Laburnum Drug Interactions, Uses, Safety & More
What is this page for?
First and foremost: how Laburnum interacts with medications. The heart of this page is the interaction list — every drug Laburnum is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what Laburnum is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
Check Laburnum against your medication
Add one medicationDrugs that interact with Laburnum
0 medications have a known interaction with Laburnum, graded by severity. Select any drug for the full evidence-based detail.
We don’t currently list any known drug interactions for Laburnum. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.
What Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact Laburnum combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Laburnum: Uses, Safety & Side Effects
Laburnum is a poisonous ornamental tree, not a safe dietary supplement. All parts of the plant—especially the seeds—contain the toxic alkaloid cytisine and can cause serious poisoning. Do not eat or take any part of the Laburnum plant; consult a doctor or poison control immediately if ingestion is suspected.
- Scientific name
- Laburnum anagyroides
- Family
- Fabaceae
- Part used
- Seeds, flowers, bark, and other plant parts (all considered toxic)
- Common forms
- Not used as a commercial supplement; the plant is grown as an ornamental tree
- Historically explored as a smoking-cessation aid (due to cytisine content)
- Traditional folk use as a purgative or emetic
- Ornamental garden plant
- Source of the alkaloid cytisine
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
All parts of the plant are poisonous and ingestion can cause severe toxicity.
When used orally. All parts of the plant contain toxic alkaloids that are reported to cross the placenta and enter breast milk.
Read the full pregnancy detailWhen used orally. All parts of the plant contain toxic alkaloids that are reported to cross the placenta and enter breast milk.
Read the full breastfeeding detailPregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
Laburnum, often called the "golden chain" tree, is a small ornamental tree in the pea family (Fabaceae). It is native to parts of Europe and is widely planted in gardens for its showy, hanging clusters of bright yellow flowers.
Despite its beauty, Laburnum is well known to be poisonous. All parts of the plant—seeds, pods, flowers, bark, and leaves—contain toxic compounds. The seeds, which look like small peas, are the most dangerous and have caused accidental poisonings, especially in curious children.
Laburnum is not sold or used as a dietary supplement. Its main connection to health products is that it contains cytisine, an alkaloid that has been studied separately in carefully controlled, purified pharmaceutical forms for helping people quit smoking. The raw plant itself should never be consumed.
Uses & effectiveness
There is no evidence supporting the safe use of Laburnum plant material as a supplement or remedy. In traditional folk practice it was sometimes used as a strong purgative or to cause vomiting, but these effects come from its toxicity, not from any proven benefit.
The plant contains cytisine, and purified cytisine (a separate, regulated medicine in some countries) has been studied as a stop-smoking aid. However, this research applies to controlled pharmaceutical preparations—not to eating or brewing the Laburnum plant, which is dangerous and unpredictable.
In short, there are no reliable human studies showing any safe, effective use for the Laburnum plant itself.
How it works
Laburnum's main active compound is cytisine, an alkaloid that is chemically similar to nicotine. Cytisine acts on the same receptors in the brain that nicotine does (nicotinic acetylcholine receptors). This is why purified cytisine has been explored to help reduce cravings in people quitting smoking.
The same receptor activity is also responsible for the plant's toxicity. In larger amounts, cytisine overstimulates these receptors, leading to nausea, vomiting, rapid heartbeat, and—in severe cases—seizures and breathing problems.
Most of what is known about cytisine comes from laboratory studies and from research on purified, dose-controlled preparations, not from the raw plant.
Safety & precautions
Laburnum is a poisonous plant. The seeds are especially toxic, and even a small number eaten by a child can cause serious illness. Keep the tree and its fallen pods away from children and pets.
No part of Laburnum should be eaten, chewed, brewed into tea, or used to make a home remedy. If someone swallows any part of the plant, seek emergency medical care or contact a poison control center right away.
Pregnancy and breastfeeding: Laburnum should be strictly avoided. It is a toxic plant and there is no safe amount during pregnancy or while breastfeeding.
People with heart conditions, seizure disorders, or any health problem are at particular risk from poisoning and should never come into contact with the plant in any consumable form.
Side effects
Because Laburnum is toxic, "side effects" really mean signs of poisoning. These can begin within an hour of ingestion and include:
- Nausea, vomiting, and stomach pain
- Drowsiness, dizziness, or confusion
- Sweating and increased saliva
- Rapid or irregular heartbeat
- Headache
In more serious poisonings, people may experience seizures, muscle twitching, low blood pressure, difficulty breathing, and loss of consciousness. Severe poisoning can be life-threatening. Always treat suspected Laburnum ingestion as a medical emergency.
Laburnum: Reported Adverse Effects
Documented safety reports on Laburnum from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.
Orally, the fatal adult dose of laburnum is estimated to be about 15-20 seeds or 3-4 unripe berries. Many cases of poisoning involve children who ingest small quantities of seeds and experience primarily gastrointestinal symptoms, with a relatively rapid recovery. Symptoms of more severe laburnum poisoning include nausea and vomiting, diarrhea, dizziness, excessive salivation, and pain in the mouth, throat, and stomach. This can be accompanied by sweating, headaches, hypertension, tachycardia, tremors, weakness, and incoordination. After ingestion of high doses, a later, delayed phase of poisoning can cause hypotension, bradycardia, dyspnea, coma, respiratory failure, and death.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Bramley A, Goulding R. Laburnum "poisoning". Br Med J (Clin Res Ed). 1981;283(6301):1220-1.
- Schep LJ, Slaughter RJ, Beasley DMG. Nicotinic plant poisoning. Clin Toxicol (Phila). 2009;47(8):771-81. doi: 10.1080/15563650903252186.
- Musshoff F, Madea B. Fatal cytisine intoxication and analysis of biological samples with LC-MS/MS. Forensic Sci Int. 2009;186(1-3):e1-4. doi: 10.1016/j.forsciint.2009.01.011.
Arrhythmia Cardiovascular
In the early phases of severe laburnum poisoning, hypertension and tachycardia occur, along with constriction of peripheral blood vessels leading to coldness in the limbs. In the later, delayed phase, hypotension, bradycardia, and cardiac arrhythmias are seen.
Cluster headache Neurologic/CNS
Symptoms of laburnum poisoning include headache, dizziness, weakness, drowsiness, incoordination, ataxia, tremors, confusion, delirium, coma, and seizures.
Diarrhea Gastrointestinal
The most common symptoms of laburnum poisoning include mouth, throat, and stomach pain, and nausea and vomiting. In more severe cases there is excessive salivation, and diarrhea.
- Bramley A, Goulding R. Laburnum "poisoning". Br Med J (Clin Res Ed). 1981;283(6301):1220-1.
- Schep LJ, Slaughter RJ, Beasley DMG. Nicotinic plant poisoning. Clin Toxicol (Phila). 2009;47(8):771-81. doi: 10.1080/15563650903252186.
- Musshoff F, Madea B. Fatal cytisine intoxication and analysis of biological samples with LC-MS/MS. Forensic Sci Int. 2009;186(1-3):e1-4. doi: 10.1016/j.forsciint.2009.01.011.
Poisoning Pulmonary/Respiratory
Severe laburnum poisoning can lead to tachypnea, then dyspnea, respiratory failure, and death.
- Bramley A, Goulding R. Laburnum "poisoning". Br Med J (Clin Res Ed). 1981;283(6301):1220-1.
- Schep LJ, Slaughter RJ, Beasley DMG. Nicotinic plant poisoning. Clin Toxicol (Phila). 2009;47(8):771-81. doi: 10.1080/15563650903252186.
- Musshoff F, Madea B. Fatal cytisine intoxication and analysis of biological samples with LC-MS/MS. Forensic Sci Int. 2009;186(1-3):e1-4. doi: 10.1016/j.forsciint.2009.01.011.
Poisoning Ocular/Otic
Laburnum poisoning can result in dilation of the pupils. It can also cause other visual and hearing disturbances.
- Bramley A, Goulding R. Laburnum "poisoning". Br Med J (Clin Res Ed). 1981;283(6301):1220-1.
- Musshoff F, Madea B. Fatal cytisine intoxication and analysis of biological samples with LC-MS/MS. Forensic Sci Int. 2009;186(1-3):e1-4. doi: 10.1016/j.forsciint.2009.01.011.
- Schep LJ, Slaughter RJ, Beasley DMG. Nicotinic plant poisoning. Clin Toxicol (Phila). 2009;47(8):771-81. doi: 10.1080/15563650903252186.
Poisoning Dermatologic
Laburnum poisoning is associated with excessive sweating and clammy skin.
- Schep LJ, Slaughter RJ, Beasley DMG. Nicotinic plant poisoning. Clin Toxicol (Phila). 2009;47(8):771-81. doi: 10.1080/15563650903252186.
- Musshoff F, Madea B. Fatal cytisine intoxication and analysis of biological samples with LC-MS/MS. Forensic Sci Int. 2009;186(1-3):e1-4. doi: 10.1016/j.forsciint.2009.01.011.
Adverse-effects data: Natural Medicines, Therapeutic Research Center
Dosing
There is no safe or established dose of Laburnum. It is not a dietary supplement, and no amount of the raw plant is considered safe to consume.
Any information you may see about cytisine doses refers to purified, prescription-type products used under medical supervision in certain countries—not to the Laburnum plant. Do not attempt to make or take anything from this tree. If you are interested in cytisine for quitting smoking, talk to a pharmacist or doctor about approved options.
Laburnum & Pregnancy
Laburnum & Breastfeeding
© 2026 Therapeutic Research Center
Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center
References & further reading
The 4 references that drive our Laburnum monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Bramley A, Goulding R. Laburnum "poisoning". Br Med J (Clin Res Ed). 1981;283(6301):1220-1.
- Schep LJ, Slaughter RJ, Beasley DMG. Nicotinic plant poisoning. Clin Toxicol (Phila). 2009;47(8):771-81. doi: 10.1080/15563650903252186. PubMed
- Musshoff F, Madea B. Fatal cytisine intoxication and analysis of biological samples with LC-MS/MS. Forensic Sci Int. 2009;186(1-3):e1-4. doi: 10.1016/j.forsciint.2009.01.011. PubMed
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Brands that make products with Laburnum
2 brands in our database make a supplement containing Laburnum.
Supplement products with Laburnum
11 products in our database contain Laburnum. Open any to see its full ingredient list and every drug interaction we check.
Laburnum: Common Questions
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Products that contain Laburnum
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