Drug & supplement interaction

Ip-6 + Indapamide

Indapamide brand names: Lozol, Lozide.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 27, 2026
The bottom line No known interaction

We found no known interaction between Ip-6 and Indapamide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Ip-6 and Indapamide

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Indapamide and Ip-6 in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Ip-6 safety at a glance

Ip-6 overall Use caution Generally considered low-risk in food amounts, but supplement safety is not well studied and it can reduce absorption of minerals.
Pregnancy Likely Safe When consumed in amounts commonly found in foods. There is insufficient reliable information available about the safety of IP-6 when used in amounts greater tha... Read the full pregnancy detail
Breastfeeding Likely Safe When consumed in amounts commonly found in foods. There is insufficient reliable information available about the safety of IP-6 when used in amounts greater tha... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Indapamide and Ip-6? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Indapamide

Interactions in our licensed database are recorded against drug classes, not just single drug names. Indapamide is filed under 5 classifications — including thiazide diuretics, diuretic drugs, qt interval-prolonging drugs. Ip-6 has documented interactions with 1 drug class — the most serious being anticoagulant/antiplatelet drugs (moderate) — and none of Indapamide’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Ip-6 Does Interact With Other Medications

Ip-6 has 122 moderate known drug interactions in our database — Indapamide isn’t one of them. If you take anything else, check it against the full list below.

Moderate 122 No known interaction 2,708 (incl. Indapamide)
Taking anything else?

Check Another of Your Medications Against Ip-6

Covers the 2,830 medications we’ve checked against Ip-6. Pick one to open its full report.

What to actually watch for

What Indapamide’s Own FDA Label Lists

This is not an interaction — none of it involves Ip-6. These are the most notable effects listed in the ADVERSE REACTIONS section of Indapamide’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 8 of them are worth acting on rather than waiting out — marked below.

  • Low sodium Worth acting on mentioned in 7.4% of FDA reports for Indapamide
  • Low potassium Worth acting on
  • High blood sugar Worth acting on
  • Chest pain Worth acting on
  • Low mood Worth acting on
  • Hives Worth acting on
  • A higher chance of infection Worth acting on
  • An allergic reaction Worth acting on
  • A change in sex drive
  • Passing urine more often

Showing the 10 most notable of 40 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Indapamide. Read the label on DailyMed › Where a percentage is shown, it is the share of 17,821 voluntary FDA FAERS reports for Indapamide that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Ip-6’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Ip-6 side to compare — that is a limit of the record, not a statement that Ip-6 has no side effects.

Special populations

Ip-6 in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When consumed in amounts commonly found in foods. There is insufficient reliable information available about the safety of IP-6 when used in amounts greater than those found in foods; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Indapamide

This page covers Ip-6 only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Indapamide page lists 215 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Arsenic (major) and Cesium (major).

By severity: 13 major · 179 moderate · 23 minor.

From our pharmacist’s overview on the Indapamide page

“A water pill like indapamide (Lozol) lowers blood pressure and pulls potassium down, and most of the 215 supplements and herbs on file press on those same levers. Thirteen entries rate major, so this is a list to read with real care rather than skim.”

Reviewed by 2 · Jul 18, 2026

Open the Indapamide interaction page

One more smart check

Taking Ip-6 as Part of a Dietary Supplement Product? Check It for Interactions

We hold 189 real supplement products containing Ip-6, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Ip-6. Even though Ip-6 itself has no known interaction with Indapamide, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Ip-6 and Indapamide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Ip-6
Top half

#418 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Indapamide
Top half

#967 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Ip-6 reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Ip-6 and Indapamide records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Ip-6

What is Ip-6?

  • Antioxidant support
  • Cancer prevention interest
  • Kidney stone prevention
  • Heart and immune support
  • Reducing excess iron

IP-6 (inositol hexaphosphate, also called phytic acid or phytate) is a natural compound found in high-fiber plant foods and sold as a supplement, often paired with inositol. It is most studied as an antioxidant and mineral binder, but human evidence for its popular uses—such as cancer prevention—is limited and not conclusive. Talk to your pharmacist or doctor before using it, especially if you have low mineral levels or a chronic condition.

Naturally found in whole grains, legumes, nuts, and seeds; supplements are usually made from rice bran or corn · Capsules, tablets, powders (often combined with inositol)

An interaction check asks whether these two react with each other — it does not ask whether Ip-6 is a good idea for someone in your situation. Here is what our Ip-6 record says about it on its own.

Ip-6: dosing

There is no officially established or standardized dose for IP-6 supplements. Products vary widely, and many combine IP-6 with inositol.The best approach is to follow the directions on the product label and not exceed them.

From our Ip-6 monograph — the full record covers uses, side effects and every documented interaction.

Read the full Ip-6 monograph & all interactions
Medication

About Indapamide

What Is Indapamide Used For?

Brand names: Lozol, Lozide

Indapamide tablets are used to treat high blood pressure (hypertension), either on their own or together with other blood pressure medications. Lowering blood pressure helps reduce the risk of related complications.

Indapamide tablets are also used to treat salt and fluid retention (edema) associated with congestive heart failure. In certain cases, indapamide may also be appropriate during pregnancy when swelling is caused by a medical condition rather than normal pregnancy changes — but routine use in otherwise healthy pregnant women is not recommended.

Most-Reported Side Effects for Indapamide

From FAERS, the FDA’s public side-effect reporting system (17,821 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Hyponatraemia 1,318 reports
Acute kidney injury 949 reports
Dyspnea 920 reports
Dizziness 899 reports
Nausea 881 reports
See full Indapamide drug information
Keep checking

Other Drugs & Ip-6

Browse every other medication we’ve checked against Ip-6 — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
122Moderate
0Minor
2,707No known interaction
122 Moderate 2,707 No interaction
Moderate

122 interactions

Showing 60 of 122 moderate interactions — see all 122 on the Ip-6 page.

No interaction 2,707 drugs checked — show the list

We also checked Ip-6 against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,707 medications checked with no known interaction — see the full Ip-6 list.

See the full Ip-6 interactions page
See every supplement checked against Indapamide, ranked by severity
Evidence & sources

Ip-6 References

The 3 references that drive our Ip-6 monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Steinmetz KA, Potter JD. Vegetables, fruit, and cancer prevention: a review. J Am Diet Assoc 1996;96:1027-39. PubMed
  2. Vucenik I, Podczasy JJ, Shamsuddin AM. Antiplatelet activity of inositol hexaphosphate. Anticancer Res 1999;19:3689-93.
  3. Ikenaga T, Kakumoto K, Kohda N, Yamamoto T. Effect of Inositol Hexaphosphate (IP6) on Serum Uric Acid in Hyperuricemic Subjects: a Randomized, Double-Blind, Placebo-Controlled, Crossover Study. Plant Foods Hum Nutr. 2019 Sep;74(3):316-321. DOI

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Ip-6 and Indapamide Together: Common Questions

Is it safe to take Ip-6 with Indapamide?
We do not list a known interaction between Ip-6 and Indapamide. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Ip-6 and Indapamide combination checked?
Interactions in our licensed database are recorded against drug classes. Indapamide is filed under 5 classifications, and Ip-6 has documented interactions with 1 drug class — none of Indapamide's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Ip-6 interact with any other medications?
Yes. Ip-6 has 122 documented drug interactions in our database — Indapamide is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Indapamide interact with any supplements?
Yes. Indapamide has documented interactions with 215 supplements in our database — Ip-6 is not one of them. The Indapamide interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Ip-6 monograph Uses, safety profile, and every drug interaction in one place Indapamide drug information The full plain-English guide to this medication Indapamide supplement interactions Every supplement checked against Indapamide, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Indapamide and Ip-6?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.