Herb & supplement monograph

Garden Cress Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS ·Updated June 2026

What is this page for?

First and foremost: how Garden Cress interacts with medications. The heart of this page is the interaction list — every drug Garden Cress is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Garden Cress is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Reviewed by licensed pharmacists Sourced from Natural Medicines

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Garden Cress Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Garden Cress drug interaction appears low for most people. None of the listed interactions are rated major, and nearly all rest on animal research rather than documented effects in people.

Interactions deserving the most attention

The best-supported concern involves lithium, since garden cress may act like a diuretic and slow how the body clears lithium, raising its levels. Animal studies also suggest garden cress could raise levels of phenytoin, a seizure medicine with a narrow safety margin, and add to the effects of blood pressure medications such as amlodipine, losartan, and metoprolol. People taking blood thinners, diabetes medicines, or theophylline may also want to watch for changes, though none of these effects have been confirmed in humans.

What the rest of the list means

A long list of possible interactions does not mean each combination is harmful. Most entries here are predictions from animal or lab studies, often based on how garden cress might affect the way the body absorbs or clears medicines. In some of that research, the predicted effect did not actually change how the drug worked, as seen with gliclazide and blood sugar.

Check your medications against Garden Cress

Based on HelloPharmacist’s Garden Cress interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Garden Cress

398 medications have a known interaction with Garden Cress, graded by severity. Select any drug for the full evidence-based detail.

Don’t want to scroll the list? Just ask.

Tell us the medications you take and we’ll check each one against Garden Cress using our pharmacist-reviewed interaction data.

AI summaries are generated from our Garden Cress interaction data for education only — always confirm with your pharmacist. How we use AI

2,830 drugs

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
Each drug listed above links to the full report for that exact Garden Cress combination — clinical detail, likelihood, evidence level, and citations.
Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

The big picture

The kinds of drugs Garden Cress affects

Every type of medication (drug category) Garden Cress is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 14 drug categories Garden Cress interacts with

Amlodipine (norvasc)Anticoagulant/antiplatelet DrugsAntidiabetes DrugsAntihypertensive DrugsCarbamazepine (tegretol)Clopidogrel (plavix)Diuretic DrugsGliclazide (diamicron, Others)LithiumLosartan (cozaar)Metoprolol (toprol)Phenytoin (dilantin)Sildenafil (viagra)Theophylline

Amlodipine (Norvasc)

Theoretically, taking garden cress seeds with amlodipine might increase the risk of hypotension.
Animal research indicates that giving garden cress seeds with amlodipine increases maximum concentrations of amlodipine by 83%. Blood pressure was also reduced when compared with amlodipine alone. However, the area under the curve was not significantly affected.