Drug & supplement interaction

Laburnum + Bumetanide

Bumetanide brand name: Burinex.

No Known Interaction
The bottom line No known interaction

We found no known interaction between Laburnum and Bumetanide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Laburnum and Bumetanide

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Bumetanide and Laburnum in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Laburnum at all — not against Bumetanide, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Laburnum safety at a glance

Laburnum overall Avoid All parts of the plant are poisonous and ingestion can cause severe toxicity.
Pregnancy Unsafe When used orally. All parts of the plant contain toxic alkaloids that are reported to cross the placenta and enter breast milk. Read the full pregnancy detail
Breastfeeding Unsafe When used orally. All parts of the plant contain toxic alkaloids that are reported to cross the placenta and enter breast milk. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Bumetanide and Laburnum? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Laburnum Itself Has Been Linked To

This is not an interaction — nothing below involves Bumetanide. It is the side-effect record for Laburnum on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Laburnum, this list is the first place to look. 4 entries are worth acting on rather than waiting out — marked below.

  • Unsteadiness / Confusion / Seizures Worth acting on Additional detail

    “Symptoms of laburnum poisoning include headache, dizziness, weakness, drowsiness, incoordination, ataxia, tremors, confusion, delirium, coma, and seizures.”

    Laburnum · Natural Medicines adverse-effect record, reported in cluster headache.

    2 sources cited
    1. 101220. Bramley A, Goulding R. Laburnum "poisoning". Br Med J (Clin Res Ed). 1981;283(6301):1220-1.
    2. 101221. Schep LJ, Slaughter RJ, Beasley DMG. Nicotinic plant poisoning. Clin Toxicol (Phila). 2009;47(8):771-81. doi: 10.1080/15563650903252186. PubMed
  • A slow heartbeat / Raised blood pressure Worth acting on Additional detail

    “Orally, the fatal adult dose of laburnum is estimated to be about 15-20 seeds or 3-4 unripe berries (18). Many cases of poisoning involve children who ingest small quantities of seeds and experience primarily gastrointestinal symptoms, with a relatively rapid recovery.”

    Laburnum · Natural Medicines adverse-effect record, reported in diarrhea.

    4 sources cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
    2. 101220. Bramley A, Goulding R. Laburnum "poisoning". Br Med J (Clin Res Ed). 1981;283(6301):1220-1.
    3. 101221. Schep LJ, Slaughter RJ, Beasley DMG. Nicotinic plant poisoning. Clin Toxicol (Phila). 2009;47(8):771-81. doi: 10.1080/15563650903252186. PubMed
    4. 101222. Musshoff F, Madea B. Fatal cytisine intoxication and analysis of biological samples with LC-MS/MS. Forensic Sci Int. 2009;186(1-3):e1-4. doi: 10.1016/j.forsciint.2009.01.011. PubMed

    “In the early phases of severe laburnum poisoning, hypertension and tachycardia occur, along with constriction of peripheral blood vessels leading to coldness in the limbs. In the later, delayed phase, hypotension, bradycardia, and cardiac arrhythmias are seen.”

    Laburnum · Natural Medicines adverse-effect record, reported in arrhythmia.

    2 sources cited
    1. 101220. Bramley A, Goulding R. Laburnum "poisoning". Br Med J (Clin Res Ed). 1981;283(6301):1220-1.
    2. 101221. Schep LJ, Slaughter RJ, Beasley DMG. Nicotinic plant poisoning. Clin Toxicol (Phila). 2009;47(8):771-81. doi: 10.1080/15563650903252186. PubMed
  • An irregular heartbeat Worth acting on Additional detail

    Recorded for Laburnum in the same Natural Medicines adverse-effect record shown under A slow heartbeat / Raised blood pressure above.

  • Shortness of breath Worth acting on Additional detail

    “Severe laburnum poisoning can lead to tachypnea, then dyspnea, respiratory failure, and death.”

    Laburnum · Natural Medicines adverse-effect record, reported in poisoning.

    3 sources cited
    1. 101220. Bramley A, Goulding R. Laburnum "poisoning". Br Med J (Clin Res Ed). 1981;283(6301):1220-1.
    2. 101221. Schep LJ, Slaughter RJ, Beasley DMG. Nicotinic plant poisoning. Clin Toxicol (Phila). 2009;47(8):771-81. doi: 10.1080/15563650903252186. PubMed
    3. 101222. Musshoff F, Madea B. Fatal cytisine intoxication and analysis of biological samples with LC-MS/MS. Forensic Sci Int. 2009;186(1-3):e1-4. doi: 10.1016/j.forsciint.2009.01.011. PubMed
  • Sweating Additional detail

    “Laburnum poisoning is associated with excessive sweating and clammy skin.”

    Laburnum · Natural Medicines adverse-effect record, reported in poisoning.

    2 sources cited
    1. 101221. Schep LJ, Slaughter RJ, Beasley DMG. Nicotinic plant poisoning. Clin Toxicol (Phila). 2009;47(8):771-81. doi: 10.1080/15563650903252186. PubMed
    2. 101222. Musshoff F, Madea B. Fatal cytisine intoxication and analysis of biological samples with LC-MS/MS. Forensic Sci Int. 2009;186(1-3):e1-4. doi: 10.1016/j.forsciint.2009.01.011. PubMed
  • A fast or pounding heartbeat / Low blood pressure Additional detail

    Recorded for Laburnum in the same Natural Medicines adverse-effect record shown under A slow heartbeat / Raised blood pressure above.

Showing the 10 most notable of 17 recorded effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

Everything above comes from the Natural Medicines adverse-effect record for Laburnum — expand a row for the licensed statement it rests on. We haven’t matched Bumetanide to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Bumetanide.

Special populations

Laburnum in Pregnancy & Breastfeeding

Pregnancy And Lactation Unsafe

When used orally. All parts of the plant contain toxic alkaloids that are reported to cross the placenta and enter breast milk.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Laburnum or Bumetanide

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Laburnum or Bumetanide, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Bumetanide

This page covers Laburnum only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Bumetanide page lists 218 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Lithium (major) and Oleander (major).

By severity: 7 major · 187 moderate · 24 minor.

From our pharmacist’s overview on the Bumetanide page

“Bumetanide (Burinex) is a potent loop diuretic, a water pill that pulls off fluid quickly and takes potassium with it, so I treat its interaction list as one of the serious ones. Seven of the 218 ingredients on file carry a major rating, and those belong at the top of your reading.”

Reviewed by 2 · Jul 18, 2026

Open the Bumetanide interaction page

One more smart check

Taking Laburnum as Part of a Dietary Supplement Product? Check It for Interactions

We hold 11 real supplement products containing Laburnum, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Laburnum. Even though Laburnum itself has no known interaction with Bumetanide, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Laburnum and Bumetanide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Laburnum
Steady interest

#1,266 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Bumetanide
Top 25%

#528 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Laburnum reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Laburnum and Bumetanide records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Laburnum

What is Laburnum?

  • Historically explored as a smoking-cessation aid (due to cytisine content)
  • Traditional folk use as a purgative or emetic
  • Ornamental garden plant
  • Source of the alkaloid cytisine

Laburnum is a poisonous ornamental tree, not a safe dietary supplement. All parts of the plant—especially the seeds—contain the toxic alkaloid cytisine and can cause serious poisoning. Do not eat or take any part of the Laburnum plant; consult a doctor or poison control immediately if ingestion is suspected.

Laburnum anagyroides · Fabaceae · Seeds, flowers, bark, and other plant parts (all considered toxic) · Not used as a commercial supplement; the plant is grown as an ornamental tree

An interaction check asks whether these two react with each other — it does not ask whether Laburnum is a good idea for someone in your situation. Here is what our Laburnum record says about it on its own.

Laburnum: dosing

There is no safe or established dose of Laburnum. It is not a dietary supplement, and no amount of the raw plant is considered safe to consume.Any information you may see about cytisine doses refers to purified, prescription-type products used under medical supervision in certain countries—not to the Laburnum plant. Do not attempt to make or take anything from this tree.

From our Laburnum monograph — the full record covers uses, side effects and every documented interaction.

Read the full Laburnum monograph & all interactions
Medication

About Bumetanide

What Is Bumetanide Used For?

Brand name: Burinex

Bumetanide treats edema — excess fluid that builds up in the body — caused by congestive heart failure, hepatic (liver) disease, and renal (kidney) disease, including a condition called nephrotic syndrome. This applies to the oral tablets (bumetanide and Bumex), the injection (Bumetanide Injection), and the nasal spray.

Enbumyst (bumetanide nasal spray) is specifically approved for these same uses in adults. Enbumyst is not intended for long-term use and should be switched to an oral diuretic as soon as practical.

Most-Reported Side Effects for Bumetanide

From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Dyspnea 2,650 reports
Fatigue 1,734 reports
Acute kidney injury 1,692 reports
Diarrhea 1,577 reports
Nausea 1,545 reports
See full Bumetanide drug information
Keep checking

Other Drugs & Laburnum

Browse every other medication we’ve checked against Laburnum — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
No interaction 2,829 drugs checked — show the list
Evidence & sources

Laburnum References

The 4 references that drive our Laburnum monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Bramley A, Goulding R. Laburnum "poisoning". Br Med J (Clin Res Ed). 1981;283(6301):1220-1.
  3. Schep LJ, Slaughter RJ, Beasley DMG. Nicotinic plant poisoning. Clin Toxicol (Phila). 2009;47(8):771-81. doi: 10.1080/15563650903252186. PubMed
  4. Musshoff F, Madea B. Fatal cytisine intoxication and analysis of biological samples with LC-MS/MS. Forensic Sci Int. 2009;186(1-3):e1-4. doi: 10.1016/j.forsciint.2009.01.011. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Laburnum and Bumetanide Together: Common Questions

Is it safe to take Laburnum with Bumetanide?
We do not list a known interaction between Laburnum and Bumetanide. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Bumetanide interact with any supplements?
Yes. Bumetanide has documented interactions with 218 supplements in our database — Laburnum is not one of them. The Bumetanide interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Bumetanide and Laburnum?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.