Dicloxacillin

Generic name: Pronounced as (dye klox a sill' in)
Brand names
  • Dycill
  • Dynapen
  • Pathocil
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 05/15/2018

Dicloxacillin is used to treat infections caused by certain types of bacteria. Dicloxacillin is in a class of medications called penicillins. It works by killing bacteria.

Antibiotics such as dicloxacillin will not work for colds, flu, or other viral infections. Using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment.

Dicloxacillin comes as a capsule to take by mouth. It is usually taken every 6 hours (four times a day). Dicloxacillin should be taken on an empty stomach at least 1 hour before or 2 hours after a meal or snack, The length of your treatment depends on the type of infection that you have. Take dicloxacillin at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take dicloxacillin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Take dicloxacillin while you are sitting or standing up with at least 4 ounces (120 mL) of water. Do not lay down or go to sleep immediately after taking dicloxacillin.

Take dicloxacillin until you finish the prescription, even if you feel better. Do not stop taking dicloxacillin without talking to your doctor. If you stop taking dicloxacillin too soon or if you skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking dicloxacillin,

  • tell your doctor and pharmacist if you are allergic to dicloxacillin, other penicillin antibiotics, cephalosporin antibiotics such as cefaclor, cefadroxil, cefazolin (Ancef, Kefzol), cefepime (Maxipime), cefixime (Suprax), cefotaxime (Claforan), cefotetan, cefoxitin (Mefoxin), cefpodoxime, cefprozil, ceftaroline (Teflaro), ceftazidime (Fortaz, Tazicef, in Avycaz), ceftibuten, ceftriaxone, cefuroxime (Ceftin, Zinacef), and cephalexin (Keflex); any other medications, or any of the ingredients in dicloxacillin capsules. Ask your pharmacist for a list of the ingredients.

  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following; probenecid (Probalan, in Col-probenecid); tetracycline antibiotics such as demeclocycline, doxycycline (Doxy, Oracea, Vibramycin, others), minocycline (Dynacin, Minocin, Solodyn, others), tetracycline (Achromycin V, in Pylera), and tigecycline (Tygacil); and warfarin (Coumadin, Jantoven). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • tell your doctor if you have or have ever had allergies, asthma, or kidney disease.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking dicloxacillin, call your doctor.

Unless your doctor tells you otherwise, continue your normal diet.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Dicloxacillin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • diarrhea

    • nausea

    • vomiting

    • black, hairy tongue

    • mouth irritation

    • swollen joints

  • If you experience any of the following symptoms, call your doctor immediately:

    • rash

    • itching

    • hives

    • difficulty swallowing or breathing

    • wheezing

    • swelling of the face, throat, tongue, lips, or eyes

    • joint or muscle pain

    • abdominal pain

    • unusual bleeding or bruising

    • a return of fever, sore throat, chills, or other signs of infection

    • severe diarrhea (watery or bloody stools) that may occur with or without fever and stomach cramps (may occur up to 2 months or more after your treatment)

  • Dicloxacillin may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medicine in the container it came in, tightly closed, and out of reach of children. Store the capsules at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your response to dicloxacillin.

Do not let anyone else take your medication. Your prescription is probably not refillable. If you still have symptoms of infection after you finish the dicloxacillin, call your doctor.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Moxifloxacin Moxifloxacin The serum concentration of Moxifloxacin can be increased when it is combined with Dicloxacillin.
Aminophylline Aminophylline The metabolism of Aminophylline can be increased when combined with Dicloxacillin.
Fenofibrate Fenofibrate The metabolism of Fenofibrate can be increased when combined with Dicloxacillin.
Mycophenolate Mycophenolate The serum concentration of Mycophenolic acid can be decreased when it is combined with Dicloxacillin.
Tacrolimus Tacrolimus The metabolism of Tacrolimus can be increased when combined with Dicloxacillin.
Doxycycline Injection Doxycycline Injection The therapeutic efficacy of Dicloxacillin can be decreased when used in combination with Doxycycline.
Levofloxacin Injection Levofloxacin Injection The serum concentration of Levofloxacin can be increased when it is combined with Dicloxacillin.
Meperidine Injection Meperidine Injection The metabolism of Meperidine can be increased when combined with Dicloxacillin.
Cyclosporine Cyclosporine The metabolism of Cyclosporine can be increased when combined with Dicloxacillin.
Dofetilide Dofetilide The metabolism of Dofetilide can be increased when combined with Dicloxacillin.
Tenofovir Tenofovir The metabolism of Tenofovir can be increased when combined with Dicloxacillin.
Sirolimus Sirolimus The metabolism of Sirolimus can be increased when combined with Dicloxacillin.
Aripiprazole Aripiprazole The metabolism of Aripiprazole can be increased when combined with Dicloxacillin.
Atazanavir Atazanavir The metabolism of Atazanavir can be increased when combined with Dicloxacillin.
Rosuvastatin Rosuvastatin The metabolism of Rosuvastatin can be increased when combined with Dicloxacillin.
Gemifloxacin Gemifloxacin The serum concentration of Gemifloxacin can be increased when it is combined with Dicloxacillin.
Progesterone Progesterone The metabolism of Progesterone can be increased when combined with Dicloxacillin.
Duloxetine Duloxetine The metabolism of Duloxetine can be increased when combined with Dicloxacillin.
Norethindrone Norethindrone The metabolism of Norethisterone can be increased when combined with Dicloxacillin.
Erlotinib Erlotinib The serum concentration of Erlotinib can be decreased when it is combined with Dicloxacillin.
Eszopiclone Eszopiclone The serum concentration of Eszopiclone can be decreased when it is combined with Dicloxacillin.
Ranolazine Ranolazine The metabolism of Ranolazine can be increased when combined with Dicloxacillin.
Bortezomib Bortezomib The metabolism of Bortezomib can be increased when combined with Dicloxacillin.
Retapamulin Retapamulin The metabolism of Retapamulin can be increased when combined with Dicloxacillin.
Sorafenib Sorafenib The metabolism of Sorafenib can be increased when combined with Dicloxacillin.
Sunitinib Sunitinib The metabolism of Sunitinib can be increased when combined with Dicloxacillin.
Dasatinib Dasatinib The metabolism of Dasatinib can be increased when combined with Dicloxacillin.
Temsirolimus Temsirolimus The metabolism of Temsirolimus can be increased when combined with Dicloxacillin.
Nilotinib Nilotinib The metabolism of Nilotinib can be increased when combined with Dicloxacillin.
Ixabepilone Injection Ixabepilone Injection The metabolism of Ixabepilone can be increased when combined with Dicloxacillin.
Irinotecan Injection Irinotecan Injection The metabolism of Irinotecan can be increased when combined with Dicloxacillin.
Rufinamide Rufinamide The metabolism of Rufinamide can be increased when combined with Dicloxacillin.
Milnacipran Milnacipran The metabolism of Milnacipran can be increased when combined with Dicloxacillin.
Lacosamide Lacosamide The metabolism of Lacosamide can be increased when combined with Dicloxacillin.
Everolimus Everolimus The metabolism of Everolimus can be increased when combined with Dicloxacillin.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The metabolism of Tolvaptan can be increased when combined with Dicloxacillin.
Dronedarone Dronedarone The metabolism of Dronedarone can be increased when combined with Dicloxacillin.
Romidepsin Injection Romidepsin Injection The metabolism of Romidepsin can be increased when combined with Dicloxacillin.
Pazopanib Pazopanib The metabolism of Pazopanib can be increased when combined with Dicloxacillin.
Albendazole Albendazole The metabolism of Albendazole can be increased when combined with Dicloxacillin.
Ulipristal Ulipristal The metabolism of Ulipristal can be increased when combined with Dicloxacillin.
Levonorgestrel Levonorgestrel The metabolism of Levonorgestrel can be increased when combined with Dicloxacillin.
Cabazitaxel Injection Cabazitaxel Injection The metabolism of Cabazitaxel can be increased when combined with Dicloxacillin.
Busulfan Injection Busulfan Injection The metabolism of Busulfan can be increased when combined with Dicloxacillin.
Roflumilast Roflumilast The metabolism of Roflumilast can be increased when combined with Dicloxacillin.
Linagliptin Linagliptin The metabolism of Linagliptin can be increased when combined with Dicloxacillin.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Cyclophosphamide can be increased when combined with Dicloxacillin.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The metabolism of Brentuximab vedotin can be increased when combined with Dicloxacillin.
Ruxolitinib Ruxolitinib The metabolism of Ruxolitinib can be increased when combined with Dicloxacillin.
Vandetanib Vandetanib The metabolism of Vandetanib can be increased when combined with Dicloxacillin.
Vemurafenib Vemurafenib The metabolism of Vemurafenib can be increased when combined with Dicloxacillin.
Axitinib Axitinib The metabolism of Axitinib can be increased when combined with Dicloxacillin.
Crizotinib Crizotinib The metabolism of Crizotinib can be increased when combined with Dicloxacillin.
Cabergoline Cabergoline The metabolism of Cabergoline can be increased when combined with Dicloxacillin.
Regorafenib Regorafenib The metabolism of Regorafenib can be increased when combined with Dicloxacillin.
Bosutinib Bosutinib The metabolism of Bosutinib can be increased when combined with Dicloxacillin.
Ponatinib Ponatinib The metabolism of Ponatinib can be increased when combined with Dicloxacillin.
Pomalidomide Pomalidomide The metabolism of Pomalidomide can be increased when combined with Dicloxacillin.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The metabolism of Trastuzumab emtansine can be increased when combined with Dicloxacillin.
Dabrafenib Dabrafenib The metabolism of Dabrafenib can be increased when combined with Dicloxacillin.
Levomilnacipran Levomilnacipran The metabolism of Levomilnacipran can be increased when combined with Dicloxacillin.
Tigecycline Injection Tigecycline Injection The therapeutic efficacy of Dicloxacillin can be decreased when used in combination with Tigecycline.
Perampanel Perampanel The metabolism of Perampanel can be increased when combined with Dicloxacillin.
Lomitapide Lomitapide The metabolism of Lomitapide can be increased when combined with Dicloxacillin.
Ceritinib Ceritinib The metabolism of Ceritinib can be increased when combined with Dicloxacillin.
Idelalisib Idelalisib The metabolism of Idelalisib can be increased when combined with Dicloxacillin.
Vorapaxar Vorapaxar The metabolism of Vorapaxar can be increased when combined with Dicloxacillin.
Suvorexant Suvorexant The metabolism of Suvorexant can be increased when combined with Dicloxacillin.
Olaparib Olaparib The metabolism of Olaparib can be increased when combined with Dicloxacillin.
Tasimelteon Tasimelteon The metabolism of Tasimelteon can be increased when combined with Dicloxacillin.
Nintedanib Nintedanib The metabolism of Nintedanib can be increased when combined with Dicloxacillin.
Palbociclib Palbociclib The metabolism of Palbociclib can be increased when combined with Dicloxacillin.
Panobinostat Panobinostat The metabolism of Panobinostat can be increased when combined with Dicloxacillin.
Sonidegib Sonidegib The metabolism of Sonidegib can be increased when combined with Dicloxacillin.
Ziprasidone Injection Ziprasidone Injection The metabolism of Ziprasidone can be increased when combined with Dicloxacillin.
Cobimetinib Cobimetinib The metabolism of Cobimetinib can be increased when combined with Dicloxacillin.
Trabectedin Injection Trabectedin Injection The metabolism of Trabectedin can be increased when combined with Dicloxacillin.
Osimertinib Osimertinib The metabolism of Osimertinib can be increased when combined with Dicloxacillin.
Alectinib Alectinib The metabolism of Alectinib can be increased when combined with Dicloxacillin.
Ixazomib Ixazomib The metabolism of Ixazomib can be increased when combined with Dicloxacillin.
Venetoclax Venetoclax The metabolism of Venetoclax can be increased when combined with Dicloxacillin.
Ribociclib Ribociclib The metabolism of Ribociclib can be increased when combined with Dicloxacillin.
Brigatinib Brigatinib The metabolism of Brigatinib can be increased when combined with Dicloxacillin.
Midostaurin Midostaurin The metabolism of Midostaurin can be increased when combined with Dicloxacillin.
Neratinib Neratinib The metabolism of Neratinib can be increased when combined with Dicloxacillin.
Enasidenib Enasidenib The metabolism of Enasidenib can be increased when combined with Dicloxacillin.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The metabolism of Fosaprepitant can be increased when combined with Dicloxacillin.
Copanlisib Injection Copanlisib Injection The metabolism of Copanlisib can be increased when combined with Dicloxacillin.
Delafloxacin Delafloxacin The serum concentration of Delafloxacin can be increased when it is combined with Dicloxacillin.
Abemaciclib Abemaciclib The metabolism of Abemaciclib can be increased when combined with Dicloxacillin.
Acalabrutinib Acalabrutinib The metabolism of Acalabrutinib can be increased when combined with Dicloxacillin.
Baricitinib Baricitinib The metabolism of Baricitinib can be increased when combined with Dicloxacillin.
Plazomicin Injection Plazomicin Injection The serum concentration of Plazomicin can be decreased when it is combined with Dicloxacillin.
Ivosidenib Ivosidenib The metabolism of Ivosidenib can be increased when combined with Dicloxacillin.
Eravacycline Injection Eravacycline Injection The therapeutic efficacy of Dicloxacillin can be decreased when used in combination with Eravacycline.
Dacomitinib Dacomitinib The metabolism of Dacomitinib can be increased when combined with Dicloxacillin.
Duvelisib Duvelisib The metabolism of Duvelisib can be increased when combined with Dicloxacillin.
Omadacycline Omadacycline The therapeutic efficacy of Dicloxacillin can be decreased when used in combination with Omadacycline.
Sarecycline Sarecycline The therapeutic efficacy of Dicloxacillin can be decreased when used in combination with Sarecycline.
Gilteritinib Gilteritinib The metabolism of Gilteritinib can be increased when combined with Dicloxacillin.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be increased when combined with Dicloxacillin.
Prucalopride Prucalopride The metabolism of Prucalopride can be increased when combined with Dicloxacillin.
Siponimod Siponimod The metabolism of Siponimod can be increased when combined with Dicloxacillin.
Erdafitinib Erdafitinib The metabolism of Erdafitinib can be increased when combined with Dicloxacillin.
Alpelisib Alpelisib The metabolism of Alpelisib can be increased when combined with Dicloxacillin.
Entrectinib Entrectinib The metabolism of Entrectinib can be increased when combined with Dicloxacillin.
Pexidartinib Pexidartinib The metabolism of Pexidartinib can be increased when combined with Dicloxacillin.
Lefamulin Lefamulin The metabolism of Lefamulin can be increased when combined with Dicloxacillin.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Fosphenytoin can be increased when combined with Dicloxacillin.
Zanubrutinib Zanubrutinib The metabolism of Zanubrutinib can be increased when combined with Dicloxacillin.
Lumateperone Lumateperone The serum concentration of Lumateperone can be decreased when it is combined with Dicloxacillin.
Tazemetostat Tazemetostat The metabolism of Tazemetostat can be increased when combined with Dicloxacillin.
Rimegepant Rimegepant The metabolism of Rimegepant can be increased when combined with Dicloxacillin.
Selpercatinib Selpercatinib The serum concentration of Selpercatinib can be decreased when it is combined with Dicloxacillin.
Capmatinib Capmatinib The serum concentration of Capmatinib can be decreased when it is combined with Dicloxacillin.
Lemborexant Lemborexant The serum concentration of Lemborexant can be decreased when it is combined with Dicloxacillin.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Drospirenone can be increased when combined with Dicloxacillin.
Tobramycin Injection Tobramycin Injection The serum concentration of Tobramycin can be decreased when it is combined with Dicloxacillin.
Theophylline Theophylline The metabolism of Theophylline can be increased when combined with Dicloxacillin.
Methotrexate Injection Methotrexate Injection The excretion of Methotrexate can be decreased when combined with Dicloxacillin.
Chlorpromazine Chlorpromazine The metabolism of Chlorpromazine can be increased when combined with Dicloxacillin.
Lorazepam Lorazepam The metabolism of Lorazepam can be increased when combined with Dicloxacillin.
Tetracycline Tetracycline The therapeutic efficacy of Dicloxacillin can be decreased when used in combination with Tetracycline.
Minocycline Minocycline The therapeutic efficacy of Dicloxacillin can be decreased when used in combination with Minocycline.
Demeclocycline Demeclocycline The therapeutic efficacy of Dicloxacillin can be decreased when used in combination with Demeclocycline.
Prochlorperazine Prochlorperazine The metabolism of Prochlorperazine can be increased when combined with Dicloxacillin.
Phentermine Phentermine The metabolism of Phentermine can be increased when combined with Dicloxacillin.
Doxorubicin Doxorubicin The metabolism of Doxorubicin can be increased when combined with Dicloxacillin.
Carbamazepine Carbamazepine The metabolism of Carbamazepine can be increased when combined with Dicloxacillin.
Clonidine Clonidine The metabolism of Clonidine can be increased when combined with Dicloxacillin.
Gentamicin Injection Gentamicin Injection The serum concentration of Gentamicin can be decreased when it is combined with Dicloxacillin.
Warfarin Warfarin The metabolism of Warfarin can be increased when combined with Dicloxacillin.
Clonazepam Clonazepam The metabolism of Clonazepam can be increased when combined with Dicloxacillin.
Lactulose Lactulose The therapeutic efficacy of Lactulose can be decreased when used in combination with Dicloxacillin.
Isosorbide Isosorbide The metabolism of Isosorbide can be increased when combined with Dicloxacillin.
Clindamycin Injection Clindamycin Injection The metabolism of Clindamycin can be increased when combined with Dicloxacillin.
Probenecid Probenecid The excretion of Dicloxacillin can be decreased when combined with Probenecid.
Quinidine Quinidine The metabolism of Quinidine can be increased when combined with Dicloxacillin.
Tamoxifen Tamoxifen The metabolism of Tamoxifen can be increased when combined with Dicloxacillin.
Nortriptyline Nortriptyline The metabolism of Nortriptyline can be increased when combined with Dicloxacillin.
Amikacin Injection Amikacin Injection The serum concentration of Amikacin can be decreased when it is combined with Dicloxacillin.
Cephalexin Cephalexin The metabolism of Cephalexin can be increased when combined with Dicloxacillin.
Thiotepa Injection Thiotepa Injection The metabolism of Thiotepa can be increased when combined with Dicloxacillin.
Vincristine Injection Vincristine Injection The metabolism of Vincristine can be increased when combined with Dicloxacillin.
Vinblastine Vinblastine The metabolism of Vinblastine can be increased when combined with Dicloxacillin.
Metoprolol Metoprolol The metabolism of Metoprolol can be increased when combined with Dicloxacillin.
Etoposide Etoposide The metabolism of Etoposide can be increased when combined with Dicloxacillin.
Pimozide Pimozide The metabolism of Pimozide can be increased when combined with Dicloxacillin.
Amiodarone Amiodarone The metabolism of Amiodarone can be increased when combined with Dicloxacillin.
Ciprofloxacin Ciprofloxacin The serum concentration of Ciprofloxacin can be increased when it is combined with Dicloxacillin.
Ofloxacin Ofloxacin The serum concentration of Ofloxacin can be increased when it is combined with Dicloxacillin.
Amlodipine Amlodipine The metabolism of Amlodipine can be increased when combined with Dicloxacillin.
Teniposide Injection Teniposide Injection The metabolism of Teniposide can be increased when combined with Dicloxacillin.
Zolpidem Zolpidem The metabolism of Zolpidem can be increased when combined with Dicloxacillin.
Doxazosin Doxazosin The metabolism of Doxazosin can be increased when combined with Dicloxacillin.
Cisapride Cisapride The metabolism of Cisapride can be increased when combined with Dicloxacillin.
Famciclovir Famciclovir The metabolism of Famciclovir can be increased when combined with Dicloxacillin.
Tramadol Tramadol The metabolism of Tramadol can be increased when combined with Dicloxacillin.
Vinorelbine Injection Vinorelbine Injection The metabolism of Vinorelbine can be increased when combined with Dicloxacillin.
Ifosfamide Injection Ifosfamide Injection The metabolism of Ifosfamide can be increased when combined with Dicloxacillin.
Ticlopidine Ticlopidine The metabolism of Ticlopidine can be increased when combined with Dicloxacillin.
Docetaxel Injection Docetaxel Injection The metabolism of Docetaxel can be increased when combined with Dicloxacillin.
Clomipramine Clomipramine The metabolism of Clomipramine can be increased when combined with Dicloxacillin.
Zafirlukast Zafirlukast The metabolism of Zafirlukast can be increased when combined with Dicloxacillin.
Azithromycin Azithromycin The metabolism of Azithromycin can be increased when combined with Dicloxacillin.
Bicalutamide Bicalutamide The metabolism of Bicalutamide can be increased when combined with Dicloxacillin.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists