Medication interaction hub

What Supplements Interact with Chlorthalidone?

Chlorthalidone brand names: Hygroton, Thalitone. Every interaction below applies to the brands too.

222 Interactions 8 Major 190 Moderate 24 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Chlorthalidone? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Chlorthalidone against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Chlorthalidone (Hygroton, Thalitone) lowers blood pressure by helping the kidneys shed salt and water, and that mechanism makes its supplement interactions worth genuine care. Most of the 222 ingredients on file either add to its blood-pressure-lowering effect or act as diuretics themselves, so pressure or potassium can fall further than intended. Eight entries rate major. Dolomite and other calcium sources stand out because thiazide-type drugs already hold calcium back, and activated charcoal can soak up the medication before it reaches your bloodstream.

The 190 moderate entries echo those pressure and fluid themes at lower strength, and another 24 rate minor. A smaller cluster adds sun sensitivity, worth knowing since chlorthalidone can make skin burn more easily. Herbs like yellow dock can deepen the potassium loss this drug already causes, so unexplained weakness or muscle cramps deserve attention. Read the eight majors first; they set the tone for everything below.

— , Clinical Pharmacist · July 18, 2026

Major 8 Moderate 190 Minor 24 No known interaction 1,230

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Chlorthalidone: Top Interactions at a Glance

The Chlorthalidone supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 222 interacting ingredients — plus 1,230 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Chlorthalidone Combinations Today

The Chlorthalidone + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Apple Cider Vinegar + Chlorthalidonei

Theoretically, concomitant use of apple cider vinegar with diuretic drugs might increase the risk of hypokalemia.

Read the full interaction Moderate Likelihood Possible Danshen + Chlorthalidonei

Theoretically, taking danshen with antihypertensive drugs might increase the risk of hypotension.

Read the full interaction Minor Likelihood Possible Blond Psyllium + Chlorthalidonei

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Read the full interaction Moderate Likelihood Possible Lovage + Chlorthalidonei

Theoretically, lovage root might interfere with diuretic therapy due to its aquaretic effects.

Read the full interaction Minor Likelihood Possible Juniper + Chlorthalidonei

Theoretically, juniper berry might increase the risk of adverse effects from diuretic drugs.

Read the full interaction Moderate Likelihood Possible Quassia + Chlorthalidonei

Overuse of quassia might compound diuretic-induced potassium loss.

Read the full interaction
The complete list

Every Supplement Checked Against Chlorthalidone

All 1,452 ingredients in our database, ranked by severity — 222 with a Chlorthalidone interaction on file and 1,230 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Chlorthalidone?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Apple Cider Vinegar with Chlorthalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of apple cider vinegar with diuretic drugs might increase the risk of hypokalemia.

Full Apple Cider Vinegar + Chlorthalidone answer

Can you take Danshen with Chlorthalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking danshen with antihypertensive drugs might increase the risk of hypotension.

Full Danshen + Chlorthalidone answer

Can you take Blond Psyllium with Chlorthalidone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Blond Psyllium + Chlorthalidone answer

Can you take Lovage with Chlorthalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, lovage root might interfere with diuretic therapy due to its aquaretic effects.

Full Lovage + Chlorthalidone answer

Can you take Juniper with Chlorthalidone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, juniper berry might increase the risk of adverse effects from diuretic drugs.

Full Juniper + Chlorthalidone answer

Can you take Ashwagandha with Chlorthalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.

Full Ashwagandha + Chlorthalidone answer

Can you take Asparagus with Chlorthalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, asparagus root might increase diuresis and electrolyte loss when used with diuretic drugs.

Full Asparagus + Chlorthalidone answer

Can you take Asparagus Racemosus with Chlorthalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, asparagus racemosus root might increase diuresis and electrolyte loss when used with diuretic drugs.

Full Asparagus Racemosus + Chlorthalidone answer

Can you take Baikal Skullcap with Chlorthalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of Baikal skullcap with antihypertensive drugs might have additive effects and increase the risk of hypotensi...

Full Baikal Skullcap + Chlorthalidone answer

Can you take Basil with Chlorthalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, basil might increase the risk of hypotension when taken with antihypertensive drugs.

Full Basil + Chlorthalidone answer

Can you take Berberine with Chlorthalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, berberine might have additive effects with antihypertensive drugs.

Full Berberine + Chlorthalidone answer

Can you take Beta-glucans with Chlorthalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking beta-glucans with antihypertensive drugs might increase the risk of hypotension.

Full Beta-glucans + Chlorthalidone answer

Can you take Betony with Chlorthalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, betony might have additive effects with blood pressure lowering drugs due to hypotensive activity of the glycosides found in...

Full Betony + Chlorthalidone answer

Can you take Bishop's Weed with Chlorthalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bishop's weed constituents seem to cause photosensitivity.

Full Bishop's Weed + Chlorthalidone answer

Can you take Black Hellebore with Chlorthalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of potassium depleting diuretics and black hellebore can increase the risk of cardiac glycoside toxicity due...

Full Black Hellebore + Chlorthalidone answer

Can you take Black Root with Chlorthalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Overuse of black root might compound diuretic-induced potassium loss.There is some concern that people taking black root along with potassiu...

Full Black Root + Chlorthalidone answer

Can you take Black Seed with Chlorthalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking black seed with antihypertensive drugs might increase the risk of hypotension.

Full Black Seed + Chlorthalidone answer

Can you take Black Tea with Chlorthalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, using black tea with diuretic drugs might increase the risk of hypokalemia.

Full Black Tea + Chlorthalidone answer

Can you take Blue Cohosh with Chlorthalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Constituents in blue cohosh might increase blood pressure by causing coronary vasoconstriction.

Full Blue Cohosh + Chlorthalidone answer

Can you take Blue Flag with Chlorthalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Overuse of blue flag might compound diuretic-induced potassium loss.

Full Blue Flag + Chlorthalidone answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Chlorthalidone is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Chlorthalidone, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Chlorthalidone sits in 5 interaction categories. Open any one to see what the group means:

Antihypertensive Drugs 119 ingredients

Blood-pressure-lowering medications. Supplements that lower (or raise) blood pressure can amplify or fight these drugs.

119 of the supplement ingredients on this page reach Chlorthalidone through this category.

Diuretic Drugs 73 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

73 of the supplement ingredients on this page reach Chlorthalidone through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Chlorthalidone through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Chlorthalidone through this category.

Thiazide Diuretics 5 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

5 of the supplement ingredients on this page reach Chlorthalidone through this category.

About Chlorthalidone

A water pill that helps treat high blood pressure and reduce excess fluid buildup in the body.

Generic name: Chlorthalidone  ·  Brand names: Hygroton, Thalitone.

See the full Chlorthalidone drug information

Related: does Chlorthalidone deplete any nutrients?

Chlorthalidone has 18 reported nutrient associations in the research literature — see the Chlorthalidone nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Chlorthalidone

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Chlorthalidone.

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Products that contain Chlorthalidone-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Chlorthalidone.

TNT Thermanite by GEC Genetic Edge Compounds contains Tyramine Diablos ECA Fire Caps by Innovative Laboratories contains Tyramine Ultimate Burn by Schwartz Laboratories contains Tyramine Final Cutz by Infinite Labs contains Tyramine
Pharmacist Counseling Corner

Chlorthalidone & Supplements: Common Questions

What supplements interact with Chlorthalidone?
In our interaction database, 222 supplement and herbal ingredients have an interaction with Chlorthalidone on file — 8 rated major, 190 moderate, and 24 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: American Hellebore, Tyramine, Activated Charcoal.
Which Chlorthalidone supplement interactions are the most serious?
Focus on the major group: American Hellebore, Tyramine, Activated Charcoal, American Mistletoe and Dolomite, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Chlorthalidone?
That depends entirely on which supplement. The honest answer for Chlorthalidone is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Hygroton have the same supplement interactions as Chlorthalidone?
Yes — Hygroton, Thalitone all contain Chlorthalidone, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Chlorthalidone deplete any vitamins or nutrients?
It might — Chlorthalidone has 18 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Chlorthalidone nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Chlorthalidone and my other medications?
This page covers Chlorthalidone against supplements and herbal ingredients. Checking Chlorthalidone against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Chlorthalidone drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.