prostatitis
- 500 mg every 24 hours for 28 days
- Adjust dose for creatinine clearance less than 50 mL/minute
- Inhalational Anthrax (Post-Exposure), adults and pediatric patients 50 kg or greater
- 500 mg every 24 hours for 60 days
- Tablets cannot be given to pediatric patients under 30 kg
- Inhalational Anthrax (Post-Exposure), pediatric patients 30 kg to less than 50 kg
- 250 mg every 12 hours for 60 days
- Tablets cannot be given to pediatric patients under 30 kg
- Plague, adults and pediatric patients 50 kg or greater
- 500 mg every 24 hours for 10 to 14 days
- Tablets cannot be given to pediatric patients under 30 kg
- Plague, pediatric patients 30 kg to less than 50 kg
- 250 mg every 12 hours for 10 to 14 days
- Tablets cannot be given to pediatric patients under 30 kg
Read the label’s full dosing text
2 DOSAGE AND ADMINISTRATION • Administer levofloxacin tablets to pediatric patients weighing 30 kg and greater only ( 2.1 , 2.2 ). • Levofloxacin tablets cannot be administered to pediatric patients who weigh less than 30 kg because of the limitations of the available strengths. Alternative formulations of levofloxacin may be considered for pediatric patients who weigh less than 30 kg ( 2.2 ). Dosage in Adult and Pediatric Patients with Creatinine Clearance greater than or equal to 50 mL/minute ( 2.1 , 2.2 ) Type of Infection Dose Every 24 hours Duration (days) Nosocomial Pneumonia ( 1.1 ) 750 mg 7 to 14 Community Acquired Pneumonia ( 1.2 ) 500 mg 7 to 14 Community Acquired Pneumonia ( 1.3 ) 750 mg 5 Complicated SSSI ( 1.4 ) 750 mg 7 to 14 Uncomplicated SSSI ( 1.5 ) 500 mg 7 to 10 Chronic Bacterial Prostatitis ( 1.6 ) 500 mg 28 Inhalational Anthrax (Post-Exposure) ( 1.7 ) Adults and Pediatric Patients 50 kg or greater 500 mg 60 Pediatric Patients 30 kg to less than 50 kg (2.2) 250 mg every 12 hours 60 Plague ( 1.8 ) Adults and Pediatric Patients 50 kg or greater 500 mg 10 to 14 Pediatric Patients 30 kg to less than 50 kg (2.2) 250 mg every 12 hours 10 to 14 Complicated UTI ( 1.9 ) or Acute Pyelonephritis ( 1.11 ) 750 mg 5 Complicated UTI ( 1.10 ) or Acute Pyelonephritis ( 1.11 ) 250 mg 10 Uncomplicated UTI ( 1.12 ) 250 mg 3 Acute Bacterial Exacerbation of Chronic Bronchitis ( 1.13 ) 500 mg 7 Acute Bacterial Sinusitis ( 1.14 ) 750 mg 5 500 mg 10 to 14 • Adjust dose for creatinine clearance less than 50 mL/minute ( 2.3 , 8.6 , 12.3 ) 2.1 Dosage of Levofloxacin Tablets in Adult Patients with Creatinine Clearance ≥ 50 mL/minute The usual dose of levofloxacin tablets is 250 mg, 500 mg, or 750 mg administered orally every 24 hours, as indicated by infection and described in Table 1. These recommendations apply to patients with creatinine clearance ≥ 50 mL/minute. For patients with creatinine clearance less than 50 mL/min, adjustments to the dosing regimen are required [see Dosage and Administration ( 2.3 )] . Table 1 Dosage of Levofloxacin Tablets in Adult Patients with Creatinine Clearance greater than or equal to 50 mL/minute * Due to the designated pathogens [see Indications and Usage ( 1 )] . † Sequential therapy (intravenous levofloxacin to oral levofloxacin tablets) may be instituted at the discretion of the healthcare provider.
Excerpted — the section continues on the label. Read the full Dosage and Administration section on DailyMed →
Levofloxacin side effects
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The most common side effects are:
Common side effects
- Nausea
- Headache
- Diarrhea
- Trouble sleeping (insomnia)
- Constipation
- Dizziness
When to get medical help
- Tendon pain, swelling or a snap or rupture, such as in the back of the ankle: stop the medicine and call your doctor right away.
- Burning, tingling, numbness or weakness in the hands or feet.
- Hallucinations, severe anxiety, depression, thoughts of suicide, confusion or seizures.
- Worsening muscle weakness if you have myasthenia gravis.
- Rash, swelling of the face or throat, or trouble breathing (allergic reaction).
- Yellow skin or eyes, or signs of hepatitis (liver inflammation).
- Diarrhea that is severe or persists, which can happen even weeks after treatment.
- Fast or irregular heartbeat, or fainting (QT prolongation).
Call your doctor right away for tendon pain, numbness or tingling, mood changes, rash, severe diarrhea, or yellow skin or eyes.
Levofloxacin warnings and precautions
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The biggest risks are disabling, possibly permanent tendon, nerve and brain effects. It should be avoided in people with myasthenia gravis.
- Severe allergic reactions can occur after the first dose.
- Liver injury, sometimes fatal.
- Serious C. difficile diarrhea.
- QT prolongation and abnormal heart rhythms.
- Blood sugar swings and sun sensitivity.
- Aortic aneurysm and dissection.
- Seizures, especially in people at risk.
Levofloxacin interactions
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Several medicines and products can change how levofloxacin works or raise risks.
- Antacids, metal cations and didanosine: lower absorption if taken within 2 hours.
- Magnesium-containing IV solutions: do not share an IV line.
- Warfarin: stronger effect and bleeding risk.
- Diabetes medicines: blood sugar may go too high or too low.
- NSAIDs: may raise seizure risk.
- Theophylline: monitor levels.
- Heart rhythm medicines: avoid because of QT risk.
Interactions listed in the FDA-approved label
From the Levofloxacin prescribing information (“Drug Interactions”): what the manufacturer studied or reported to the FDA.
- Multivalent cation-containing products including antacids, metal cations or didanosine: Absorption of levofloxacin is decreased when the tablet or oral solution formulation is taken within 2 hours of these products. Do not co-administer the intravenous formulation in the same IV line with a multivalent cation, e.g., magnesium
- Warfarin: Effect may be enhanced; elevations of prothrombin time with concurrent use have been associated with episodes of bleeding. Monitor prothrombin time, INR, watch for bleeding
- Anti-diabetic agents: Disturbances of blood glucose, including hyperglycemia and hypoglycemia, have been reported with concomitant fluoroquinolones and an anti-diabetic agent. Carefully monitor blood glucose
- Non-steroidal anti-inflammatory drugs: Concomitant administration with a fluoroquinolone may increase the risk of CNS stimulation and convulsive seizures.
- Theophylline: No significant effect of levofloxacin on theophylline was detected in a study in healthy volunteers, but other fluoroquinolones with theophylline have resulted in prolonged half-life and elevated serum theophylline levels. Theophylline levels should be closely monitored and appropriate dosage adjustments made
- Cyclosporine: No significant effect of levofloxacin on cyclosporine was detected; differences seen are not considered clinically significant. No dosage adjustment is required
- Digoxin: No significant effect of levofloxacin on digoxin was detected in healthy volunteers. No dosage adjustment is required
- Probenecid and cimetidine: Levofloxacin AUC and half-life were higher and clearance lower with concomitant use, but no significant effect on Cmax. These changes do not warrant dosage adjustment
- Laboratory or diagnostic testing (opiate screens): Some fluoroquinolones may produce false-positive urine screening results for opiates using commercial immunoassay kits. Confirmation of positive opiate screens by more specific methods may be necessary
Read the label’s full interactions text
7 DRUG INTERACTIONS Interacting Drug Interaction Multivalent cation-containing products including antacids, metal cations or didanosine Absorption of levofloxacin is decreased when the tablet formulation is taken within 2 hours of this product. (2.4 , 7.1) Warfarin Effect may be enhanced. Monitor prothrombin time, INR, watch for bleeding (7.2) Antidiabetic agents Carefully monitor blood glucose ( 5.12 , 7.3) 7.1 Chelation Agents: Antacids, Sucralfate, Metal Cations, Multivitamins Levofloxacin Tablets While the chelation by divalent cations is less marked than with other fluoroquinolones, concurrent administration of levofloxacin tablets with antacids containing magnesium, or aluminum, as well as sucralfate, metal cations such as iron, and multivitamin preparations with zinc may interfere with the gastrointestinal absorption of levofloxacin, resulting in systemic levels considerably lower than desired. Tablets with antacids containing magnesium, aluminum, as well as sucralfate, metal cations such as iron, and multivitamin preparations with zinc or didanosine may substantially interfere with the gastrointestinal absorption of levofloxacin, resulting in systemic levels considerably lower than desired. These agents should be taken at least two hours before or two hours after oral levofloxacin administration. 7.2 Warfarin No significant effect of levofloxacin on the peak plasma concentrations, AUC, and other disposition parameters for R- and S- warfarin was detected in a clinical study involving healthy volunteers. Similarly, no apparent effect of warfarin on levofloxacin absorption and disposition was observed. However, there have been reports during the postmarketing experience in patients that levofloxacin enhances the effects of warfarin. Elevations of the prothrombin time in the setting of concurrent warfarin and levofloxacin use have been associated with episodes of bleeding.
Excerpted — the section continues on the label. Read the full Drug Interactions section on DailyMed →
Not a complete list. The label covers the interactions the manufacturer studied or reported, and our own interaction database does not cover every medicine either. Bring your full medication list, including vitamins and herbal products, to your pharmacist.
Before taking Levofloxacin
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- Do not use if allergic to levofloxacin or other quinolones.
- Tell your doctor about myasthenia gravis, tendon problems or past nerve damage.
- Tell your doctor about seizures, depression or heart rhythm problems.
- Adults over 60 and people on corticosteroids have higher tendon risk.
- Older adults have more liver and QT concerns.
- Children: used only for anthrax (post-exposure) and plague.
- Breastfeeding: pump and discard milk during treatment and for 2 days after, or avoid breastfeeding.
Levofloxacin overdose
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In an acute overdose, the stomach should be emptied and the patient observed with hydration maintained. Levofloxacin is not efficiently removed by dialysis. Animals given very high doses showed unsteadiness, tremors and convulsions.
How your body processes Levofloxacin
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Levofloxacin tablets are very well absorbed, with nearly complete bioavailability. Blood levels from the tablet and IV forms are similar for the same dose. The half-life is roughly 6 to 8 hours in healthy adults. Kidney problems slow clearance, so dosing may be adjusted.
How to store Levofloxacin
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Store at 20°C to 25° C (68°F to 77° F) . Dispense in a well closed container as described in the USP.
Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →
Supplements & herbs that interact with Levofloxacin
155 supplements and herbal products have documented interactions with Levofloxacin in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.
- Major · 13
- Moderate · 121
- Minor · 21
Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.
Nutrient depletion considerations
Levofloxacin has been associated with lower levels of 11 nutrients in the clinical literature. This does not mean a deficiency will occur — it means these may be worth discussing with your pharmacist or healthcare provider, especially with long-term use.
- Higher significance · 10
- Moderate · 1
Educational information from a licensed clinical database (Natural Medicines) — not medical advice. Do not start or stop medications or supplements without professional guidance.
Levofloxacin: pharmacist answers to common questions
Quick, plain-English answers to the questions patients ask most about Levofloxacin — the kind of thing our pharmacy team would talk through with you at the counter.
What is levofloxacin used for?
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How should I take it?
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What side effects are common?
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When should I stop and call my doctor?
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Does it interact with my other medicines?
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Can I take it while breastfeeding?
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Is Levofloxacin available over the counter?
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When was Levofloxacin first available?
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Who makes Levofloxacin?
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Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →
More about Levofloxacin on HelloPharmacist
Levofloxacin forms and strengths (how it comes)
Levofloxacin is available in 4 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.
Tablet
How this form is used
- Levofloxacin tablets treat infections like pneumonia, skin infections, urinary tract infections, chronic bacterial prostatitis, bronchitis flare-ups and sinusitis in adults.
- Levofloxacin tablets are also used in children for inhalational anthrax (post-exposure) and plague.
- Levofloxacin tablets are taken by mouth, usually once every 24 hours.
- Levofloxacin tablets are used in children only if they weigh 30 kg or more.
- Take Levofloxacin tablets at least 2 hours apart from antacids, metal cations or didanosine.
Injection
How this form is used
- Levofloxacin injection treats adult infections when giving it through a vein is advantageous, such as when a patient cannot tolerate an oral form.
- Levofloxacin injection is infused slowly into a vein over about 60 to 90 minutes.
- Levofloxacin injection should not run through the same IV line as solutions with multivalent cations like magnesium.
Show 1 more strength Show fewer strengths
Oral solution
How this form is used
- Levofloxacin oral solution treats the same adult infections as the tablets, including pneumonia, urinary tract and skin infections.
- Levofloxacin oral solution is taken by mouth, usually once every 24 hours.
- Absorption of Levofloxacin oral solution drops if taken within 2 hours of antacids, metal cations or didanosine.
Eye drops
How this form is used
- Levofloxacin eye drops treat bacterial conjunctivitis caused by susceptible bacteria.
- Levofloxacin eye drops are also used for corneal ulcer caused by susceptible bacteria, depending on the product.
Levofloxacin on the U.S. market: products, makers and brands
How Levofloxacin appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.
40 companies list 120 Levofloxacin product records with the FDA, mostly as tablet, injection, oral solution; the earliest marketing or approval year on record is 1996. Brand names on the directory include Levaquin; the rest are generics.
FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.
Also listed with the FDA, not a patient dose form: Powder (22) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.
Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.
How widely Levofloxacin is used (Medicaid data)
A general measure of how commonly Levofloxacin is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.
Think of this as a proxy for how widely Levofloxacin is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.
How commonly is Levofloxacin prescribed? Of the 1,601 medications we measure, Levofloxacin ranks #270 by Medicaid prescriptions — more than 83% of them.
Utilization by Levofloxacin product
Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.
levofloxacin 500 MG Oral Tablet Most dispensed
Summed across the 7 of 256 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 199885
levofloxacin 750 MG Oral Tablet
Summed across the 7 of 198 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 311296
levofloxacin 250 MG Oral Tablet
Summed across the 7 of 105 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 199884
levofloxacin 25 MG/ML Oral Solution
Summed across the 6 of 18 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 477391
150 ML levofloxacin 5 MG/ML Injection
Summed across the 6 of 17 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1665515
100 ML levofloxacin 5 MG/ML Injection
Summed across the 5 of 16 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1665507
50 ML levofloxacin 5 MG/ML Injection
Summed across the 2 of 17 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1665497
Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.
Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Levofloxacin, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 40 of 627 listed Levofloxacin NDCs with Medicaid activity.
Compare Levofloxacin products
A representative set of FDA-listed product records for Levofloxacin — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)
| Strength | Route | Manufacturer / Labeler | Category ⓘ | Details |
|---|---|---|---|---|
| 💊Eye drops | ||||
| 5 mg/mL | Ophthalmic | Advagen Pharma Limited | ANDA | View NDC → |
| 15 mg/mL | Ophthalmic | Bpi Labs Llc | ANDA | View NDC → |
| 💊Injection | ||||
| 25 mg/mL | Intravenous | Baxter Healthcare Corporation | ANDA | View NDC → |
| 250 mg/50 mL | Intravenous | Eugia US LLC | ANDA | View NDC → |
| 500 mg/20 mL | Intravenous | Eugia US LLC | ANDA | View NDC → |
| 500 mg/100 mL | Intravenous | Eugia US LLC | ANDA | View NDC → |
| 750 mg/30 mL | Intravenous | Eugia US LLC | ANDA | View NDC → |
| 750 mg/150 mL | Intravenous | Eugia US LLC | ANDA | View NDC → |
| 5 mg/mL | Intravenous | Fresenius Kabi USA, LLC | ANDA | View NDC → |
| 25 mg/mL | Intravenous | Gland Pharma Limited × 2 listings | ANDA | View NDC → |
| 250 mg/50 mL | Intravenous | Gland Pharma Limited | ANDA | View NDC → |
| 500 mg/100 mL | Intravenous | Gland Pharma Limited | ANDA | View NDC → |
| 750 mg/150 mL | Intravenous | Gland Pharma Limited | ANDA | View NDC → |
| 250 mg/50 mL | Intravenous | Hikma Pharmaceuticals USA Inc. × 2 listings | ANDA | View NDC → |
| 500 mg/100 mL | Intravenous | Hikma Pharmaceuticals USA Inc. × 2 listings | ANDA | View NDC → |
| 750 mg/150 mL | Intravenous | Hikma Pharmaceuticals USA Inc. × 2 listings | ANDA | View NDC → |
| 250 mg/50 mL | Intravenous | Hospira, Inc | ANDA | View NDC → |
| 500 mg/100 mL | Intravenous | Hospira, Inc | ANDA | View NDC → |
| 750 mg/150 mL | Intravenous | Hospira, Inc | ANDA | View NDC → |
| 5 mg/mL | Intravenous | Sagent Pharmaceuticals | ANDA | View NDC → |
| 5 mg/mL | Intravenous | WG Critical Care, LLC × 3 listings | ANDA | View NDC → |
| 💊Oral solution | ||||
| 25 mg/mL | Oral | ANI Pharmaceuticals, Inc. | ANDA | View NDC → |
| 25 mg/mL | Oral | Lannett Company, Inc. | ANDA | View NDC → |
| 💊Tablet | ||||
| 250 mg | Oral | A-S Medication Solutions | ANDA | View NDC → |
| 500 mg | Oral | A-S Medication Solutions × 2 listings | ANDA | View NDC → |
| 750 mg | Oral | A-S Medication Solutions | ANDA | View NDC → |
| 500 mg | Oral | Advanced Rx of Tennessee, LLC | ANDA | View NDC → |
| 750 mg | Oral | Advanced Rx of Tennessee, LLC | ANDA | View NDC → |
| 500 mg | Oral | Advanced Rx Pharmacy Of Tennessee, Llc | ANDA | View NDC → |
| 250 mg | Oral | Asclemed USA, Inc. | ANDA | View NDC → |
| 500 mg | Oral | Asclemed USA, Inc. | ANDA | View NDC → |
| 750 mg | Oral | Asclemed USA, Inc. | ANDA | View NDC → |
| 250 mg | Oral | Aurobindo Pharma Limited | ANDA | View NDC → |
| 500 mg | Oral | Aurobindo Pharma Limited | ANDA | View NDC → |
| 750 mg | Oral | Aurobindo Pharma Limited | ANDA | View NDC → |
| 250 mg | Oral | Bryant Ranch Prepack × 2 listings | ANDA | View NDC → |
| 500 mg | Oral | Bryant Ranch Prepack × 2 listings | ANDA | View NDC → |
| 750 mg | Oral | Bryant Ranch Prepack × 2 listings | ANDA | View NDC → |
| 250 mg | Oral | Cadila Healthcare Limited | ANDA | View NDC → |
| 500 mg | Oral | Cadila Healthcare Limited | ANDA | View NDC → |
| 750 mg | Oral | Cadila Healthcare Limited | ANDA | View NDC → |
| 250 mg | Oral | Camber Pharmaceuticals, Inc. | ANDA | View NDC → |
| 500 mg | Oral | Camber Pharmaceuticals, Inc. | ANDA | View NDC → |
| 750 mg | Oral | Camber Pharmaceuticals, Inc. | ANDA | View NDC → |
| 500 mg | Oral | Cardinal Health 107, LLC | ANDA | View NDC → |
| 750 mg | Oral | Cardinal Health 107, LLC | ANDA | View NDC → |
| 250 mg | Oral | Chartwell RX, LLC | ANDA | View NDC → |
| 500 mg | Oral | Chartwell RX, LLC | ANDA | View NDC → |
| 750 mg | Oral | Chartwell RX, LLC | ANDA | View NDC → |
| 250 mg | Oral | Coupler LLC | ANDA | View NDC → |
| 500 mg | Oral | Coupler LLC | ANDA | View NDC → |
| 500 mg | Oral | Direct Rx | ANDA | View NDC → |
| 750 mg | Oral | DirectRx | ANDA | View NDC → |
| 250 mg | Oral | Dr. Reddy's Laboratories Limited | ANDA | View NDC → |
| 500 mg | Oral | Dr. Reddy's Laboratories Limited | ANDA | View NDC → |
| 750 mg | Oral | Dr. Reddy's Laboratories Limited | ANDA | View NDC → |
| 250 mg | Oral | Golden State Medical Supply, Inc. | ANDA | View NDC → |
| 500 mg | Oral | Golden State Medical Supply, Inc. | ANDA | View NDC → |
| 750 mg | Oral | Golden State Medical Supply, Inc. | ANDA | View NDC → |
| 250 mg | Oral | Hawaii Repack, Inc. | ANDA | View NDC → |
| 500 mg | Oral | Hawaii Repack, Inc. | ANDA | View NDC → |
| 750 mg | Oral | Hawaii Repack, Inc. | ANDA | View NDC → |
| 250 mg | Oral | Lupin Pharmaceuticals, Inc. | ANDA | View NDC → |
| 500 mg | Oral | Lupin Pharmaceuticals, Inc. | ANDA | View NDC → |
| 750 mg | Oral | Lupin Pharmaceuticals, Inc. | ANDA | View NDC → |
| 250 mg | Oral | Macleods Pharmaceuticals Limited | ANDA | View NDC → |
| 500 mg | Oral | Macleods Pharmaceuticals Limited | ANDA | View NDC → |
| 750 mg | Oral | Macleods Pharmaceuticals Limited | ANDA | View NDC → |
| 250 mg | Oral | Major Pharmaceuticals | ANDA | View NDC → |
| 500 mg | Oral | Major Pharmaceuticals | ANDA | View NDC → |
| 750 mg | Oral | Major Pharmaceuticals | ANDA | View NDC → |
| 250 mg | Oral | Northwind Health Company, LLC | ANDA | View NDC → |
| 500 mg | Oral | Northwind Health Company, LLC | ANDA | View NDC → |
| 750 mg | Oral | Northwind Health Company, LLC | ANDA | View NDC → |
| 250 mg | Oral | NuCare Pharmaceuticals, Inc. | ANDA | View NDC → |
| 500 mg | Oral | NuCare Pharmaceuticals,Inc. × 3 listings | ANDA | View NDC → |
| 750 mg | Oral | NuCare Pharmaceuticals,Inc. × 3 listings | ANDA | View NDC → |
| 500 mg | Oral | PD-Rx Pharmaceuticals, Inc. × 3 listings | ANDA | View NDC → |
| 750 mg | Oral | PD-Rx Pharmaceuticals, Inc. × 2 listings | ANDA | View NDC → |
Showing 96 of 120 products — FDA National Drug Code Directory. See every product, package size and price: browse all 120 Levofloxacin NDCs →
Levofloxacin side effects reported to the FDA (FAERS)
After a medicine reaches the market, patients, doctors and drugmakers can send the FDA reports of problems they think may be linked to it. Here’s what’s been reported for Levofloxacin — a signal of what to watch for, not proof the drug caused it.
Source: openFDA, from the FDA Adverse Event Reporting System (FAERS). These are voluntary reports — they don’t prove the drug caused the effect, and counts reflect how often something was reported, not how often it actually happens. Reports also often name the very problem the medicine is taken for — a common reason to file one is that the drug didn’t help — so for a pain reliever you may see “pain” high on the list; that points to why the report was filed, not to the drug causing the symptom. This counts every report that lists Levofloxacin in any role, so the total runs higher than the FDA’s official dashboard, which counts only cases where the drug is the suspect. For the authoritative figures, see the FDA FAERS Public Dashboard. Always talk to your pharmacist or doctor.
Levofloxacin FDA approval history
How Levofloxacin went from FDA review to the pharmacy shelf — the key milestones in its regulatory journey.
Source: Drugs@FDA.
Levofloxacin recall history
A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.
The FDA’s enforcement reports list one Levofloxacin recall since July 2021. It is no longer listed as ongoing. A recall names specific lots from one company, so check the lot number on your own bottle rather than assuming every product is affected; your pharmacist can check whether your supply came from an affected lot.
- Levofloxacin Tablets, 500 mg, 100-count unit dose box, Rx only, MFG: Major Pharma, NDC 0904-6352-61 Lots: McKesson Medical-Surgical (MMS) is not able to identify the particular lot number received by a particular consignee for the recalled prescription products. Each letter includes the date it was distributed to customers and the dates that i… FDA record D-1088-2022 →
Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Sep 24, 2026.
RxNorm Concept Web — From Ingredient to Every Form and Strength
This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.
RxCUI 82122 4 dose forms · 11 strengths
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Dose form (SCDF) Injection RxCUI 1665494In current FDA listingsClinical drug / strength (SCD) 20 ML levofloxacin 25 MG/MLRxCUI 166551730 ML levofloxacin 25 MG/MLRxCUI 166551950 ML levofloxacin 5 MG/MLRxCUI 1665497100 ML levofloxacin 5 MG/MLRxCUI 1665507150 ML levofloxacin 5 MG/MLRxCUI 1665515 -
Dose form (SCDF) Ophthalmic Solution RxCUI 376884In current FDA listings -
Dose form (SCDF) Oral Solution RxCUI 477392In current FDA listingsClinical drug / strength (SCD) 25 MG/MLRxCUI 477391 -
Dose form (SCDF) Oral Tablet RxCUI 372588In current FDA listings
Look up RxCUI 82122 in the RxCUI Atlas →
RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.
Levofloxacin supply and shortage status
Whether Levofloxacin is in short supply in the U.S. right now, plus any shortage history the FDA has on record. A shortage usually reflects a manufacturing or demand issue — not a safety problem with the drug.
Source: openFDA, from the FDA Drug Shortages database.
💵 What Levofloxacin costs pharmacies (NADAC benchmark)
The national average invoice price pharmacies pay for the drug itself, from CMS's NADAC survey (data as of Sep 30, 2026). This is a supply-cost benchmark — not a retail price and not what you'd pay at the counter.
| Form | Strength | Pharmacy acquisition benchmark | |
|---|---|---|---|
| Tablet, Film Coated · Oral | 500 mg | $0.133 per tablet | NDC details & price history |
| Tablet, Film Coated · Oral | 750 mg | $0.259 per tablet | NDC details & price history |
| Tablet, Film Coated · Oral | 250 mg | $0.109 per tablet | NDC details & price history |
| Tablet · Oral | 750 mg | $0.259 per tablet | NDC details & price history |
| Tablet · Oral | 500 mg | $0.133 per tablet | NDC details & price history |
| Tablet · Oral | 250 mg | $0.109 per tablet | NDC details & price history |
| Solution · Oral | 25 mg/mL | $1.47–$1.79 per mL | NDC details & price history |
Source: CMS National Average Drug Acquisition Cost (NADAC), a survey of retail pharmacy invoice prices. Benchmarks shown are the range across package sizes of a representative product for each form and strength — other manufacturers' products may differ.
Levofloxacin brand names
Levofloxacin is sold under one brand name in the FDA directory — Levaquin. A brand and its generic contain the same active ingredient; the brand name belongs to one company's product.
Who makes Levofloxacin: manufacturers and labelers
40 companies list Levofloxacin products with the FDA. By number of product records, the largest are NuCare Pharmaceuticals,Inc., Remedyrepack Inc., Bryant Ranch Prepack. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.
…and 16 more on the FDA NDC directory.
Levofloxacin drug class (RxNorm)
Levofloxacin belongs to the Fluoroquinolone Antibacterial class.
Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.
Sources for this Levofloxacin page
Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.
How this page is built
HelloPharmacist combines public FDA and NLM records and does not author the underlying clinical facts. The plain-language sections are written with AI from the FDA-approved label text and reviewed by our pharmacy team before publication. Preferred Pharmaceuticals Inc is the representative DailyMed label linked for verification and dates. This is general education, not medical advice: always talk to your doctor or pharmacist about your own medicines. How we build and review drug pages →