Medication interaction hub

What Supplements Interact with Bendroflumethiazide?

Bendroflumethiazide brand names: Naturetin, Aprinox, Neo-NaClex. Every interaction below applies to the brands too.

227 Interactions 10 Major 192 Moderate 25 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Bendroflumethiazide? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Bendroflumethiazide against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Bendroflumethiazide, a thiazide water pill prescribed for high blood pressure, sits at the serious end of the interaction spectrum, and the ten major-rated entries deserve attention first. Most of the 227 supplements on file either stack their own blood-pressure-lowering effect on top of the drug's or deepen the potassium loss it already causes. Calcium supplements pull the opposite direction, since thiazides make the body hold onto calcium, and adding more can push levels dangerously high.

A smaller group of photosensitizing ingredients can amplify the sun sensitivity thiazides already bring, and activated charcoal can soak up the dose before it absorbs, so space the two well apart. Beyond that, 192 entries rate moderate and 25 minor, but with ten majors, lithium among them, this page rewards a slow read before a new bottle joins the shelf.

— , Clinical Pharmacist · July 18, 2026

Major 10 Moderate 192 Minor 25 No known interaction 1,225

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Bendroflumethiazide: Top Interactions at a Glance

The Bendroflumethiazide supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 227 interacting ingredients — plus 1,225 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Bendroflumethiazide Combinations Today

The Bendroflumethiazide + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Probable Calcium + Bendroflumethiazidei

Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.

Read the full interaction Moderate Likelihood Probable Vitamin D + Bendroflumethiazidei

Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.

Read the full interaction Moderate Likelihood Probable Fish Oil + Bendroflumethiazidei

Theoretically, taking fish oil with antihypertensive drugs might increase the risk of hypotension.

Read the full interaction Minor Likelihood Possible Coenzyme Q10 + Bendroflumethiazidei

Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.

Read the full interaction Moderate Likelihood Probable Sodium + Bendroflumethiazidei

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.

Read the full interaction Moderate Likelihood Possible Horsetail + Bendroflumethiazidei

Theoretically, taking horsetail with diuretic drugs might increase potassium loss and the risk of hypokalemia.

Read the full interaction
The complete list

Every Supplement Checked Against Bendroflumethiazide

All 1,452 ingredients in our database, ranked by severity — 227 with a Bendroflumethiazide interaction on file and 1,225 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Bendroflumethiazide?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Calcium with Bendroflumethiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.

Full Calcium + Bendroflumethiazide answer

Can you take Vitamin D with Bendroflumethiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.

Full Vitamin D + Bendroflumethiazide answer

Can you take Fish Oil with Bendroflumethiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking fish oil with antihypertensive drugs might increase the risk of hypotension.

Full Fish Oil + Bendroflumethiazide answer

Can you take Coenzyme Q10 with Bendroflumethiazide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.

Full Coenzyme Q10 + Bendroflumethiazide answer

Can you take Sodium with Bendroflumethiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.

Full Sodium + Bendroflumethiazide answer

Can you take Swamp Milkweed with Bendroflumethiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, potassium depleting diuretics might increase the risk of toxicity with swamp milkweed.

Full Swamp Milkweed + Bendroflumethiazide answer

Can you take Theanine with Bendroflumethiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theanine might lower blood pressure, potentiating the effects of antihypertensive drugs.

Full Theanine + Bendroflumethiazide answer

Can you take Tragacanth with Bendroflumethiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Bendroflumethiazide answer

Can you take Tree Turmeric with Bendroflumethiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking tree turmeric along with antihypertensive drugs might have additive effects and increase the risk of hypotension.

Full Tree Turmeric + Bendroflumethiazide answer

Can you take Tribulus with Bendroflumethiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.

Full Tribulus + Bendroflumethiazide answer

Can you take Uzara with Bendroflumethiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of potassium-depleting diuretics and uzara can increase the risk of cardiac glycoside toxicity due to potassi...

Full Uzara + Bendroflumethiazide answer

Can you take Vitamin B6 with Bendroflumethiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.

Full Vitamin B6 + Bendroflumethiazide answer

Can you take Wahoo with Bendroflumethiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of potassium-depleting diuretics with wahoo can increase the risk of cardiac glycoside toxicity due to potass...

Full Wahoo + Bendroflumethiazide answer

Can you take Wallflower with Bendroflumethiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of potassium-depleting diuretics and wallflower can increase the risk of cardiac glycoside toxicity due to po...

Full Wallflower + Bendroflumethiazide answer

Can you take White Horehound with Bendroflumethiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research suggests that taking white horehound extract lowers blood pressure.

Full White Horehound + Bendroflumethiazide answer

Can you take Yerba Mate with Bendroflumethiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, the caffeine in yerba mate might increase the risk of hypokalemia when used concomitantly with other diuretics.

Full Yerba Mate + Bendroflumethiazide answer

Can you take American Ivy with Bendroflumethiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. The berries of American ivy contain up to 2% oxalic acid, which can be toxic because it has the potential to cause kidney failure by precipi...

Full American Ivy + Bendroflumethiazide answer

Can you take Thyroid Extract with Bendroflumethiazide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Food and medications can interfere with thyroid hormone absorption.

Full Thyroid Extract + Bendroflumethiazide answer

Can you take Agar with Bendroflumethiazide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.

Full Agar + Bendroflumethiazide answer

Can you take Algin with Bendroflumethiazide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, algin can alter the absorption of oral drugs.

Full Algin + Bendroflumethiazide answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Bendroflumethiazide is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Bendroflumethiazide, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Bendroflumethiazide sits in 6 interaction categories. Open any one to see what the group means:

Antihypertensive Drugs 119 ingredients

Blood-pressure-lowering medications. Supplements that lower (or raise) blood pressure can amplify or fight these drugs.

119 of the supplement ingredients on this page reach Bendroflumethiazide through this category.

Diuretic Drugs 73 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

73 of the supplement ingredients on this page reach Bendroflumethiazide through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Bendroflumethiazide through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Bendroflumethiazide through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Bendroflumethiazide through this category.

Thiazide Diuretics 5 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

5 of the supplement ingredients on this page reach Bendroflumethiazide through this category.

Related: does Bendroflumethiazide deplete any nutrients?

Bendroflumethiazide has 21 reported nutrient associations in the research literature — see the Bendroflumethiazide nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Bendroflumethiazide

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Bendroflumethiazide.

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Pharmacist Counseling Corner

Bendroflumethiazide & Supplements: Common Questions

What supplements interact with Bendroflumethiazide?
Our database currently documents 227 ingredients with a known Bendroflumethiazide interaction (10 major, 192 moderate, 25 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 227. The highest-ranked right now: American Hellebore, Siberian Cocklebur, Tyramine.
Which Bendroflumethiazide supplement interactions are the most serious?
The 10 major-rated combinations — led by American Hellebore, Siberian Cocklebur, Tyramine, Activated Charcoal and American Mistletoe — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Bendroflumethiazide?
Plenty of supplements coexist fine with Bendroflumethiazide; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Naturetin have the same supplement interactions as Bendroflumethiazide?
Yes — Naturetin, Aprinox, Neo-NaClex all contain Bendroflumethiazide, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Bendroflumethiazide deplete any vitamins or nutrients?
It might — Bendroflumethiazide has 21 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Bendroflumethiazide nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Bendroflumethiazide and my other medications?
This page covers Bendroflumethiazide against supplements and herbal ingredients. Checking Bendroflumethiazide against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.