Interactions on record — worth a quick check against your medications. Based on 5 of 6 ingredients. Check your meds →
Dietary supplement

Joy Tonic Ingredients & Drug Interactions

by Urban Moonshine

Liquid Category: Botanical
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Joy Tonic is a dietary supplement by Urban Moonshine with 6 active ingredients. Its ingredients are commonly taken for anxiety and stress, heart palpitations, menstrual discomfort.Based on those ingredients, 859 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are org. Lemongrass extract, org. Lemon Balm leaf extract, organic Motherwort leaf and flower extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Joy Tonic by Urban Moonshine

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 6 active ingredients.
  • “Proprietary Herbal Blend” is a proprietary blend — the label gives one combined amount (5 mL) without saying how much of each component you get.

Joy Tonic contains six active ingredients: rose petal extract, motherwort leaf and flower extract, linden leaf and flower extract, lemon balm leaf extract, lemongrass extract, and mugwort leaf extract. These are delivered in a liquid form with water and organic alcohol as inactive ingredients.

The product is formulated as a proprietary herbal blend, so the exact proportions of each herb aren't listed on the label — you'll see them grouped together. Each of the named botanicals has its own traditional use: motherwort and mugwort have been used historically for women's health, lemon balm and linden for calming, and lemongrass for digestive and general wellness support.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Stress support and occasional anxiety relief.
  • We looked for evidence on: Anxiety, Stress, Nervousness, Restlessness.
  • The strongest evidence on file: Lemon Balm is rated "Possibly Effective" for Stress (Natural Medicines).
  • Also on file: Mugwort is rated "Insufficient Reliable Evidence To Rate" for Anxiety.
  • Also on file: Motherwort is rated "Insufficient Reliable Evidence To Rate" for Anxiety.

The evidence for Joy Tonic's ingredients is mixed. Lemon balm is possibly effective for cold sores, stress, and depression — that's the strongest rating we have for any single ingredient here.

Motherwort is possibly effective for bleeding support. For the other uses these herbs are traditionally marketed for — anxiety, sleep, menstrual regularity — the evidence we hold is insufficient to rate them reliably.

Linden, lemongrass, and mugwort all lack established effectiveness ratings in our data for the conditions they're commonly used for.

The evidence, ingredient by ingredient Motherwort Linden Lemon Balm Lemongrass Mugwort

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most of these herbs are generally well tolerated for short-term use in healthy adults, but the safety data overall are limited, especially for long-term or high-dose use. Motherwort may cause diarrhea or stomach irritation orally; at doses over 3 grams it can cause uterine bleeding.

Linden has one case report of an allergic reaction to its pollen. Lemon balm can occasionally cause dizziness or sedation, though trials suggest this doesn't happen more often than with placebo.

Lemongrass should be used cautiously in concentrated or medicinal amounts. Mugwort may trigger allergic reactions, especially if you're sensitive to ragweed.

For pregnancy: motherwort, lemongrass, and mugwort are all traditionally thought to stimulate the uterus and are rated likely unsafe in pregnancy — avoid them. Lemon balm and linden lack enough safety data in pregnancy; talk to your doctor before use if you're pregnant.

Breastfeeding safety data for these herbs are also limited; check with your pharmacist or doctor before using while nursing.

Side effects, ingredient by ingredient Motherwort Linden Lemon Balm Lemongrass Mugwort

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 5 matched ingredients can interact with medications — Motherwort, Lemon Balm, Linden, Lemongrass.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: lithium.
  • For scale: 860 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Joy Tonic, double-check these medication types with your pharmacist: central nervous system depressants (sleeping pills, anxiety meds, narcotic pain relievers) — Motherwort and Lemon Balm both carry Moderate risk. Thyroid hormone replacement like levothyroxine (Moderate risk from Lemon Balm).

Lithium for bipolar disorder (Moderate risk from Linden). CYP3A4 substrate medications, which include many statins, blood pressure drugs, and immunosuppressants (Moderate risk from Lemongrass).

Glucuronidated drugs like certain pain relievers and psychiatric medications (Moderate risk from Lemongrass). Pentobarbital or other barbiturate sedatives (Moderate risk from Lemongrass).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Joy Tonic is a six-herb liquid blend that's generally well tolerated for short-term use but comes with significant documented interactions — especially if you take sedatives, thyroid hormones, lithium, or certain heart and cholesterol medications. If you're pregnant, several of these herbs should be avoided.

Before you start, check your exact medications using the tool on this page, and talk to your pharmacist or doctor, especially if you take any prescription drugs.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Joy Tonic, straight from the product label.

Brand Urban Moonshine
Barcode (UPC) 851588002272
Net contents 1 fl. Oz.; 30 mL
Market status On market
Date entered into DSLD Sep 25, 2015
DSLD ID 50398
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Organic, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Joy Tonic by Urban Moonshine, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
5 mL
Maximum serving Sizes:
5 mL
Servings per container
6
UPC/BARCODE
851588002272
IngredientAmount% DV
Proprietary Herbal Blend5 mL--
org. Rose petal extract0 NP--
organic Motherwort leaf and flower extract0 NP--
org. Linden leaf and flower extract0 NP--
org. Lemon Balm leaf extract0 NP--
org. Lemongrass extract0 NP--
org. Mugwort leaf extract0 NP--

Other ingredients: Water, organic Alcohol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General

02

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General Statements

VOF Certified

Herbal Apothecary

Stress Support Fast-Acting for occasional anxiety

Calm, Peaceful, Inspired

Seals/Symbols

USDA ORGANIC

FDA Statement of Identity

Herbal Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: Enjoy 5ml (35 sprays) 1-3 times a day.

Formula

45-50% Alcohol.

Formulation

Gluten Free.

Precautions

Not to be used during pregnancy.

See for yourself

Joy Tonic by Urban Moonshine label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Joy Tonic by Urban Moonshine

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size5 mL Dosage formLiquid Servings per container6 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Other (inactive) ingredients: Water, Organic Alcohol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Joy Tonic by Urban Moonshine Drug Interactions

Want to check YOUR meds against Joy Tonic?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker

Each ingredient & the kinds of drugs it affects

For each ingredient in Joy Tonic with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

org. Lemongrass extract3 drug types · 708 drugs

Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, lemongrass might decrease the metabolism of CYP3A4 substrates.
Animal research shows that lemongrass and its constituent citral inhibit CYP3A4.

Likelihood Possible Evidence D
Glucuronidated Drugs

Theoretically, lemongrass might increase the clearance and decrease the levels of glucuronidated drugs.
Animal research shows that lemongrass and its constituent citral induce uridine diphosphoglucuronosyl transferase (UGT), the major phase 2 enzyme that is responsible for glucuronidation.

Likelihood Possible Evidence D
Pentobarbital (Nembutal)

Theoretically, lemongrass might increase the effects and adverse effects of pentobarbital.
Animal research shows that high doses of lemongrass essential oil increases sleep time and decreases time to fall asleep in animals administered pentobarbital.

Likelihood Possible Evidence D

org. Lemon Balm leaf extract2 drug types · 264 drugs

Cns Depressants

Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Lemon balm seems to have CNS depressant activity in animals and in humans.

Likelihood Possible Evidence B
Thyroid Hormone

Theoretically, lemon balm might interfere with thyroid hormone replacement therapy.
In vitro, constituents of lemon balm extract bind to thyroid stimulating hormone (TSH), preventing TSH receptor-binding and leading to the inhibition of TSH-stimulated adenylate cyclase activity. In animals, lemon balm extract has been shown to decrease levels of circulating TSH and inhibit thyroid secretion.

Likelihood Possible Evidence D

organic Motherwort leaf and flower extract1 drug type · 248 drugs

Cns Depressants

Theoretically, taking motherwort concomitantly with other CNS depressants may increase the risk of sedation.
Motherwort has been reported to cause CNS depression and sedation.

Likelihood Possible Evidence D

org. Linden leaf and flower extract1 drug type · 1 drug

Lithium

Theoretically, due to its potential diuretic effects, linden might increase the effects and adverse effects of lithium.
Linden is thought to have diuretic properties. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
The maker

Brand information

Manufacturer and brand details for Joy Tonic, from the product label.

Urban Moonshine

See all Urban Moonshine products
Name
Urban Moonshine
Street Address
255 S. Champlain St.
City
Burlington
State
VT
ZipCode
05401
Phone Number
802-428-4707
Web Address
urbanmoonshine.com
Pharmacist Counseling Corner

Joy Tonic by Urban Moonshine: Common Questions

Does Joy Tonic by Urban Moonshine interact with any medications?
Yes. Based on its ingredients, Joy Tonic has a known interaction with 859 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Joy Tonic contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Joy Tonic while I'm pregnant?
Three of the six ingredients — motherwort, lemongrass, and mugwort — are traditionally thought to stimulate the uterus and are rated likely unsafe in pregnancy, so you should avoid them. Lemon balm and linden don't have enough safety data during pregnancy; talk to your doctor or pharmacist for personalized advice before use.
Is it okay to use Joy Tonic while breastfeeding?
Safety information during breastfeeding is limited for these herbs. Lemon balm has limited safety info but caution is advised; check with your doctor before use. For the others — motherwort, linden, lemongrass, and mugwort — there isn't enough data on file. Talk to your pharmacist or doctor before using while nursing.
What's motherwort in this product for?
Motherwort has been traditionally used for women's health and bleeding support — and it's possibly effective for bleeding based on the evidence we hold. That said, human safety data are limited, and doses over 3 grams can cause uterine bleeding, so it's best used short-term and under guidance.
Does lemon balm actually help with stress?
Lemon balm is rated possibly effective for stress in the evidence we hold, and it's also possibly effective for cold sores and depression. It's generally well tolerated for short-term use, though high doses and long-term safety aren't well studied.
What side effects might I notice from Joy Tonic?
The most common reported side effects are diarrhea and stomach irritation from motherwort. Lemon balm can occasionally cause dizziness or sedation, though trials suggest these don't happen more often than placebo. Mugwort may trigger allergic reactions if you're sensitive to ragweed. Stop use and contact your pharmacist if you notice any unexpected reactions.
Why can't you check rose petal extract for interactions?
We don't hold safety data for rose petal extract, so we couldn't check it against medications. That doesn't mean it's unsafe — just that we have no monograph on file for it. If you have concerns, ask your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Joy Tonic label
Go deeper

The Full Monographs Behind Joy Tonic’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

Joy Tonic's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 29 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Motherwort 6 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  4. Wojtyniak K, Szymanski M, Matlawska I. Leonurus cardiaca L. (motherwort): a review of its phytochemistry and pharmacology. Phytother Res 2013;27(8):1115-20.
  5. Xia WT, Zhou H, Wang Y, et al. Motherwort injection in preventing post-abortion hemorrhage after induced abortion: A multi-center, prospective, randomized controlled trial. Explore (NY). 2019. pii: S1550-8307(19)30447-1. PubMed
  6. Cao Shan DOSOGC, Zhang W, Zhao Z, et al. Post-marketing safety surveillance and reevaluation of Motherwort injection: A clinical study of 10 094 cases. J Tradit Chin Med. 2018 Aug;38(4):625-635. DOI

See these in context on the Motherwort monograph →

Linden 2 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.

See these in context on the Linden monograph →

Lemon Balm 12 references
  1. Wolbling RH, Leonhardt K. Local therapy of herpes simplex with dried extract from Melissa officinalis. Phytomedicine 1994;1:25-31.
  2. Akhondzadeh S, Noroozian M, Mohammadi M, et al. Melissa officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease: a double blind, randomised, placebo controlled trial. J Neurol Neurosurg Psychiatry 2003;74:863-6. PubMed
  3. Kennedy DO, Scholey AB, Tildesley NT, et al. Modulation of mood and cognitive performance following acute administration of Melissa officinalis (lemon balm). Pharmacol Biochem Behav 2002;72:953-64. PubMed
  4. Albrecht M, Berger W, Laux P, Schmidt U, et al. Psychopharmaka und Verkehrssicherheit. Der Einfluß von Euvegal® - Dragees forte auf die Fahrtüchtigkeit und Kombinationswirkungen mit Alkohol Z Allg Med 1995;71:1215-25.
  5. Herberg, KW. Nebenwirkungen pflanzlicher Beruhigungsmittel/ Leistung und Befinden nach Einnahme einer Baldrian-Hopfen-Kombination. Z.Allg Med 1996;72:234-240.
  6. Soulimani R, Fleurentin J, Mortier F, et al. Neurotropic action of the hydroalcoholic extract of Melissa officinalis in the mouse. Planta Med. 1991 Apr;57:105-9.
  7. Sourgens H, Winterhoff H, Gumbinger HG, et al. Antihormonal effects of plant extracts. TSH- and prolactin-suppressing properties of Lithospermum officinale and other plants. Planta Med. 1982 Jun;45:78-86. DOI
  8. Auf'mkolk M, Ingbar JC, Amir SM, et al. Inhibition by certain plant extracts of the binding and adenylate cyclase stimulatory effect of bovine thyrotropin in human thyroid membranes. Endocrinology. 1984 Aug;115:527-34. PubMed
  9. Santini F, Vitti P, Ceccarini G, et al. In vitro assay of thyroid disruptors affecting TSH-stimulated adenylate cyclase activity. J Endocrinol Invest. 2003 Oct;26:950-5. PubMed
  10. Alijaniha F, et al. Heart palpitation relief with Melissa officinalis leaf extract: double blind, randomized, placebo controlled trial of efficacy and safety. J Ethnopharmacol. 2015;164:378-384. doi: 10.1016/j.jep.2015.02.007. Epub 2015 Feb 11. PubMed
  11. Araj-Khodaei M, Noorbala AA, Yarani R, et al. A double-blind, randomized pilot study for comparison of Melissa officinalis L. and Lavandula angustifolia Mill. with Fluoxetine for the treatment of depression. BMC Complement Med Ther. 2020;20(1):207. PubMed
  12. Kucuk U, Pham M, Raza Raja MH, Saad Shaukat MH, Clark R. Transient complete atrioventricular block associated with herbal supplement use. S D Med 2023;76(7):311-313.

See these in context on the Lemon Balm monograph →

Lemongrass 2 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Li CC, Yu HF, Chang CH, Liu YT, Yao HT. Effects of lemongrass oil and citral on hepatic drug-metabolizing enzymes, oxidative stress, and acetaminophen toxicity in rats. J Food Drug Anal 2018;26(1):432-8. PubMed

See these in context on the Lemongrass monograph →

Mugwort 7 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Borghesan F, Mistrello G, Amato S, Giuffrida MG, Villalta D, Asero R. Mugwort-fennel-allergy-syndrome associated with sensitization to an allergen homologous to Api g 5. Eur Ann Allergy Clin Immunol. 2013;45(4):130-7.
  4. Kim SH, Lee SM, Park HW, et al. Chinese bellflower root anaphylaxis: IgE-binding components and cross-reactivity with mugwort and birch. Korean J Intern Med. 2009;24(3):279-82. PubMed
  5. Silva R, Lopes C, Castro E, et al. Anaphylaxis to mango fruit and crossreactivity with Artemisia vulgaris pollen. J Investig Allergol Clin Immunol. 2009;19(5):420-2.
  6. Rodrigues-Alves R, Pregal A, Pereira-Santos MC, et al. Anaphylaxis to pine nut: cross-reactivity to Artemisia vulgaris? Allergol Immunopathol (Madr). 2008;36(2):113-6. PubMed
  7. Di Lorenzo C, Ferretti F, Moro E, et al. Identification and quantification of thujone in a case of poisoning due to repeated ingestion of an infusion of Artemisia vulgaris L. J Food Sci. 2018;83(8):2257-2264.

See these in context on the Mugwort monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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