Medication interaction hub

What Supplements Interact with Indapamide?

Indapamide brand names: Lozol, Lozide. Every interaction below applies to the brands too.

215 Interactions 13 Major 179 Moderate 23 Minor
Curated & coded by · Clinical Pharmacist · Updated October 5, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Indapamide? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Indapamide against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

A water pill like indapamide (Lozol) lowers blood pressure and pulls potassium down, and most of the 215 supplements and herbs on file press on those same levers. Thirteen entries rate major, so this is a list to read with real care rather than skim. The largest group deepens the blood-pressure drop, another compounds the fluid and potassium loss, and a smaller cluster, grapefruit in large amounts included, can stretch the heart's electrical rhythm the way low potassium already does.

Activated charcoal earns its major rating differently, soaking up the medication itself, so the two should be taken well apart. Most of the 179 moderate entries add small extra dips in blood pressure, and only 23 rate minor. The one that surprises people is calcium; because indapamide slows how the kidneys shed it, heavy supplement doses can climb to harmful levels.

— , Clinical Pharmacist · July 18, 2026

Major 13 Moderate 179 Minor 23 No known interaction 1,237

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Indapamide: Top Interactions at a Glance

The Indapamide supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 215 interacting ingredients — plus 1,237 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Indapamide Combinations Today

The Indapamide + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Kiwi + Indapamidei

Clinical research suggests that consuming kiwi reduces systolic and diastolic blood pressure in hypertensive individuals.

Read the full interaction Minor Likelihood Likely Thyroid Extract + Indapamidei

Food and medications can interfere with thyroid hormone absorption.

Read the full interaction Moderate Likelihood Probable Vitamin D + Indapamidei

Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.

Read the full interaction Moderate Likelihood Possible Black Tea + Indapamidei

Theoretically, using black tea with diuretic drugs might increase the risk of hypokalemia.

Read the full interaction Moderate Likelihood Possible Soy + Indapamidei

Theoretically soy protein may have additive effects with antihypertensive drugs and increase the risk of hypotension.

Read the full interaction Moderate Likelihood Probable L-arginine + Indapamidei

Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.

Read the full interaction
The complete list

Every Supplement Checked Against Indapamide

All 1,452 ingredients in our database, ranked by severity — 215 with a Indapamide interaction on file and 1,237 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Indapamide?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Kiwi with Indapamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Clinical research suggests that consuming kiwi reduces systolic and diastolic blood pressure in hypertensive individuals.

Full Kiwi + Indapamide answer

Can you take Thyroid Extract with Indapamide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Food and medications can interfere with thyroid hormone absorption.

Full Thyroid Extract + Indapamide answer

Can you take Vitamin D with Indapamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.

Full Vitamin D + Indapamide answer

Can you take Black Tea with Indapamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, using black tea with diuretic drugs might increase the risk of hypokalemia.

Full Black Tea + Indapamide answer

Can you take Soy with Indapamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically soy protein may have additive effects with antihypertensive drugs and increase the risk of hypotension.

Full Soy + Indapamide answer

Can you take Royal Jelly with Indapamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, royal jelly might increase the risk of hypotension when taken with antihypertensive drugs.

Full Royal Jelly + Indapamide answer

Can you take Saffron with Indapamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of saffron with antihypertensive drugs might have additive effects.

Full Saffron + Indapamide answer

Can you take Sage with Indapamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sage might increase or decrease the effects of antihypertensive drugs.

Full Sage + Indapamide answer

Can you take Sea Buckthorn with Indapamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking sea buckthorn with antihypertensive drugs might increase the risk of hypotension.

Full Sea Buckthorn + Indapamide answer

Can you take Senna with Indapamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, senna might increase the risk of hypokalemia when taken with diuretic drugs.

Full Senna + Indapamide answer

Can you take Slippery Elm with Indapamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Indapamide answer

Can you take Sodium Bicarbonate with Indapamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sodium bicarbonate may increase the risk of hypokalemia in patients taking thiazide diuretics.

Full Sodium Bicarbonate + Indapamide answer

Can you take Squill with Indapamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Squill contains cardiac glycosides.

Full Squill + Indapamide answer

Can you take Star Of Bethlehem with Indapamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking diuretics with star of Bethlehem might increase the risk of toxicity.

Full Star Of Bethlehem + Indapamide answer

Can you take Stinging Nettle with Indapamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining stinging nettle with diuretic drugs may have additive effects.

Full Stinging Nettle + Indapamide answer

Can you take Strophanthus with Indapamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of potassium-depleting diuretics and strophanthus can increase the risk of cardiac glycoside toxicity due to...

Full Strophanthus + Indapamide answer

Can you take Swamp Milkweed with Indapamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, potassium depleting diuretics might increase the risk of toxicity with swamp milkweed.

Full Swamp Milkweed + Indapamide answer

Can you take Theanine with Indapamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theanine might lower blood pressure, potentiating the effects of antihypertensive drugs.

Full Theanine + Indapamide answer

Can you take Tragacanth with Indapamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Indapamide answer

Can you take Tree Turmeric with Indapamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking tree turmeric along with antihypertensive drugs might have additive effects and increase the risk of hypotension.

Full Tree Turmeric + Indapamide answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Indapamide is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Indapamide, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Indapamide sits in 5 interaction categories. Open any one to see what the group means:

Antihypertensive Drugs 119 ingredients

Blood-pressure-lowering medications. Supplements that lower (or raise) blood pressure can amplify or fight these drugs.

119 of the supplement ingredients on this page reach Indapamide through this category.

Diuretic Drugs 73 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

73 of the supplement ingredients on this page reach Indapamide through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Indapamide through this category.

Qt Interval-Prolonging Drugs 13 ingredients

Medications that can affect the heart's electrical rhythm (the QT interval). Supplements with similar effects can add to that risk.

13 of the supplement ingredients on this page reach Indapamide through this category.

Thiazide Diuretics 5 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

5 of the supplement ingredients on this page reach Indapamide through this category.

About Indapamide

Indapamide is a thiazide-type water pill (diuretic) used to treat high blood pressure and to ease salt and fluid retention from congestive heart failure.

Generic name: Indapamide  ·  Brand names: Lozol, Lozide.

See the full Indapamide drug information

Related: does Indapamide deplete any nutrients?

Indapamide has 18 reported nutrient associations in the research literature — see the Indapamide nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Indapamide

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Indapamide.

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Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

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Prefer typing? The interaction checker looks up products by name too.

Products that contain Indapamide-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Indapamide.

TNT Thermanite by GEC Genetic Edge Compounds contains Tyramine Diablos ECA Fire Caps by Innovative Laboratories contains Tyramine Ultimate Burn by Schwartz Laboratories contains Tyramine Final Cutz by Infinite Labs contains Tyramine
Pharmacist Counseling Corner

Indapamide & Supplements: Common Questions

What supplements interact with Indapamide?
Our database currently documents 215 ingredients with a known Indapamide interaction (13 major, 179 moderate, 23 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 215. The highest-ranked right now: American Hellebore, Tyramine, Activated Charcoal.
Which Indapamide supplement interactions are the most serious?
Focus on the major group: American Hellebore, Tyramine, Activated Charcoal, American Mistletoe and Arsenic, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Indapamide?
Plenty of supplements coexist fine with Indapamide; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Lozol have the same supplement interactions as Indapamide?
Yes — Lozol, Lozide all contain Indapamide, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Indapamide deplete any vitamins or nutrients?
It might — Indapamide has 18 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Indapamide nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Indapamide and my other medications?
This page covers Indapamide against supplements and herbal ingredients. Checking Indapamide against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Indapamide drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of October 5, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.