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Indapamide

Indapamide is a thiazide-type water pill (diuretic) used to treat high blood pressure and to ease salt and fluid retention from congestive heart failure.

Brand name Lozol
Drug class Thiazide-like Diuretic
Rx Form 1
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026 Content updated Oct 2, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 13 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

✓No current FDA shortage listed · checked Oct 5, 2026
Indapamide at a glance The quick version — the full detail is in the Patient Information Guide below.
Dr. Brian Staiger, PharmD, BCPS
The Pharmacist’s Take By · Clinical pharmacist · Written

Indapamide is a thiazide-like diuretic (a “water pill”) for high blood pressure and fluid retention from congestive heart failure, lowering resistance in the blood vessels and helping the body shed salt and fluid; on the market since the early 1980s and available as a generic, it belongs to the first-choice family of blood pressure drugs, though it is less familiar than hydrochlorothiazide. Most people tolerate it well, noticing at most mild dizziness, headache or extra trips to the bathroom. The thing to watch is low sodium and low potassium, which can turn serious even at usual doses, mostly in older women, so report marked weakness, confusion, cramps or an irregular heartbeat.

Clinical pearls

  • Take it in the morning, since the extra urination it causes can otherwise keep you up at night.
  • Expect regular blood tests for sodium and potassium, and these matter more if you take digoxin or have an irregular heartbeat.
  • If you take lithium, flag it before starting, because indapamide can push lithium to toxic levels.
  • Mention any sulfa (sulfonamide) drug allergy, since indapamide is sulfonamide-derived and is off-limits if you react to them.
How you get itPrescription only
Comes asTablet
Earliest FDA record1983
Companies listing it with the FDA8
FDA label last updatedMay 13, 2026
FDA’s strongest warning (boxed)None on the label

Patient information guide A plain-language walkthrough of Indapamide, written from its FDA label.

What Indapamide is used for

▾

Indapamide is a water pill with blood pressure–lowering action. Supported uses for indapamide tablets:

  • High blood pressure (hypertension), alone or with other blood pressure medicines
  • Salt and fluid retention (edema) from congestive heart failure
  • Swelling in pregnancy only when it is due to a medical cause, not normal pregnancy swelling

How Indapamide works

▾

Indapamide is the first of a class called indolines, which act as both blood pressure medicines and diuretics. It lowers resistance in the blood vessels while having little or no effect on cardiac output, heart rate or rhythm. It also increases loss of salt and fluid.

Indapamide dosage

▾

Indapamide tablets are taken by mouth once a day in the morning. Doses are usually started low and raised only if needed after a few weeks, and the lowest effective dose is preferred.

  • For high blood pressure, your doctor may add another medicine rather than keep raising the dose.
  • When combined with other blood pressure drugs, the other drugs’ doses are often reduced at first.
  • Higher doses did not add benefit but increased low potassium.

Follow your prescriber and the label for your exact dose.

Dosing details from the FDA-approved label

From the Indapamide prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.

  • Hypertension
    • Adult starting dose 1.25 mg as a single daily dose taken in the morning
    • If response is not satisfactory after 4 weeks, may be increased to 2.5 mg once daily
    • If response to 2.5 mg is not satisfactory after 4 weeks, may be increased to 5.0 mg once daily, but adding another antihypertensive should be considered
    • Doses of 5.0 mg and larger have not appeared to provide additional effects on blood pressure but are associated with a greater degree of hypokalemia; minimal clinical trial experience with doses greater than 5.0 mg once a day
  • Edema of Congestive Heart Failure
    • Adult starting dose 2.5 mg as a single daily dose taken in the morning
    • If response is not satisfactory after one week, may be increased to 5.0 mg once daily
    • Doses of 5.0 mg and larger have not appeared to provide additional effects on heart failure but are associated with a greater degree of hypokalemia
Read the label’s full dosing text

DOSAGE & ADMINISTRATION Hypertension : The adult starting indapamide dose for hypertension is 1.25 mg as a single daily dose taken in the morning. If the response to 1.25 mg is not satisfactory after 4 weeks, the daily dose may be increased to 2.5 mg taken once daily. If the response to 2.5 mg is not satisfactory after 4 weeks, the daily dose may be increased to 5.0 mg taken once daily, but adding another antihypertensive should be considered. Edema of Congestive Heart Failure : The adult starting indapamide dose for edema of congestive heart failure is 2.5 mg as a single daily dose taken in the morning. If the response to 2.5 mg is not satisfactory after one week, the daily dose may be increased to 5.0 mg taken once daily. If the antihypertensive response to indapamide is insufficient, indapamide may be combined with other antihypertensive drugs, with careful monitoring of blood pressure. It is recommended that the usual dose of other agents be reduced by 50% during initial combination therapy. As the blood pressure response becomes evident, further dosage adjustments may be necessary. In general, doses of 5.0 mg and larger have not appeared to provide additional effects on blood pressure or heart failure, but are associated with a greater degree of hypokalemia. There is minimal clinical trial experience in patients with doses greater than 5.0 mg once a day.

Read the full Dosage and Administration section on DailyMed →

Indapamide side effects

▾

Most side effects in studies were mild and temporary. Common ones include:

Common side effects

  • Headache
  • Dizziness or lightheadedness
  • Tiredness, weakness or low energy
  • Constipation, nausea or diarrhea
  • Muscle cramps
  • Runny nose or cough
  • Frequent urination
  • Swelling in the legs or ankles

When to get medical help

  • Call your doctor if you feel very weak, confused, have muscle cramps, or have an irregular heartbeat. These can be signs of low potassium or low sodium.
  • Get help for a rash, hives, itching or swelling. These can be allergic reactions.
  • Tell your doctor about severe vomiting, diarrhea or marked weakness, since fluid and salt levels can shift.
  • Seek urgent help for signs of overdose, such as severe weakness, vomiting, very low blood pressure or slowed breathing.

Indapamide warnings and precautions

▾

Low sodium and low potassium are the biggest risks. Severe low sodium has been reported at recommended doses, mostly in older women, and appears linked to higher doses.

Electrolyte monitoring is essential, especially with irregular heartbeat or heart glycoside use. Diuretics should generally not be given with lithium.

Indapamide interactions

▾

Indapamide can interact with the following:

  • Lithium: reduced clearance raises the risk of lithium toxicity.
  • Other blood pressure medicines: effects can add together.
  • Cardiac glycosides: low potassium is riskier with these.
  • Norepinephrine: response may be slightly reduced.
  • After sympathectomy: the blood pressure effect may be stronger.

Interactions listed in the FDA-approved label

From the Indapamide prescribing information (“Drug Interactions”): what the manufacturer studied or reported to the FDA.

  • Other antihypertensives: Indapamide may add to or potentiate the action of other antihypertensive drugs; in limited controlled trials there was no notable change in the nature or frequency of adverse reactions with combined therapy. If the antihypertensive response is insufficient, may be combined with other antihypertensives with careful monitoring of blood pressure; usual dose of other agents recommended to be reduced by 50% during initial combination therapy.
  • Lithium: The label refers to the WARNINGS section. See WARNINGS.
  • Post-sympathectomy patient: The antihypertensive effect of the drug may be enhanced in the post-sympathectomized patient.
  • Norepinephrine: Indapamide, like the thiazides, may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use.
Read the label’s full interactions text

Drug Interactions Other Antihypertensives : Indapamide may add to or potentiate the action of other antihypertensive drugs. In limited controlled trials that compared the effect of indapamide combined with other antihypertensive drugs with the effect of the other drugs administered alone, there was no notable change in the nature or frequency of adverse reactions associated with the combined therapy. Lithium : See WARNINGS . Post-Sympathectomy Patient : The antihypertensive effect of the drug may be enhanced in the post-sympathectomized patient. Norepinephrine : Indapamide, like the thiazides, may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use.

Read the full Drug Interactions section on DailyMed →

Not a complete list. The label covers the interactions the manufacturer studied or reported, and our own interaction database does not cover every medicine either. Bring your full medication list, including vitamins and herbal products, to your pharmacist.

Before taking Indapamide

▾
  • Do not use if you have anuria (cannot make urine).
  • Do not use if allergic to indapamide or sulfonamide-derived drugs.
  • Older adults, especially women, have higher risk of low sodium.
  • Tell your doctor if you are pregnant; routine diuretic use in healthy pregnancy is not appropriate.
  • Kidney impairment can reduce the diuretic effect.
  • Tell your doctor about irregular heartbeat or heart medicines.

Indapamide overdose

▾

Overdose can cause nausea, vomiting, weakness, stomach upset and electrolyte imbalance. In severe cases, low blood pressure and slowed breathing can occur. There is no specific antidote, so treatment supports breathing and circulation, empties the stomach, and carefully checks fluid and electrolyte balance.

What Indapamide does in the body

▾

Indapamide lowers blood pressure in a dose-related way and reduces peripheral resistance, with little or no effect on heart rate, rhythm or output. It has little effect on kidney filtration with long-term use. It lowers potassium and raises uric acid, with larger changes at higher doses.

How your body processes Indapamide

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Indapamide reaches peak blood levels within about two hours after a dose. Its half-life in whole blood is about 14 hours. It is extensively metabolized, with only about 7% of a dose leaving unchanged in urine over 48 hours. At least 70% of a dose is eliminated by the kidneys and about 23% through the digestive tract.

How to store Indapamide

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Store at controlled room temperature 20° to 25°C (68° to 77°F) . Avoid excessive heat. Dispense in a tight, light-resistant container as defined in the USP.

Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

215

Supplements & herbs that interact with Indapamide

215 supplements and herbal products have documented interactions with Indapamide in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.

Severity mix
  • Major · 13
  • Moderate · 179
  • Minor · 23
Every supplement checked against Indapamide — ranked by severity The full interaction hub: 13 major · 179 moderate · 23 minor · every one linked to its full report. Check Indapamide against your exact supplements

Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.

8

Nutrient depletion considerations

Indapamide has been associated with lower levels of 8 nutrients in the clinical literature. This does not mean a deficiency will occur — it means these may be worth discussing with your pharmacist or healthcare provider, especially with long-term use.

Evidence & significance mix
  • Higher significance · 2
  • Moderate · 3
  • Unrated · 3
See the full Indapamide nutrient depletion report

Educational information from a licensed clinical database (Natural Medicines) — not medical advice. Do not start or stop medications or supplements without professional guidance.

Indapamide: pharmacist answers to common questions

Quick, plain-English answers to the questions patients ask most about Indapamide — the kind of thing our pharmacy team would talk through with you at the counter.

What is indapamide for?

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It treats high blood pressure, either alone or with other blood pressure medicines. It also treats salt and fluid buildup from congestive heart failure. It works as a water pill and also relaxes resistance in the blood vessels.

When and how should I take it?

▾
It’s taken by mouth once a day in the morning. Your doctor may adjust the dose after a few weeks if needed. Stick to the prescribed dose, since higher doses mostly raise the risk of low potassium.

What side effects should I expect?

▾
Most are mild and temporary, like headache, dizziness, tiredness, constipation, nausea or muscle cramps. You may also urinate more often. Call me or your doctor if you have severe weakness, confusion, an irregular heartbeat, or a rash or hives.

Why do I need blood tests?

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Indapamide can lower your potassium and sodium. Low levels can cause serious problems, especially in older women and people with heart rhythm issues. Blood tests help catch this early.

Can I take it with my other medicines?

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Often yes, but tell us everything you take. Indapamide can add to the effect of other blood pressure drugs, so doses may need adjusting. Lithium is a major concern because levels can become toxic.

Is it safe in pregnancy?

▾
Water pills aren’t meant for routine use in healthy pregnancies. Indapamide may be used when swelling is caused by a medical condition. Talk to your doctor if you are pregnant or planning to be.

Is Indapamide available over the counter?

▾
No. Indapamide is a prescription medicine: every Indapamide product listed with the FDA is prescription only, so it is not sold over the counter. Your prescriber decides whether it is appropriate for you, and your pharmacist dispenses it.

When was Indapamide first available?

▾
The earliest FDA record we hold for Indapamide is from 1983: its first approval in Drugs@FDA or its earliest product listing in the NDC Directory, whichever is older. Many older medicines were in use before their first formal FDA approval, so this is the earliest date on record, not necessarily when Indapamide was first used.

Who makes Indapamide?

▾
8 companies currently list Indapamide products in the FDA's NDC Directory, including Bryant Ranch Prepack, A-S Medication Solutions, ANI Pharmaceuticals, Inc.. That count includes repackagers and distributors as well as manufacturers (companies that sell only the raw ingredient are not counted), so fewer companies actually make it; the label on your bottle names the one that supplied yours.

Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

More about Indapamide on HelloPharmacist

Detailed data & references for Indapamide Forms & strengths, pricing, billing codes, manufacturers, safety reports and sourcing — the data behind the page. Most people can stop here. Each section below opens on a tap.

Indapamide forms and strengths (how it comes)

Indapamide is available in 1 form. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Tablet

By mouth
How this form is used
What it may be used for
  • Indapamide tablets are used to treat high blood pressure, alone or with other blood pressure medicines.
  • Indapamide tablets are also used for salt and fluid retention from congestive heart failure.
Important instructions
  • Indapamide tablets are taken by mouth once daily in the morning.
  • Indapamide tablets may be adjusted by your prescriber if the response is not enough after a few weeks (about one week for heart failure swelling).
Available strengths 2 strengths
37 FDA-listed product records ⓘ

Indapamide on the U.S. market: products, makers and brands

How Indapamide appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

8 companies list 17 Indapamide product records with the FDA, mostly as tablet; the earliest marketing or approval year on record is 1983. Brand names on the directory include Lozol; the rest are generics.

1
Dose forms ⓘ
8
Labelers (makers, repackagers, distributors)
1
Brand names
17
FDA-listed product records ⓘ
1983
Earliest FDA record ⓘ

Also listed with the FDA, not a patient dose form: Powder (5) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.

Bryant Ranch Prepack29%
A-S Medication Solutions12%
ANI Pharmaceuticals, Inc.12%
Actavis Pharma, Inc.12%
Golden State Medical Supply, Inc.12%
Rising Pharma Holdings, Inc.12%
Other makers12%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

How widely Indapamide is used (Medicaid data)

A general measure of how commonly Indapamide is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Indapamide is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

32,997
Medicaid prescriptions filled (Q1–Q4 2025)
$387,619 gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Indapamide prescribed? Of the 1,601 medications we measure, Indapamide ranks #717 by Medicaid prescriptions — more than 55% of them.

Where Indapamide ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5

Utilization by Indapamide product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

The 1.25 mg oral tablet is the most-dispensed Indapamide product — about 57% of these Medicaid prescriptions.

indapamide 1.25 MG Oral Tablet Most dispensed

18,792 Medicaid prescriptions (Q1–Q4 2025) 57% of Indapamide prescriptions shown $212,320 gross reimbursement (before rebates) ≈ $11 per prescription (gross)

Summed across the 3 of 18 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 197815

indapamide 2.5 MG Oral Tablet

14,205 Medicaid prescriptions (Q1–Q4 2025) 43% of Indapamide prescriptions shown $175,299 gross reimbursement (before rebates) ≈ $12 per prescription (gross)

Summed across the 4 of 22 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 197816

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Indapamide, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 7 of 40 listed Indapamide NDCs with Medicaid activity.

Compare Indapamide products

A representative set of FDA-listed product records for Indapamide — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Showing 17 of 17 products — FDA National Drug Code Directory. See every product, package size and price: browse all 17 Indapamide NDCs →

Indapamide recall history

A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.

The FDA’s enforcement reports list no Indapamide recalls since July 2021.

✅No Indapamide recalls on record since July 2021

Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Sep 24, 2026.

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.

Ingredient (IN) Indapamide RxCUI 5764 2 dose forms · 3 strengths
  1. Dose form (SCDF) Extended Release Oral Tablet RxCUI 372468 No current FDA listing
    Clinical drug / strength (SCD) 24 HR indapamide 1.5 MG RxCUI 433844
  2. Dose form (SCDF) Oral Tablet RxCUI 370682 In current FDA listings
    Clinical drug / strength (SCD) 1.25 MG RxCUI 197815 2.5 MG RxCUI 197816

Look up RxCUI 5764 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

💵 What Indapamide costs pharmacies (NADAC benchmark)

The national average invoice price pharmacies pay for the drug itself, from CMS's NADAC survey (data as of Sep 30, 2026). This is a supply-cost benchmark — not a retail price and not what you'd pay at the counter.

FormStrengthPharmacy acquisition benchmark
Tablet, Film Coated · Oral 2.5 mg $0.108 per tablet NDC details & price history
Tablet, Film Coated · Oral 1.25 mg $0.109 per tablet NDC details & price history
Tablet, Film Coated 2.5 mg $0.108 per tablet NDC details & price history
Tablet, Film Coated 1.25 mg $0.109 per tablet NDC details & price history
Tablet · Oral 1.25 mg $0.109 per tablet NDC details & price history
Tablet · Oral 2.5 mg $0.108 per tablet NDC details & price history
Why show this? Your out-of-pocket cost depends on insurance, pharmacy markup, and discounts — but the acquisition benchmark tells you whether the medication itself is inexpensive or costly, which strengths cost more per dose, and whether a cash-price quote is in a reasonable range. Each row links to the NDC-level record with its full price history.

Source: CMS National Average Drug Acquisition Cost (NADAC), a survey of retail pharmacy invoice prices. Benchmarks shown are the range across package sizes of a representative product for each form and strength — other manufacturers' products may differ.

Indapamide brand names

Indapamide is sold under one brand name in the FDA directory — Lozol. A brand and its generic contain the same active ingredient; the brand name belongs to one company's product.

Lozol

Who makes Indapamide: manufacturers and labelers

8 companies list Indapamide products with the FDA. By number of product records, the largest are Bryant Ranch Prepack, A-S Medication Solutions, ANI Pharmaceuticals, Inc.. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.

Bryant Ranch Prepack 5 A-S Medication Solutions 2 ANI Pharmaceuticals, Inc. 2 Actavis Pharma, Inc. 2 Golden State Medical Supply, Inc. 2 Rising Pharma Holdings, Inc. 2 Direct_Rx 1 Preferred Pharmaceuticals Inc. 1

Indapamide drug class (RxNorm)

Indapamide belongs to the Thiazide-like Diuretic class.

Pharmacologic class Thiazide-like Diuretic
Drug family (ATC) Sulfonamides, plain

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

Sources for this Indapamide page

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective May 13, 2026
🏭
Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Indapamide.
📈
Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
🚨
Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Indapamide after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
13
Finished products in the current FDA directory
17
Companies listing them (makers, repackagers, distributors)
8
FDA labeler codes behind them ⓘ
10
Linked representative label ⓘ
Preferred Pharmaceuticals Inc.
Linked label effective
May 13, 2026
Composite sections available
14
Linked SPL Set ID
59cd3331-7afe-432a-8b50-39533fd5f392
Linked SPL Document ID
821a8777-e8a6-4cac-9936-7ba9615ae44a
Open the linked representative label on DailyMed ↗

How this page is built

HelloPharmacist combines public FDA and NLM records and does not author the underlying clinical facts. The plain-language sections are written with AI from the FDA-approved label text and reviewed by our pharmacy team before publication. Preferred Pharmaceuticals Inc. is the representative DailyMed label linked for verification and dates. This is general education, not medical advice: always talk to your doctor or pharmacist about your own medicines. How we build and review drug pages →