Medication interaction hub

What Supplements Interact with Trichlormethiazide?

Trichlormethiazide brand names: Metahydrin, Naqua, Marazide II, Aq 4B Aquazide. Every interaction below applies to the brands too.

227 Interactions 10 Major 192 Moderate 25 Minor
Curated & coded by · Clinical Pharmacist · Updated September 23, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Trichlormethiazide? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Trichlormethiazide against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line

227 supplements and herbal ingredients have interactions with Trichlormethiazide on file in the HelloPharmacist interaction database — 10 rated major, 192 moderate, and 25 minor. The most serious involve American Hellebore, Siberian Cocklebur, Tyramine, Activated Charcoal and American Mistletoe.

Our assessment: with 10 major-rated interactions on the list, this one deserves real attention — know the major entries before combining anything with Trichlormethiazide.

Major 10 Moderate 192 Minor 25 No known interaction 1,225

Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Trichlormethiazide: Top Interactions at a Glance

The Trichlormethiazide supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 227 interacting ingredients — plus 1,225 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Trichlormethiazide Combinations Today

The Trichlormethiazide + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Danshen + Trichlormethiazidei

Theoretically, taking danshen with antihypertensive drugs might increase the risk of hypotension.

Read the full interaction Moderate Likelihood Possible White Horehound + Trichlormethiazidei

Evidence from animal research suggests that taking white horehound extract lowers blood pressure.

Read the full interaction Moderate Likelihood Possible Apple Cider Vinegar + Trichlormethiazidei

Theoretically, concomitant use of apple cider vinegar with diuretic drugs might increase the risk of hypokalemia.

Read the full interaction Moderate Likelihood Possible Cocoa + Trichlormethiazidei

Theoretically, taking cocoa with antihypertensive drugs might increase the risk of hypotension.

Read the full interaction Moderate Likelihood Possible Parsley + Trichlormethiazidei

Theoretically, parsley might enhance or interfere with the effects of diuretic drugs.

Read the full interaction Moderate Likelihood Possible Cascara Sagrada + Trichlormethiazidei

Theoretically, cascara sagrada might increase the risk of hypokalemia when taken with diuretic drugs.

Read the full interaction
The complete list

Every Supplement Checked Against Trichlormethiazide

All 1,452 ingredients in our database, ranked by severity — 227 with a Trichlormethiazide interaction on file and 1,225 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Trichlormethiazide?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Danshen with Trichlormethiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking danshen with antihypertensive drugs might increase the risk of hypotension.

Full Danshen + Trichlormethiazide answer

Can you take White Horehound with Trichlormethiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research suggests that taking white horehound extract lowers blood pressure.

Full White Horehound + Trichlormethiazide answer

Can you take Apple Cider Vinegar with Trichlormethiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of apple cider vinegar with diuretic drugs might increase the risk of hypokalemia.

Full Apple Cider Vinegar + Trichlormethiazide answer

Can you take Cocoa with Trichlormethiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking cocoa with antihypertensive drugs might increase the risk of hypotension.

Full Cocoa + Trichlormethiazide answer

Can you take Parsley with Trichlormethiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, parsley might enhance or interfere with the effects of diuretic drugs.

Full Parsley + Trichlormethiazide answer

Can you take Beet with Trichlormethiazide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Beet and beetroot contain nitrates, which can cause vasodilation, potentially leading to lower blood pressure.

Full Beet + Trichlormethiazide answer

Can you take Birch with Trichlormethiazide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, birch might interfere with diuretic therapy.

Full Birch + Trichlormethiazide answer

Can you take Black Psyllium with Trichlormethiazide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Black Psyllium + Trichlormethiazide answer

Can you take Blond Psyllium with Trichlormethiazide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Blond Psyllium + Trichlormethiazide answer

Can you take Carob with Trichlormethiazide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, carob might also impair the absorption of oral drugs.

Full Carob + Trichlormethiazide answer

Can you take Coenzyme Q10 with Trichlormethiazide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.

Full Coenzyme Q10 + Trichlormethiazide answer

Can you take Dendrobium with Trichlormethiazide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. The dendrobium constituent dendrobine is reported to have hypotensive effects.

Full Dendrobium + Trichlormethiazide answer

Can you take Fenugreek with Trichlormethiazide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Fenugreek may also have an additive effect on blood pressure-lowering medications.

Full Fenugreek + Trichlormethiazide answer

Can you take Humann Superbeets Heart Chews with Trichlormethiazide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Each serving of HumanN SuperBeets includes 500mg of beetroot powder (2 chews).

Full Humann Superbeets Heart Chews + Trichlormethiazide answer

Can you take Juniper with Trichlormethiazide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, juniper berry might increase the risk of adverse effects from diuretic drugs.

Full Juniper + Trichlormethiazide answer

Can you take Karaya Gum with Trichlormethiazide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Co-administration of oral drugs with bulk forming laxatives such as karaya gum may decrease, increase, or have no effect on the absorption o...

Full Karaya Gum + Trichlormethiazide answer

Can you take Marshmallow with Trichlormethiazide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, mucilage in marshmallow might impair absorption of oral drugs.

Full Marshmallow + Trichlormethiazide answer

Can you take N-methyltyramine with Trichlormethiazide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. In animal research, N-methyltyramine increased blood pressure.

Full N-methyltyramine + Trichlormethiazide answer

Can you take Nicotinamide Riboside with Trichlormethiazide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.

Full Nicotinamide Riboside + Trichlormethiazide answer

Can you take Pu-erh Tea with Trichlormethiazide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, using pu-erh tea with diuretic drugs might increase the risk of hypokalemia.

Full Pu-erh Tea + Trichlormethiazide answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Trichlormethiazide is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Trichlormethiazide, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Trichlormethiazide sits in 6 interaction categories. Open any one to see what the group means:

Antihypertensive Drugs 119 ingredients

Blood-pressure-lowering medications. Supplements that lower (or raise) blood pressure can amplify or fight these drugs.

119 of the supplement ingredients on this page reach Trichlormethiazide through this category.

Diuretic Drugs 73 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

73 of the supplement ingredients on this page reach Trichlormethiazide through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Trichlormethiazide through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Trichlormethiazide through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Trichlormethiazide through this category.

Thiazide Diuretics 5 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

5 of the supplement ingredients on this page reach Trichlormethiazide through this category.

Related: does Trichlormethiazide deplete any nutrients?

Trichlormethiazide has 36 reported nutrient associations in the research literature — see the Trichlormethiazide nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Trichlormethiazide

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Trichlormethiazide.

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Pharmacist Counseling Corner

Trichlormethiazide & Supplements: Common Questions

What supplements interact with Trichlormethiazide?
Our database currently documents 227 ingredients with a known Trichlormethiazide interaction (10 major, 192 moderate, 25 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 227. The highest-ranked right now: American Hellebore, Siberian Cocklebur, Tyramine.
Which Trichlormethiazide supplement interactions are the most serious?
The 10 major-rated combinations — led by American Hellebore, Siberian Cocklebur, Tyramine, Activated Charcoal and American Mistletoe — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Trichlormethiazide?
Plenty of supplements coexist fine with Trichlormethiazide; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Metahydrin have the same supplement interactions as Trichlormethiazide?
Yes — Metahydrin, Naqua, Marazide II, Aq 4B Aquazide all contain Trichlormethiazide, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Trichlormethiazide deplete any vitamins or nutrients?
It might — Trichlormethiazide has 36 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Trichlormethiazide nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Trichlormethiazide and my other medications?
This page covers Trichlormethiazide against supplements and herbal ingredients. Checking Trichlormethiazide against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 23, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.