Cefaclor

Generic name: Pronounced as (sef' a klor)
Brand names
  • Ceclor®
  • Ceclor® CD
  • Raniclor®
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Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 06/15/2016

Cefaclor is used to treat certain infections caused by bacteria, such as pneumonia and other lower respiratory tract (lung) infections; and infections of the skin, ears, throat, tonsils, and urinary tract. Cefaclor is in a class of medications called cephalosporin antibiotics. It works by stopping the growth of bacteria.

Antibiotics such as cefaclor will not work for colds, flu, or other viral infections. Using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment.

Cefaclor comes as a capsule, an extended-release (long-acting) tablet, and a suspension (liquid) to take by mouth. The capsule and liquid are usually taken with or without food every 8 or 12 hours . The long-acting tablet is usually taken within 1 hour of eating a meal every 12 hours (twice a day) for 7 to 10 days . Take cefaclor at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take cefaclor exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Shake the suspension well before each use to mix the medication evenly.

Swallow the long-acting tablets whole; do not split, chew, or crush them.

You should begin to feel better during the first few days of treatment with cefaclor. If your symptoms do not improve or get worse, call your doctor.

Take cefaclor until you finish the prescription, even if you feel better. If you stop taking cefaclor too soon or skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking cefaclor,

  • tell your doctor and pharmacist if you are allergic to cefaclor, other cephalosporin antibiotics such as cefadroxil , cefazolin (Ancef, Kefzol), cefdinir , cefditoren (Spectracef), cefepime (Maxipime), cefixime (Suprax), cefotaxime (Claforan), cefotetan, cefoxitin (Mefoxin), cefpodoxime , cefprozil (Cefzil), ceftaroline (Teflaro), ceftazidime ( Fortaz, Tazicef, in Avycaz), ceftibuten (Cedax), ceftriaxone (Rocephin), cefuroxime (Ceftin, Kefurox, Zinacef), and cephalexin (Keflex); penicillin antibiotics; or any other medications. Also tell your doctor if you are allergic to any of the ingredients in cefaclor capsules, extended release tablets, or suspension. Ask your pharmacist for a list of the ingredients.

  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention either of the following: anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven), and probenecid (Probalan). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • tell your doctor if you have or have ever had any kind of allergies, gastrointestinal disease (GI; affecting the stomach or intestines), especially colitis (condition that causes swelling in the lining of the colon [large intestine]), or kidney disease.

  • if you are taking antacids that contain magnesium or aluminum, take them 1 hour before or 1 hour after cefaclor extended release tablets.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking cefaclor, call your doctor.

Unless your doctor tells you otherwise, continue your normal diet.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Cefaclor may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • diarrhea

    • nausea

    • vomiting

    • stomach pain

    • headache

    • genital itching

  • Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately or get emergency medical treatment:

    • rash

    • itching, prickling, burning, or stinging feeling on the skin

    • hives

    • difficulty breathing or swallowing

    • wheezing

    • swelling of the face, throat, tongue, lips, eyes, arms or legs

    • lack of energy, or feeling faint

    • joint pain

    • watery or bloody stools, stomach cramps, or fever during treatment or for up to two or more months after stopping treatment

    • a return of fever, sore throat, chills, or other signs of infection

  • Cefaclor may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store the capsules and tablets at room temperature and away from excess heat and moisture (not in the bathroom). The tablets should also be stored away from light. Keep liquid medicine in the refrigerator, tightly closed, and dispose of any unused medication after 14 days.

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include the following:

  • nausea

  • vomiting

  • stomach pain

  • diarrhea

Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your body's response to cefaclor.

Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking cefaclor.

If you are diabetic and test your urine for sugar, use Clinistix or TesTape (not Clinitest) to test your urine while taking this medication.

Do not let anyone else take your medication. Your prescription is probably not refillable.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Pamidronate Injection Pamidronate Injection The risk or severity of nephrotoxicity and hypocalcemia can be increased when Cefaclor is combined with Pamidronic acid.
Vancomycin Injection Vancomycin Injection Cefaclor may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Zidovudine Injection Zidovudine Injection The excretion of Cefaclor can be decreased when combined with Zidovudine.
Tenofovir Tenofovir Cefaclor may increase the nephrotoxic activities of Tenofovir.
Tinidazole Tinidazole Cefaclor may decrease the excretion rate of Tinidazole which could result in a higher serum level.
Ibandronate Ibandronate The risk or severity of nephrotoxicity and hypocalcemia can be increased when Cefaclor is combined with Ibandronate.
Rasagiline Rasagiline Cefaclor may decrease the excretion rate of Rasagiline which could result in a higher serum level.
Azacitidine Injection Azacitidine Injection Cefaclor may decrease the excretion rate of Azacitidine which could result in a higher serum level.
Doripenem Injection Doripenem Injection Cefaclor may decrease the excretion rate of Doripenem which could result in a higher serum level.
Ceftaroline Injection Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Cefaclor which could result in a higher serum level.
Ipilimumab Injection Ipilimumab Injection Cefaclor may decrease the excretion rate of Ipilimumab which could result in a higher serum level.
Terbutaline Injection Terbutaline Injection Cefaclor may decrease the excretion rate of Terbutaline which could result in a higher serum level.
Roflumilast Roflumilast Cefaclor may decrease the excretion rate of Roflumilast which could result in a higher serum level.
Rivaroxaban Rivaroxaban Cefaclor may decrease the excretion rate of Rivaroxaban which could result in a higher serum level.
Ticagrelor Ticagrelor The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Cefaclor.
Ruxolitinib Ruxolitinib Cefaclor may decrease the excretion rate of Ruxolitinib which could result in a higher serum level.
Deferiprone Deferiprone Cefaclor may decrease the excretion rate of Deferiprone which could result in a higher serum level.
Enzalutamide Enzalutamide Cefaclor may decrease the excretion rate of Enzalutamide which could result in a higher serum level.
Mirabegron Mirabegron Cefaclor may decrease the excretion rate of Mirabegron which could result in a higher serum level.
Teriflunomide Teriflunomide The excretion of Cefaclor can be decreased when combined with Teriflunomide.
Teduglutide Injection Teduglutide Injection Cefaclor may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Alogliptin Alogliptin Cefaclor may decrease the excretion rate of Alogliptin which could result in a higher serum level.
Pomalidomide Pomalidomide Cefaclor may decrease the excretion rate of Pomalidomide which could result in a higher serum level.
Apixaban Apixaban The therapeutic efficacy of Apixaban can be decreased when used in combination with Cefaclor.
Canagliflozin Canagliflozin Cefaclor may decrease the excretion rate of Canagliflozin which could result in a higher serum level.
Dabrafenib Dabrafenib The excretion of Cefaclor can be decreased when combined with Dabrafenib.
Trametinib Trametinib Cefaclor may decrease the excretion rate of Trametinib which could result in a higher serum level.
Dolutegravir Dolutegravir The excretion of Cefaclor can be decreased when combined with Dolutegravir.
Levomilnacipran Levomilnacipran Cefaclor may decrease the excretion rate of Levomilnacipran which could result in a higher serum level.
Testosterone Injection Testosterone Injection Cefaclor may decrease the excretion rate of Testosterone which could result in a higher serum level.
Macitentan Macitentan Cefaclor may decrease the excretion rate of Macitentan which could result in a higher serum level.
Defibrotide Injection Defibrotide Injection The therapeutic efficacy of Defibrotide can be decreased when used in combination with Cefaclor.
Lixisenatide Injection Lixisenatide Injection Cefaclor may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives Drospirenone may increase the excretion rate of Cefaclor which could result in a lower serum level and potentially a reduction in efficacy.
Viloxazine Viloxazine Cefaclor may decrease the excretion rate of Viloxazine which could result in a higher serum level.
Tobramycin Injection Tobramycin Injection Tobramycin may decrease the excretion rate of Cefaclor which could result in a higher serum level.
Tolmetin Tolmetin Tolmetin may decrease the excretion rate of Cefaclor which could result in a higher serum level.
Sulindac Sulindac Sulindac may decrease the excretion rate of Cefaclor which could result in a higher serum level.
Sucralfate Sucralfate Cefaclor may decrease the excretion rate of Sucralfate which could result in a higher serum level.
Tetracycline Tetracycline Cefaclor may decrease the excretion rate of Tetracycline which could result in a higher serum level.
Sulfadiazine Sulfadiazine Cefaclor may decrease the excretion rate of Sulfadiazine which could result in a higher serum level.
Benztropine Benztropine Cefaclor may decrease the excretion rate of Benzatropine which could result in a higher serum level.
Azathioprine Azathioprine Cefaclor may decrease the excretion rate of Azathioprine which could result in a higher serum level.
Warfarin Warfarin Cefaclor may decrease the excretion rate of Warfarin which could result in a higher serum level.
Triamterene Triamterene The risk or severity of nephrotoxicity can be increased when Triamterene is combined with Cefaclor.
Sulfinpyrazone Sulfinpyrazone Cefaclor may decrease the excretion rate of Sulfinpyrazone which could result in a higher serum level.
Valproic Acid Valproic Acid The excretion of Valproic acid can be decreased when combined with Cefaclor.
Tamoxifen Tamoxifen Tamoxifen may decrease the excretion rate of Cefaclor which could result in a higher serum level.
Liothyronine Liothyronine Cefaclor may decrease the excretion rate of Liothyronine which could result in a higher serum level.
Tolbutamide Tolbutamide Cefaclor may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Tolazamide Tolazamide Cefaclor may decrease the excretion rate of Tolazamide which could result in a higher serum level.
Baclofen Baclofen Cefaclor may decrease the excretion rate of Baclofen which could result in a higher serum level.
Mercaptopurine Mercaptopurine The excretion of Mercaptopurine can be decreased when combined with Cefaclor.
Vincristine Injection Vincristine Injection Vincristine may decrease the excretion rate of Cefaclor which could result in a higher serum level.
Vinblastine Vinblastine Vinblastine may decrease the excretion rate of Cefaclor which could result in a higher serum level.
Aspirin Aspirin Cefaclor may decrease the excretion rate of Acetylsalicylic acid which could result in a higher serum level.
Temazepam Temazepam Cefaclor may decrease the excretion rate of Temazepam which could result in a higher serum level.
Triazolam Triazolam Cefaclor may decrease the excretion rate of Triazolam which could result in a higher serum level.
Trimethoprim Trimethoprim Cefaclor may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Timolol Timolol Cefaclor may decrease the excretion rate of Timolol which could result in a higher serum level.
Verapamil Verapamil Cefaclor may decrease the excretion rate of Verapamil which could result in a higher serum level.
Atenolol Atenolol Atenolol may decrease the excretion rate of Cefaclor which could result in a higher serum level.
Auranofin Auranofin Cefaclor may decrease the excretion rate of Auranofin which could result in a higher serum level.
Dipivefrin Ophthalmic Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Cefaclor which could result in a higher serum level.
Aztreonam Injection Aztreonam Injection Cefaclor may decrease the excretion rate of Aztreonam which could result in a higher serum level.
Tramadol Tramadol Cefaclor may decrease the excretion rate of Tramadol which could result in a higher serum level.
Ticlopidine Ticlopidine Cefaclor may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
Gemcitabine Injection Gemcitabine Injection Cefaclor may decrease the excretion rate of Gemcitabine which could result in a higher serum level.
Indinavir Indinavir Indinavir may decrease the excretion rate of Cefaclor which could result in a higher serum level.
Nelfinavir Nelfinavir Nelfinavir may decrease the excretion rate of Cefaclor which could result in a higher serum level.
Celecoxib Celecoxib Celecoxib may decrease the excretion rate of Cefaclor which could result in a higher serum level.
Tolterodine Tolterodine Cefaclor may decrease the excretion rate of Tolterodine which could result in a higher serum level.
Rabeprazole Rabeprazole Cefaclor may decrease the excretion rate of Rabeprazole which could result in a higher serum level.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists