Herb & supplement monograph

Mugwort Drug Interactions, Uses, Effectiveness, Safety & More

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Interaction report

Drugs that interact with Mugwort

0 medications have a known interaction with Mugwort, graded by severity. Select any drug for the full evidence-based detail.

We don’t currently list any known drug interactions for Mugwort. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Mugwort combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Monograph

Mugwort: Uses, Safety & Side Effects

The bottom line

Mugwort is a traditional herb used for digestion, menstrual issues, and sleep, but there is very little high-quality human research to confirm these uses. It is closely related to ragweed and can trigger allergic reactions, and it should be avoided in pregnancy. Talk with your pharmacist or doctor before using it.

Mugwort
Scientific name
Artemisia vulgaris
Family
Asteraceae
Part used
Leaves, flowering tops, and root; sometimes essential oil
Common forms
Tea, capsules, tincture, dried herb, essential oil, and moxa (used in moxibustion)
People commonly use it for
  • Digestive upset and poor appetite
  • Menstrual discomfort
  • Sleep support and vivid dreaming
  • Used in moxibustion (traditional Chinese medicine)
  • Mild anxiety or relaxation

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

May cause allergic reactions, especially in people sensitive to ragweed and related plants.

PregnancyLikely Unsafe

When used orally. Mugwort is said to be an abortifacient and a menstrual and uterine stimulant.

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

Mugwort (Artemisia vulgaris) is a tall, aromatic perennial plant in the daisy family. It is native to Europe and Asia and now grows in many parts of North America, often as a roadside weed.

People have used mugwort for centuries in traditional European, Asian, and folk medicine. The leaves and flowering tops are dried for teas, tinctures, and capsules. In traditional Chinese medicine, dried mugwort is also burned near the skin in a practice called moxibustion.

Today it is sold as a dietary supplement and herbal tea, and people use it mainly for digestion, menstrual symptoms, and sleep. It also has a long history in spiritual and cultural traditions.

How it works

Mugwort contains a mix of plant compounds, including volatile oils (such as cineole and thujone), flavonoids, and bitter substances called sesquiterpene lactones.

The bitter compounds are thought to stimulate digestive juices, which is the traditional reason it is used for the stomach. Its essential oils may have mild effects on muscles, which could explain its folk use for menstrual symptoms.

Most of these ideas come from laboratory or animal research, not from well-designed human trials. So while these mechanisms are plausible, they do not prove that mugwort works or is safe in people.

Effectiveness

Does Mugwort work?

Evidence overview · 8 uses evaluated
8 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.

For Mugwort, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 8 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Anxiety
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral mugwort root for anxiety, there is insufficient reliable information about the clinical effects of mugwort for this purpose.

Insufficient Reliable Evidence To Rate Colic
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral mugwort for colic, there is insufficient reliable information about the clinical effects of mugwort for this purpose.

Insufficient Reliable Evidence To Rate Dysmenorrhea
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral mugwort for dysmenorrhea, there is insufficient reliable information about the clinical effects of mugwort for this purpose.

Insufficient Reliable Evidence To Rate Epilepsy
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral mugwort for epilepsy, there is insufficient reliable information about the clinical effects of mugwort for this purpose.

Insufficient Reliable Evidence To Rate Hypertension
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral mugwort for hypertension, there is insufficient reliable information about the clinical effects of mugwort for this purpose.

Insufficient Reliable Evidence To Rate Hypertrophic scars
Rating & evidence shown verbatim from Natural Medicines

Topical mugwort has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Insomnia
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral mugwort root for insomnia, there is insufficient reliable information about the clinical effects of mugwort for this purpose.

Insufficient Reliable Evidence To Rate Intestinal parasite infection
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral mugwort for intestinal parasite infections, there is insufficient reliable information about the clinical effects of mugwort for this purpose.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

Mugwort is part of the same plant family as ragweed, daisies, marigolds, and chrysanthemums. People allergic to these plants may react to mugwort. It is also a well-known cause of pollen allergy and can be linked to food allergies (sometimes called "celery-mugwort-spice syndrome").

Mugwort essential oil contains thujone, which can be toxic in large amounts. Concentrated oils should not be taken by mouth.

Pregnancy: Avoid mugwort. It has traditionally been used to bring on menstruation and may stimulate the uterus, which could be harmful during pregnancy.

Breastfeeding: Avoid mugwort because there is not enough safety information.

People with allergies, asthma, or who are taking other medicines should check with a pharmacist or doctor before using it.

Side effects

For many people, small amounts of mugwort tea cause few problems, but reactions can occur.

Possible side effects include:

  • Allergic reactions such as skin rash, itching, sneezing, or runny nose
  • Contact dermatitis (skin irritation) from handling the plant
  • Stomach upset

Rarely, mugwort can trigger serious allergic reactions, including severe breathing problems (anaphylaxis), especially in people with plant or pollen allergies. Stop using it and seek medical care if you have trouble breathing, swelling, or hives. Large doses of products containing thujone may be harmful.

Mugwort: Reported Adverse Effects

Documented safety reports on Mugwort from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Reports by condition
Allergic rhinitis (hay fever) Immunologic
Poisoning Psychiatric

Orally, mania has been reported in a 49-year-old male following the intake of 1 liter of an infusion thought to contain mugwort. The presence of thujone in the patient's serum and urine was confirmed, and thujone poisoning was considered to be the cause of these symptoms. Although thujone levels are normally low in mugwort, concentrations can be variable. It was postulated that the mugwort infusion contained an unusually high amount of thujone. It was also considered to be possible that the metabolism of thujone was decreased in this particular patient or that the poisoning was related to the chronic intake of small amounts. However, a sample of the plant was not analyzed, and adulteration or contamination by a related species cannot be ruled out.

  1. Di Lorenzo C, Ferretti F, Moro E, et al. Identification and quantification of thujone in a case of poisoning due to repeated ingestion of an infusion of Artemisia vulgaris L. J Food Sci. 2018;83(8):2257-2264.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no well-established, standardized dose for mugwort. The amount in teas, capsules, and tinctures varies a lot between products.

If you choose to use mugwort, follow the directions on the product label and do not exceed them. Avoid swallowing the concentrated essential oil. Because doses are not standardized and quality can vary, it is wise to talk with a pharmacist or doctor first, especially if you have allergies or take other medicines.

Pregnancy & Breastfeeding

Mugwort & Pregnancy

Likely Unsafe

When used orally. Mugwort is said to be an abortifacient and a menstrual and uterine stimulant.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.

Mugwort & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 7 references that drive our Mugwort monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Borghesan F, Mistrello G, Amato S, Giuffrida MG, Villalta D, Asero R. Mugwort-fennel-allergy-syndrome associated with sensitization to an allergen homologous to Api g 5. Eur Ann Allergy Clin Immunol. 2013;45(4):130-7.
  4. Kim SH, Lee SM, Park HW, et al. Chinese bellflower root anaphylaxis: IgE-binding components and cross-reactivity with mugwort and birch. Korean J Intern Med. 2009;24(3):279-82. PubMed
  5. Silva R, Lopes C, Castro E, et al. Anaphylaxis to mango fruit and crossreactivity with Artemisia vulgaris pollen. J Investig Allergol Clin Immunol. 2009;19(5):420-2.
  6. Rodrigues-Alves R, Pregal A, Pereira-Santos MC, et al. Anaphylaxis to pine nut: cross-reactivity to Artemisia vulgaris? Allergol Immunopathol (Madr). 2008;36(2):113-6. PubMed
  7. Di Lorenzo C, Ferretti F, Moro E, et al. Identification and quantification of thujone in a case of poisoning due to repeated ingestion of an infusion of Artemisia vulgaris L. J Food Sci. 2018;83(8):2257-2264.
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Product directory

Supplement products with Mugwort

88 products in our database contain Mugwort. Open any to see its full ingredient list and every drug interaction we check.

Ai Ye by Herbal Terra Liquid 4 Fluid Ounce(s) · 120 mL View ingredients & interactions Ai Ye by Hawaii Pharm Liquid 4 Fluid Ounce(s) · 120 mL View ingredients & interactions Ai Ye by Herbal Terra Liquid 4 Fluid Ounce(s) · 120 mL View ingredients & interactions Ai Ye Non-Alcohol by Hawaii Pharm Liquid 4 Fluid Ounce(s) · 120 mL View ingredients & interactions Angelica Rasayana - 7 by Ayurvedic Rasayanas Other (e.g. Tea Bag) 10.7 Ounce(s) · 300 Gram(s) View ingredients & interactions Artemisia Combination by Nature's Sunshine Capsule 100 Capsule(s) View ingredients & interactions Artemisia Combination (Mugwort / Wormwood) Powder by TerraVita Powder 1 oz. View ingredients & interactions Artemisia Combination (Mugwort and Wormwood) 450 mg by TerraVita Premium Collection Capsule 100 Capsule(s) View ingredients & interactions Artemisia Combination (Mugwort and Wormwood) Powder by TerraVita Premium Collection Powder 1 Ounce(s) View ingredients & interactions Artemisia Combination (Mugwort and Wormwood) Powder by TerraVita Premium Collection Powder 4 Ounce(s) View ingredients & interactions Avena Sativa by Nestmann Liquid 1.69 fl. Oz. · 50 mL View ingredients & interactions Avena Sativa by Nestmann Liquid 3.38 fl. Oz. · 100 mL View ingredients & interactions Cellular Support by Wise Woman Herbals Liquid 2 Fluid Ounce(s) · 60 mL View ingredients & interactions Cholesterol Support by Signature Supplements Capsule 100 Capsule(s) View ingredients & interactions Dream Trap by Hawaii Pharm Liquid 4 Fluid Ounce(s) · 120 mL View ingredients & interactions Dream Trap Non-Alcohol by Hawaii Pharm Liquid 4 Fluid Ounce(s) · 120 mL View ingredients & interactions Guduchi Rasayana 25 by Ayurvedic Rasayanas Other (e.g. Tea Bag) 10.7 Ounce(s) · 300 Gram(s) View ingredients & interactions Happy Mood Enhancer by New Sun Capsule 100 Capsule(s) View ingredients & interactions Herbal Alkalizer by MBi Nutraceuticals Capsule 100 Capsule(s) View ingredients & interactions Joy Tonic by Urban Moonshine Liquid 1 fl. Oz. · 30 mL View ingredients & interactions Joy Tonic by Urban Moonshine Liquid 8.4 fl. Oz. · 250 mL View ingredients & interactions Joy Tonic by Urban Moonshine Liquid 4.2 fl. Oz. · 125 mL View ingredients & interactions Joy Tonic by Urban Moonshine Liquid 2 fl. Oz. · 59 mL View ingredients & interactions Liver Decongestant by Mountain Meadow Herbs Liquid 4 fl. Oz. · 120 mL View ingredients & interactions
Pharmacist Counseling Corner

Mugwort: Common Questions

What is Mugwort used for, and does it work?
People use Mugwort for a range of reasons, but according to the Natural Medicines database the current clinical evidence is insufficient to confirm it works for the specific conditions it has been studied for. See the graded list on this page, and talk to your pharmacist or doctor before relying on it for any condition.
Does Mugwort interact with prescription medications?
We do not currently list any known drug interactions for Mugwort. This does not guarantee that none exist, so always confirm with your pharmacist before combining it with your medications.
How are Mugwort interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Mugwort with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Mugwort interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Mugwort used for?
It is traditionally used for digestive upset, menstrual discomfort, and sleep, and it is burned in a practice called moxibustion. However, strong scientific evidence supporting these uses is lacking.
Is Mugwort safe to take?
Small amounts in tea are often tolerated, but Mugwort can cause allergic reactions, especially in people sensitive to ragweed and related plants. Check with a pharmacist or doctor before using it.
Can I use Mugwort while pregnant or breastfeeding?
No. Mugwort has traditionally been used to stimulate menstruation and may affect the uterus, so it should be avoided during pregnancy and while breastfeeding.
Does Mugwort cause vivid dreams?
Some people use it hoping for more vivid dreams, but this is based on folklore rather than reliable scientific evidence.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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