Drug & supplement interaction

Acerola + Bumetanide

Bumetanide brand name: Burinex.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Acerola and Bumetanide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Acerola and Bumetanide

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Bumetanide and Acerola in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Acerola safety at a glance

Acerola overall Generally safe Generally considered safe when used in food amounts or as directed on supplement labels.
Pregnancy Use caution Food amounts are likely fine, but talk to your doctor before using concentrated supplements.
Breastfeeding Use caution Food amounts are likely fine, but safety of concentrated supplements is not well studied.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Bumetanide and Acerola? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Bumetanide

Interactions in our licensed database are recorded against drug classes, not just single drug names. Bumetanide is filed under 5 classifications — including loop diuretics, diuretic drugs, antihypertensive drugs. Acerola has documented interactions with 6 drug classes — the most serious being alkylating agents (moderate), antitumor antibiotics (moderate) and aluminum (minor) — and none of Bumetanide’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Acerola Does Interact With Other Medications

Acerola has 39 moderate, 89 minor known drug interactions in our database — Bumetanide isn’t one of them. If you take anything else, check it against the full list below.

Moderate 39 Minor 89 No known interaction 2,702 (incl. Bumetanide)
Taking anything else?

Check Another of Your Medications Against Acerola

Covers the 2,830 medications we’ve checked against Acerola. Pick one to open its full report.

What to actually watch for

What Acerola Itself Has Been Linked To

This is not an interaction — nothing below involves Bumetanide. It is the side-effect record for Acerola on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Acerola, this list is the first place to look. 2 entries are worth acting on rather than waiting out — marked below.

  • Dehydration Worth acting on Additional detail

    “Osmotic diarrhea and gastrointestinal upset have been reported with doses of vitamin C greater than the tolerable upper intake level (UL) of 2000 mg daily. Theoretically this could occur with large doses of oral acerola. A case report describes rectal obstruction with mass consisting of partially digested acerola fruits in a 5-year-old child who had ingested an unknown quantity of fruits daily for 7 days.”

    Acerola · Natural Medicines adverse-effect record, reported in constipation.

    2 sources cited
    1. 4844. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: National Academy Press, 2000. Available at: http://www.nap.edu/books/0309069351/html/.
    2. 93205. Denadai R, Souza FM, Valle MR. Fecal impaction by rectal acerola bezoar. Indian J Pediatr 2013;80(5):432-3. PubMed
  • Shortness of breath / Hives Worth acting on Additional detail

    “There is a case report of a 37 year old man who developed a pruritic rash, dyspnea, and tachycardia 5 minutes after drinking a mixture of apple and acerola juices. He had a history of hay fever, oral allergy symptoms with avocado, celery, walnut, and curry, and contact urticaria with latex, but tolerated apples and apple juice. IgE antibodies to acerola were identified in the patient's serum.”

    Acerola · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    1 source cited
    1. 93206. Raulf-Heimsoth M, Stark R, Sander I, et al. Anaphylactic reaction to apple juice containing acerola: cross-reactivity to latex due to prohevein. J Allergy Clin Immunol 2002;109(4):715-6. PubMed
  • A fast or pounding heartbeat / A skin rash Additional detail

    Recorded for Acerola in the same Natural Medicines adverse-effect record shown under Shortness of breath / Hives above.

  • Stomach upset / Constipation / Stomach pain / Diarrhea / Vomiting Additional detail

    Recorded for Acerola in the same Natural Medicines adverse-effect record shown under Dehydration above.

Everything above comes from the Natural Medicines adverse-effect record for Acerola — expand a row for the licensed statement it rests on. We haven’t matched Bumetanide to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Bumetanide.

From our Q&A

Questions About Acerola or Bumetanide

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Acerola or Bumetanide, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Bumetanide

This page covers Acerola only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Bumetanide page lists 218 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Lithium (major) and Oleander (major).

By severity: 7 major · 187 moderate · 24 minor.

From our pharmacist’s overview on the Bumetanide page

“Bumetanide (Burinex) is a potent loop diuretic, a water pill that pulls off fluid quickly and takes potassium with it, so I treat its interaction list as one of the serious ones. Seven of the 218 ingredients on file carry a major rating, and those belong at the top of your reading.”

Reviewed by 2 · Jul 18, 2026

Open the Bumetanide interaction page

One more smart check

Taking Acerola as Part of a Dietary Supplement Product? Check It for Interactions

We hold 2,642 real supplement products containing Acerola, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Acerola. Even though Acerola itself has no known interaction with Bumetanide, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Acerola and Bumetanide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Acerola
Top 10%

#133 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Bumetanide
Top 5%

#118 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Acerola reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Acerola and Bumetanide records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Acerola

What is Acerola?

Acerola
  • Vitamin C source
  • Immune support
  • Antioxidant support
  • General wellness
  • Skin health

Acerola is a small tropical fruit prized for its very high natural vitamin C content, and it is mostly used as a food-based source of vitamin C and antioxidants. While vitamin C itself has well-known roles in the body, strong human studies showing that acerola specifically treats or prevents disease are limited. It is generally considered safe in food amounts, but check with your pharmacist or doctor before using concentrated supplements.

Malpighia emarginata · Malpighiaceae · Fruit (cherry) · Capsules, tablets, chewables, powder, juice, gummies

An interaction check asks whether these two react with each other — it does not ask whether Acerola is a good idea for someone in your situation. Here is what our Acerola record says about it on its own.

Acerola: dosing

There is no official standardized dose for acerola. Products vary widely in their strength and in how much vitamin C they provide.The best approach is to follow the directions on the product label and not exceed the recommended amount.

From our Acerola monograph — the full record covers uses, side effects and every documented interaction.

Read the full Acerola monograph & all interactions
Medication

About Bumetanide

What Is Bumetanide Used For?

Brand name: Burinex

Bumetanide treats edema — excess fluid that builds up in the body — caused by congestive heart failure, hepatic (liver) disease, and renal (kidney) disease, including a condition called nephrotic syndrome. This applies to the oral tablets (bumetanide and Bumex), the injection (Bumetanide Injection), and the nasal spray.

Enbumyst (bumetanide nasal spray) is specifically approved for these same uses in adults. Enbumyst is not intended for long-term use and should be switched to an oral diuretic as soon as practical.

Most-Reported Side Effects for Bumetanide

From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Dyspnea 2,650 reports
Fatigue 1,734 reports
Acute kidney injury 1,692 reports
Diarrhea 1,577 reports
Nausea 1,545 reports
See full Bumetanide drug information
Keep checking

Other Drugs & Acerola

Browse every other medication we’ve checked against Acerola — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
39Moderate
89Minor
2,701No known interaction
39 Moderate 89 Minor 2,701 No interaction
Moderate

39 interactions

Minor

89 interactions

Showing 60 of 89 minor interactions — see all 89 on the Acerola page.

No interaction 2,701 drugs checked — show the list

We also checked Acerola against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,701 medications checked with no known interaction — see the full Acerola list.

See the full Acerola interactions page
See every supplement checked against Bumetanide, ranked by severity
Evidence & sources

Acerola References

The 20 references that drive our Acerola monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Back DJ, Breckenridge AM, MacIver M, et al. Interaction of ethinyloestradiol with ascorbic acid in man. Br Med J (Clin Res Ed) 1981;282:1516.
  2. Morris JC, Beeley L, Ballantine N. Interaction of ethinyloestradiol with ascorbic acid in man [letter]. Br Med J (Clin Res Ed) 1981;283:503.
  3. Labriola D, Livingston R. Possible interactions between dietary antioxidants and chemotherapy. Oncology 1999;13:1003-8.
  4. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  5. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: National Academy Press, 2000. Available at: http://www.nap.edu/books/0309069351/html/.
  6. Rosenthal G. Interaction of ascorbic acid and warfarin. JAMA 1971;215:1671. DOI
  7. Hume R, Johnstone JM, Weyers E. Interaction of ascorbic acid and warfarin. JAMA 1972;219:1479. DOI
  8. Smith EC, Skalski RJ, Johnson GC, Rossi GV. Interaction of ascorbic acid and warfarin. JAMA 1972;221:1166. DOI
  9. Domingo JL, Gomez M, Llobet JM, Richart C. Effect of ascorbic acid on gastrointestinal aluminum absorption (letter). Lancet 1991;338:1467.
  10. Domingo JL, Gomez M, Llobet JM, Corbella J. Influence of some dietary constituents on aluminum absorption and retention in rats. Kidney Int 1991;39:598-601. PubMed
  11. Partridge NA, Regnier FE, White JL, Hem SL. Influence of dietary constituents on intestinal absorption of aluminum. Kidney Int 1989;35:1413-7. PubMed
  12. Mc Leod DC, Nahata MC. Inefficacy of ascorbic acid as a urinary acidifier (letter). N Engl J Med 1977;296:1413. DOI
  13. Hansten PD, Hayton WL. Effect of antacid and ascorbic acid on serum salicylate concentration. J Clin Pharmacol 1980;20:326-31. PubMed
  14. Vihtamaki T, Parantainen J, Koivisto AM, et al. Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy. Maturitas 2002;42:129-35. PubMed
  15. Feetam CL, Leach RH, Meynell MJ. Lack of a clinically important interaction between warfarin and ascorbic acid. Toxicol Appl Pharmacol 1975;31:544-7. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Acerola and Bumetanide Together: Common Questions

Is it safe to take Acerola with Bumetanide?
We do not list a known interaction between Acerola and Bumetanide. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Acerola and Bumetanide combination checked?
Interactions in our licensed database are recorded against drug classes. Bumetanide is filed under 5 classifications, and Acerola has documented interactions with 6 drug classes — none of Bumetanide's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Acerola interact with any other medications?
Yes. Acerola has 128 documented drug interactions in our database — Bumetanide is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Bumetanide interact with any supplements?
Yes. Bumetanide has documented interactions with 218 supplements in our database — Acerola is not one of them. The Bumetanide interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Acerola monograph Uses, safety profile, and every drug interaction in one place Bumetanide drug information The full plain-English guide to this medication Bumetanide supplement interactions Every supplement checked against Bumetanide, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 20 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Bumetanide and Acerola?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.