Indapamide
Indapamide is a thiazide-type water pill (diuretic) used to treat high blood pressure and to ease salt and fluid retention from congestive heart failure.
🧬 Where this information comes from Click to expand
The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 13 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →
Indapamide is a thiazide-like diuretic (a “water pill”) for high blood pressure and fluid retention from congestive heart failure, lowering resistance in the blood vessels and helping the body shed salt and fluid; on the market since the early 1980s and available as a generic, it belongs to the first-choice family of blood pressure drugs, though it is less familiar than hydrochlorothiazide. Most people tolerate it well, noticing at most mild dizziness, headache or extra trips to the bathroom. The thing to watch is low sodium and low potassium, which can turn serious even at usual doses, mostly in older women, so report marked weakness, confusion, cramps or an irregular heartbeat.
Clinical pearls
- Take it in the morning, since the extra urination it causes can otherwise keep you up at night.
- Expect regular blood tests for sodium and potassium, and these matter more if you take digoxin or have an irregular heartbeat.
- If you take lithium, flag it before starting, because indapamide can push lithium to toxic levels.
- Mention any sulfa (sulfonamide) drug allergy, since indapamide is sulfonamide-derived and is off-limits if you react to them.
Patient information guide A plain-language walkthrough of Indapamide, written from its FDA label.
What Indapamide is used for
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Indapamide is a water pill with blood pressure–lowering action. Supported uses for indapamide tablets:
- High blood pressure (hypertension), alone or with other blood pressure medicines
- Salt and fluid retention (edema) from congestive heart failure
- Swelling in pregnancy only when it is due to a medical cause, not normal pregnancy swelling
How Indapamide works
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Indapamide is the first of a class called indolines, which act as both blood pressure medicines and diuretics. It lowers resistance in the blood vessels while having little or no effect on cardiac output, heart rate or rhythm. It also increases loss of salt and fluid.
Indapamide dosage
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Indapamide tablets are taken by mouth once a day in the morning. Doses are usually started low and raised only if needed after a few weeks, and the lowest effective dose is preferred.
- For high blood pressure, your doctor may add another medicine rather than keep raising the dose.
- When combined with other blood pressure drugs, the other drugs’ doses are often reduced at first.
- Higher doses did not add benefit but increased low potassium.
Follow your prescriber and the label for your exact dose.
Dosing details from the FDA-approved label
From the Indapamide prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.
- Hypertension
- Adult starting dose 1.25 mg as a single daily dose taken in the morning
- If response is not satisfactory after 4 weeks, may be increased to 2.5 mg once daily
- If response to 2.5 mg is not satisfactory after 4 weeks, may be increased to 5.0 mg once daily, but adding another antihypertensive should be considered
- Doses of 5.0 mg and larger have not appeared to provide additional effects on blood pressure but are associated with a greater degree of hypokalemia; minimal clinical trial experience with doses greater than 5.0 mg once a day
- Edema of Congestive Heart Failure
- Adult starting dose 2.5 mg as a single daily dose taken in the morning
- If response is not satisfactory after one week, may be increased to 5.0 mg once daily
- Doses of 5.0 mg and larger have not appeared to provide additional effects on heart failure but are associated with a greater degree of hypokalemia
Read the label’s full dosing text
DOSAGE & ADMINISTRATION Hypertension : The adult starting indapamide dose for hypertension is 1.25 mg as a single daily dose taken in the morning. If the response to 1.25 mg is not satisfactory after 4 weeks, the daily dose may be increased to 2.5 mg taken once daily. If the response to 2.5 mg is not satisfactory after 4 weeks, the daily dose may be increased to 5.0 mg taken once daily, but adding another antihypertensive should be considered. Edema of Congestive Heart Failure : The adult starting indapamide dose for edema of congestive heart failure is 2.5 mg as a single daily dose taken in the morning. If the response to 2.5 mg is not satisfactory after one week, the daily dose may be increased to 5.0 mg taken once daily. If the antihypertensive response to indapamide is insufficient, indapamide may be combined with other antihypertensive drugs, with careful monitoring of blood pressure. It is recommended that the usual dose of other agents be reduced by 50% during initial combination therapy. As the blood pressure response becomes evident, further dosage adjustments may be necessary. In general, doses of 5.0 mg and larger have not appeared to provide additional effects on blood pressure or heart failure, but are associated with a greater degree of hypokalemia. There is minimal clinical trial experience in patients with doses greater than 5.0 mg once a day.
Read the full Dosage and Administration section on DailyMed →
Indapamide side effects
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Most side effects in studies were mild and temporary. Common ones include:
Common side effects
- Headache
- Dizziness or lightheadedness
- Tiredness, weakness or low energy
- Constipation, nausea or diarrhea
- Muscle cramps
- Runny nose or cough
- Frequent urination
- Swelling in the legs or ankles
When to get medical help
- Call your doctor if you feel very weak, confused, have muscle cramps, or have an irregular heartbeat. These can be signs of low potassium or low sodium.
- Get help for a rash, hives, itching or swelling. These can be allergic reactions.
- Tell your doctor about severe vomiting, diarrhea or marked weakness, since fluid and salt levels can shift.
- Seek urgent help for signs of overdose, such as severe weakness, vomiting, very low blood pressure or slowed breathing.
Indapamide warnings and precautions
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Low sodium and low potassium are the biggest risks. Severe low sodium has been reported at recommended doses, mostly in older women, and appears linked to higher doses.
Electrolyte monitoring is essential, especially with irregular heartbeat or heart glycoside use. Diuretics should generally not be given with lithium.
Indapamide interactions
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Indapamide can interact with the following:
- Lithium: reduced clearance raises the risk of lithium toxicity.
- Other blood pressure medicines: effects can add together.
- Cardiac glycosides: low potassium is riskier with these.
- Norepinephrine: response may be slightly reduced.
- After sympathectomy: the blood pressure effect may be stronger.
Interactions listed in the FDA-approved label
From the Indapamide prescribing information (“Drug Interactions”): what the manufacturer studied or reported to the FDA.
- Other antihypertensives: Indapamide may add to or potentiate the action of other antihypertensive drugs; in limited controlled trials there was no notable change in the nature or frequency of adverse reactions with combined therapy. If the antihypertensive response is insufficient, may be combined with other antihypertensives with careful monitoring of blood pressure; usual dose of other agents recommended to be reduced by 50% during initial combination therapy.
- Lithium: The label refers to the WARNINGS section. See WARNINGS.
- Post-sympathectomy patient: The antihypertensive effect of the drug may be enhanced in the post-sympathectomized patient.
- Norepinephrine: Indapamide, like the thiazides, may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use.
Read the label’s full interactions text
Drug Interactions Other Antihypertensives : Indapamide may add to or potentiate the action of other antihypertensive drugs. In limited controlled trials that compared the effect of indapamide combined with other antihypertensive drugs with the effect of the other drugs administered alone, there was no notable change in the nature or frequency of adverse reactions associated with the combined therapy. Lithium : See WARNINGS . Post-Sympathectomy Patient : The antihypertensive effect of the drug may be enhanced in the post-sympathectomized patient. Norepinephrine : Indapamide, like the thiazides, may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use.
Not a complete list. The label covers the interactions the manufacturer studied or reported, and our own interaction database does not cover every medicine either. Bring your full medication list, including vitamins and herbal products, to your pharmacist.
Before taking Indapamide
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- Do not use if you have anuria (cannot make urine).
- Do not use if allergic to indapamide or sulfonamide-derived drugs.
- Older adults, especially women, have higher risk of low sodium.
- Tell your doctor if you are pregnant; routine diuretic use in healthy pregnancy is not appropriate.
- Kidney impairment can reduce the diuretic effect.
- Tell your doctor about irregular heartbeat or heart medicines.
Indapamide overdose
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Overdose can cause nausea, vomiting, weakness, stomach upset and electrolyte imbalance. In severe cases, low blood pressure and slowed breathing can occur. There is no specific antidote, so treatment supports breathing and circulation, empties the stomach, and carefully checks fluid and electrolyte balance.
What Indapamide does in the body
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Indapamide lowers blood pressure in a dose-related way and reduces peripheral resistance, with little or no effect on heart rate, rhythm or output. It has little effect on kidney filtration with long-term use. It lowers potassium and raises uric acid, with larger changes at higher doses.
How your body processes Indapamide
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Indapamide reaches peak blood levels within about two hours after a dose. Its half-life in whole blood is about 14 hours. It is extensively metabolized, with only about 7% of a dose leaving unchanged in urine over 48 hours. At least 70% of a dose is eliminated by the kidneys and about 23% through the digestive tract.
How to store Indapamide
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Store at controlled room temperature 20° to 25°C (68° to 77°F) . Avoid excessive heat. Dispense in a tight, light-resistant container as defined in the USP.
Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →
Supplements & herbs that interact with Indapamide
215 supplements and herbal products have documented interactions with Indapamide in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.
- Major · 13
- Moderate · 179
- Minor · 23
Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.
Nutrient depletion considerations
Indapamide has been associated with lower levels of 8 nutrients in the clinical literature. This does not mean a deficiency will occur — it means these may be worth discussing with your pharmacist or healthcare provider, especially with long-term use.
- Higher significance · 2
- Moderate · 3
- Unrated · 3
Educational information from a licensed clinical database (Natural Medicines) — not medical advice. Do not start or stop medications or supplements without professional guidance.
Indapamide: pharmacist answers to common questions
Quick, plain-English answers to the questions patients ask most about Indapamide — the kind of thing our pharmacy team would talk through with you at the counter.
What is indapamide for?
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When and how should I take it?
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What side effects should I expect?
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Why do I need blood tests?
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Can I take it with my other medicines?
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Is it safe in pregnancy?
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Is Indapamide available over the counter?
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When was Indapamide first available?
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Who makes Indapamide?
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Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →
More about Indapamide on HelloPharmacist
Indapamide forms and strengths (how it comes)
Indapamide is available in 1 form. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.
Tablet
How this form is used
- Indapamide tablets are used to treat high blood pressure, alone or with other blood pressure medicines.
- Indapamide tablets are also used for salt and fluid retention from congestive heart failure.
- Indapamide tablets are taken by mouth once daily in the morning.
- Indapamide tablets may be adjusted by your prescriber if the response is not enough after a few weeks (about one week for heart failure swelling).
Indapamide on the U.S. market: products, makers and brands
How Indapamide appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.
8 companies list 17 Indapamide product records with the FDA, mostly as tablet; the earliest marketing or approval year on record is 1983. Brand names on the directory include Lozol; the rest are generics.
Also listed with the FDA, not a patient dose form: Powder (5) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.
Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.
How widely Indapamide is used (Medicaid data)
A general measure of how commonly Indapamide is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.
Think of this as a proxy for how widely Indapamide is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.
How commonly is Indapamide prescribed? Of the 1,601 medications we measure, Indapamide ranks #717 by Medicaid prescriptions — more than 55% of them.
Utilization by Indapamide product
Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.
indapamide 1.25 MG Oral Tablet Most dispensed
Summed across the 3 of 18 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 197815
indapamide 2.5 MG Oral Tablet
Summed across the 4 of 22 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 197816
Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.
Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Indapamide, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 7 of 40 listed Indapamide NDCs with Medicaid activity.
Compare Indapamide products
A representative set of FDA-listed product records for Indapamide — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)
| Strength | Route | Manufacturer / Labeler | Category ⓘ | Details |
|---|---|---|---|---|
| 💊Tablet | ||||
| 1.25 mg | Oral | A-S Medication Solutions | ANDA | View NDC → |
| 2.5 mg | Oral | A-S Medication Solutions | ANDA | View NDC → |
| 1.25 mg | Oral | Actavis Pharma, Inc. | ANDA | View NDC → |
| 2.5 mg | Oral | Actavis Pharma, Inc. | ANDA | View NDC → |
| 1.25 mg | Oral | ANI Pharmaceuticals, Inc. | ANDA | View NDC → |
| 2.5 mg | Oral | ANI Pharmaceuticals, Inc. | ANDA | View NDC → |
| 1.25 mg | Oral | Bryant Ranch Prepack × 3 listings | ANDA | View NDC → |
| 2.5 mg | Oral | Bryant Ranch Prepack × 2 listings | ANDA | View NDC → |
| 2.5 mg | Oral | Direct_Rx | ANDA | View NDC → |
| 1.25 mg | Oral | Golden State Medical Supply, Inc. | ANDA | View NDC → |
| 2.5 mg | Oral | Golden State Medical Supply, Inc. | ANDA | View NDC → |
| 2.5 mg | Oral | Preferred Pharmaceuticals Inc. | ANDA | View NDC → |
| 1.25 mg | Oral | Rising Pharma Holdings, Inc. | ANDA | View NDC → |
| 2.5 mg | Oral | Rising Pharma Holdings, Inc. | ANDA | View NDC → |
Showing 17 of 17 products — FDA National Drug Code Directory. See every product, package size and price: browse all 17 Indapamide NDCs →
Indapamide side effects reported to the FDA (FAERS)
After a medicine reaches the market, patients, doctors and drugmakers can send the FDA reports of problems they think may be linked to it. Here’s what’s been reported for Indapamide — a signal of what to watch for, not proof the drug caused it.
Source: openFDA, from the FDA Adverse Event Reporting System (FAERS). These are voluntary reports — they don’t prove the drug caused the effect, and counts reflect how often something was reported, not how often it actually happens. Reports also often name the very problem the medicine is taken for — a common reason to file one is that the drug didn’t help — so for a pain reliever you may see “pain” high on the list; that points to why the report was filed, not to the drug causing the symptom. This counts every report that lists Indapamide in any role, so the total runs higher than the FDA’s official dashboard, which counts only cases where the drug is the suspect. For the authoritative figures, see the FDA FAERS Public Dashboard. Always talk to your pharmacist or doctor.
Indapamide FDA approval history
How Indapamide went from FDA review to the pharmacy shelf — the key milestones in its regulatory journey.
Source: Drugs@FDA.
Indapamide recall history
A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.
The FDA’s enforcement reports list no Indapamide recalls since July 2021.
✅No Indapamide recalls on record since July 2021Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Sep 24, 2026.
RxNorm Concept Web — From Ingredient to Every Form and Strength
This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.
RxCUI 5764 2 dose forms · 3 strengths
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Dose form (SCDF) Extended Release Oral Tablet RxCUI 372468No current FDA listingClinical drug / strength (SCD) 24 HR indapamide 1.5 MGRxCUI 433844 -
Dose form (SCDF) Oral Tablet RxCUI 370682In current FDA listings
Look up RxCUI 5764 in the RxCUI Atlas →
RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.
Indapamide supply and shortage status
Whether Indapamide is in short supply in the U.S. right now, plus any shortage history the FDA has on record. A shortage usually reflects a manufacturing or demand issue — not a safety problem with the drug.
Source: openFDA, from the FDA Drug Shortages database.
💵 What Indapamide costs pharmacies (NADAC benchmark)
The national average invoice price pharmacies pay for the drug itself, from CMS's NADAC survey (data as of Sep 30, 2026). This is a supply-cost benchmark — not a retail price and not what you'd pay at the counter.
| Form | Strength | Pharmacy acquisition benchmark | |
|---|---|---|---|
| Tablet, Film Coated · Oral | 2.5 mg | $0.108 per tablet | NDC details & price history |
| Tablet, Film Coated · Oral | 1.25 mg | $0.109 per tablet | NDC details & price history |
| Tablet, Film Coated | 2.5 mg | $0.108 per tablet | NDC details & price history |
| Tablet, Film Coated | 1.25 mg | $0.109 per tablet | NDC details & price history |
| Tablet · Oral | 1.25 mg | $0.109 per tablet | NDC details & price history |
| Tablet · Oral | 2.5 mg | $0.108 per tablet | NDC details & price history |
Source: CMS National Average Drug Acquisition Cost (NADAC), a survey of retail pharmacy invoice prices. Benchmarks shown are the range across package sizes of a representative product for each form and strength — other manufacturers' products may differ.
Indapamide brand names
Indapamide is sold under one brand name in the FDA directory — Lozol. A brand and its generic contain the same active ingredient; the brand name belongs to one company's product.
Who makes Indapamide: manufacturers and labelers
8 companies list Indapamide products with the FDA. By number of product records, the largest are Bryant Ranch Prepack, A-S Medication Solutions, ANI Pharmaceuticals, Inc.. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.
Indapamide drug class (RxNorm)
Indapamide belongs to the Thiazide-like Diuretic class.
Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.
Sources for this Indapamide page
Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.
How this page is built
HelloPharmacist combines public FDA and NLM records and does not author the underlying clinical facts. The plain-language sections are written with AI from the FDA-approved label text and reviewed by our pharmacy team before publication. Preferred Pharmaceuticals Inc. is the representative DailyMed label linked for verification and dates. This is general education, not medical advice: always talk to your doctor or pharmacist about your own medicines. How we build and review drug pages →