Zaleplon

Generic name: Pronounced as (zal' e plon)
Brand names
  • Sonata®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 12/15/2019

Zaleplon may cause serious or possibly life-threatening sleep behaviors. Some people who took zaleplon got out of bed and drove their cars, prepared and ate food, had sex, made phone calls, sleep-walked, or were involved in other activities while not fully awake. After they woke up, these people were unable to remember what they had done. These activities may occur with zaleplon whether or not you drink alcohol or also take other sleep medications. Tell your doctor if you have ever had an unusual sleep behavior while taking zaleplon. Be sure that your family or caregiver knows that these symptoms may be serious so they can call your doctor if any of these effects occur. Stop taking zaleplon and call your doctor right away if you find out that you have been driving or doing anything else unusual while you were sleeping.

Zaleplon is used on a short-term basis to treat insomnia (difficulty falling asleep). Zaleplon does not help you to stay asleep longer or decrease the number of times that you awaken during the night. Zaleplon is in a class of medications called hypnotics. It works by slowing activity in the brain to allow sleep.

Zaleplon comes as a capsule to take by mouth. It is usually taken as needed at bedtime or after trying unsuccessfully to fall asleep. Do not take zaleplon with or shortly after a heavy, high-fat meal. Zaleplon may not work well if it is taken with high fat foods. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take zaleplon exactly as directed.

You will probably become very sleepy soon after you take zaleplon and will remain sleepy for some time after you take the medication. Plan to go to bed right after you take zaleplon and to stay in bed for 7 to 8 hours. Do not take zaleplon if you will be unable to go to bed right away and remain asleep for 7 to 8 hours after taking the medication. If you continue to walk around after taking zaleplon, you may experience dizziness, lightheadedness, problems with memory and coordination, or hallucinations (seeing things or hearing voices that do not exist). If you get up too soon after taking zaleplon, you may experience memory problems.

You should be sleeping well within 7 to 10 days after you start taking zaleplon. Call your doctor if your sleep problems do not improve during this time, if they get worse at any time during your treatment, or if you notice any changes in your thoughts or behavior.

Zaleplon can be habit-forming. Do not take a larger dose, take it more often, or take it for a longer time than prescribed by your doctor.

Do not stop taking zaleplon without talking to your doctor. If you suddenly stop taking zaleplon, you may experience withdrawal symptoms such as unpleasant feelings, stomach and muscle cramps, vomiting, sweating, shakiness, and rarely, seizures. Your doctor will probably decrease your dose gradually.

You may have more difficulty falling asleep or staying asleep on the first few nights after you stop taking zaleplon than you did before you started taking the medication. This is normal and usually gets better without treatment after one or two nights.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with zaleplon and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking zaleplon,

  • tell your doctor and pharmacist if you are allergic to zaleplon, aspirin, any other medications, tartrazine (a yellow dye in some processed foods and drugs), or any of the ingredients in zaleplon capsules. Ask your pharmacist for a list of the ingredients.

  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: antihistamines such as diphenhydramine (Benadryl) or promethazine; barbiturates; cimetidine (Tagamet); cough and cold medicines; erythromycin; ibuprofen; imipramine (Tofranil); ketoconazole (Nizoral); medications for allergies such as diphenhydramine (Benadryl), depression, or mental illness; certain medications for seizures such as phenytoin (Dilantin), carbamazepine (Epitol, Tegretol, others), and phenobarbital; pain relievers; promethazine (Promethegan); rifampin (Rifadin, Rimactane); sedatives, other sleeping pills, thioridazine, and tranquilizers. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • tell your doctor if you drink or have ever drunk large amounts of alcohol and if you use or have ever used street drugs or have overused prescription medications. Also tell your doctor if you have ever thought about killing yourself or tried to do so and if you have or have ever had depression, mental illness, seizures, lung disease or breathing problems, or kidney or liver disease.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking zaleplon, call your doctor.

  • talk to your doctor about the risks and benefits of taking zaleplon if you are 65 years of age or older. Older adults should not usually take zaleplon because it is not as safe or effective as other medications that can be used to treat the same condition.

  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking zaleplon.

  • you should know that this medication may cause drowsiness, decreased mental alertness, prolonged reaction time, problems with coordination the day after you take it, blurry or double vision, and may increase the risk that you could fall. Take extra care to be sure you do not fall, especially if you get out of bed in the middle of the night. Your ability to drive or operate machinery the day after you take zaleplon may be impaired even if you feel fully awake. Do not drive a car or operate machinery until you know how zaleplon affects you.

  • do not drink alcohol while you are taking zaleplon. Alcohol can make the side effects of zaleplon worse.

  • you should know that your mental health may change in unexpected ways while you are taking this medication. These changes may be caused by zaleplon or they may be caused by physical or mental illnesses that you already have or that you develop during your treatment. Tell your doctor right away if you experience any of the following symptoms: aggressiveness, strange or unusually outgoing behavior, hallucinations (seeing things or hearing voices that do not exist), feeling as if you are outside of your body, memory problems, new or worsening depression, thinking about killing yourself, confusion, and any other changes in your usual thoughts or behavior. Be sure that your family knows which symptoms may be serious so that they can call the doctor if you are unable to seek treatment on your own.

Unless your doctor tells you otherwise, continue your normal diet.

Zaleplon should only be taken at bedtime. If you did not take zaleplon before you went to bed and you are unable to fall asleep, you may take zaleplon if you will be able to stay in bed for at least 8 hours afterward. Do not take a double dose of zaleplon to make up for a missed dose.

  • Zaleplon may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • drowsiness

    • dizziness

    • lightheadedness

    • lack of coordination

    • numbness, burning, or tingling in the hands or feet

    • headache

    • loss of appetite

    • vision problems

    • eye pain

    • sensitivity to noise

    • distorted sense of smell

    • painful menstrual periods

  • Some side effects can be serious. If you experience any of the following symptoms or those listed in the IMPORTANT WARNINGS or SPECIAL PRECAUTIONS sections, call your doctor immediately:

    • rash

    • itching

    • hives

    • swelling of the face, throat, tongue, lips, or eyes

    • hoarseness

    • difficulty breathing or swallowing

  • Zaleplon may cause other side effects. Tell your doctor if you experience any unusual problems while you are taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Keep zaleplon in a safe place so no one else can take it accidentally or on purpose. Keep track of how many capsules are left so you will know if any are missing.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include the following:

  • drowsiness

  • confusion

  • problems with coordination

  • floppy muscles

  • slow or difficult breathing

  • coma (loss of consciousness for a period of time)

Keep all appointments with your doctor.

Do not let anyone else take your medication. Zaleplon is a controlled substance. Prescriptions may be refilled only a limited number of times; ask your pharmacist if you have any questions.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Delavirdine Delavirdine The metabolism of Zaleplon can be decreased when combined with Delavirdine.
Nevirapine Nevirapine The metabolism of Zaleplon can be decreased when combined with Nevirapine.
Atorvastatin Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Zaleplon.
Dolasetron Dolasetron The risk or severity of adverse effects can be increased when Dolasetron is combined with Zaleplon.
Aminophylline Aminophylline Zaleplon may increase the excretion rate of Aminophylline which could result in a lower serum level and potentially a reduction in efficacy.
Cilostazol Cilostazol Zaleplon may decrease the excretion rate of Cilostazol which could result in a higher serum level.
Clopidogrel Clopidogrel The metabolism of Zaleplon can be decreased when combined with Clopidogrel.
Diphenoxylate Diphenoxylate The risk or severity of adverse effects can be increased when Zaleplon is combined with Diphenoxylate.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The metabolism of Zaleplon can be decreased when combined with Erythromycin.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) Conjugated estrogens may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Fenofibrate Fenofibrate Zaleplon may decrease the excretion rate of Fenofibrate which could result in a higher serum level.
Guanfacine Guanfacine The risk or severity of adverse effects can be increased when Zaleplon is combined with Guanfacine.
Magnesium Hydroxide Magnesium Hydroxide Zaleplon may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level.
Mycophenolate Mycophenolate Zaleplon may decrease the excretion rate of Mycophenolic acid which could result in a higher serum level.
Naratriptan Naratriptan The risk or severity of adverse effects can be increased when Naratriptan is combined with Zaleplon.
Olsalazine Olsalazine Olsalazine may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Paregoric Paregoric The risk or severity of adverse effects can be increased when Morphine is combined with Zaleplon.
Pentazocine Pentazocine The risk or severity of adverse effects can be increased when Pentazocine is combined with Zaleplon.
Potassium Potassium Potassium may increase the excretion rate of Zaleplon which could result in a lower serum level and potentially a reduction in efficacy.
Prednisone Prednisone Prednisone may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Ranitidine Ranitidine Ranitidine may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Reserpine Reserpine Reserpine may increase the central nervous system depressant (CNS depressant) activities of Zaleplon.
Rizatriptan Rizatriptan Rizatriptan may increase the central nervous system depressant (CNS depressant) activities of Zaleplon.
Sumatriptan Sumatriptan Sumatriptan may increase the central nervous system depressant (CNS depressant) activities of Zaleplon.
Tacrolimus Tacrolimus The metabolism of Tacrolimus can be decreased when combined with Zaleplon.
Tizanidine Tizanidine The risk or severity of adverse effects can be increased when Tizanidine is combined with Zaleplon.
Triamcinolone Triamcinolone The metabolism of Zaleplon can be increased when combined with Triamcinolone.
Zolmitriptan Zolmitriptan The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Zaleplon.
Ampicillin Injection Ampicillin Injection Ampicillin may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Doxycycline Injection Doxycycline Injection Doxycycline may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Fluconazole Injection Fluconazole Injection Fluconazole may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Foscarnet Injection Foscarnet Injection Foscarnet may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Hydromorphone Injection Hydromorphone Injection The risk or severity of adverse effects can be increased when Hydromorphone is combined with Zaleplon.
Levofloxacin Injection Levofloxacin Injection Zaleplon may decrease the excretion rate of Levofloxacin which could result in a higher serum level.
Meperidine Injection Meperidine Injection The risk or severity of adverse effects can be increased when Meperidine is combined with Zaleplon.
Metoclopramide Injection Metoclopramide Injection The risk or severity of sedation can be increased when Zaleplon is combined with Metoclopramide.
Metronidazole Injection Metronidazole Injection The therapeutic efficacy of Zaleplon can be decreased when used in combination with Metronidazole.
Morphine Injection Morphine Injection The risk or severity of adverse effects can be increased when Morphine is combined with Zaleplon.
Pamidronate Injection Pamidronate Injection Pamidronic acid may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Vancomycin Injection Vancomycin Injection Zaleplon may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Altretamine Altretamine Amphetamine may increase the central nervous system depressant (CNS depressant) activities of Zaleplon.
Cefuroxime Cefuroxime Cefuroxime may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Cyclosporine Cyclosporine The metabolism of Cyclosporine can be decreased when combined with Zaleplon.
Ondansetron Ondansetron The risk or severity of adverse effects can be increased when Ondansetron is combined with Zaleplon.
Granisetron Granisetron The risk or severity of adverse effects can be increased when Granisetron is combined with Zaleplon.
Torsemide Torsemide Torasemide may increase the excretion rate of Zaleplon which could result in a lower serum level and potentially a reduction in efficacy.
Olanzapine Olanzapine The risk or severity of adverse effects can be increased when Olanzapine is combined with Zaleplon.
Alosetron Alosetron The risk or severity of adverse effects can be increased when Zaleplon is combined with Alosetron.
Entacapone Entacapone The risk or severity of adverse effects can be increased when Entacapone is combined with Zaleplon.
Hydroxychloroquine Hydroxychloroquine The therapeutic efficacy of Hydroxychloroquine can be decreased when used in combination with Zaleplon.
Meloxicam Meloxicam Meloxicam may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Orlistat Orlistat Orlistat can cause a decrease in the absorption of Zaleplon resulting in a reduced serum concentration and potentially a decrease in efficacy.
Oxcarbazepine Oxcarbazepine The metabolism of Zaleplon can be increased when combined with Oxcarbazepine.
Pantoprazole Pantoprazole Pantoprazole may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Temozolomide Temozolomide Temozolomide may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Anakinra Anakinra The metabolism of Zaleplon can be increased when combined with Anakinra.
Desloratadine Desloratadine The risk or severity of adverse effects can be increased when Zaleplon is combined with Desloratadine.
Linezolid Linezolid The risk or severity of adverse effects can be increased when Linezolid is combined with Zaleplon.
Trimipramine Trimipramine The risk or severity of adverse effects can be increased when Trimipramine is combined with Zaleplon.
Etanercept Injection Etanercept Injection The metabolism of Zaleplon can be increased when combined with Etanercept.
Glycopyrrolate Glycopyrrolate Zaleplon may increase the central nervous system depressant (CNS depressant) activities of Glycopyrronium.
Modafinil Modafinil The metabolism of Zaleplon can be increased when combined with Modafinil.
Perindopril Perindopril Perindopril may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Tenofovir Tenofovir Tenofovir may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Choline Magnesium Trisalicylate Choline Magnesium Trisalicylate Choline magnesium trisalicylate may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Sirolimus Sirolimus The metabolism of Sirolimus can be decreased when combined with Zaleplon.
Dutasteride Dutasteride The metabolism of Dutasteride can be decreased when combined with Zaleplon.
Eplerenone Eplerenone Eplerenone may increase the excretion rate of Zaleplon which could result in a lower serum level and potentially a reduction in efficacy.
Escitalopram Escitalopram The risk or severity of adverse effects can be increased when Zaleplon is combined with Escitalopram.
Zonisamide Zonisamide The risk or severity of adverse effects can be increased when Zonisamide is combined with Zaleplon.
Adalimumab Injection Adalimumab Injection The metabolism of Zaleplon can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole The risk or severity of adverse effects can be increased when Zaleplon is combined with Aripiprazole.
Atomoxetine Atomoxetine The risk or severity of adverse effects can be increased when Atomoxetine is combined with Zaleplon.
Dexmethylphenidate Dexmethylphenidate The risk or severity of adverse effects can be increased when Zaleplon is combined with Dexmethylphenidate.
Atazanavir Atazanavir Atazanavir may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Almotriptan Almotriptan Almotriptan may increase the central nervous system depressant (CNS depressant) activities of Zaleplon.
Eletriptan Eletriptan The risk or severity of adverse effects can be increased when Eletriptan is combined with Zaleplon.
Mefloquine Mefloquine The therapeutic efficacy of Zaleplon can be decreased when used in combination with Mefloquine.
Rosuvastatin Rosuvastatin The metabolism of Rosuvastatin can be decreased when combined with Zaleplon.
Vardenafil Vardenafil The metabolism of Zaleplon can be decreased when combined with Vardenafil.
Aprepitant Aprepitant The metabolism of Zaleplon can be decreased when combined with Aprepitant.
Emtricitabine Emtricitabine Emtricitabine may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Memantine Memantine Zaleplon may decrease the excretion rate of Memantine which could result in a higher serum level.
Tadalafil Tadalafil Tadalafil may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Frovatriptan Frovatriptan The risk or severity of adverse effects can be increased when Zaleplon is combined with Frovatriptan.
Progesterone Progesterone The metabolism of Zaleplon can be increased when combined with Progesterone.
Apomorphine Injection Apomorphine Injection The risk or severity of adverse effects can be increased when Apomorphine is combined with Zaleplon.
Infliximab Injection Infliximab Injection The metabolism of Zaleplon can be increased when combined with Infliximab.
Protriptyline Protriptyline The risk or severity of adverse effects can be increased when Protriptyline is combined with Zaleplon.
Duloxetine Duloxetine The risk or severity of adverse effects can be increased when Zaleplon is combined with Duloxetine.
Norethindrone Norethindrone The metabolism of Zaleplon can be increased when combined with Norethisterone.
Tinidazole Tinidazole Tinidazole may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Trospium Trospium Zaleplon may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Cefditoren Cefditoren Cefdinir may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Cyanocobalamin Injection Cyanocobalamin Injection Hydroxocobalamin may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Erlotinib Erlotinib The metabolism of Zaleplon can be decreased when combined with Erlotinib.
Eszopiclone Eszopiclone The risk or severity of CNS depression can be increased when Zaleplon is combined with Eszopiclone.
Ganciclovir Ganciclovir The therapeutic efficacy of Ganciclovir can be decreased when used in combination with Zaleplon.
Ribavirin Ribavirin Ribavirin may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Solifenacin Solifenacin Zaleplon may increase the central nervous system depressant (CNS depressant) activities of Solifenacin.
Valganciclovir Valganciclovir The therapeutic efficacy of Valganciclovir can be decreased when used in combination with Zaleplon.
Voriconazole Voriconazole The metabolism of Zaleplon can be decreased when combined with Voriconazole.
Adefovir Adefovir Adefovir may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Dextroamphetamine Dextroamphetamine Amphetamine may increase the central nervous system depressant (CNS depressant) activities of Zaleplon.
Sodium Oxybate Sodium Oxybate Zaleplon may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Isocarboxazid Isocarboxazid The risk or severity of adverse effects can be increased when Zaleplon is combined with Isocarboxazid.
Ramelteon Ramelteon The risk or severity of adverse effects can be increased when Zaleplon is combined with Ramelteon.
Darifenacin Darifenacin Zaleplon may increase the central nervous system depressant (CNS depressant) activities of Darifenacin.
Fentanyl Fentanyl The risk or severity of adverse effects can be increased when Fentanyl is combined with Zaleplon.
Pregabalin Pregabalin The therapeutic efficacy of Zaleplon can be increased when used in combination with Pregabalin.
Felbamate Felbamate The risk or severity of adverse effects can be increased when Felbamate is combined with Zaleplon.
Ranolazine Ranolazine Ranolazine may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Abatacept Injection Abatacept Injection The metabolism of Zaleplon can be increased when combined with Abatacept.
Rasagiline Rasagiline Zaleplon may increase the central nervous system depressant (CNS depressant) activities of Rasagiline.
Imatinib Imatinib The metabolism of Zaleplon can be decreased when combined with Imatinib.
Sitagliptin Sitagliptin Zaleplon may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Varenicline Varenicline Zaleplon may decrease the excretion rate of Varenicline which could result in a higher serum level.
Gefitinib Gefitinib The metabolism of Zaleplon can be decreased when combined with Gefitinib.
Albuterol Albuterol Zaleplon may decrease the excretion rate of Salbutamol which could result in a higher serum level.
Paliperidone Paliperidone The risk or severity of adverse effects can be increased when Zaleplon is combined with Paliperidone.
Clofarabine Injection Clofarabine Injection Clofarabine may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Lubiprostone Lubiprostone Zaleplon may decrease the excretion rate of Lubiprostone which could result in a higher serum level.
Pemetrexed Injection Pemetrexed Injection Zaleplon may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Dimenhydrinate Dimenhydrinate The risk or severity of adverse effects can be increased when Zaleplon is combined with Dimenhydrinate.
Nabilone Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Zaleplon.
Sorafenib Sorafenib The metabolism of Zaleplon can be decreased when combined with Sorafenib.
Sunitinib Sunitinib The metabolism of Sunitinib can be decreased when combined with Zaleplon.
Dronabinol Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Zaleplon.
Lapatinib Lapatinib The metabolism of Lapatinib can be decreased when combined with Zaleplon.
Levocetirizine Levocetirizine The risk or severity of adverse effects can be increased when Zaleplon is combined with Levocetirizine.
Pegaptanib Injection Pegaptanib Injection Zaleplon may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Dasatinib Dasatinib The metabolism of Dasatinib can be decreased when combined with Zaleplon.
Armodafinil Armodafinil The metabolism of Zaleplon can be increased when combined with Armodafinil.
Azacitidine Injection Azacitidine Injection Azacitidine may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Temsirolimus Temsirolimus The metabolism of Temsirolimus can be decreased when combined with Zaleplon.
Lenalidomide Lenalidomide Lenalidomide may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Budesonide Budesonide The metabolism of Zaleplon can be increased when combined with Budesonide.
Chloramphenicol Injection Chloramphenicol Injection The metabolism of Zaleplon can be decreased when combined with Chloramphenicol.
Desmopressin Desmopressin Desmopressin may decrease the excretion rate of Zaleplon which could result in a higher serum level.
OnabotulinumtoxinA Injection OnabotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Zaleplon.
RimabotulinumtoxinB Injection RimabotulinumtoxinB Injection The risk or severity of adverse effects can be increased when Botulinum Toxin Type B is combined with Zaleplon.
Doripenem Injection Doripenem Injection Zaleplon may decrease the excretion rate of Doripenem which could result in a higher serum level.
Arsenic Trioxide Injection Arsenic Trioxide Injection Zaleplon may decrease the excretion rate of Arsenic trioxide which could result in a higher serum level.
Desvenlafaxine Desvenlafaxine The risk or severity of adverse effects can be increased when Zaleplon is combined with Desvenlafaxine.
Cevimeline Cevimeline Cevimeline may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Tretinoin Tretinoin The metabolism of Zaleplon can be decreased when combined with Tretinoin.
Certolizumab Injection Certolizumab Injection The metabolism of Zaleplon can be increased when combined with Certolizumab pegol.
Irinotecan Injection Irinotecan Injection The metabolism of Zaleplon can be decreased when combined with Irinotecan.
Daptomycin Injection Daptomycin Injection Daptomycin may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Praziquantel Praziquantel The metabolism of Praziquantel can be decreased when combined with Zaleplon.
Methylnaltrexone Injection Methylnaltrexone Injection Zaleplon may decrease the excretion rate of Methylnaltrexone which could result in a higher serum level.
Rufinamide Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Zaleplon.
Midazolam Midazolam The risk or severity of adverse effects can be increased when Midazolam is combined with Zaleplon.
Dexrazoxane Injection Dexrazoxane Injection Dexrazoxane may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Milnacipran Milnacipran The risk or severity of adverse effects can be increased when Zaleplon is combined with Milnacipran.
Plerixafor Injection Plerixafor Injection Zaleplon may decrease the excretion rate of Plerixafor which could result in a higher serum level.
Sodium Phosphate Sodium Phosphate The therapeutic efficacy of Zaleplon can be decreased when used in combination with Sodium phosphate, monobasic.
Fesoterodine Fesoterodine Zaleplon may increase the central nervous system depressant (CNS depressant) activities of Fesoterodine.
Iloperidone Iloperidone The risk or severity of adverse effects can be increased when Zaleplon is combined with Iloperidone.
Prasugrel Prasugrel Zaleplon may decrease the excretion rate of Prasugrel which could result in a higher serum level.
Lacosamide Lacosamide The risk or severity of adverse effects can be increased when Zaleplon is combined with Lacosamide.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) Tolvaptan may increase the excretion rate of Zaleplon which could result in a lower serum level and potentially a reduction in efficacy.
Dronedarone Dronedarone The metabolism of Zaleplon can be decreased when combined with Dronedarone.
AbobotulinumtoxinA Injection AbobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Zaleplon.
Pralatrexate Injection Pralatrexate Injection Zaleplon may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
Palonosetron Injection Palonosetron Injection Palonosetron may increase the central nervous system depressant (CNS depressant) activities of Zaleplon.
Saxagliptin Saxagliptin Zaleplon may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
Telavancin Injection Telavancin Injection Zaleplon may decrease the excretion rate of Telavancin which could result in a higher serum level.
Romidepsin Injection Romidepsin Injection The metabolism of Romidepsin can be decreased when combined with Zaleplon.
Tapentadol Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Zaleplon.
Topotecan Topotecan Zaleplon may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Golimumab Injection Golimumab Injection The metabolism of Zaleplon can be increased when combined with Golimumab.
Asenapine Asenapine The risk or severity of adverse effects can be increased when Zaleplon is combined with Asenapine.
Vigabatrin Vigabatrin The risk or severity of adverse effects can be increased when Zaleplon is combined with Vigabatrin.
Ulipristal Ulipristal The metabolism of Ulipristal can be increased when combined with Zaleplon.
Levonorgestrel Levonorgestrel The metabolism of Zaleplon can be increased when combined with Levonorgestrel.
Oxymorphone Oxymorphone The risk or severity of adverse effects can be increased when Zaleplon is combined with Oxymorphone.
Tocilizumab Injection Tocilizumab Injection The metabolism of Zaleplon can be increased when combined with Tocilizumab.
Dalfampridine Dalfampridine Zaleplon may decrease the excretion rate of Dalfampridine which could result in a higher serum level.
IncobotulinumtoxinA Injection IncobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Zaleplon.
Cabazitaxel Injection Cabazitaxel Injection The metabolism of Cabazitaxel can be decreased when combined with Zaleplon.
Ceftaroline Injection Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Lurasidone Lurasidone The risk or severity of adverse effects can be increased when Zaleplon is combined with Lurasidone.
Acetaminophen Injection Acetaminophen Injection Acetaminophen may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Vilazodone Vilazodone The risk or severity of adverse effects can be increased when Zaleplon is combined with Vilazodone.
Ipilimumab Injection Ipilimumab Injection Zaleplon may decrease the excretion rate of Ipilimumab which could result in a higher serum level.
Denileukin Diftitox Injection Denileukin Diftitox Injection Aldesleukin may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Terbutaline Injection Terbutaline Injection Terbutaline may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Roflumilast Roflumilast Zaleplon may decrease the excretion rate of Roflumilast which could result in a higher serum level.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Zaleplon can be decreased when combined with Cyclophosphamide.
Rivaroxaban Rivaroxaban Zaleplon may decrease the excretion rate of Rivaroxaban which could result in a higher serum level.
Ruxolitinib Ruxolitinib Zaleplon may decrease the excretion rate of Ruxolitinib which could result in a higher serum level.
Clobazam Clobazam The risk or severity of adverse effects can be increased when Clobazam is combined with Zaleplon.
Ivacaftor Ivacaftor The metabolism of Ivacaftor can be decreased when combined with Zaleplon.
Deferiprone Deferiprone Zaleplon may decrease the excretion rate of Deferiprone which could result in a higher serum level.
Axitinib Axitinib The metabolism of Axitinib can be decreased when combined with Zaleplon.
Crizotinib Crizotinib The metabolism of Zaleplon can be decreased when combined with Crizotinib.
Cabergoline Cabergoline The risk or severity of adverse effects can be increased when Cabergoline is combined with Zaleplon.
Naloxone Injection Naloxone Injection Zaleplon may decrease the excretion rate of Naloxone which could result in a higher serum level.
Ambrisentan Ambrisentan The metabolism of Ambrisentan can be decreased when combined with Zaleplon.
Fondaparinux Injection Fondaparinux Injection Fondaparinux may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Ezogabine Ezogabine The risk or severity of adverse effects can be increased when Tiagabine is combined with Zaleplon.
Enzalutamide Enzalutamide Zaleplon may decrease the excretion rate of Enzalutamide which could result in a higher serum level.
Mirabegron Mirabegron Zaleplon may decrease the excretion rate of Mirabegron which could result in a higher serum level.
Teduglutide Injection Teduglutide Injection Zaleplon may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Alogliptin Alogliptin Zaleplon may decrease the excretion rate of Alogliptin which could result in a higher serum level.
Ponatinib Ponatinib The metabolism of Ponatinib can be decreased when combined with Zaleplon.
Pomalidomide Pomalidomide The risk or severity of adverse effects can be increased when Zaleplon is combined with Pomalidomide.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The metabolism of Trastuzumab emtansine can be decreased when combined with Zaleplon.
Apixaban Apixaban The metabolism of Apixaban can be decreased when combined with Zaleplon.
Canagliflozin Canagliflozin Zaleplon may increase the excretion rate of Canagliflozin which could result in a lower serum level and potentially a reduction in efficacy.
Methazolamide Methazolamide Methazolamide may increase the excretion rate of Zaleplon which could result in a lower serum level and potentially a reduction in efficacy.
Trametinib Trametinib Zaleplon may decrease the excretion rate of Trametinib which could result in a higher serum level.
Levomilnacipran Levomilnacipran The risk or severity of adverse effects can be increased when Zaleplon is combined with Levomilnacipran.
Ertapenem Injection Ertapenem Injection Ertapenem may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Vortioxetine Vortioxetine Zaleplon may increase the central nervous system depressant (CNS depressant) activities of Vortioxetine.
Perampanel Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Zaleplon.
Ibrutinib Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Zaleplon.
Ketorolac Injection Ketorolac Injection Ketorolac may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Sofosbuvir Sofosbuvir Zaleplon may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Dapagliflozin Dapagliflozin Dapagliflozin may increase the excretion rate of Zaleplon which could result in a lower serum level and potentially a reduction in efficacy.
Apremilast Apremilast The metabolism of Zaleplon can be increased when combined with Apremilast.
Droxidopa Droxidopa Zaleplon may decrease the excretion rate of Droxidopa which could result in a higher serum level.
Siltuximab Injection Siltuximab Injection The metabolism of Zaleplon can be increased when combined with Siltuximab.
Eslicarbazepine Eslicarbazepine The risk or severity of adverse effects can be increased when Zaleplon is combined with Eslicarbazepine.
Testosterone Injection Testosterone Injection Testosterone may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Hydrocodone Hydrocodone Zaleplon may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Suvorexant Suvorexant Zaleplon may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Edoxaban Edoxaban Zaleplon may decrease the excretion rate of Edoxaban which could result in a higher serum level.
Olaparib Olaparib The metabolism of Olaparib can be decreased when combined with Zaleplon.
Methamphetamine Methamphetamine Zaleplon may increase the central nervous system depressant (CNS depressant) activities of Metamfetamine.
Tasimelteon Tasimelteon The risk or severity of adverse effects can be increased when Zaleplon is combined with Tasimelteon.
Secukinumab Injection Secukinumab Injection The metabolism of Zaleplon can be increased when combined with Secukinumab.
Risperidone Injection Risperidone Injection The risk or severity of adverse effects can be increased when Risperidone is combined with Zaleplon.
Haloperidol Injection Haloperidol Injection The risk or severity of CNS depression can be increased when Haloperidol is combined with Zaleplon.
Amiloride Amiloride Amiloride may increase the excretion rate of Zaleplon which could result in a lower serum level and potentially a reduction in efficacy.
Macitentan Macitentan Zaleplon may decrease the excretion rate of Macitentan which could result in a higher serum level.
Flibanserin Flibanserin The risk or severity of adverse effects can be increased when Zaleplon is combined with Flibanserin.
Daclatasvir Daclatasvir The metabolism of Daclatasvir can be decreased when combined with Zaleplon.
Brexpiprazole Brexpiprazole The risk or severity of adverse effects can be increased when Zaleplon is combined with Brexpiprazole.
Ziprasidone Injection Ziprasidone Injection The risk or severity of adverse effects can be increased when Ziprasidone is combined with Zaleplon.
Cariprazine Cariprazine The risk or severity of adverse effects can be increased when Zaleplon is combined with Cariprazine.
Penicillin G Procaine Injection Penicillin G Procaine Injection Zaleplon may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level.
Ixazomib Ixazomib Zaleplon may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Lesinurad Lesinurad Zaleplon may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection Amphotericin B may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Dexamethasone Injection Dexamethasone Injection The metabolism of Zaleplon can be increased when combined with Dexamethasone.
Brivaracetam Injection Brivaracetam Injection The risk or severity of adverse effects can be increased when Zaleplon is combined with Brivaracetam.
Cobicistat Cobicistat The metabolism of Zaleplon can be decreased when combined with Cobicistat.
Pimavanserin Pimavanserin The risk or severity of adverse effects can be increased when Zaleplon is combined with Pimavanserin.
Diphenhydramine Injection Diphenhydramine Injection The risk or severity of adverse effects can be increased when Zaleplon is combined with Diphenhydramine.
Furosemide Injection Furosemide Injection Furosemide may increase the excretion rate of Zaleplon which could result in a lower serum level and potentially a reduction in efficacy.
Rucaparib Rucaparib The metabolism of Zaleplon can be decreased when combined with Rucaparib.
Lixisenatide Injection Lixisenatide Injection Zaleplon may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Doxepin (Insomnia) Doxepin (Insomnia) Zaleplon may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Deutetrabenazine Deutetrabenazine The risk or severity of sedation and somnolence can be increased when Zaleplon is combined with Deutetrabenazine.
Valbenazine Valbenazine Zaleplon may decrease the excretion rate of Valbenazine which could result in a higher serum level.
Deflazacort Deflazacort The metabolism of Zaleplon can be increased when combined with Deflazacort.
Safinamide Safinamide The risk or severity of adverse effects can be increased when Zaleplon is combined with Safinamide.
Naldemedine Naldemedine Zaleplon may decrease the excretion rate of Naldemedine which could result in a higher serum level.
Midostaurin Midostaurin The metabolism of Zaleplon can be increased when combined with Midostaurin.
Benznidazole Benznidazole Zaleplon may decrease the excretion rate of Benznidazole which could result in a higher serum level.
Copanlisib Injection Copanlisib Injection The metabolism of Copanlisib can be decreased when combined with Zaleplon.
Delafloxacin Delafloxacin Zaleplon may decrease the excretion rate of Delafloxacin which could result in a higher serum level.
Acalabrutinib Acalabrutinib The metabolism of Zaleplon can be decreased when combined with Acalabrutinib.
Letermovir Letermovir The metabolism of Zaleplon can be decreased when combined with Letermovir.
Tetrabenazine Tetrabenazine The risk or severity of sedation and somnolence can be increased when Zaleplon is combined with Tetrabenazine.
Ertugliflozin Ertugliflozin Ertugliflozin may increase the excretion rate of Zaleplon which could result in a lower serum level and potentially a reduction in efficacy.
Buprenorphine Injection Buprenorphine Injection Zaleplon may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Apalutamide Apalutamide Zaleplon may decrease the excretion rate of Apalutamide which could result in a higher serum level.
Baricitinib Baricitinib Zaleplon may decrease the excretion rate of Baricitinib which could result in a higher serum level.
Lofexidine Lofexidine The therapeutic efficacy of Zaleplon can be increased when used in combination with Lofexidine.
Plazomicin Injection Plazomicin Injection Zaleplon may decrease the excretion rate of Plazomicin which could result in a higher serum level.
Doravirine Doravirine The metabolism of Doravirine can be decreased when combined with Zaleplon.
Cannabidiol Cannabidiol The risk or severity of adverse effects can be increased when Cannabidiol is combined with Zaleplon.
Stiripentol Stiripentol The risk or severity of adverse effects can be increased when Zaleplon is combined with Stiripentol.
Lorlatinib Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Zaleplon.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Zaleplon.
Prucalopride Prucalopride Zaleplon may decrease the excretion rate of Prucalopride which could result in a higher serum level.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Zaleplon can be increased when combined with Emapalumab.
Acyclovir Ophthalmic Acyclovir Ophthalmic Acyclovir may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Brexanolone Injection Brexanolone Injection The risk or severity of adverse effects can be increased when Zaleplon is combined with Brexanolone.
Solriamfetol Solriamfetol The risk or severity of adverse effects can be increased when Zaleplon is combined with Solriamfetol.
Istradefylline Istradefylline The metabolism of Istradefylline can be decreased when combined with Zaleplon.
Pitolisant Pitolisant The serum concentration of Zaleplon can be decreased when it is combined with Pitolisant.
Phenytoin Injection Phenytoin Injection The metabolism of Zaleplon can be increased when combined with Phenytoin.
Fosphenytoin Injection Fosphenytoin Injection The risk or severity of adverse effects can be increased when Zaleplon is combined with Fosphenytoin.
Lumateperone Lumateperone The risk or severity of adverse effects can be increased when Zaleplon is combined with Lumateperone.
Lasmiditan Lasmiditan The risk or severity of adverse effects can be increased when Zaleplon is combined with Lasmiditan.
Cenobamate Cenobamate The serum concentration of Zaleplon can be decreased when it is combined with Cenobamate.
Selumetinib Selumetinib The metabolism of Selumetinib can be decreased when combined with Zaleplon.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Zaleplon.
Lemborexant Lemborexant The risk or severity of adverse effects can be increased when Zaleplon is combined with Lemborexant.
Fenfluramine Fenfluramine The risk or severity of adverse effects can be increased when Fenfluramine is combined with Zaleplon.
Pralsetinib Pralsetinib The metabolism of Zaleplon can be decreased when combined with Pralsetinib.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Zaleplon can be decreased when it is combined with Satralizumab.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Drospirenone can be increased when combined with Zaleplon.
Viloxazine Viloxazine Zaleplon may increase the central nervous system depressant (CNS depressant) activities of Viloxazine.
Tobramycin Injection Tobramycin Injection Tobramycin may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Theophylline Theophylline Zaleplon may increase the excretion rate of Theophylline which could result in a lower serum level and potentially a reduction in efficacy.
Fenoprofen Fenoprofen Fenoprofen may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Indomethacin Indomethacin Indomethacin may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Mefenamic Acid Mefenamic Acid Mefenamic acid may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Naproxen Naproxen Naproxen may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Tolmetin Tolmetin Tolmetin may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Sulindac Sulindac Sulindac may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Trazodone Trazodone The risk or severity of adverse effects can be increased when Zaleplon is combined with Trazodone.
Isotretinoin Isotretinoin Zaleplon may decrease the excretion rate of Isotretinoin which could result in a higher serum level.
Sucralfate Sucralfate Sucralfate may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Floxuridine Floxuridine Floxuridine may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Phenobarbital Phenobarbital The metabolism of Zaleplon can be increased when combined with Phenobarbital.
Metaxalone Metaxalone The risk or severity of adverse effects can be increased when Metaxalone is combined with Zaleplon.
Methotrexate Injection Methotrexate Injection Methotrexate may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Levorphanol Levorphanol The risk or severity of adverse effects can be increased when Levorphanol is combined with Zaleplon.
Primidone Primidone The risk or severity of adverse effects can be increased when Primidone is combined with Zaleplon.
Methsuximide Methsuximide The risk or severity of adverse effects can be increased when Zaleplon is combined with Methsuximide.
Diethylpropion Diethylpropion The risk or severity of adverse effects can be increased when Diethylpropion is combined with Zaleplon.
Chlorpromazine Chlorpromazine The risk or severity of adverse effects can be increased when Chlorpromazine is combined with Zaleplon.
Diazepam Diazepam The risk or severity of adverse effects can be increased when Diazepam is combined with Zaleplon.
Oxazepam Oxazepam The risk or severity of adverse effects can be increased when Oxazepam is combined with Zaleplon.
Flurazepam Flurazepam The risk or severity of adverse effects can be increased when Flurazepam is combined with Zaleplon.
Clorazepate Clorazepate The risk or severity of adverse effects can be increased when Clorazepic acid is combined with Zaleplon.
Lorazepam Lorazepam The risk or severity of adverse effects can be increased when Lorazepam is combined with Zaleplon.
Carmustine Carmustine Carmustine may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Amantadine Amantadine Amantadine may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Codeine Codeine The risk or severity of adverse effects can be increased when Codeine is combined with Zaleplon.
Meprobamate Meprobamate The risk or severity of adverse effects can be increased when Meprobamate is combined with Zaleplon.
Chlordiazepoxide Chlordiazepoxide The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Zaleplon.
Bromocriptine Bromocriptine The risk or severity of adverse effects can be increased when Zaleplon is combined with Bromocriptine.
Tranylcypromine Tranylcypromine The risk or severity of adverse effects can be increased when Tranylcypromine is combined with Zaleplon.
Phenelzine Phenelzine The risk or severity of adverse effects can be increased when Phenelzine is combined with Zaleplon.
Procarbazine Procarbazine The risk or severity of adverse effects can be increased when Zaleplon is combined with Procarbazine.
Ergoloid Mesylates Ergoloid Mesylates The risk or severity of adverse effects can be increased when Zaleplon is combined with Ergoloid mesylate.
Tetracycline Tetracycline Tetracycline may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Minocycline Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Zaleplon.
Prochlorperazine Prochlorperazine The risk or severity of adverse effects can be increased when Prochlorperazine is combined with Zaleplon.
Thioridazine Thioridazine The risk or severity of adverse effects can be increased when Thioridazine is combined with Zaleplon.
Trifluoperazine Trifluoperazine The risk or severity of adverse effects can be increased when Trifluoperazine is combined with Zaleplon.
Bleomycin Bleomycin Bleomycin may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Dapsone Dapsone The metabolism of Zaleplon can be decreased when combined with Dapsone.
Sulfadiazine Sulfadiazine Sulfadiazine may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Oxycodone Oxycodone The risk or severity of adverse effects can be increased when Oxycodone is combined with Zaleplon.
Methadone Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Zaleplon.
Oxybutynin Oxybutynin Zaleplon may increase the central nervous system depressant (CNS depressant) activities of Oxybutynin.
Benztropine Benztropine Zaleplon may increase the central nervous system depressant (CNS depressant) activities of Benzatropine.
Maprotiline Maprotiline Zaleplon may increase the central nervous system depressant (CNS depressant) activities of Maprotiline.
Ibuprofen Ibuprofen Ibuprofen may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Trihexyphenidyl Trihexyphenidyl Zaleplon may increase the central nervous system depressant (CNS depressant) activities of Trihexyphenidyl.
Orphenadrine Orphenadrine Zaleplon may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Perphenazine Perphenazine The risk or severity of adverse effects can be increased when Perphenazine is combined with Zaleplon.
Azathioprine Azathioprine Zaleplon may decrease the excretion rate of Azathioprine which could result in a higher serum level.
Fluphenazine Fluphenazine The risk or severity of adverse effects can be increased when Fluphenazine is combined with Zaleplon.
Methylphenidate Methylphenidate The therapeutic efficacy of Zaleplon can be decreased when used in combination with Methylphenidate.
Amoxapine Amoxapine Zaleplon may increase the central nervous system depressant (CNS depressant) activities of Amoxapine.
Sulfasalazine Sulfasalazine Sulfasalazine may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Hydrocortisone Hydrocortisone The metabolism of Zaleplon can be decreased when combined with Hydrocortisone.
Phenazopyridine Phenazopyridine Phenazopyridine may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Carbamazepine Carbamazepine Carbamazepine may increase the Change in thyroid function activities of Zaleplon.
Molindone Molindone The risk or severity of adverse effects can be increased when Zaleplon is combined with Molindone.
Methyldopa Methyldopa Zaleplon may decrease the excretion rate of Methyldopa which could result in a higher serum level.
Clonidine Clonidine The risk or severity of sedation can be increased when Clonidine is combined with Zaleplon.
Hydralazine Hydralazine Zaleplon may decrease the excretion rate of Hydralazine which could result in a higher serum level.
Cimetidine Cimetidine The metabolism of Zaleplon can be decreased when combined with Cimetidine.
Gentamicin Injection Gentamicin Injection Gentamicin may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Warfarin Warfarin Warfarin may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Clonazepam Clonazepam The risk or severity of adverse effects can be increased when Zaleplon is combined with Clonazepam.
Promethazine Promethazine The risk or severity of adverse effects can be increased when Zaleplon is combined with Promethazine.
Meclofenamate Meclofenamate Meclofenamic acid may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Daunorubicin Daunorubicin The metabolism of Zaleplon can be increased when combined with Daunorubicin.
Nitrofurantoin Nitrofurantoin Nitrofurantoin may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Digoxin Digoxin Zaleplon may decrease the excretion rate of Digoxin which could result in a higher serum level.
Loxapine Loxapine The risk or severity of adverse effects can be increased when Loxapine is combined with Zaleplon.
Chloroquine Chloroquine The therapeutic efficacy of Zaleplon can be decreased when used in combination with Chloroquine.
Quinine Quinine The risk or severity of adverse effects can be increased when Quinine is combined with Zaleplon.
Ethosuximide Ethosuximide The risk or severity of adverse effects can be increased when Ethosuximide is combined with Zaleplon.
Triamterene Triamterene Triamterene may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Chlorothiazide Chlorothiazide Chlorothiazide may increase the excretion rate of Zaleplon which could result in a lower serum level and potentially a reduction in efficacy.
Chlorthalidone Chlorthalidone Chlorthalidone may increase the excretion rate of Zaleplon which could result in a lower serum level and potentially a reduction in efficacy.
Metolazone Metolazone Metolazone may increase the excretion rate of Zaleplon which could result in a lower serum level and potentially a reduction in efficacy.
Isosorbide Isosorbide The metabolism of Zaleplon can be increased when combined with Isosorbide.
Clindamycin Injection Clindamycin Injection The metabolism of Clindamycin can be decreased when combined with Zaleplon.
Secobarbital Secobarbital The risk or severity of adverse effects can be increased when Secobarbital is combined with Zaleplon.
Desipramine Desipramine Zaleplon may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Amitriptyline Amitriptyline Zaleplon may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Imipramine Imipramine Zaleplon may increase the central nervous system depressant (CNS depressant) activities of Imipramine.
Probenecid Probenecid Zaleplon may decrease the excretion rate of Probenecid which could result in a higher serum level.
Quinidine Quinidine The metabolism of Quinidine can be decreased when combined with Zaleplon.
Procainamide Procainamide Zaleplon may decrease the excretion rate of Procainamide which could result in a higher serum level.
Isoniazid Isoniazid The therapeutic efficacy of Zaleplon can be decreased when used in combination with Isoniazid.
Pyrazinamide Pyrazinamide Pyrazinamide may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Rifampin Rifampin The metabolism of Zaleplon can be increased when combined with Rifampicin.
Disopyramide Disopyramide Zaleplon may increase the central nervous system depressant (CNS depressant) activities of Disopyramide.
Valproic Acid Valproic Acid The risk or severity of adverse effects can be increased when Valproic acid is combined with Zaleplon.
Tamoxifen Tamoxifen The metabolism of Zaleplon can be decreased when combined with Tamoxifen.
Butabarbital Butabarbital The risk or severity of adverse effects can be increased when Butabarbital is combined with Zaleplon.
Liothyronine Liothyronine Liothyronine may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Methimazole Methimazole Methimazole may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Chlorpropamide Chlorpropamide Chlorpropamide may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Tolbutamide Tolbutamide Zaleplon may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Tolazamide Tolazamide Tolazamide may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Dextromethorphan Dextromethorphan The risk or severity of adverse effects can be increased when Dextromethorphan is combined with Zaleplon.
Cyclobenzaprine Cyclobenzaprine The risk or severity of CNS depression can be increased when Zaleplon is combined with Cyclobenzaprine.
Baclofen Baclofen The risk or severity of adverse effects can be increased when Baclofen is combined with Zaleplon.
Doxylamine Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Zaleplon.
Cyproheptadine Cyproheptadine Zaleplon may increase the central nervous system depressant (CNS depressant) activities of Cyproheptadine.
Clemastine Clemastine The risk or severity of adverse effects can be increased when Clemastine is combined with Zaleplon.
Chlorpheniramine Chlorpheniramine The risk or severity of adverse effects can be increased when Zaleplon is combined with Chlorpheniramine.
Brompheniramine Brompheniramine The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Zaleplon.
Meclizine Meclizine The risk or severity of adverse effects can be increased when Meclizine is combined with Zaleplon.
Ethambutol Ethambutol Ethambutol may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Methyclothiazide Methyclothiazide Methyclothiazide may increase the excretion rate of Zaleplon which could result in a lower serum level and potentially a reduction in efficacy.
Hydrochlorothiazide Hydrochlorothiazide Hydrochlorothiazide may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Dantrolene Dantrolene The risk or severity of adverse effects can be increased when Zaleplon is combined with Dantrolene.
Chlorzoxazone Chlorzoxazone The risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Zaleplon.
Carisoprodol Carisoprodol The risk or severity of adverse effects can be increased when Carisoprodol is combined with Zaleplon.
Methocarbamol Methocarbamol The risk or severity of adverse effects can be increased when Methocarbamol is combined with Zaleplon.
Pyridoxine Pyridoxine Pyridoxine may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Folic Acid Folic Acid Folic acid may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Disulfiram Disulfiram The therapeutic efficacy of Zaleplon can be decreased when used in combination with Disulfiram.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) Propranolol may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Nortriptyline Nortriptyline Zaleplon may increase the central nervous system depressant (CNS depressant) activities of Nortriptyline.
Spironolactone Spironolactone Spironolactone may increase the excretion rate of Zaleplon which could result in a lower serum level and potentially a reduction in efficacy.
Amphotericin B Injection Amphotericin B Injection Amphotericin B may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Mercaptopurine Mercaptopurine Zaleplon may increase the excretion rate of Mercaptopurine which could result in a lower serum level and potentially a reduction in efficacy.
Phytonadione Phytonadione Zaleplon may decrease the excretion rate of Phylloquinone which could result in a higher serum level.
Amikacin Injection Amikacin Injection Amikacin may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Nadolol Nadolol Zaleplon may decrease the excretion rate of Nadolol which could result in a higher serum level.
Butorphanol Injection Butorphanol Injection The risk or severity of adverse effects can be increased when Butorphanol is combined with Zaleplon.
Nalbuphine Injection Nalbuphine Injection The risk or severity of adverse effects can be increased when Nalbuphine is combined with Zaleplon.
Allopurinol Allopurinol Allopurinol may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Trimethobenzamide Trimethobenzamide The risk or severity of adverse effects can be increased when Trimethobenzamide is combined with Zaleplon.
Flavoxate Flavoxate Zaleplon may increase the central nervous system depressant (CNS depressant) activities of Flavoxate.
Colchicine Colchicine Zaleplon may decrease the excretion rate of Colchicine which could result in a higher serum level.
Cefaclor Cefaclor Cefaclor may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Cefadroxil Cefadroxil Cefadroxil may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Cefazolin Injection Cefazolin Injection Cefazolin may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Cephalexin Cephalexin Cephalexin may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Cefoxitin Injection Cefoxitin Injection Cefoxitin may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Dacarbazine Dacarbazine Dacarbazine may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Acetazolamide Acetazolamide The risk or severity of adverse effects can be increased when Acetazolamide is combined with Zaleplon.
Cefotaxime Injection Cefotaxime Injection Cefotaxime may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Calcitonin Salmon Injection Calcitonin Salmon Injection Salmon calcitonin may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Ketoconazole Ketoconazole The metabolism of Zaleplon can be decreased when combined with Ketoconazole.
Pyrantel Pyrantel The risk or severity of adverse effects can be increased when Zaleplon is combined with Pyrantel.
Vincristine Injection Vincristine Injection The metabolism of Zaleplon can be decreased when combined with Vincristine.
Ethacrynic Acid Ethacrynic Acid Etacrynic acid may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Colistimethate Injection Colistimethate Injection Colistimethate may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Metoprolol Metoprolol Metoprolol may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Hydroxyzine Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Zaleplon.
Thiothixene Thiothixene The risk or severity of adverse effects can be increased when Zaleplon is combined with Thiothixene.
Aspirin Aspirin Acetylsalicylic acid may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Salsalate Salsalate Salsalate may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Chlorambucil Chlorambucil The therapeutic efficacy of Zaleplon can be decreased when used in combination with Chlorambucil.
Alprazolam Alprazolam The risk or severity of adverse effects can be increased when Alprazolam is combined with Zaleplon.
Temazepam Temazepam The risk or severity of adverse effects can be increased when Temazepam is combined with Zaleplon.
Triazolam Triazolam The risk or severity of adverse effects can be increased when Triazolam is combined with Zaleplon.
Dicyclomine Dicyclomine Zaleplon may increase the central nervous system depressant (CNS depressant) activities of Dicyclomine.
Hyoscyamine Hyoscyamine Zaleplon may increase the central nervous system depressant (CNS depressant) activities of Hyoscyamine.
Propantheline Propantheline Zaleplon may increase the central nervous system depressant (CNS depressant) activities of Propantheline.
Trimethoprim Trimethoprim Trimethoprim may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Diltiazem Diltiazem The metabolism of Zaleplon can be decreased when combined with Diltiazem.
Nifedipine Nifedipine Zaleplon may decrease the excretion rate of Nifedipine which could result in a higher serum level.
Timolol Timolol Timolol may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Verapamil Verapamil The metabolism of Zaleplon can be decreased when combined with Verapamil.
Pindolol Pindolol Pindolol may increase the central nervous system depressant (CNS depressant) activities of Zaleplon.
Cisplatin Injection Cisplatin Injection Zaleplon may decrease the excretion rate of Cisplatin which could result in a higher serum level.
Diflunisal Diflunisal Diflunisal may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Piroxicam Piroxicam Piroxicam may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Bumetanide Bumetanide Bumetanide may increase the excretion rate of Zaleplon which could result in a lower serum level and potentially a reduction in efficacy.
Etoposide Etoposide The metabolism of Zaleplon can be decreased when combined with Etoposide.
Glyburide Glyburide The metabolism of Glyburide can be decreased when combined with Zaleplon.
Glipizide Glipizide Zaleplon may decrease the excretion rate of Glipizide which could result in a higher serum level.
Indapamide Indapamide Indapamide may increase the excretion rate of Zaleplon which could result in a lower serum level and potentially a reduction in efficacy.
Amoxicillin Amoxicillin Zaleplon may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
Oxacillin Injection Oxacillin Injection Oxacillin may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Pentoxifylline Pentoxifylline Zaleplon may increase the excretion rate of Pentoxifylline which could result in a lower serum level and potentially a reduction in efficacy.
Pentamidine Injection Pentamidine Injection Pentamidine may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Ceftriaxone Injection Ceftriaxone Injection Ceftriaxone may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Labetalol Labetalol Labetalol may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Auranofin Auranofin Zaleplon may decrease the excretion rate of Auranofin which could result in a higher serum level.
Leuprolide Injection Leuprolide Injection Leuprolide may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Gemfibrozil Gemfibrozil Zaleplon may decrease the excretion rate of Gemfibrozil which could result in a higher serum level.
Dipivefrin Ophthalmic Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Ceftazidime Injection Ceftazidime Injection Ceftazidime may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Ketoprofen Ketoprofen Ketoprofen may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Cefotetan Injection Cefotetan Injection Cefotetan may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Pimozide Pimozide The metabolism of Pimozide can be decreased when combined with Zaleplon.
Flurbiprofen Flurbiprofen Flurbiprofen may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Aztreonam Injection Aztreonam Injection Aztreonam may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Buspirone Buspirone Buspirone may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Lovastatin Lovastatin The metabolism of Zaleplon can be decreased when combined with Lovastatin.
Ciprofloxacin Ciprofloxacin The metabolism of Zaleplon can be decreased when combined with Ciprofloxacin.
Mesalamine Mesalamine Mesalazine may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Diclofenac Diclofenac Diclofenac may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Fluoxetine Fluoxetine Zaleplon may increase the central nervous system depressant (CNS depressant) activities of Fluoxetine.
Clozapine Clozapine The risk or severity of adverse effects can be increased when Clozapine is combined with Zaleplon.
Estazolam Estazolam The risk or severity of adverse effects can be increased when Zaleplon is combined with Estazolam.
Didanosine Didanosine Didanosine may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Pentostatin Injection Pentostatin Injection Pentostatin may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Clarithromycin Clarithromycin The metabolism of Zaleplon can be decreased when combined with Clarithromycin.
Etodolac Etodolac Etodolac may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Felodipine Felodipine The metabolism of Felodipine can be decreased when combined with Zaleplon.
Fosinopril Fosinopril Fosinopril may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Nabumetone Nabumetone Nabumetone may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Simvastatin Simvastatin The metabolism of Zaleplon can be decreased when combined with Simvastatin.
Teniposide Injection Teniposide Injection The metabolism of Zaleplon can be decreased when combined with Teniposide.
Itraconazole Itraconazole The metabolism of Zaleplon can be decreased when combined with Itraconazole.
Lisinopril Lisinopril Lisinopril may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Oxaprozin Oxaprozin Oxaprozin may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Bisoprolol Bisoprolol Bisoprolol may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Zolpidem Zolpidem Zaleplon may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Isradipine Isradipine Isradipine may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Cisapride Cisapride The risk or severity of adverse effects can be increased when Cisapride is combined with Zaleplon.
Gabapentin Gabapentin The risk or severity of adverse effects can be increased when Zaleplon is combined with Gabapentin.
Fluvastatin Fluvastatin The metabolism of Fluvastatin can be decreased when combined with Zaleplon.
Venlafaxine Venlafaxine The risk or severity of adverse effects can be increased when Venlafaxine is combined with Zaleplon.
Fluvoxamine Fluvoxamine The risk or severity of adverse effects can be increased when Zaleplon is combined with Fluvoxamine.
Nefazodone Nefazodone The risk or severity of adverse effects can be increased when Nefazodone is combined with Zaleplon.
Lamotrigine Lamotrigine The risk or severity of adverse effects can be increased when Lamotrigine is combined with Zaleplon.
Valacyclovir Valacyclovir Valaciclovir may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Tramadol Tramadol The risk or severity of CNS depression can be increased when Zaleplon is combined with Tramadol.
Carboplatin Injection Carboplatin Injection Carboplatin may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Ifosfamide Injection Ifosfamide Injection The metabolism of Ifosfamide can be decreased when combined with Zaleplon.
Nicardipine Nicardipine Zaleplon may increase the central nervous system depressant (CNS depressant) activities of Nicardipine.
Bupropion Bupropion The risk or severity of adverse effects can be increased when Zaleplon is combined with Bupropion.
Ticlopidine Ticlopidine Ticlopidine may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Saquinavir Saquinavir The metabolism of Zaleplon can be decreased when combined with Saquinavir.
Metformin Metformin Metformin may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Nisoldipine Nisoldipine Nisoldipine may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Lamivudine Lamivudine Lamivudine may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Riluzole Riluzole The risk or severity of adverse effects can be increased when Riluzole is combined with Zaleplon.
Acarbose Acarbose Acarbose may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Gemcitabine Injection Gemcitabine Injection Gemcitabine may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Indinavir Indinavir The metabolism of Zaleplon can be decreased when combined with Indinavir.
Ritonavir Ritonavir The serum concentration of Zaleplon can be increased when it is combined with Ritonavir.
Docetaxel Injection Docetaxel Injection The metabolism of Docetaxel can be decreased when combined with Zaleplon.
Cidofovir Injection Cidofovir Injection Cidofovir may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Meropenem Injection Meropenem Injection Meropenem may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Clomipramine Clomipramine The risk or severity of adverse effects can be increased when Zaleplon is combined with Clomipramine.
Fosfomycin Fosfomycin Fosfomycin may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Mirtazapine Mirtazapine Zaleplon may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
Topiramate Topiramate The risk or severity of adverse effects can be increased when Topiramate is combined with Zaleplon.
Pramipexole Pramipexole Zaleplon may increase the sedative activities of Pramipexole.
Donepezil Donepezil The risk or severity of adverse effects can be increased when Donepezil is combined with Zaleplon.
Nelfinavir Nelfinavir The metabolism of Zaleplon can be decreased when combined with Nelfinavir.
Nilutamide Nilutamide Nilutamide may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Flutamide Flutamide Flutamide may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Selegiline Selegiline The risk or severity of adverse effects can be increased when Zaleplon is combined with Selegiline.
Sertraline Sertraline The risk or severity of adverse effects can be increased when Zaleplon is combined with Sertraline.
Tamsulosin Tamsulosin Tamsulosin may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Ropinirole Ropinirole Zaleplon may increase the sedative activities of Ropinirole.
Finasteride Finasteride The metabolism of Finasteride can be decreased when combined with Zaleplon.
Quetiapine Quetiapine Zaleplon may increase the central nervous system depressant (CNS depressant) activities of Quetiapine.
Cefepime Injection Cefepime Injection Cefepime may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Cefprozil Cefprozil Cefprozil may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Cefpodoxime Cefpodoxime Cefpodoxime may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Cetirizine Cetirizine The risk or severity of adverse effects can be increased when Cetirizine is combined with Zaleplon.
Paroxetine Paroxetine The risk or severity of adverse effects can be increased when Zaleplon is combined with Paroxetine.
Tolcapone Tolcapone The risk or severity of adverse effects can be increased when Tolcapone is combined with Zaleplon.
Citalopram Citalopram The risk or severity of adverse effects can be increased when Zaleplon is combined with Citalopram.
Capecitabine Capecitabine Zaleplon may decrease the excretion rate of Capecitabine which could result in a higher serum level.
Efavirenz Efavirenz The metabolism of Zaleplon can be increased when combined with Efavirenz.
Abacavir Abacavir Zaleplon may decrease the excretion rate of Abacavir which could result in a higher serum level.
Sildenafil Sildenafil The metabolism of Zaleplon can be decreased when combined with Sildenafil.
Celecoxib Celecoxib Celecoxib may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Rosiglitazone Rosiglitazone Rosiglitazone may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Tolterodine Tolterodine Zaleplon may increase the central nervous system depressant (CNS depressant) activities of Tolterodine.
Thalidomide Thalidomide Zaleplon may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Oseltamivir Oseltamivir Oseltamivir may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Balsalazide Balsalazide Balsalazide may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Nateglinide Nateglinide Nateglinide may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Levetiracetam Levetiracetam The risk or severity of adverse effects can be increased when Zaleplon is combined with Levetiracetam.
Rabeprazole Rabeprazole Zaleplon may decrease the excretion rate of Rabeprazole which could result in a higher serum level.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists

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