Zaleplon

24 interactions 3 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Nalbuphine Injection Hydromorphone Rectal Lacosamide Injection Butorphanol Injection Butorphanol Nasal Spray Midazolam Nasal Spray
23 Major 1 Moderate
All (24) Major (23) Moderate (1)

Major

Zaleplon Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of respiratory and CNS depression Details Zaleplon Abametapir Explained Increased exposure of CYP3A4 substrate Details Zaleplon Buprenorphine Belbuca Explained An increased risk of respiratory depression and CNS depression Details Zaleplon Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Zaleplon Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Zaleplon Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Zaleplon Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Zaleplon Diazepam Nasal Spray Valtoco Increased risk of CNS depression Details Zaleplon Diazepam Rectal Diastat Increased risk of CNS depression Details Zaleplon Esketamine Nasal Spray Spravato Increased risk of sedation Details Zaleplon Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Zaleplon Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression Details Zaleplon Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression Details Zaleplon Ketoconazole Topical Extina® Foam Increased zaleplon exposure Details Zaleplon Lacosamide Injection Motpoly An increased risk of CNS depression Details Zaleplon Letermovir Injection Prevymis Increased CYP3A substrate exposure Details Zaleplon Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Zaleplon Metoclopramide Injection Gimoti Increased risk of CNS depression Details Zaleplon Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Zaleplon Midazolam Nasal Spray Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Zaleplon Midazolam Injection Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Zaleplon Morphine Injection Astramorph® PF Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Zaleplon Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression Details

Moderate

Zaleplon Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.