Dicloxacillin

31 interactions 2 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Dicloxacillin Acetaminophen And Codeine Capital® & Codeine Explained Reduced codeine and morphine exposure, reduced opioid efficacy and precipitation of opioid withdrawal Details Dicloxacillin Atogepant Qulipta Reduced atogepant exposure Details Dicloxacillin Cariprazine Vraylar Explained Effects on the cariprazine exposure has not been evaluated and the net effect is unclear Details Dicloxacillin Amlodipine Amvaz® Reduced amLODIPine exposure Details Dicloxacillin Demeclocycline Declomycin® Decreased antibacterial effectiveness Details Dicloxacillin Digoxin Cardoxin® Reduced digoxin exposure Details Dicloxacillin Doxycycline Injection Acticlate Decreased antibacterial effectiveness Details Dicloxacillin Eravacycline Injection Xerava Decreased antibacterial effectiveness Details Dicloxacillin Estradiol Delestrogen Reduced hormonal contraceptive exposure, reduced hormonal contraceptive effectiveness and an increased risk of breakthrough bleedi... Details Dicloxacillin Estradiol Topical Divigel Reduced hormonal contraceptive exposure, reduced hormonal contraceptive effectiveness and an increased risk of breakthrough bleedi... Details Dicloxacillin Estradiol Transdermal Patch Alora® Reduced hormonal contraceptive exposure, reduced hormonal contraceptive effectiveness and an increased risk of breakthrough bleedi... Details Dicloxacillin Exenatide Injection Bydureon Reduced oral antibiotics absorption and reduced efficacy of oral antibiotics Details Dicloxacillin Fentanyl Transdermal Patch Duragesic® Reduced exposure of fentaNYL, reduced efficacy of fentaNYL and/or onset of opioid withdrawal symptoms Details Dicloxacillin Hydroxychloroquine Plaquenil An increased risk of seizures Details Dicloxacillin Levonorgestrel After banger Reduced levonorgestrel exposure, reduced efficacy of levonorgestrel and an increased risk of breakthrough bleeding and/or contrace... Details Dicloxacillin Levonorgestrel Intrauterine System Kyleena Reduced levonorgestrel exposure, reduced efficacy of levonorgestrel and an increased risk of breakthrough bleeding and/or contrace... Details Dicloxacillin Lumateperone Caplyta Reduced lumateperone exposure Details Dicloxacillin Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Dicloxacillin Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Dicloxacillin Minocycline Amzeeq Decreased antibacterial effectiveness Details Dicloxacillin Minocycline Topical Amzeeq Decreased antibacterial effectiveness Details Dicloxacillin Nifedipine Adalat® Reduced NIFEdipine exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.