Medication interaction hub

What Supplements Interact with Bumetanide?

Bumetanide brand name: Burinex. Every interaction below applies to the brands too.

218 Interactions 7 Major 187 Moderate 24 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Bumetanide? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Bumetanide against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Bumetanide (Burinex) is a potent loop diuretic, a water pill that pulls off fluid quickly and takes potassium with it, so I treat its interaction list as one of the serious ones. Seven of the 218 ingredients on file carry a major rating, and those belong at the top of your reading. Most of the others push in a direction the drug already leans: 119 can deepen its blood-pressure-lowering effect, and 73 have diuretic activity of their own, which can compound fluid and potassium loss.

Among the majors, lithium stands out because loop diuretics can slow its removal and let levels climb, while yellow dock and oleander become riskier as potassium falls. Twenty ingredients add sun sensitivity, and the remaining count runs 187 moderate and 24 minor. Lightheadedness on standing and muscle cramps are early signs that a supplement is stacking onto what bumetanide already does.

— , Clinical Pharmacist · July 18, 2026

Major 7 Moderate 187 Minor 24 No known interaction 1,234

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Bumetanide: Top Interactions at a Glance

The Bumetanide supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 218 interacting ingredients — plus 1,234 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Bumetanide Combinations Today

The Bumetanide + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Senna + Bumetanidei

Theoretically, senna might increase the risk of hypokalemia when taken with diuretic drugs.

Read the full interaction Minor Likelihood Possible Fenugreek + Bumetanidei

Fenugreek may also have an additive effect on blood pressure-lowering medications.

Read the full interaction Minor Likelihood Possible Juniper + Bumetanidei

Theoretically, juniper berry might increase the risk of adverse effects from diuretic drugs.

Read the full interaction Moderate Likelihood Possible Stinging Nettle + Bumetanidei

Theoretically, combining stinging nettle with diuretic drugs may have additive effects.

Read the full interaction Minor Likelihood Possible Birch + Bumetanidei

Theoretically, birch might interfere with diuretic therapy.

Read the full interaction Moderate Likelihood Possible Black Tea + Bumetanidei

Theoretically, using black tea with diuretic drugs might increase the risk of hypokalemia.

Read the full interaction
The complete list

Every Supplement Checked Against Bumetanide

All 1,452 ingredients in our database, ranked by severity — 218 with a Bumetanide interaction on file and 1,234 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Bumetanide?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Senna with Bumetanide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, senna might increase the risk of hypokalemia when taken with diuretic drugs.

Full Senna + Bumetanide answer

Can you take Fenugreek with Bumetanide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Fenugreek may also have an additive effect on blood pressure-lowering medications.

Full Fenugreek + Bumetanide answer

Can you take Juniper with Bumetanide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, juniper berry might increase the risk of adverse effects from diuretic drugs.

Full Juniper + Bumetanide answer

Can you take Stinging Nettle with Bumetanide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining stinging nettle with diuretic drugs may have additive effects.

Full Stinging Nettle + Bumetanide answer

Can you take Birch with Bumetanide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, birch might interfere with diuretic therapy.

Full Birch + Bumetanide answer

Can you take Hesperidin with Bumetanide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking hesperidin with antihypertensive drugs might increase the risk of hypotension.

Full Hesperidin + Bumetanide answer

Can you take Hibiscus Sabdariffa with Bumetanide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Hibiscus sabdariffa with antihypertensive drugs might increase the risk of hypotension.

Full Hibiscus Sabdariffa + Bumetanide answer

Can you take Hoodia with Bumetanide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Clinical research shows that hoodia can increase blood pressure.

Full Hoodia + Bumetanide answer

Can you take Horny Goat Weed with Bumetanide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, horny goat weed might increase the risk of hypotension.

Full Horny Goat Weed + Bumetanide answer

Can you take Horsetail with Bumetanide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking horsetail with diuretic drugs might increase potassium loss and the risk of hypokalemia.

Full Horsetail + Bumetanide answer

Can you take Ilex Guayusa with Bumetanide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the risk of hypokalemia.

Full Ilex Guayusa + Bumetanide answer

Can you take Indian Cassia with Bumetanide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Indian cassia might increase the risk of potassium depletion in patients taking diuretic drugs.

Full Indian Cassia + Bumetanide answer

Can you take Indian Snakeroot with Bumetanide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of Indian snakeroot and antihypertensive drugs might increase the risk of hypotension.

Full Indian Snakeroot + Bumetanide answer

Can you take Isopropylnorsynephrine with Bumetanide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, isopropylnorsynephrine might decrease the effects of antihypertensive drugs.

Full Isopropylnorsynephrine + Bumetanide answer

Can you take Jalap with Bumetanide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Jalap has diuretic effects.

Full Jalap + Bumetanide answer

Can you take Khat with Bumetanide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Human research shows that khat and its constituent, cathinone, can increase blood pressure.

Full Khat + Bumetanide answer

Can you take Khella with Bumetanide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might result in increased photosensitivity.

Full Khella + Bumetanide answer

Can you take Kiwi with Bumetanide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Clinical research suggests that consuming kiwi reduces systolic and diastolic blood pressure in hypertensive individuals.

Full Kiwi + Bumetanide answer

Can you take Korean Pine with Bumetanide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research shows that Korean pine nut oil reduces blood pressure in spontaneously hypertensive rats.

Full Korean Pine + Bumetanide answer

Can you take L-citrulline with Bumetanide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotensio...

Full L-citrulline + Bumetanide answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Bumetanide is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Bumetanide, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Bumetanide sits in 5 interaction categories. Open any one to see what the group means:

Antihypertensive Drugs 119 ingredients

Blood-pressure-lowering medications. Supplements that lower (or raise) blood pressure can amplify or fight these drugs.

119 of the supplement ingredients on this page reach Bumetanide through this category.

Diuretic Drugs 73 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

73 of the supplement ingredients on this page reach Bumetanide through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Bumetanide through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Bumetanide through this category.

Loop Diuretics 2 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

2 of the supplement ingredients on this page reach Bumetanide through this category.

About Bumetanide

Bumetanide is a diuretic (water pill) used to treat fluid retention caused by heart, kidney, and liver disease.

Generic name: Bumetanide  ·  Brand name: Burinex.

See the full Bumetanide drug information

Related: does Bumetanide deplete any nutrients?

Bumetanide has 8 reported nutrient associations in the research literature — see the Bumetanide nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Bumetanide

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Bumetanide.

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

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Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

Open the label scanner

Prefer typing? The interaction checker looks up products by name too.

Products that contain Bumetanide-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Bumetanide.

TNT Thermanite by GEC Genetic Edge Compounds contains Tyramine Diablos ECA Fire Caps by Innovative Laboratories contains Tyramine Ultimate Burn by Schwartz Laboratories contains Tyramine Final Cutz by Infinite Labs contains Tyramine
Pharmacist Counseling Corner

Bumetanide & Supplements: Common Questions

What supplements interact with Bumetanide?
More than you might expect — 218 in total, though they are far from equal: 7 are rated major, 187 moderate, and 24 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: American Hellebore, Tyramine, Activated Charcoal.
Which Bumetanide supplement interactions are the most serious?
The 7 major-rated combinations — led by American Hellebore, Tyramine, Activated Charcoal, American Mistletoe and Lithium — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Bumetanide?
Usually yes — most people on Bumetanide can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Burinex have the same supplement interactions as Bumetanide?
Yes — Burinex all contain Bumetanide, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Bumetanide deplete any vitamins or nutrients?
It might — Bumetanide has 8 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Bumetanide nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Bumetanide and my other medications?
This page covers Bumetanide against supplements and herbal ingredients. Checking Bumetanide against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Bumetanide drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.